| Trade Date | Insider | Insider Title | Security Type | Execution Date | Exercise Date | Expiration Date | Share Price | Quantity | Shares Owned | Shares Code | Transaction Code | Swap | Under SEC Title | Under Sec Shares | Nature of Ownership | SEC Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2020-07-28 | Third Rock Ventures Iii, L.p. | Series A-2 Preferred Stock | $0.00 | 875,000 | 0 | D | C | 0 | Common Stock | 875,000 | D | Form 4 | ||||
| 2020-07-28 | Third Rock Ventures Iii, L.p. | Series B Preferred Stock | $0.00 | 4,508,333 | 0 | D | C | 0 | Common Stock | 4,508,333 | D | Form 4 | ||||
| 2020-07-28 | Third Rock Ventures Iii, L.p. | Series D Preferred Stock | $0.00 | 39,216 | 0 | D | C | 0 | Common Stock | 39,216 | D | Form 4 | ||||
| 2020-07-28 | Column Group L P | Series A-1 Preferred Stock | $0.00 | 600,000 | 0 | D | C | 0 | Common Stock | 600,000 | D | Form 4 | ||||
| 2020-07-28 | Column Group L P | Series A-2 Preferred Stock | $0.00 | 875,000 | 0 | D | C | 0 | Common Stock | 875,000 | D | Form 4 | ||||
| 2020-07-28 | Column Group L P | Series B Preferred Stock | $0.00 | 1,836,000 | 0 | D | C | 0 | Common Stock | 1,836,000 | D | Form 4 | ||||
| 2020-07-28 | Column Group L P | Series B Preferred Stock | $0.00 | 1,989,000 | 0 | D | C | 0 | Common Stock | 1,989,000 | D | Form 4 | ||||
| 2020-07-28 | Column Group L P | Series D Preferred Stock | $0.00 | 686,274 | 0 | D | C | 0 | Common Stock | 686,274 | D | Form 4 | ||||
| 2020-07-28 | Column Group L P | Series D Preferred Stock | $0.00 | 686,274 | 0 | D | C | 0 | Common Stock | 686,274 | D | Form 4 | ||||
| 2020-07-28 | Column Group L P | Series A-1 Preferred Stock | $0.00 | 600,000 | 0 | D | C | 0 | Common Stock | 600,000 | D | Form 4 | ||||
| 2020-07-28 | Column Group L P | Series A-2 Preferred Stock | $0.00 | 875,000 | 0 | D | C | 0 | Common Stock | 875,000 | D | Form 4 | ||||
| 2020-07-28 | Column Group L P | Series B Preferred Stock | $0.00 | 1,836,000 | 0 | D | C | 0 | Common Stock | 1,836,000 | D | Form 4 | ||||
| 2020-07-28 | Column Group L P | Series B Preferred Stock | $0.00 | 1,989,000 | 0 | D | C | 0 | Common Stock | 1,989,000 | D | Form 4 | ||||
| 2020-07-28 | Column Group L P | Series D Preferred Stock | $0.00 | 686,274 | 0 | D | C | 0 | Common Stock | 686,274 | D | Form 4 | ||||
| 2020-07-28 | Column Group L P | Series D Preferred Stock | $0.00 | 686,274 | 0 | D | C | 0 | Common Stock | 686,274 | D | Form 4 | ||||
| 2020-07-28 | Robert Tjian | Series A-2 Preferred Stock | $0.00 | 41,666 | 0 | D | C | 0 | Common Stock | 41,666 | I | Form 4 | ||||
| 2020-07-28 | Robert Tjian | Series B Preferred Stock | $0.00 | 50,000 | 0 | D | C | 0 | Common Stock | 50,000 | I | Form 4 | ||||
| 2020-07-28 | Group, Llc Redmile | Series D Redeemable Convertible Preferred Stock | $0.00 | 1,176,470 | 0 | D | C | 0 | Common Stock | 1,176,470 | I | Form 4 | ||||
| 2020-07-28 | Wellington Biomedical Innovation Master Investors (cayman) I L.p. | Series D Preferred Stock | $0.00 | 784,313 | 0 | D | C | 0 | Common Stock | 784,313 | D | Form 4 | ||||
| 2020-10-21 | Arthur T Sands | Stock Option (right to buy) | 2030-10-20 | $0.00 | 804,170 | 804,170 | A | A | 0 | Common Stock | 804,170 | D | Form 4 | |||
| 2020-11-30 | Gwenn Hansen | Employee Stock Option (right to buy) | 2026-02-10 | $0.00 | 12,000 | 31,333 | D | M | 0 | Common Stock | 12,000 | D | Form 4 | |||
| 2021-02-11 | Arthur T Sands | Employee Stock Option (right to buy) | 2031-02-10 | $0.00 | 150,000 | 150,000 | A | A | 0 | Common Stock | 150,000 | D | Form 4 | |||
| 2021-02-11 | Pierre Beaurang | Employee Stock Option (right to buy) | 2031-02-10 | $0.00 | 40,000 | 40,000 | A | A | 0 | Common Stock | 40,000 | D | Form 4 | |||
| 2021-02-11 | Gwenn Hansen | Employee Stock Option (right to buy) | 2031-02-10 | $0.00 | 60,000 | 60,000 | A | A | 0 | Common Stock | 60,000 | D | Form 4 | |||
| 2021-02-11 | Christine Ring | Employee Stock Option (right to buy) | 2031-02-10 | $0.00 | 40,000 | 40,000 | A | A | 0 | Common Stock | 40,000 | D | Form 4 | |||
| 2021-02-11 | Houte Hans Van | Employee Stock Option (right to buy) | 2031-02-10 | $0.00 | 40,000 | 40,000 | A | A | 0 | Common Stock | 40,000 | D | Form 4 | |||
| 2021-02-18 | Pierre Beaurang | Employee Stock Option (right to buy) | 2026-01-27 | $0.00 | 9,107 | 14,226 | D | M | 0 | Common Stock | 9,107 | D | Form 4 | |||
| 2021-02-18 | Pierre Beaurang | Employee Stock Option (right to buy) | 2030-02-26 | $0.00 | 3,797 | 72,869 | D | M | 0 | Common Stock | 3,797 | D | Form 4 | |||
| 2021-02-18 | Pierre Beaurang | Employee Stock Option (right to buy) | 2030-06-27 | $0.00 | 2,096 | 14,678 | D | M | 0 | Common Stock | 2,096 | D | Form 4 | |||
| 2021-02-18 | Gwenn Hansen | Employee Stock Option (right to buy) | 2030-02-26 | $0.00 | 800 | 75,866 | D | M | 0 | Common Stock | 800 | D | Form 4 | |||
| 2021-02-18 | Christine Ring | Employee Stock Option (right to buy) | 2029-09-30 | $0.00 | 2,000 | 119,666 | D | M | 0 | Common Stock | 2,000 | D | Form 4 | |||
| 2021-02-18 | Houte Hans Van | Employee Stock Option (right to buy) | 2026-01-27 | $0.00 | 13,583 | 69,750 | D | M | 0 | Common Stock | 13,583 | D | Form 4 | |||
| 2021-02-22 | Houte Hans Van | Employee Stock Option (right to buy) | 2026-04-26 | $0.00 | 1,417 | 68,333 | D | M | 0 | Common Stock | 1,417 | D | Form 4 | |||
| 2021-02-22 | Houte Hans Van | Employee Stock Option (right to buy) | 2028-03-01 | $0.00 | 3,913 | 29,420 | D | M | 0 | Common Stock | 3,913 | D | Form 4 | |||
| 2021-02-24 | Houte Hans Van | Employee Stock Option (right to buy) | 2028-03-01 | $0.00 | 20,393 | 9,027 | D | M | 0 | Common Stock | 20,393 | D | Form 4 | |||
| 2021-02-24 | Houte Hans Van | Employee Stock Option (right to buy) | 2029-08-28 | $0.00 | 13,197 | 20,136 | D | M | 0 | Common Stock | 13,197 | D | Form 4 | |||
| 2021-02-24 | Houte Hans Van | Employee Stock Option (right to buy) | 2030-02-26 | $0.00 | 1,829 | 36,504 | D | M | 0 | Common Stock | 1,829 | D | Form 4 | |||
| 2021-03-01 | Gwenn Hansen | Employee Stock Option (right to buy) | 2030-02-26 | $0.00 | 800 | 75,066 | D | M | 0 | Common Stock | 800 | D | Form 4 |
