| Trade Date | Insider | Insider Title | Security Type | Execution Date | Exercise Date | Expiration Date | Share Price | Quantity | Shares Owned | Shares Code | Transaction Code | Swap | Under SEC Title | Under Sec Shares | Nature of Ownership | SEC Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2020-02-05 | Group, Llc Redmile | Stock Option (Right to Buy) | 2030-02-05 | $0.00 | 10,000 | 10,000 | A | A | 0 | Common Stock | 10,000 | I | Form 4 | |||
| 2020-06-04 | Bruce Keyt | Stock Option (right to buy) | 2029-02-01 | $0.00 | 2,837 | 6,242 | D | M | 0 | Common Stock | 2,837 | I | Form 4 | |||
| 2020-06-04 | Bruce Keyt | Stock Option (right to buy) | 2030-02-05 | $0.00 | 150 | 2,250 | D | M | 0 | Common Stock | 150 | I | Form 4 | |||
| 2020-08-11 | Daniel Shinyu Chen | Stock Option (right to buy) | 2028-12-30 | $0.00 | 950 | 360,140 | D | M | 0 | Common Stock | 950 | D | Form 4 | |||
| 2020-09-01 | Daniel Shinyu Chen | Stock Option (right to buy) | 2028-12-30 | $0.00 | 950 | 359,190 | D | M | 0 | Common Stock | 950 | D | Form 4 | |||
| 2020-09-17 | Daniel Shinyu Chen | Stock Option (right to buy) | 2028-12-30 | $0.00 | 950 | 358,240 | D | M | 0 | Common Stock | 950 | D | Form 4 | |||
| 2020-10-01 | Daniel Shinyu Chen | Stock Option (right to buy) | 2028-12-30 | $0.00 | 2,850 | 355,390 | D | M | 0 | Common Stock | 2,850 | D | Form 4 | |||
| 2020-11-02 | Daniel Shinyu Chen | Stock Option (right to buy) | 2028-12-30 | $0.00 | 950 | 354,440 | D | M | 0 | Common Stock | 950 | D | Form 4 | |||
| 2020-12-01 | Daniel Shinyu Chen | Stock Option (right to buy) | 2028-12-30 | $0.00 | 950 | 353,490 | D | M | 0 | Common Stock | 950 | D | Form 4 | |||
| 2020-12-07 | Daniel Shinyu Chen | Stock Option (right to buy) | 2028-12-30 | $0.00 | 1,900 | 351,590 | D | M | 0 | Common Stock | 1,900 | D | Form 4 | |||
| 2020-12-11 | Baker Bros. Advisors Lp | Pre-funded Warrants | - | $89.99 | 49,820 | 49,820 | A | P | 0 | Common Stock | 49,820 | I | Form 4 | |||
| 2020-12-11 | Baker Bros. Advisors Lp | Pre-funded Warrants | - | $89.99 | 616,846 | 616,846 | A | P | 0 | Common Stock | 616,846 | I | Form 4 | |||
| 2020-12-16 | Bruce Keyt | Stock Option (right to buy) | 2025-03-10 | $0.00 | 2,500 | 27,764 | D | M | 0 | Common Stock | 2,500 | D | Form 4 | |||
| 2020-12-21 | Misbah Tahir | Stock Option (right to buy) | 2029-01-03 | $0.00 | 2,750 | 122,847 | D | M | 0 | Common Stock | 2,750 | D | Form 4 | |||
| 2021-01-04 | Daniel Shinyu Chen | Stock Option (right to buy) | 2028-12-30 | $0.00 | 1,900 | 349,690 | D | M | 0 | Common Stock | 1,900 | D | Form 4 | |||
| 2021-01-04 | Bruce Keyt | Stock Option (right to buy) | 2025-03-10 | $0.00 | 2,500 | 25,264 | D | M | 0 | Common Stock | 2,500 | D | Form 4 | |||
| 2021-01-27 | Baker Bros. Advisors Lp | Non-Qualified Stock Options (right to buy) | - | 2029-09-17 | 5,377 | 6,723 | D | M | 0 | Common Stock | 5,377 | I | Form 4 | |||
| 2021-01-27 | Baker Bros. Advisors Lp | Non-Qualified Stock Options (right to buy) | - | 2029-09-17 | 5,377 | 6,723 | D | M | 0 | Common Stock | 5,377 | I | Form 4 | |||
| 2021-01-27 | Baker Bros. Advisors Lp | Non-Qualified Stock Options (right to buy) | - | 2030-02-05 | 5,833 | 2,527 | D | M | 0 | Common Stock | 5,833 | I | Form 4 | |||
| 2021-01-27 | Baker Bros. Advisors Lp | Non-Qualified Stock Options (right to buy) | - | 2030-02-05 | 5,833 | 2,527 | D | M | 0 | Common Stock | 5,833 | I | Form 4 | |||
| 2021-02-02 | Daniel Shinyu Chen | Stock Option (right to buy) | 2028-12-30 | $0.00 | 1,900 | 347,790 | D | M | 0 | Common Stock | 1,900 | D | Form 4 | |||
| 2021-02-02 | Bruce Keyt | Stock Option (right to buy) | 2025-03-10 | $0.00 | 2,500 | 22,764 | D | M | 0 | Common Stock | 2,500 | D | Form 4 | |||
| 2021-02-19 | Baker Bros. Advisors Lp | Non-Qualified Stock Option (right to buy) | - | 2031-02-19 | $0.00 | 6,423 | 6,423 | A | A | 0 | Common Stock | 6,423 | I | Form 4 | ||
| 2021-02-19 | M Kathleen Behrens | Stock Option (right to buy) | 2031-02-19 | $0.00 | 6,423 | 6,423 | A | A | 0 | Common Stock | 6,423 | D | Form 4 | |||
| 2021-02-19 | Michael D Loberg | Stock Option (right to buy) | 2031-02-19 | $0.00 | 6,423 | 6,423 | A | A | 0 | Common Stock | 6,423 | D | Form 4 | |||
| 2021-02-19 | Group, Llc Redmile | Stock Option (Right to Buy) | 2031-02-19 | $0.00 | 6,423 | 6,423 | A | A | 0 | Common Stock | 6,423 | I | Form 4 | |||
| 2021-02-19 | Michael Stewart Lee | Stock Option (Right to Buy) | 2031-02-19 | $0.00 | 6,423 | 6,423 | A | A | 0 | Common Stock | 6,423 | D | Form 4 | |||
| 2021-02-19 | Daniel Shinyu Chen | Stock Option (right to buy) | 2031-02-19 | $0.00 | 40,000 | 40,000 | A | A | 0 | Common Stock | 40,000 | D | Form 4 | |||
| 2021-02-19 | Julie Hambleton | Stock Option (right to buy) | 2031-02-19 | $0.00 | 6,423 | 6,423 | A | A | 0 | Common Stock | 6,423 | D | Form 4 | |||
| 2021-02-19 | Bruce Keyt | Stock Option (right to buy) | 2031-02-19 | $0.00 | 50,000 | 50,000 | A | A | 0 | Common Stock | 50,000 | D | Form 4 | |||
| 2021-02-19 | Fred Schwarzer | Stock Option (right to buy) | 2031-02-19 | $0.00 | 125,000 | 125,000 | A | A | 0 | Common Stock | 125,000 | D | Form 4 | |||
| 2021-02-19 | William Strohl | Stock Option (right to buy) | 2031-02-19 | $0.00 | 6,423 | 6,423 | A | A | 0 | Common Stock | 6,423 | D | Form 4 | |||
| 2021-02-19 | Misbah Tahir | Stock Option (right to buy) | 2031-02-19 | $0.00 | 40,000 | 40,000 | A | A | 0 | Common Stock | 40,000 | D | Form 4 | |||
| 2021-02-19 | Christina Teng Topsoe | Stock Option (right to buy) | 2031-02-19 | $0.00 | 6,423 | 6,423 | A | A | 0 | Common Stock | 6,423 | D | Form 4 | |||
| 2021-02-19 | Jakob Haldor Topsoe | Stock Option (right to buy) | 2031-02-19 | $0.00 | 6,423 | 6,423 | A | A | 0 | Common Stock | 6,423 | D | Form 4 | |||
| 2021-03-01 | Daniel Shinyu Chen | Stock Option (right to buy) | 2028-12-30 | $0.00 | 1,900 | 345,890 | D | M | 0 | Common Stock | 1,900 | D | Form 4 | |||
| 2021-03-01 | Bruce Keyt | Stock Option (right to buy) | 2025-03-10 | $0.00 | 2,500 | 20,264 | D | M | 0 | Common Stock | 2,500 | D | Form 4 | |||
| 2021-03-05 | Misbah Tahir | Stock Option (right to buy) | 2029-01-03 | $0.00 | 2,750 | 120,097 | D | M | 0 | Common Stock | 2,750 | D | Form 4 | |||
| 2021-04-05 | Daniel Shinyu Chen | Stock Option (right to buy) | 2028-12-30 | $0.00 | 1,900 | 343,990 | D | M | 0 | Common Stock | 1,900 | D | Form 4 | |||
| 2021-04-05 | Bruce Keyt | Stock Option (right to buy) | 2025-03-10 | $0.00 | 2,500 | 17,764 | D | M | 0 | Common Stock | 2,500 | D | Form 4 | |||
| 2021-05-03 | Daniel Shinyu Chen | Stock Option (right to buy) | 2028-12-30 | $0.00 | 950 | 343,040 | D | M | 0 | Common Stock | 950 | D | Form 4 | |||
| 2021-05-03 | Bruce Keyt | Stock Option (right to buy) | 2025-03-10 | $0.00 | 2,500 | 15,264 | D | M | 0 | Common Stock | 2,500 | D | Form 4 | |||
| 2021-05-14 | Daniel Shinyu Chen | Stock Option (right to buy) | 2028-12-30 | $0.00 | 900 | 342,140 | D | M | 0 | Common Stock | 900 | D | Form 4 | |||
| 2021-06-01 | Daniel Shinyu Chen | Stock Option (right to buy) | 2028-12-30 | $0.00 | 1,900 | 340,240 | D | M | 0 | Common Stock | 1,900 | D | Form 4 | |||
| 2021-06-01 | Bruce Keyt | Stock Option (right to buy) | 2025-03-10 | $0.00 | 2,500 | 12,764 | D | M | 0 | Common Stock | 2,500 | D | Form 4 | |||
| 2021-07-01 | Daniel Shinyu Chen | Stock Option (right to buy) | 2028-12-30 | $0.00 | 1,900 | 338,340 | D | M | 0 | Common Stock | 1,900 | D | Form 4 | |||
| 2021-07-01 | Bruce Keyt | Stock Option (right to buy) | 2025-03-10 | $0.00 | 2,500 | 10,264 | D | M | 0 | Common Stock | 2,500 | D | Form 4 | |||
| 2021-07-30 | Chris H Takimoto | Stock Option (right to buy) | 2031-07-30 | $0.00 | 150,000 | 150,000 | A | A | 0 | Common Stock | 150,000 | D | Form 4 | |||
| 2021-08-02 | Bruce Keyt | Stock Option (right to buy) | 2025-03-10 | $0.00 | 2,500 | 7,764 | D | M | 0 | Common Stock | 2,500 | D | Form 4 | |||
| 2021-09-01 | Bruce Keyt | Stock Option (right to buy) | 2025-03-10 | $0.00 | 2,500 | 5,264 | D | M | 0 | Common Stock | 2,500 | D | Form 4 |
