| Trade Date |
Insider |
Insider Title |
Security Type |
Execution Date |
Exercise Date |
Expiration Date |
Share Price |
Quantity |
Shares Owned |
Shares Code |
Transaction Code |
Swap |
Under SEC Title |
Under Sec Shares |
Nature of Ownership |
SEC Link |
| 2020-05-20 | Richard T Collier | | Stock Option (Right to Buy) | | | 2030-05-20 | $0.00 | 17,500 | 17,500 | A | A | 0 | Ordinary Shares | 17,500 | D | Form 4 |
| 2020-05-20 | Christopher S Henney | | Stock Option (Right to Buy) | | | 2030-05-20 | $0.00 | 17,500 | 17,500 | A | A | 0 | Ordinary Shares | 17,500 | D | Form 4 |
| 2020-05-20 | Lars Ekman | | Stock Option (Right to Buy) | | | 2030-05-20 | $0.00 | 17,500 | 17,500 | A | A | 0 | Ordinary Shares | 17,500 | D | Form 4 |
| 2020-05-20 | Shane Cooke | | Stock Option (Right to Buy) | | | 2030-05-20 | $0.00 | 17,500 | 17,500 | A | A | 0 | Ordinary Shares | 17,500 | D | Form 4 |
| 2020-05-20 | Dennis J. Selkoe | | Stock Option (Right to Buy) | | | 2030-05-20 | $0.00 | 17,500 | 17,500 | A | A | 0 | Ordinary Shares | 17,500 | D | Form 4 |
| 2020-05-20 | Harfstrand Karl Anders Olof | | Stock Option (Right to Buy) | | | 2030-05-20 | $0.00 | 17,500 | 17,500 | A | A | 0 | Ordinary Shares | 17,500 | D | Form 4 |
| 2020-05-20 | Paula K Cobb | | Stock Option (Right to Buy) | | | 2030-05-20 | $0.00 | 17,500 | 17,500 | A | A | 0 | Ordinary Shares | 17,500 | D | Form 4 |
| 2020-08-17 | Gene G. Kinney | | Stock Option (Right to Buy) | | 2017-01-29 | 2023-01-29 | $0.00 | 10,000 | 99,074 | D | M | 0 | Ordinary Shares | 10,000 | D | Form 4 |
| 2021-02-12 | Richard T Collier | | Employee Stock Option (Right to Buy) | | 2016-05-18 | 2025-05-22 | | 15,000 | 0 | D | D | 0 | Ordinary Shares | 15,000 | D | Form 4 |
| 2021-02-12 | Richard T Collier | | Employee Stock Option (Right to Buy) | | | 2025-05-22 | | 9,803 | 9,803 | A | A | 0 | Ordinary Shares | 9,803 | D | Form 4 |
| 2021-02-12 | Richard T Collier | | Employee Stock Option (Right to Buy) | | 2017-05-16 | 2026-05-20 | | 15,000 | 0 | D | D | 0 | Ordinary Shares | 15,000 | D | Form 4 |
| 2021-02-12 | Richard T Collier | | Employee Stock Option (Right to Buy) | | | 2026-05-20 | | 8,426 | 8,426 | A | A | 0 | Ordinary Shares | 8,426 | D | Form 4 |
| 2021-02-12 | Richard T Collier | | Employee Stock Option (Right to Buy) | | 2018-05-14 | 2027-05-18 | | 12,000 | 0 | D | D | 0 | Ordinary Shares | 12,000 | D | Form 4 |
| 2021-02-12 | Richard T Collier | | Employee Stock Option (Right to Buy) | | | 2027-05-18 | | 6,315 | 6,315 | A | A | 0 | Ordinary Shares | 6,315 | D | Form 4 |
| 2021-02-12 | Christopher S Henney | | Employee Stock Option (Right to Buy) | | 2016-05-18 | 2025-05-22 | | 15,000 | 0 | D | D | 0 | Ordinary Shares | 15,000 | D | Form 4 |
| 2021-02-12 | Christopher S Henney | | Employee Stock Option (Right to Buy) | | | 2025-05-22 | | 9,803 | 9,803 | A | A | 0 | Ordinary Shares | 9,803 | D | Form 4 |
| 2021-02-12 | Christopher S Henney | | Employee Stock Option (Right to Buy) | | 2017-05-16 | 2026-05-20 | | 15,000 | 0 | D | D | 0 | Ordinary Shares | 15,000 | D | Form 4 |
| 2021-02-12 | Christopher S Henney | | Employee Stock Option (Right to Buy) | | | 2026-05-20 | | 8,426 | 8,426 | A | A | 0 | Ordinary Shares | 8,426 | D | Form 4 |
| 2021-02-12 | Christopher S Henney | | Employee Stock Option (Right to Buy) | | 2018-05-14 | 2027-05-18 | | 12,000 | 0 | D | D | 0 | Ordinary Shares | 12,000 | D | Form 4 |
| 2021-02-12 | Christopher S Henney | | Employee Stock Option (Right to Buy) | | | 2027-05-18 | | 6,315 | 6,315 | A | A | 0 | Ordinary Shares | 6,315 | D | Form 4 |
| 2021-02-12 | Lars Ekman | | Employee Stock Option (Right to Buy) | | 2016-05-18 | 2025-05-22 | | 15,000 | 0 | D | D | 0 | Ordinary Shares | 15,000 | D | Form 4 |
| 2021-02-12 | Lars Ekman | | Employee Stock Option (Right to Buy) | | | 2025-05-22 | | 9,803 | 9,803 | A | A | 0 | Ordinary Shares | 9,803 | D | Form 4 |
| 2021-02-12 | Lars Ekman | | Employee Stock Option (Right to Buy) | | 2017-05-16 | 2026-05-20 | | 15,000 | 0 | D | D | 0 | Ordinary Shares | 15,000 | D | Form 4 |
| 2021-02-12 | Lars Ekman | | Employee Stock Option (Right to Buy) | | | 2026-05-20 | | 8,426 | 8,426 | A | A | 0 | Ordinary Shares | 8,426 | D | Form 4 |
| 2021-02-12 | Lars Ekman | | Employee Stock Option (Right to Buy) | | 2018-05-14 | 2027-05-18 | | 12,000 | 0 | D | D | 0 | Ordinary Shares | 12,000 | D | Form 4 |
| 2021-02-12 | Lars Ekman | | Employee Stock Option (Right to Buy) | | | 2027-05-18 | | 6,315 | 6,315 | A | A | 0 | Ordinary Shares | 6,315 | D | Form 4 |
| 2021-02-12 | Tran Nguyen | | Employee Stock Option (Right to Buy) | | 2019-03-11 | 2025-03-11 | | 55,000 | 0 | D | D | 0 | Ordinary Shares | 55,000 | D | Form 4 |
| 2021-02-12 | Tran Nguyen | | Employee Stock Option (Right to Buy) | | | 2025-03-11 | | 50,000 | 50,000 | A | A | 0 | Ordinary Shares | 50,000 | D | Form 4 |
| 2021-02-12 | Tran Nguyen | | Employee Stock Option (Right to Buy) | | 2020-02-24 | 2026-02-24 | | 65,000 | 0 | D | D | 0 | Ordinary Shares | 65,000 | D | Form 4 |
| 2021-02-12 | Tran Nguyen | | Employee Stock Option (Right to Buy) | | | 2026-02-24 | | 40,625 | 40,625 | A | A | 0 | Ordinary Shares | 40,625 | D | Form 4 |
| 2021-02-12 | Tran Nguyen | | Employee Stock Option (Right to Buy) | | | 2027-02-22 | | 75,000 | 0 | D | D | 0 | Ordinary Shares | 75,000 | D | Form 4 |
| 2021-02-12 | Tran Nguyen | | Employee Stock Option (Right to Buy) | | | 2027-02-22 | | 39,062 | 39,062 | A | A | 0 | Ordinary Shares | 39,062 | D | Form 4 |
| 2021-02-12 | Tran Nguyen | | Employee Stock Option (Right to Buy) | | | 2028-02-21 | | 80,000 | 0 | D | D | 0 | Ordinary Shares | 80,000 | D | Form 4 |
| 2021-02-12 | Tran Nguyen | | Employee Stock Option (Right to Buy) | | | 2028-02-21 | | 60,150 | 60,150 | A | A | 0 | Ordinary Shares | 60,150 | D | Form 4 |
| 2021-02-12 | Shane Cooke | | Employee Stock Option (Right to Buy) | | 2016-05-18 | 2025-05-22 | | 15,000 | 0 | D | D | 0 | Ordinary Shares | 15,000 | D | Form 4 |
| 2021-02-12 | Shane Cooke | | Employee Stock Option (Right to Buy) | | | 2025-05-22 | | 9,803 | 9,803 | A | A | 0 | Ordinary Shares | 9,803 | D | Form 4 |
| 2021-02-12 | Shane Cooke | | Employee Stock Option (Right to Buy) | | 2017-05-16 | 2026-05-20 | | 15,000 | 0 | D | D | 0 | Ordinary Shares | 15,000 | D | Form 4 |
| 2021-02-12 | Shane Cooke | | Employee Stock Option (Right to Buy) | | | 2026-05-20 | | 8,426 | 8,426 | A | A | 0 | Ordinary Shares | 8,426 | D | Form 4 |
| 2021-02-12 | Shane Cooke | | Employee Stock Option (Right to Buy) | | 2018-05-14 | 2027-05-18 | | 12,000 | 0 | D | D | 0 | Ordinary Shares | 12,000 | D | Form 4 |
| 2021-02-12 | Shane Cooke | | Employee Stock Option (Right to Buy) | | | 2027-05-18 | | 6,315 | 6,315 | A | A | 0 | Ordinary Shares | 6,315 | D | Form 4 |
| 2021-02-12 | Carol D. Karp | | Employee Stock Option (Right to Buy) | | 2020-12-14 | 2026-12-14 | | 100,000 | 0 | D | D | 0 | Ordinary Shares | 100,000 | D | Form 4 |
| 2021-02-12 | Carol D. Karp | | Employee Stock Option (Right to Buy) | | | 2026-12-14 | | 51,282 | 51,282 | A | A | 0 | Ordinary Shares | 51,282 | D | Form 4 |
| 2021-02-12 | Carol D. Karp | | Employee Stock Option (Right to Buy) | | | 2028-02-21 | | 60,000 | 0 | D | D | 0 | Ordinary Shares | 60,000 | D | Form 4 |
| 2021-02-12 | Carol D. Karp | | Employee Stock Option (Right to Buy) | | | 2028-02-21 | | 45,112 | 45,112 | A | A | 0 | Ordinary Shares | 45,112 | D | Form 4 |
| 2021-02-12 | Dennis J. Selkoe | | Employee Stock Option (Right to Buy) | | 2016-05-18 | 2025-05-22 | | 15,000 | 0 | D | D | 0 | Ordinary Shares | 15,000 | D | Form 4 |
| 2021-02-12 | Dennis J. Selkoe | | Employee Stock Option (Right to Buy) | | | 2025-05-22 | | 9,803 | 9,803 | A | A | 0 | Ordinary Shares | 9,803 | D | Form 4 |
| 2021-02-12 | Dennis J. Selkoe | | Employee Stock Option (Right to Buy) | | 2017-05-16 | 2026-05-20 | | 15,000 | 0 | D | D | 0 | Ordinary Shares | 15,000 | D | Form 4 |
| 2021-02-12 | Dennis J. Selkoe | | Employee Stock Option (Right to Buy) | | | 2026-05-20 | | 8,426 | 8,426 | A | A | 0 | Ordinary Shares | 8,426 | D | Form 4 |
| 2021-02-12 | Dennis J. Selkoe | | Employee Stock Option (Right to Buy) | | 2018-05-14 | 2027-05-18 | | 12,000 | 0 | D | D | 0 | Ordinary Shares | 12,000 | D | Form 4 |
| 2021-02-12 | Dennis J. Selkoe | | Employee Stock Option (Right to Buy) | | | 2027-05-18 | | 6,315 | 6,315 | A | A | 0 | Ordinary Shares | 6,315 | D | Form 4 |
| 2021-02-12 | Gene G. Kinney | | Employee Stock Option (Right to Buy) | | 2019-03-11 | 2025-03-11 | | 65,000 | 0 | D | D | 0 | Ordinary Shares | 65,000 | D | Form 4 |
| 2021-02-12 | Gene G. Kinney | | Employee Stock Option (Right to Buy) | | | 2025-03-11 | | 59,090 | 59,090 | A | A | 0 | Ordinary Shares | 59,090 | D | Form 4 |
| 2021-02-12 | Gene G. Kinney | | Employee Stock Option (Right to Buy) | | 2020-02-24 | 2026-02-24 | | 65,000 | 0 | D | D | 0 | Ordinary Shares | 65,000 | D | Form 4 |
| 2021-02-12 | Gene G. Kinney | | Employee Stock Option (Right to Buy) | | | 2026-02-24 | | 40,625 | 40,625 | A | A | 0 | Ordinary Shares | 40,625 | D | Form 4 |
| 2021-02-12 | Gene G. Kinney | | Employee Stock Option (Right to Buy) | | 2020-09-01 | 2026-09-01 | | 50,000 | 0 | D | D | 0 | Ordinary Shares | 50,000 | D | Form 4 |
| 2021-02-12 | Gene G. Kinney | | Employee Stock Option (Right to Buy) | | | 2026-09-01 | | 25,125 | 25,125 | A | A | 0 | Ordinary Shares | 25,125 | D | Form 4 |
| 2021-02-12 | Gene G. Kinney | | Employee Stock Option (Right to Buy) | | 2020-09-30 | 2026-11-02 | | 30,000 | 0 | D | D | 0 | Ordinary Shares | 30,000 | D | Form 4 |
| 2021-02-12 | Gene G. Kinney | | Employee Stock Option (Right to Buy) | | | 2026-11-02 | | 16,759 | 16,759 | A | A | 0 | Ordinary Shares | 16,759 | D | Form 4 |
| 2021-02-12 | Gene G. Kinney | | Employee Stock Option (Right to Buy) | | | 2027-02-22 | | 120,000 | 0 | D | D | 0 | Ordinary Shares | 120,000 | D | Form 4 |
| 2021-02-12 | Gene G. Kinney | | Employee Stock Option (Right to Buy) | | | 2027-02-22 | | 62,500 | 62,500 | A | A | 0 | Ordinary Shares | 62,500 | D | Form 4 |
| 2021-02-12 | Gene G. Kinney | | Employee Stock Option (Right to Buy) | | | 2028-02-21 | | 187,000 | 0 | D | D | 0 | Ordinary Shares | 187,000 | D | Form 4 |
| 2021-02-12 | Gene G. Kinney | | Employee Stock Option (Right to Buy) | | | 2028-02-21 | | 140,601 | 140,601 | A | A | 0 | Ordinary Shares | 140,601 | D | Form 4 |
| 2021-02-12 | Karin L Walker | | Employee Stock Option (Right to Buy) | | 2019-03-11 | 2025-03-11 | | 17,500 | 0 | D | D | 0 | Ordinary Shares | 17,500 | D | Form 4 |
| 2021-02-12 | Karin L Walker | | Employee Stock Option (Right to Buy) | | | 2025-03-11 | | 15,909 | 15,909 | A | A | 0 | Ordinary Shares | 15,909 | D | Form 4 |
| 2021-02-12 | Karin L Walker | | Employee Stock Option (Right to Buy) | | 2020-02-24 | 2026-02-24 | | 25,000 | 0 | D | D | 0 | Ordinary Shares | 25,000 | D | Form 4 |
| 2021-02-12 | Karin L Walker | | Employee Stock Option (Right to Buy) | | | 2026-02-24 | | 15,625 | 15,625 | A | A | 0 | Ordinary Shares | 15,625 | D | Form 4 |
| 2021-02-12 | Karin L Walker | | Employee Stock Option (Right to Buy) | | | 2027-02-22 | | 30,000 | 0 | D | D | 0 | Ordinary Shares | 30,000 | D | Form 4 |
| 2021-02-12 | Karin L Walker | | Employee Stock Option (Right to Buy) | | | 2027-02-22 | | 15,625 | 15,625 | A | A | 0 | Ordinary Shares | 15,625 | D | Form 4 |
| 2021-02-12 | Karin L Walker | | Employee Stock Option (Right to Buy) | | | 2028-02-21 | | 25,000 | 0 | D | D | 0 | Ordinary Shares | 25,000 | D | Form 4 |
| 2021-02-12 | Karin L Walker | | Employee Stock Option (Right to Buy) | | | 2028-02-21 | | 18,796 | 18,796 | A | A | 0 | Ordinary Shares | 18,796 | D | Form 4 |
| 2021-02-12 | Harfstrand Karl Anders Olof | | Employee Stock Option (Right to Buy) | | 2018-05-14 | 2025-06-29 | | 30,000 | 0 | D | D | 0 | Ordinary Shares | 30,000 | D | Form 4 |
| 2021-02-12 | Harfstrand Karl Anders Olof | | Employee Stock Option (Right to Buy) | | | 2025-06-29 | | 15,873 | 15,873 | A | A | 0 | Ordinary Shares | 15,873 | D | Form 4 |
| 2021-02-12 | Harfstrand Karl Anders Olof | | Employee Stock Option (Right to Buy) | | 2017-05-16 | 2026-05-20 | | 15,000 | 0 | D | D | 0 | Ordinary Shares | 15,000 | D | Form 4 |
| 2021-02-12 | Harfstrand Karl Anders Olof | | Employee Stock Option (Right to Buy) | | | 2026-05-20 | | 8,426 | 8,426 | A | A | 0 | Ordinary Shares | 8,426 | D | Form 4 |
| 2021-02-12 | Harfstrand Karl Anders Olof | | Employee Stock Option (Right to Buy) | | 2018-05-14 | 2027-05-18 | | 12,000 | 0 | D | D | 0 | Ordinary Shares | 12,000 | D | Form 4 |
| 2021-02-12 | Harfstrand Karl Anders Olof | | Employee Stock Option (Right to Buy) | | | 2027-05-18 | | 6,315 | 6,315 | A | A | 0 | Ordinary Shares | 6,315 | D | Form 4 |
| 2021-02-12 | Radhika Tripuraneni | | Employee Stock Option (Right to Buy) | | | 2028-04-02 | | 50,000 | 0 | D | D | 0 | Ordinary Shares | 50,000 | D | Form 4 |
| 2021-02-12 | Radhika Tripuraneni | | Employee Stock Option (Right to Buy) | | | 2028-04-02 | | 37,037 | 37,037 | A | A | 0 | Ordinary Shares | 37,037 | D | Form 4 |
| 2021-02-12 | Wagner M. Zago | | Stock Option (Right to Buy) | | | 2023-01-29 | $0.00 | 7,560 | 7,540 | D | M | 0 | Ordinary Shares | 7,560 | D | Form 4 |
| 2021-02-12 | Wagner M. Zago | | Stock Option (Right to Buy) | | | 2029-02-27 | $0.00 | 18,750 | 31,250 | D | M | 0 | Ordinary Shares | 18,750 | D | Form 4 |
| 2021-02-17 | Capital, Llc Ecor1 | | Call Option | | 2021-02-17 | 2021-06-30 | $3.68 | 2,500 | 2,500 | A | P | 0 | Ordinary Shares | 250,000 | I | Form 4 |
| 2021-02-18 | Wagner M. Zago | | Stock Option (Right to Buy) | | | 2023-01-29 | $0.00 | 7,540 | 0 | D | M | 0 | Ordinary Shares | 7,540 | D | Form 4 |
| 2021-02-25 | Tran Nguyen | | Stock Option (Right to Buy) | | | 2031-02-25 | $0.00 | 84,000 | 84,000 | A | A | 0 | Ordinary Shares | 84,000 | D | Form 4 |
| 2021-02-25 | Wagner M. Zago | | Stock Option (Right to Buy) | | | 2031-02-25 | $0.00 | 56,000 | 56,000 | A | A | 0 | Ordinary Shares | 56,000 | D | Form 4 |
| 2021-02-25 | Karin L Walker | | Employee Stock Option (Right to Buy) | | | 2031-02-25 | $0.00 | 28,000 | 28,000 | A | A | 0 | Ordinary Shares | 28,000 | D | Form 4 |
| 2021-02-25 | Carol D. Karp | | Stock Option (Right to Buy) | | | 2031-02-25 | $0.00 | 56,000 | 56,000 | A | A | 0 | Ordinary Shares | 56,000 | D | Form 4 |
| 2021-02-25 | Michael J Malecek | | Stock Option (Right to Buy) | | | 2031-02-25 | $0.00 | 56,000 | 56,000 | A | A | 0 | Ordinary Shares | 56,000 | D | Form 4 |
| 2021-02-25 | Radhika Tripuraneni | | Stock Option (Right to Buy) | | | 2031-02-25 | $0.00 | 56,000 | 56,000 | A | A | 0 | Ordinary Shares | 56,000 | D | Form 4 |
| 2021-02-25 | Gene G. Kinney | | Stock Option (Right to Buy) | | | 2031-02-25 | $0.00 | 250,000 | 250,000 | A | A | 0 | Ordinary Shares | 250,000 | D | Form 4 |
| 2021-02-25 | Gene G. Kinney | | Stock Option (Right to Buy) | | 2021-02-25 | 2030-02-25 | $0.00 | 50,000 | 50,000 | A | A | 0 | Ordinary Shares | 50,000 | D | Form 4 |
| 2021-02-25 | Brandon S. Smith | | Stock Option (Right to Buy) | | | 2031-02-25 | $0.00 | 56,000 | 56,000 | A | A | 0 | Ordinary Shares | 56,000 | D | Form 4 |
| 2021-04-05 | Hideki Garren | | Stock Option (Right to Buy) | | | 2031-04-05 | $0.00 | 250,000 | 250,000 | A | A | 0 | Ordinary Shares | 250,000 | D | Form 4 |
