Trade Date | Insider | Title | Buy or Sell | Quantity | Security Type | Price | Proceeds | Transaction Conviction | Position Quantity | Position Value | Positon Conviction | SEC Link | Nature of Ownership | 2020-07-07 | Barry E Greene | President | Buy | 22,265 | Common Stock | $9.14 | -$203,502.10 | 1.94 [ High ] | 84,501 | $772,339.14 | 7.36 [Average] | Form 4 | - | 2020-07-07 | Barry E Greene | President | Sell | 22,265 | Common Stock | $159.99 | $3,562,177.35 | 1.94 [ High ] | 62,236 | $9,957,137.64 | 5.42 [] | Form 4 | - | 2020-07-09 | Yvonne Greenstreet | Chief Operating Officer | Buy | 10,939 | Common Stock | $42.22 | -$461,844.58 | 0.95 [ High ] | 15,759 | $665,344.98 | 1.37 [Low] | Form 4 | - | 2020-07-09 | Yvonne Greenstreet | Chief Operating Officer | Buy | 297 | Common Stock | $77.10 | -$22,898.70 | 0.03 [ Very Low ] | 16,056 | $1,237,917.60 | 1.40 [Low] | Form 4 | - | 2020-07-09 | Yvonne Greenstreet | Chief Operating Officer | Sell | 11,236 | Common Stock | $161.00 | $1,808,996.00 | 0.98 [ High ] | 4,820 | $776,020.00 | 0.42 [Very Low] | Form 4 | - | 2020-04-07 | Akshay Vaishnaw | President, R&D | Buy | 5,417 | Common Stock | $0.00 | $0.00 | - | 16,632 | $0.00 | 1.45 [Low] | Form 4 | - | 2020-04-07 | Akshay Vaishnaw | President, R&D | Sell | 2,415 | Common Stock | $104.75 | $252,971.25 | 0.21 [ Low ] | 14,217 | $1,489,230.75 | 1.24 [Very Low] | Form 4 | - | 2020-04-07 | Akshay Vaishnaw | President, R&D | Sell | 98 | Common Stock | $106.52 | $10,438.96 | - | 14,119 | $1,503,955.88 | 1.23 [Very Low] | Form 4 | - | 2020-04-07 | John Maraganore | Chief Executive Officer | Buy | 14,167 | Common Stock | $0.00 | $0.00 | - | 204,160 | $0.00 | 17.78 [High] | Form 4 | - | 2020-04-07 | John Maraganore | Chief Executive Officer | Sell | 6,315 | Common Stock | $104.75 | $661,496.25 | 0.55 [ Average ] | 197,845 | $20,724,263.75 | 17.23 [Average] | Form 4 | - | 2020-04-07 | John Maraganore | Chief Executive Officer | Sell | 256 | Common Stock | $106.27 | $27,205.12 | 0.02 [ Very Low ] | 197,589 | $20,997,783.03 | 17.21 [Average] | Form 4 | - | 2020-04-07 | Laurie Keating | EVP, Chief Legal Officer | Buy | 4,167 | Common Stock | $0.00 | $0.00 | - | 16,425 | $0.00 | 1.43 [Low] | Form 4 | - | 2020-04-07 | Laurie Keating | EVP, Chief Legal Officer | Sell | 1,858 | Common Stock | $104.75 | $194,625.50 | 0.16 [ Low ] | 14,567 | $1,525,893.25 | 1.27 [Very Low] | Form 4 | - | 2020-04-07 | Laurie Keating | EVP, Chief Legal Officer | Sell | 75 | Common Stock | $105.63 | $7,922.25 | - | 14,492 | $1,530,789.96 | 1.26 [Very Low] | Form 4 | - | 2020-04-07 | Yvonne Greenstreet | Chief Operating Officer | Buy | 5,417 | Common Stock | $0.00 | $0.00 | - | 7,333 | $0.00 | 0.64 [Very Low] | Form 4 | - | 2020-04-07 | Yvonne Greenstreet | Chief Operating Officer | Sell | 2,415 | Common Stock | $104.75 | $252,971.25 | 0.21 [ Low ] | 4,918 | $515,160.50 | 0.43 [Very Low] | Form 4 | - | 2020-04-07 | Yvonne Greenstreet | Chief Operating Officer | Sell | 98 | Common Stock | $107.47 | $10,532.06 | - | 4,820 | $518,005.40 | 0.42 [Very Low] | Form 4 | - | 2020-04-07 | Barry E Greene | President | Buy | 5,417 | Common Stock | $0.00 | $0.00 | - | 63,899 | $0.00 | 5.57 [Average] | Form 4 | - | 2020-04-07 | Barry E Greene | President | Sell | 1,599 | Common Stock | $104.75 | $167,495.25 | 0.14 [ Low ] | 62,300 | $6,525,925.00 | 5.43 [Low] | Form 4 | - | 2020-04-07 | Barry E Greene | President | Sell | 64 | Common Stock | $106.65 | $6,825.60 | - | 62,236 | $6,637,469.40 | 5.42 [Low] | Form 4 | - | 2020-04-20 | Akshay Vaishnaw | President, R&D | Buy | 21,000 | Common Stock | $42.22 | -$886,620.00 | 1.83 [ High ] | 35,119 | $1,482,724.18 | 3.06 [Low] | Form 4 | - | 2020-04-20 | Akshay Vaishnaw | President, R&D | Buy | 971 | Common Stock | $42.22 | -$40,995.62 | 0.08 [ Very Low ] | 36,090 | $1,523,719.80 | 3.14 [Low] | Form 4 | - | 2020-04-20 | Akshay Vaishnaw | President, R&D | Sell | 21,971 | Common Stock | $140.00 | $3,075,940.00 | 1.91 [ High ] | 14,119 | $1,976,660.00 | 1.23 [Very Low] | Form 4 | - | 2020-04-20 | Laurie Keating | EVP, Chief Legal Officer | Buy | 10,000 | Common Stock | $77.40 | -$774,000.00 | 0.87 [ High ] | 24,492 | $1,895,680.80 | 2.13 [Low] | Form 4 | - | 2020-04-20 | Laurie Keating | EVP, Chief Legal Officer | Sell | 10,000 | Common Stock | $139.00 | $1,390,000.00 | 0.87 [ High ] | 14,492 | $2,014,388.00 | 1.26 [Very Low] | Form 4 | - | 2020-05-20 | John Maraganore | Chief Executive Officer | Buy | 34,765 | Common Stock | $9.14 | -$317,752.10 | 3.03 [ Very High ] | 232,354 | $2,123,715.56 | 20.24 [High] | Form 4 | - | 2020-05-20 | John Maraganore | Chief Executive Officer | Sell | 13,437 | Common Stock | $142.51 | $1,914,906.87 | 1.17 [ High ] | 218,917 | $31,197,861.67 | 19.07 [High] | Form 4 | - | 2020-05-20 | John Maraganore | Chief Executive Officer | Sell | 16,315 | Common Stock | $143.46 | $2,340,549.90 | 1.42 [ High ] | 202,602 | $29,065,282.92 | 17.65 [High] | Form 4 | - | 2020-05-20 | John Maraganore | Chief Executive Officer | Sell | 5,013 | Common Stock | $144.33 | $723,526.29 | 0.44 [ Average ] | 197,589 | $28,518,020.37 | 17.21 [High] | Form 4 | - | 2020-05-05 | Yvonne Greenstreet | Chief Operating Officer | Buy | 6,250 | Common Stock | $42.22 | -$263,875.00 | 0.54 [ Average ] | 11,070 | $467,375.40 | 0.96 [Very Low] | Form 4 | - | 2020-05-05 | Yvonne Greenstreet | Chief Operating Officer | Buy | 1,561 | Common Stock | $42.22 | -$65,905.42 | 0.14 [ Low ] | 12,631 | $533,280.82 | 1.10 [Very Low] | Form 4 | - | 2020-05-05 | Yvonne Greenstreet | Chief Operating Officer | Sell | 7,811 | Common Stock | $140.00 | $1,093,540.00 | 0.68 [ Average ] | 4,820 | $674,800.00 | 0.42 [Very Low] | Form 4 | - | 2020-05-06 | Yvonne Greenstreet | Chief Operating Officer | Buy | 50,000 | Common Stock | $77.10 | -$3,855,000.00 | 4.35 [ Very High ] | 54,820 | $4,226,622.00 | 4.77 [Average] | Form 4 | - | 2020-05-06 | Yvonne Greenstreet | Chief Operating Officer | Sell | 50,000 | Common Stock | $150.00 | $7,500,000.00 | 4.35 [ Very High ] | 4,820 | $723,000.00 | 0.42 [Very Low] | Form 4 | - | 2020-05-06 | Barry E Greene | President | Buy | 22,265 | Common Stock | $9.14 | -$203,502.10 | 1.94 [ High ] | 84,501 | $772,339.14 | 7.36 [Average] | Form 4 | - | 2020-05-06 | Barry E Greene | President | Sell | 22,265 | Common Stock | $149.99 | $3,339,527.35 | 1.94 [ High ] | 62,236 | $9,334,777.64 | 5.42 [Average] | Form 4 | - | 2020-07-10 | Yvonne Greenstreet | Chief Operating Officer | Buy | 46,639 | Common Stock | $77.10 | -$3,595,866.90 | 4.06 [ Very High ] | 51,459 | $3,967,488.90 | 4.48 [Low] | Form 4 | - | 2020-07-10 | Yvonne Greenstreet | Chief Operating Officer | Sell | 46,639 | Common Stock | $161.00 | $7,508,879.00 | 4.06 [ Very High ] | 4,820 | $776,020.00 | 0.42 [Very Low] | Form 4 | - | 2020-07-13 | Laurie Keating | EVP, Chief Legal Officer | Buy | 1,941 | Common Stock | $42.22 | -$81,949.02 | 0.17 [ Low ] | 16,433 | $693,801.26 | 1.43 [Low] | Form 4 | - | 2020-07-13 | Laurie Keating | EVP, Chief Legal Officer | Buy | 23,809 | Common Stock | $77.40 | -$1,842,816.60 | 2.07 [ High ] | 40,242 | $3,114,730.80 | 3.50 [Low] | Form 4 | - | 2020-07-13 | Laurie Keating | EVP, Chief Legal Officer | Buy | 3,750 | Common Stock | $119.13 | -$446,737.50 | 0.33 [ Average ] | 43,992 | $5,240,766.96 | 3.83 [Low] | Form 4 | - | 2020-07-13 | Laurie Keating | EVP, Chief Legal Officer | Buy | 6,250 | Common Stock | $119.13 | -$744,562.50 | 0.54 [ Average ] | 50,242 | $5,985,329.46 | 4.38 [Low] | Form 4 | - | 2020-07-13 | Laurie Keating | EVP, Chief Legal Officer | Sell | 4,482 | Common Stock | $157.16 | $704,391.12 | 0.39 [ Average ] | 45,760 | $7,191,641.60 | 3.99 [Low] | Form 4 | - | 2020-07-13 | Laurie Keating | EVP, Chief Legal Officer | Sell | 2,323 | Common Stock | $158.27 | $367,661.21 | 0.20 [ Low ] | 43,437 | $6,874,773.99 | 3.78 [Low] | Form 4 | - | 2020-07-13 | Laurie Keating | EVP, Chief Legal Officer | Sell | 1,061 | Common Stock | $159.22 | $168,932.42 | 0.09 [ Very Low ] | 42,376 | $6,747,106.72 | 3.69 [Low] | Form 4 | - | 2020-07-13 | Laurie Keating | EVP, Chief Legal Officer | Sell | 14,236 | Common Stock | $160.52 | $2,285,162.72 | 1.24 [ High ] | 28,140 | $4,517,032.80 | 2.45 [Low] | Form 4 | - | 2020-07-13 | Laurie Keating | EVP, Chief Legal Officer | Sell | 15,618 | Common Stock | $161.32 | $2,519,495.76 | 1.36 [ High ] | 12,522 | $2,020,049.04 | 1.09 [Very Low] | Form 4 | - | 2020-07-13 | Laurie Keating | EVP, Chief Legal Officer | Sell | 9,530 | Common Stock | $162.24 | $1,546,147.20 | 0.83 [ High ] | 2,992 | $485,422.08 | 0.26 [Very Low] | Form 4 | - | 2020-06-22 | Akshay Vaishnaw | President, R&D | Buy | 970 | Common Stock | $42.22 | -$40,953.40 | - | 15,089 | $637,057.58 | - | Form 4 | - | 2020-06-22 | Akshay Vaishnaw | President, R&D | Sell | 178 | Common Stock | $148.48 | $26,429.44 | - | 14,911 | $2,213,985.28 | - | Form 4 | - | 2020-06-22 | Akshay Vaishnaw | President, R&D | Sell | 83 | Common Stock | $149.09 | $12,374.47 | - | 14,828 | $2,210,706.52 | - | Form 4 | - | 2020-06-22 | Akshay Vaishnaw | President, R&D | Sell | 180 | Common Stock | $150.34 | $27,061.20 | - | 14,648 | $2,202,180.32 | - | Form 4 | - | 2020-06-22 | Akshay Vaishnaw | President, R&D | Sell | 334 | Common Stock | $152.22 | $50,841.48 | - | 14,314 | $2,178,877.08 | - | Form 4 | - | 2020-06-22 | Akshay Vaishnaw | President, R&D | Sell | 195 | Common Stock | $152.97 | $29,829.15 | - | 14,119 | $2,159,783.43 | - | Form 4 | - | 2020-08-10 | Barry E Greene | President | Buy | 1,587 | Common Stock | $63.00 | -$99,981.00 | 0.14 [ Low ] | 63,823 | $4,020,849.00 | 5.50 [Average] | Form 4 | - | 2020-08-10 | Barry E Greene | President | Buy | 1,036 | Common Stock | $96.45 | -$99,922.20 | 0.09 [ Very Low ] | 64,859 | $6,255,650.55 | 5.59 [Average] | Form 4 | - | 2020-08-10 | Barry E Greene | President | Buy | 1,124 | Common Stock | $88.95 | -$99,979.80 | 0.10 [ Low ] | 65,983 | $5,869,187.85 | 5.69 [Average] | Form 4 | - | 2020-08-10 | Barry E Greene | President | Buy | 1,184 | Common Stock | $42.22 | -$49,988.48 | 0.10 [ Low ] | 67,167 | $2,835,790.74 | 5.79 [Average] | Form 4 | - | 2020-08-20 | John Maraganore | Chief Executive Officer | Buy | 34,765 | Common Stock | $9.14 | -$317,752.10 | 3.00 [ Very High ] | 232,354 | $2,123,715.56 | 20.04 [High] | Form 4 | - | 2020-08-20 | John Maraganore | Chief Executive Officer | Sell | 4,775 | Common Stock | $135.09 | $645,054.75 | 0.41 [ Average ] | 227,579 | $30,743,647.11 | 19.62 [High] | Form 4 | - | 2020-08-20 | John Maraganore | Chief Executive Officer | Sell | 21,448 | Common Stock | $136.07 | $2,918,429.36 | 1.85 [ High ] | 206,131 | $28,048,245.17 | 17.77 [High] | Form 4 | - | 2020-08-20 | John Maraganore | Chief Executive Officer | Sell | 8,542 | Common Stock | $136.86 | $1,169,058.12 | 0.74 [ Average ] | 197,589 | $27,042,030.54 | 17.04 [High] | Form 4 | - | 2020-07-16 | Barry E Greene | President | Buy | 3,176 | Common Stock | $0.00 | $0.00 | - | 65,412 | $0.00 | 5.64 [Average] | Form 4 | - | 2020-09-09 | Barry E Greene | President | Buy | 44,530 | Common Stock | $9.14 | -$407,004.20 | 3.84 [ Very High ] | 114,873 | $1,049,939.22 | 9.91 [Average] | Form 4 | - | 2020-09-09 | Barry E Greene | President | Sell | 14,075 | Common Stock | $122.66 | $1,726,439.50 | 1.21 [ High ] | 100,798 | $12,363,882.68 | 8.69 [Average] | Form 4 | - | 2020-09-09 | Barry E Greene | President | Sell | 27,109 | Common Stock | $123.39 | $3,344,979.51 | 2.34 [ High ] | 73,689 | $9,092,485.71 | 6.35 [Average] | Form 4 | - | 2020-09-09 | Barry E Greene | President | Sell | 3,346 | Common Stock | $124.38 | $416,175.48 | 0.29 [ Low ] | 70,343 | $8,749,262.34 | 6.07 [Average] | Form 4 | - | 2020-07-16 | Barry E Greene | President | Buy | 155 | Common Stock | $0.00 | $0.00 | - | 155 | $0.00 | - | Form 4 | by Dependent | 2020-07-16 | Barry E Greene | President | Sell | 155 | Common Stock | $0.00 | $0.00 | - | 3,331 | $0.00 | 0.29 [Very Low] | Form 4 | by Trust | 2020-07-16 | Barry E Greene | President | Sell | 155 | Common Stock | $0.00 | $0.00 | - | 3,176 | $0.00 | 0.27 [Very Low] | Form 4 | by Trust | 2020-07-16 | Barry E Greene | President | Sell | 3,176 | Common Stock | $0.00 | $0.00 | - | 0 | $0.00 | - | Form 4 | by Trust | 2020-09-29 | Akshay Vaishnaw | President, R&D | Buy | 971 | Common Stock | $42.22 | -$40,995.62 | 0.08 [ Very Low ] | 15,090 | $637,099.80 | 1.30 [Very Low] | Form 4 | - | 2020-09-29 | Akshay Vaishnaw | President, R&D | Sell | 971 | Common Stock | $140.00 | $135,940.00 | 0.08 [ Very Low ] | 14,119 | $1,976,660.00 | 1.22 [Very Low] | Form 4 | - | 2020-11-19 | John Maraganore | Chief Executive Officer | Buy | 34,765 | Common Stock | $9.14 | -$317,752.10 | 2.99 [ Very High ] | 232,354 | $2,123,715.56 | 20.00 [High] | Form 4 | - | 2020-11-19 | John Maraganore | Chief Executive Officer | Sell | 18,987 | Common Stock | $123.55 | $2,345,843.85 | 1.63 [ High ] | 213,367 | $26,361,492.85 | 18.37 [High] | Form 4 | - | 2020-11-19 | John Maraganore | Chief Executive Officer | Sell | 5,489 | Common Stock | $124.49 | $683,325.61 | 0.47 [ Average ] | 207,878 | $25,878,732.22 | 17.89 [High] | Form 4 | - | 2020-11-19 | John Maraganore | Chief Executive Officer | Sell | 10,187 | Common Stock | $125.35 | $1,276,940.45 | 0.88 [ High ] | 197,691 | $24,780,566.85 | 17.02 [High] | Form 4 | - | 2020-11-19 | John Maraganore | Chief Executive Officer | Sell | 102 | Common Stock | $126.62 | $12,915.24 | - | 197,589 | $25,018,719.18 | 17.01 [High] | Form 4 | - | 2020-11-25 | Phillip A Sharp | - | Buy | 30,000 | Common Stock | $9.30 | -$279,000.00 | 2.58 [ Very High ] | 265,633 | $2,470,386.90 | 22.86 [High] | Form 4 | - | 2020-11-25 | Phillip A Sharp | - | Sell | 11,523 | Common Stock | $124.30 | $1,432,308.90 | 0.99 [ High ] | 254,110 | $31,585,873.00 | 21.87 [High] | Form 4 | - | 2020-11-25 | Phillip A Sharp | - | Sell | 15,715 | Common Stock | $125.05 | $1,965,160.75 | 1.35 [ High ] | 238,395 | $29,811,294.75 | 20.52 [High] | Form 4 | - | 2020-11-25 | Phillip A Sharp | - | Sell | 2,117 | Common Stock | $126.16 | $267,080.72 | 0.18 [ Low ] | 236,278 | $29,808,832.48 | 20.34 [High] | Form 4 | - | 2020-11-25 | Phillip A Sharp | - | Sell | 645 | Common Stock | $127.44 | $82,198.80 | 0.06 [ Very Low ] | 235,633 | $30,029,069.52 | 20.28 [High] | Form 4 | - | 2020-12-07 | Phillip A Sharp | - | Sell | 235,633 | Common Stock | $0.00 | $0.00 | - | 0 | $0.00 | - | Form 4 | - | 2020-12-07 | Phillip A Sharp | - | Buy | 235,633 | Common Stock | $0.00 | $0.00 | - | 266,899 | $0.00 | 22.97 [High] | Form 4 | by Trust | 2020-12-18 | Steven M Paul | - | Buy | 15,000 | Common Stock | $9.30 | -$139,500.00 | 1.29 [ High ] | 16,000 | $148,800.00 | 1.38 [Low] | Form 4 | - | 2020-12-18 | Steven M Paul | - | Sell | 15,000 | Common Stock | $140.00 | $2,100,000.00 | 1.29 [ High ] | 1,000 | $140,000.00 | 0.09 [Very Low] | Form 4 | - | 2021-01-12 | Yvonne Greenstreet | President & COO | Buy | 3,125 | Common Stock | $42.22 | -$131,937.50 | 0.27 [ Low ] | 7,945 | $335,437.90 | 0.68 [Very Low] | Form 4 | - | 2021-01-12 | Yvonne Greenstreet | President & COO | Sell | 3,125 | Common Stock | $161.00 | $503,125.00 | 0.27 [ Low ] | 4,820 | $776,020.00 | 0.41 [Very Low] | Form 4 | - | 2021-01-11 | Laurie Keating | EVP, Chief Legal Officer | Sell | 758 | Common Stock | $154.00 | $116,732.00 | 0.07 [ Very Low ] | 2,234 | $344,036.00 | 0.19 [Very Low] | Form 4 | - | 2021-01-12 | Laurie Keating | EVP, Chief Legal Officer | Buy | 1,941 | Common Stock | $42.22 | -$81,949.02 | 0.17 [ Low ] | 4,175 | $176,268.50 | 0.36 [Very Low] | Form 4 | - | 2021-01-12 | Laurie Keating | EVP, Chief Legal Officer | Buy | 13,000 | Common Stock | $77.40 | -$1,006,200.00 | 1.12 [ High ] | 17,175 | $1,329,345.00 | 1.48 [Low] | Form 4 | - | 2021-01-12 | Laurie Keating | EVP, Chief Legal Officer | Sell | 11,941 | Common Stock | $159.00 | $1,898,619.00 | 1.03 [ High ] | 5,234 | $832,206.00 | 0.45 [Very Low] | Form 4 | - | 2021-01-12 | Laurie Keating | EVP, Chief Legal Officer | Sell | 3,000 | Common Stock | $165.00 | $495,000.00 | 0.26 [ Low ] | 2,234 | $368,610.00 | 0.19 [Very Low] | Form 4 | - | 2021-01-13 | Laurie Keating | EVP, Chief Legal Officer | Buy | 3,027 | Common Stock | $77.40 | -$234,289.80 | 0.26 [ Low ] | 5,261 | $407,201.40 | 0.45 [Very Low] | Form 4 | - | 2021-01-13 | Laurie Keating | EVP, Chief Legal Officer | Buy | 6,000 | Common Stock | $85.00 | -$510,000.00 | 0.52 [ Average ] | 11,261 | $957,185.00 | 0.97 [Very Low] | Form 4 | - | 2021-01-13 | Laurie Keating | EVP, Chief Legal Officer | Sell | 5,000 | Common Stock | $169.00 | $845,000.00 | 0.43 [ Average ] | 6,261 | $1,058,109.00 | 0.54 [Very Low] | Form 4 | - | 2021-01-13 | Laurie Keating | EVP, Chief Legal Officer | Sell | 3,000 | Common Stock | $170.00 | $510,000.00 | 0.26 [ Low ] | 3,261 | $554,370.00 | 0.28 [Very Low] | Form 4 | - | 2021-01-13 | Laurie Keating | EVP, Chief Legal Officer | Sell | 1,027 | Common Stock | $174.00 | $178,698.00 | 0.09 [ Very Low ] | 2,234 | $388,716.00 | 0.19 [Very Low] | Form 4 | - 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