| Trade Date | Insider | Title | Buy or Sell | Quantity | Security Type | Price | Proceeds | Transaction Conviction | Position Quantity | Position Value | Positon Conviction | SEC Link | Nature of Ownership | 2020-04-06 | Patrick Miles | CEO | Buy | 28,268 | Common Stock | $3.93 | -$111,093.24 | 4.41 [ Very High ] | 4,179,189 | $16,424,212.77 | 652.50 [Very High] | Form 4 | - | 2020-04-06 | Kelli Mari Howell | EVP, Clinical Strategies | Buy | 11,136 | Common Stock | $3.93 | -$43,764.48 | 1.74 [ High ] | 402,015 | $1,579,918.95 | 62.77 [High] | Form 4 | - | 2020-04-06 | Craig E Hunsaker | EVP, People/Culture & GC | Buy | 17,988 | Common Stock | $3.93 | -$70,692.84 | 2.81 [ Very High ] | 880,936 | $3,462,078.48 | 137.54 [Very High] | Form 4 | - | 2020-04-06 | Jeffrey G. Black | EVP & CFO | Buy | 5,996 | Common Stock | $3.93 | -$23,564.28 | 0.94 [ High ] | 511,295 | $2,009,389.35 | 79.83 [High] | Form 4 | - | 2020-04-06 | Brian Snider | EVP, Strat. Mktg. & Prod. Dev. | Buy | 5,482 | Common Stock | $3.93 | -$21,544.26 | 0.86 [ High ] | 498,489 | $1,959,061.77 | 77.83 [High] | Form 4 | - | 2020-04-06 | David Sponsel | EVP, Sales | Buy | 2,398 | Common Stock | $3.93 | -$9,424.14 | 0.37 [ Average ] | 445,417 | $1,750,488.81 | 69.54 [High] | Form 4 | - | 2020-04-22 | Patrick Miles | CEO | Buy | 875,660 | Common Stock | $0.00 | $0.00 | - | 5,054,849 | $0.00 | 789.22 [Very High] | Form 4 | - | 2020-04-22 | Brian Snider | EVP, Strat. Mktg. & Prod. Dev. | Buy | 142,228 | Common Stock | $0.00 | $0.00 | - | 640,717 | $0.00 | 100.04 [Very High] | Form 4 | - | 2020-04-22 | David Sponsel | EVP, Sales | Buy | 216,422 | Common Stock | $0.00 | $0.00 | - | 661,839 | $0.00 | 103.33 [Very High] | Form 4 | - | 2020-04-22 | Jeffrey G. Black | EVP & CFO | Buy | 179,178 | Common Stock | $0.00 | $0.00 | - | 690,473 | $0.00 | 107.80 [Very High] | Form 4 | - | 2020-04-22 | Craig E Hunsaker | EVP, People/Culture & GC | Buy | 167,156 | Common Stock | $0.00 | $0.00 | - | 1,048,092 | $0.00 | 163.64 [Very High] | Form 4 | - | 2020-04-22 | Kelli Mari Howell | EVP, Clinical Strategies | Buy | 98,534 | Common Stock | $0.00 | $0.00 | - | 500,549 | $0.00 | 78.15 [High] | Form 4 | - | 2020-05-14 | Jeffrey G. Black | EVP & CFO | Sell | 23,774 | Common Stock | $4.06 | $96,522.44 | 3.71 [ Very High ] | 666,699 | $2,706,797.94 | 104.09 [Very High] | Form 4 | - | 2020-06-16 | Tullis James L L | - | Sell | 38,000 | Common Stock | $5.15 | $195,700.00 | - | 715,828 | $3,686,514.20 | - | Form 4 | By Tullis Growth Fund, L.P. | 2020-06-17 | Tullis James L L | - | Buy | 22,146 | Common Stock | $0.00 | $0.00 | - | 127,734 | $0.00 | - | Form 4 | - | 2020-06-17 | Karen K Mcginnis | - | Buy | 23,784 | Common Stock | $0.00 | $0.00 | - | 40,439 | $0.00 | - | Form 4 | - | 2020-06-17 | Woods Ward W Jr | - | Buy | 24,049 | Common Stock | $0.00 | $0.00 | - | 83,738 | $0.00 | - | Form 4 | - | 2020-06-17 | Jeffrey P Rydin | - | Buy | 21,142 | Common Stock | $0.00 | $0.00 | - | 414,888 | $0.00 | - | Form 4 | - | 2020-06-17 | David R Pelizzon | - | Buy | 21,142 | Common Stock | $0.00 | $0.00 | - | 137,139 | $0.00 | - | Form 4 | - | 2020-06-17 | Donald Allen Williams | - | Buy | 26,956 | Common Stock | $0.00 | $0.00 | - | 124,507 | $0.00 | - | Form 4 | - | 2020-06-17 | Evan Bakst | - | Buy | 21,142 | Common Stock | $0.00 | $0.00 | - | 766,140 | $0.00 | - | Form 4 | - | 2020-06-17 | Quentin S. Blackford | - | Buy | 28,013 | Common Stock | $0.00 | $0.00 | - | 530,180 | $0.00 | - | Form 4 | - | 2020-06-17 | Jason Hochberg | - | Buy | 21,142 | Common Stock | $0.00 | $0.00 | - | 64,154 | $0.00 | - | Form 4 | - | 2020-06-17 | David H Mowry | - | Buy | 24,313 | Common Stock | $0.00 | $0.00 | - | 81,830 | $0.00 | - | Form 4 | - | 2020-08-04 | Jeffrey G. Black | EVP & CFO | Sell | 8,929 | Common Stock | $5.03 | $44,912.87 | 1.39 [ High ] | 657,770 | $3,308,583.10 | 102.70 [Very High] | Form 4 | - | 2020-08-11 | Jeffrey G. Black | EVP & CFO | Sell | 5,000 | Common Stock | $6.42 | $32,100.00 | 0.78 [ High ] | 652,770 | $4,190,783.40 | 101.51 [Very High] | Form 4 | - | 2020-10-08 | Craig E Hunsaker | EVP, People/Culture & GC | Sell | 32,000 | Common Stock | $8.25 | $264,000.00 | 4.98 [ Very High ] | 1,016,092 | $8,382,759.00 | 158.02 [Very High] | Form 4 | - | 2020-10-08 | Craig E Hunsaker | EVP, People/Culture & GC | Sell | 30,731 | Common Stock | $9.00 | $276,579.00 | 4.78 [ Very High ] | 985,361 | $8,868,249.00 | 153.24 [Very High] | Form 4 | - | 2020-10-12 | David Sponsel | EVP, Sales | Sell | 89,999 | Common Stock | $9.47 | $852,290.53 | 14.00 [ Very High ] | 571,840 | $5,415,324.80 | 88.93 [Very High] | Form 4 | - | 2020-11-16 | Scott Lish | SVP, Development | Sell | 2,162 | Common Stock | $9.82 | $21,230.84 | 0.28 [ Low ] | 293,247 | $2,879,685.54 | 37.39 [High] | Form 4 | - | 2020-12-01 | Tullis James L L | - | Sell | 600,000 | Common Stock | $0.00 | $0.00 | - | 1,143,803 | $0.00 | 145.85 [Very High] | Form 4 | By Tullis Dickerson Capital Focus III, LP | 2020-12-01 | Tullis James L L | - | Buy | 116,355 | Common Stock | $0.00 | $0.00 | - | 116,355 | $0.00 | 14.84 [Average] | Form 4 | By Tullis-Dickerson Partners III, LLC | 2020-12-18 | David R Pelizzon | - | Buy | 1,350,135 | Common Stock | $11.11 | -$14,999,999.85 | 172.16 [ Very High ] | 2,437,092 | $27,076,092.12 | 310.75 [Very High] | Form 4 | By Squadron Capital LLC | 2020-12-18 | Tullis James L L | - | Sell | 29 | Common Stock | $0.00 | $0.00 | - | 127,705 | $0.00 | 16.28 [High] | Form 4 | - | 2021-01-21 | Tullis James L L | - | Sell | 400,000 | Common Stock | $0.00 | $0.00 | - | 315,828 | $0.00 | 40.27 [High] | Form 4 | By Tullis Growth Fund, L.P. | 2021-01-21 | Tullis James L L | - | Buy | 4,714 | Common Stock | $0.00 | $0.00 | - | 132,419 | $0.00 | 16.88 [High] | Form 4 | - | 2021-02-16 | Jeffrey G. Black | EVP & CFO | Sell | 25,000 | Common Stock | $16.28 | $407,000.00 | 3.19 [ Very High ] | 627,770 | $10,220,095.60 | 80.05 [Very High] | Form 4 | - | 2021-02-18 | Patrick Miles | CEO | Buy | 50,000 | Common Stock | $0.00 | $0.00 | - | 5,104,849 | $0.00 | 650.92 [Very High] | Form 4 | - | 2021-02-18 | Scott Lish | SVP, Development | Buy | 35,000 | Common Stock | $0.00 | $0.00 | - | 328,247 | $0.00 | 41.85 [High] | Form 4 | - | 2021-02-18 | Craig E Hunsaker | EVP, People/Culture & GC | Buy | 50,000 | Common Stock | $0.00 | $0.00 | - | 1,033,361 | $0.00 | 131.76 [Very High] | Form 4 | - | 2021-02-18 | David Sponsel | EVP, Sales | Sell | 40,000 | Common Stock | $0.00 | $0.00 | - | 612,756 | $0.00 | 78.13 [Very High] | Form 4 | - | 2021-02-18 | Kelli Mari Howell | EVP, Clinical Strategies | Buy | 20,000 | Common Stock | $0.00 | $0.00 | - | 523,941 | $0.00 | 66.81 [High] | Form 4 | - | 2021-02-18 | Brian Snider | EVP, Strat. Mktg. & Prod. Dev. | Buy | 20,000 | Common Stock | $0.00 | $0.00 | - | 666,226 | $0.00 | 84.95 [Very High] | Form 4 | - | 2021-02-23 | Tullis James L L | - | Buy | 18,337 | Common Stock | $3.50 | -$64,179.50 | 2.34 [ High ] | 150,756 | $527,646.00 | 19.22 [High] | Form 4 | - | 2021-02-23 | Tullis James L L | - | Sell | 3,887 | Common Stock | $16.51 | $64,174.37 | 0.50 [ Average ] | 146,869 | $2,424,807.19 | 18.73 [High] | Form 4 | - | 2021-02-23 | Tullis James L L | - | Buy | 320,325 | Common Stock | $3.50 | -$1,121,137.50 | 40.84 [ Very High ] | 636,153 | $2,226,535.50 | 81.12 [Very High] | Form 4 | By Tullis Growth Fund, L.P. | 2021-02-23 | Tullis James L L | - | Sell | 67,906 | Common Stock | $16.51 | $1,121,128.06 | 8.66 [ Very High ] | 568,247 | $9,381,757.97 | 72.46 [Very High] | Form 4 | By Tullis Growth Fund, L.P. | 2021-02-23 | Tullis James L L | - | Buy | 440,973 | Common Stock | $3.50 | -$1,543,405.50 | 56.23 [ Very High ] | 1,584,776 | $5,546,716.00 | 202.08 [Very High] | Form 4 | By Tullis Dickerson Capital Focus III, LP | 2021-02-23 | Tullis James L L | - | Sell | 93,483 | Common Stock | $16.51 | $1,543,404.33 | 11.92 [ Very High ] | 1,491,293 | $24,621,247.43 | 190.16 [Very High] | Form 4 | By Tullis Dickerson Capital Focus III, LP | 2021-02-23 | Tullis James L L | - | Sell | 600,000 | Common Stock | $0.00 | $0.00 | - | 891,293 | $0.00 | 113.65 [Very High] | Form 4 | By Tullis Dickerson Capital Focus III, LP | 2021-02-23 | Tullis James L L | - | Buy | 131,870 | Common Stock | $0.00 | $0.00 | - | 248,225 | $0.00 | 31.65 [High] | Form 4 | By Tullis-Dickerson Partners III, LLC |
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