| Trade Date | Insider | Title | Buy or Sell | Quantity | Security Type | Price | Proceeds | Transaction Conviction | Position Quantity | Position Value | Positon Conviction | SEC Link | Nature of Ownership | 2020-05-26 | Timothy M Shannon | - | Buy | 12,923 | Common Stock | $22.06 | -$285,081.38 | 3.30 [ Very High ] | 74,546 | $1,644,484.76 | 19.04 [High] | Form 4 | - | 2020-05-26 | Liam Ratcliffe | - | Buy | 6,500 | Common Stock | $22.06 | -$143,390.00 | 1.66 [ High ] | 6,500 | $143,390.00 | 1.66 [Low] | Form 4 | - | 2020-05-12 | Sean A Cassidy | Chief Financial Officer | Sell | 10,000 | Common Stock | $60.00 | $600,000.00 | 2.55 [ Very High ] | 150,422 | $9,025,320.00 | 38.42 [High] | Form 4 | - | 2020-05-13 | Sean A Cassidy | Chief Financial Officer | Buy | 1,356 | Common Stock | $16.00 | -$21,696.00 | 0.35 [ Average ] | 151,778 | $2,428,448.00 | 38.77 [High] | Form 4 | - | 2020-06-02 | Timothy M Shannon | - | Buy | 3,000 | Common Stock | $32.30 | -$96,900.00 | - | 77,546 | $2,504,735.80 | - | Form 4 | - | 2020-06-17 | Timothy M Shannon | - | Buy | 2,000 | Common Stock | $30.26 | -$60,520.00 | - | 79,546 | $2,407,061.96 | - | Form 4 | - | 2020-07-20 | Ix L.p. Canaan | - | Sell | 500,000 | Common Stock | $0.00 | $0.00 | - | 3,989,554 | $0.00 | 1,019.04 [Very High] | Form 4 | - | 2020-08-14 | Ronald Peck | Chief Medical Officer | Buy | 4,010 | Common Stock | $0.00 | $0.00 | - | 4,010 | $0.00 | 1.02 [Very Low] | Form 4 | - | 2020-08-14 | Ronald Peck | Chief Medical Officer | Sell | 1,256 | Common Stock | $27.46 | $34,489.76 | 0.32 [ Average ] | 2,754 | $75,624.84 | 0.70 [Very Low] | Form 4 | - | 2020-10-14 | Ix L.p. Canaan | - | Sell | 400,000 | Common Stock | $0.00 | $0.00 | - | 3,589,554 | $0.00 | 914.82 [Very High] | Form 4 | - | 2020-11-09 | Sean A Cassidy | Chief Financial Officer | Buy | 3,006 | Common Stock | $16.00 | -$48,096.00 | 0.74 [ Average ] | 154,784 | $2,476,544.00 | 38.17 [High] | Form 4 | - | 2020-11-09 | Kennedy Edward Moore Jr. | - | Buy | 8,333 | Common Stock | $23.99 | -$199,908.67 | 2.06 [ High ] | 42,718 | $1,024,804.82 | 10.53 [Average] | Form 4 | - | 2020-12-18 | Liam Ratcliffe | - | Buy | 142,857 | Common Stock | $70.00 | -$9,999,990.00 | 30.04 [ Very High ] | 822,857 | $57,599,990.00 | 173.02 [Very High] | Form 4 | See footnote | 2021-02-16 | Sean A Cassidy | Chief Financial Officer | Buy | 6,815 | Common Stock | $16.00 | -$109,040.00 | 1.43 [ High ] | 161,599 | $2,585,584.00 | 33.98 [High] | Form 4 | - | 2021-02-16 | Sean A Cassidy | Chief Financial Officer | Buy | 35,144 | Common Stock | $16.00 | -$562,304.00 | 7.39 [ Very High ] | 196,743 | $3,147,888.00 | 41.37 [High] | Form 4 | - | 2021-02-16 | Sean A Cassidy | Chief Financial Officer | Sell | 8,158 | Common Stock | $77.60 | $633,060.80 | 1.72 [ High ] | 188,585 | $14,634,196.00 | 39.65 [High] | Form 4 | - | 2021-02-16 | Sean A Cassidy | Chief Financial Officer | Sell | 19,303 | Common Stock | $78.61 | $1,517,408.83 | 4.06 [ Very High ] | 169,282 | $13,307,258.02 | 35.59 [High] | Form 4 | - | 2021-02-16 | Sean A Cassidy | Chief Financial Officer | Sell | 3,958 | Common Stock | $79.32 | $313,948.56 | 0.83 [ High ] | 165,324 | $13,113,499.68 | 34.76 [High] | Form 4 | - | 2021-02-16 | Sean A Cassidy | Chief Financial Officer | Sell | 396 | Common Stock | $80.28 | $31,790.88 | 0.08 [ Very Low ] | 164,928 | $13,240,419.84 | 34.68 [High] | Form 4 | - | 2021-02-16 | Sean A Cassidy | Chief Financial Officer | Sell | 2,793 | Common Stock | $77.62 | $216,792.66 | 0.59 [ Average ] | 162,135 | $12,584,918.70 | 34.09 [High] | Form 4 | - | 2021-02-16 | Sean A Cassidy | Chief Financial Officer | Sell | 6,160 | Common Stock | $78.65 | $484,484.00 | 1.30 [ High ] | 155,975 | $12,267,433.75 | 32.80 [High] | Form 4 | - | 2021-02-16 | Sean A Cassidy | Chief Financial Officer | Sell | 1,161 | Common Stock | $79.42 | $92,206.62 | 0.24 [ Low ] | 154,814 | $12,295,327.88 | 32.55 [High] | Form 4 | - | 2021-02-16 | Sean A Cassidy | Chief Financial Officer | Sell | 30 | Common Stock | $80.43 | $2,412.90 | - | 154,784 | $12,449,277.12 | 32.55 [High] | Form 4 | - | 2021-02-17 | Sean A Cassidy | Chief Financial Officer | Buy | 325 | Common Stock | $16.00 | -$5,200.00 | 0.07 [ Very Low ] | 155,109 | $2,481,744.00 | 32.61 [High] | Form 4 | - | 2021-02-17 | Sean A Cassidy | Chief Financial Officer | Buy | 569 | Common Stock | $16.00 | -$9,104.00 | 0.12 [ Low ] | 155,678 | $2,490,848.00 | 32.73 [High] | Form 4 | - | 2021-02-16 | Ronald Peck | Chief Medical Officer | Buy | 20,000 | Common Stock | $26.58 | -$531,600.00 | 4.21 [ Very High ] | 22,754 | $604,801.32 | 4.78 [Average] | Form 4 | - | 2021-02-16 | Ronald Peck | Chief Medical Officer | Sell | 20,000 | Common Stock | $77.35 | $1,547,000.00 | 4.21 [ Very High ] | 2,754 | $213,021.90 | 0.58 [Very Low] | Form 4 | - | 2021-02-16 | John G Houston | President and CEO | Buy | 44,000 | Common Stock | $16.00 | -$704,000.00 | 9.25 [ Very High ] | 860,000 | $13,760,000.00 | 180.83 [Very High] | Form 4 | - | 2021-02-16 | John G Houston | President and CEO | Sell | 8,928 | Common Stock | $77.62 | $692,991.36 | 1.88 [ High ] | 851,272 | $66,075,732.64 | 178.99 [Very High] | Form 4 | - | 2021-02-16 | John G Houston | President and CEO | Sell | 21,249 | Common Stock | $78.66 | $1,671,446.34 | 4.47 [ Very High ] | 830,023 | $65,289,609.18 | 174.52 [Very High] | Form 4 | - | 2021-02-16 | John G Houston | President and CEO | Sell | 13,223 | Common Stock | $79.72 | $1,054,137.56 | 2.78 [ Very High ] | 816,800 | $65,115,296.00 | 171.74 [Very High] | Form 4 | - | 2021-02-16 | John G Houston | President and CEO | Sell | 600 | Common Stock | $80.25 | $48,150.00 | 0.13 [ Low ] | 816,200 | $65,500,050.00 | 171.62 [Very High] | Form 4 | - | 2021-02-16 | John G Houston | President and CEO | Buy | 1,560 | Common Stock | $16.00 | -$24,960.00 | 0.33 [ Average ] | 817,760 | $13,084,160.00 | 171.95 [Very High] | Form 4 | - | 2021-02-19 | Ian Taylor | Chief Scientific Officer | Buy | 6,456 | Common Stock | $16.00 | -$103,296.00 | 1.36 [ High ] | 76,854 | $1,229,664.00 | 16.16 [High] | Form 4 | - | 2021-03-02 | Sean A Cassidy | Chief Financial Officer | Buy | 4,792 | Common Stock | $0.00 | $0.00 | - | 160,470 | $0.00 | 33.74 [High] | Form 4 | - | 2021-03-02 | Sean A Cassidy | Chief Financial Officer | Sell | 2,221 | Common Stock | $77.45 | $172,016.45 | 0.47 [ Average ] | 158,249 | $12,256,385.05 | 33.27 [High] | Form 4 | - | 2020-06-30 | John G Houston | President and CEO | Buy | 315 | Common Stock | $28.50 | -$8,977.50 | 0.07 [ Very Low ] | 817,938 | $23,311,233.00 | 171.98 [Very High] | Form 4 | - | 2020-12-31 | John G Houston | President and CEO | Buy | 310 | Common Stock | $29.02 | -$8,996.20 | 0.07 [ Very Low ] | 818,248 | $23,745,556.96 | 172.05 [Very High] | Form 4 | - | 2021-03-02 | John G Houston | President and CEO | Buy | 17,510 | Common Stock | $0.00 | $0.00 | - | 835,758 | $0.00 | 175.73 [Very High] | Form 4 | - | 2021-03-02 | John G Houston | President and CEO | Sell | 8,115 | Common Stock | $77.45 | $628,506.75 | 1.71 [ High ] | 827,643 | $64,100,950.35 | 174.02 [Very High] | Form 4 | - | 2021-03-02 | Ian Taylor | Chief Scientific Officer | Buy | 2,685 | Common Stock | $0.00 | $0.00 | - | 79,539 | $0.00 | 16.72 [High] | Form 4 | - | 2021-03-02 | Ian Taylor | Chief Scientific Officer | Sell | 894 | Common Stock | $77.45 | $69,240.30 | 0.19 [ Low ] | 78,645 | $6,091,055.25 | 16.54 [High] | Form 4 | - | 2021-04-05 | Ian Taylor | Chief Scientific Officer | Buy | 25,000 | Common Stock | $16.00 | -$400,000.00 | 5.12 [ Very High ] | 103,645 | $1,658,320.00 | 21.21 [High] | Form 4 | - | 2021-04-05 | Ian Taylor | Chief Scientific Officer | Sell | 4,100 | Common Stock | $66.01 | $270,641.00 | 0.84 [ High ] | 99,545 | $6,570,965.45 | 20.37 [High] | Form 4 | - | 2021-04-05 | Ian Taylor | Chief Scientific Officer | Sell | 16,450 | Common Stock | $66.80 | $1,098,860.00 | 3.37 [ Very High ] | 83,095 | $5,550,746.00 | 17.00 [High] | Form 4 | - | 2021-04-05 | Ian Taylor | Chief Scientific Officer | Sell | 4,450 | Common Stock | $67.56 | $300,642.00 | 0.91 [ High ] | 78,645 | $5,313,256.20 | 16.09 [High] | Form 4 | - |
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