| Trade Date | Insider | Insider Title | Security Type | Execution Date | Exercise Date | Expiration Date | Share Price | Quantity | Shares Owned | Shares Code | Transaction Code | Swap | Under SEC Title | Under Sec Shares | Nature of Ownership | SEC Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2020-11-05 | James R Neal | Stock Option (Right to Buy) | 2026-12-22 | $0.00 | 10,000 | 46,000 | D | M | false | Common Stock | 10,000 | D | Form 4 | |||
| 2020-04-15 | Bvf Partners L P/il | Series Y Convertible Preferred Stock | $0.00 | 656 | 0 | D | C | 0 | Common Stock, $0.0075 par value per share | 655,959 | D | Form 4 | ||||
| 2020-04-15 | Bvf Partners L P/il | Series Y Convertible Preferred Stock | $0.00 | 597 | 0 | D | C | 0 | Common Stock, $0.0075 par value per share | 596,813 | D | Form 4 | ||||
| 2020-05-20 | Jack L Wyszomierski | Non-Qualified Share Option (right to buy) | 2030-05-20 | $0.00 | 6,152 | 6,152 | A | A | false | Common Shares | 6,152 | D | Form 4 | |||
| 2020-05-20 | Joseph M Limber | Non-Qualified Share Option (right to buy) | 2030-05-20 | $0.00 | 6,152 | 6,152 | A | A | false | Common Shares | 6,152 | D | Form 4 | |||
| 2020-05-20 | Van Ness W Denman | Non-Qualified Share Option (right to buy) | 2030-05-20 | $0.00 | 6,152 | 6,152 | A | A | false | Common Shares | 6,152 | D | Form 4 | |||
| 2020-05-20 | Matthew D Perry | Non-Qualified Stock Option (right to buy) | 2030-05-20 | $0.00 | 6,152 | 6,152 | A | A | 0 | Common Stock | 6,152 | D | Form 4 | |||
| 2020-05-20 | Barbara Kosacz | Non-Qualified Share Option (right to buy) | 2030-05-20 | $0.00 | 6,152 | 6,152 | A | A | false | Common Shares | 6,152 | D | Form 4 | |||
| 2020-11-05 | Thomas M. Burns | Stock Option (Right to Buy) | 2027-02-10 | $0.00 | 8,000 | 34,000 | D | M | false | Common Stock | 8,000 | D | Form 4 | |||
| 2020-11-20 | James R Neal | Stock Option (Right to Buy) | 2026-12-22 | $0.00 | 6,874 | 39,126 | D | M | false | Common Stock | 6,874 | D | Form 4 | |||
| 2020-11-23 | James R Neal | Stock Option (Right to Buy) | 2026-12-22 | $0.00 | 13,126 | 26,000 | D | M | false | Common Stock | 13,126 | D | Form 4 | |||
| 2020-11-20 | Thomas M. Burns | Stock Option (Right to Buy) | 2027-02-10 | $0.00 | 6,875 | 27,125 | D | M | false | Common Stock | 6,875 | D | Form 4 | |||
| 2020-11-23 | Thomas M. Burns | Stock Option (Right to Buy) | 2027-02-10 | $0.00 | 5,125 | 22,000 | D | M | false | Common Stock | 5,125 | D | Form 4 | |||
| 2020-12-15 | James R Neal | Stock Option (Right to Buy) | 2017-12-22 | $0.00 | 26,000 | 0 | D | M | false | Common Stock | 26,000 | D | Form 4 | |||
| 2020-12-15 | Thomas M. Burns | Stock Option (Right to Buy) | 2027-02-10 | $0.00 | 15,000 | 7,000 | D | M | false | Common Stock | 15,000 | D | Form 4 | |||
| 2021-02-17 | James R Neal | Non-Qualified Share Option (right to buy) | 2031-02-17 | $0.00 | 60,268 | 60,268 | A | A | false | Common Shares | 60,268 | D | Form 4 | |||
| 2021-02-17 | Thomas M. Burns | Non-Qualified Stock Option (right to buy) | 2031-02-17 | $0.00 | 20,055 | 20,055 | A | A | false | Common Shares | 20,055 | D | Form 4 | |||
| 2021-03-15 | Van Ness W Denman | Non-Qualified Share Option (Right to Buy) | 2027-09-15 | $0.00 | 2,366 | 0 | D | M | false | Common Shares | 2,366 | D | Form 4 | |||
| 2021-03-15 | Van Ness W Denman | Non-Qualified Share Option (Right to Buy) | 2027-02-10 | $0.00 | 3,333 | 0 | D | M | false | Common Shares | 3,333 | D | Form 4 | |||
| 2021-05-19 | Jack L Wyszomierski | Non-Qualified Share Option (right to buy) | 2031-05-19 | $0.00 | 5,101 | 5,101 | A | A | false | Common Shares | 5,101 | D | Form 4 | |||
| 2021-05-19 | Bvf Partners L P/il | Non-Qualified Stock Option (right to buy) | 2031-05-19 | 5,101 | 5,101 | A | A | 0 | Common Stock, $0.0075 par value per share | 5,101 | I | Form 4 | ||||
| 2021-05-19 | Joseph M Limber | Non-Qualified Share Option (right to buy) | 2031-05-19 | $0.00 | 5,101 | 5,101 | A | A | false | Common Shares | 5,101 | D | Form 4 | |||
| 2021-05-19 | Van Ness W Denman | Non-Qualified Share Option (right to buy) | 2031-05-19 | $0.00 | 5,101 | 5,101 | A | A | false | Common Shares | 5,101 | D | Form 4 | |||
| 2021-05-19 | Matthew D Perry | Non-Qualified Stock Option (right to buy) | 2031-05-19 | 5,101 | 5,101 | A | A | 0 | Common Stock | 5,101 | D | Form 4 | ||||
| 2021-05-19 | Barbara Kosacz | Non-Qualified Share Option (right to buy) | 2031-05-19 | $0.00 | 5,101 | 5,101 | A | A | false | Common Shares | 5,101 | D | Form 4 | |||
| 2021-05-19 | Natasha Hernday | Non-Qualified Share Option (right to buy) | 2031-05-19 | $0.00 | 5,101 | 5,101 | A | A | false | Common Shares | 5,101 | D | Form 4 | |||
| 2021-08-06 | Heather L Franklin | Non-Qualified Share Option (right to buy) | 2031-08-06 | $0.00 | 13,136 | 13,136 | A | A | false | Common Shares | 13,136 | D | Form 4 | |||
| 2021-08-06 | Heather L Franklin | Non-Qualified Share Option (right to buy) | 2031-08-06 | $0.00 | 4,146 | 4,146 | A | A | false | Common Shares | 4,146 | D | Form 4 | |||
| 2021-12-21 | James R Neal | Non-Qualified Share Option (right to buy) | 2031-12-21 | $0.00 | 60,000 | 60,000 | A | A | false | Common Shares | 60,000 | D | Form 4 | |||
| 2022-02-22 | Thomas M. Burns | Non-Qualified Stock Option (right to buy) | 2032-02-22 | $0.00 | 28,000 | 28,000 | A | A | false | Common Shares | 28,000 | D | Form 4 | |||
| 2022-03-21 | James R Neal | Stock Option (Right to Buy) | 2027-02-10 | $0.00 | 50,000 | 106,250 | D | M | false | Common Stock | 50,000 | D | Form 4 | |||
| 2022-03-22 | James R Neal | Stock Option (Right to Buy) | 2027-02-10 | $0.00 | 2,339 | 103,911 | D | M | false | Common Stock | 2,339 | D | Form 4 | |||
| 2022-03-23 | James R Neal | Stock Option (Right to Buy) | 2027-02-10 | $0.00 | 1,111 | 102,800 | D | M | false | Common Stock | 1,111 | D | Form 4 | |||
| 2022-03-21 | Thomas M. Burns | Stock Option (Right to Buy) | 2027-02-10 | $0.00 | 12,000 | 18,000 | D | M | false | Common Stock | 12,000 | D | Form 4 | |||
| 2022-03-22 | Thomas M. Burns | Stock Option (Right to Buy) | 2027-02-10 | $0.00 | 2,339 | 15,661 | D | M | false | Common Stock | 2,339 | D | Form 4 | |||
| 2022-03-23 | Thomas M. Burns | Stock Option (Right to Buy) | 2027-02-10 | $0.00 | 161 | 15,500 | D | M | false | Common Stock | 161 | D | Form 4 | |||
| 2022-05-18 | Jack L Wyszomierski | Non-Qualified Share Option (right to buy) | 2032-05-18 | $0.00 | 8,996 | 8,996 | A | A | false | Common Shares | 8,996 | D | Form 4 | |||
| 2022-05-18 | Bvf Partners L P/il | Non-Qualified Stock Option (right to buy) | 2032-05-18 | $0.00 | 8,996 | 8,996 | A | A | 0 | Common Stock, $0.0075 par value per share | 8,996 | I | Form 4 | |||
| 2022-05-18 | Joseph M Limber | Non-Qualified Share Option (right to buy) | 2032-05-18 | $0.00 | 8,996 | 8,996 | A | A | false | Common Shares | 8,996 | D | Form 4 | |||
| 2022-05-18 | Van Ness W Denman | Non-Qualified Share Option (right to buy) | 2032-05-18 | $0.00 | 8,996 | 8,996 | A | A | false | Common Shares | 8,996 | D | Form 4 | |||
| 2022-05-18 | Heather L Franklin | Non-Qualified Share Option (right to buy) | 2032-05-18 | $0.00 | 8,996 | 8,996 | A | A | false | Common Shares | 8,996 | D | Form 4 | |||
| 2022-05-18 | Matthew D Perry | Non-Qualified Share Option (right to buy) | 2032-05-18 | $0.00 | 8,996 | 8,996 | A | A | false | Common Shares | 8,996 | D | Form 4 | |||
| 2022-05-18 | Barbara Kosacz | Non-Qualified Share Option (right to buy) | 2032-05-18 | $0.00 | 8,996 | 8,996 | A | A | false | Common Shares | 8,996 | D | Form 4 | |||
| 2022-05-18 | Natasha Hernday | Non-Qualified Share Option (right to buy) | 2032-05-18 | $0.00 | 8,996 | 8,996 | A | A | false | Common Shares | 8,996 | D | Form 4 |
