| Trade Date | Insider | Title | Buy or Sell | Quantity | Security Type | Price | Proceeds | Transaction Conviction | Position Quantity | Position Value | Positon Conviction | SEC Link | Nature of Ownership | 2020-07-01 | Dennis M Lanfear | President & CEO | Buy | 29,994 | Common Stock, $0.0001 par value | $0.01 | -$299.94 | - | 193,258 | $1,932.58 | 27.25 [High] | Form 4 | - | 2020-04-17 | Vincent R Anicetti | Chief Operating Officer | Buy | 5,000 | Common Stock | $2.50 | -$12,500.00 | 0.71 [ Average ] | 57,996 | $144,990.00 | 8.18 [Average] | Form 4 | - | 2020-04-17 | Vincent R Anicetti | Chief Operating Officer | Sell | 5,000 | Common Stock | $15.57 | $77,850.00 | 0.71 [ Average ] | 52,996 | $825,147.72 | 7.47 [Average] | Form 4 | - | 2020-04-20 | Vincent R Anicetti | Chief Operating Officer | Sell | 5,150 | Common Stock | $17.00 | $87,550.00 | 0.73 [ Average ] | 47,846 | $813,382.00 | 6.75 [Average] | Form 4 | - | 2020-05-18 | Vincent R Anicetti | Chief Operating Officer | Sell | 593 | Common Stock | $17.17 | $10,181.81 | 0.21 [ Low ] | 48,556 | $833,706.52 | 16.83 [High] | Form 4 | - | 2020-05-18 | Vincent R Anicetti | Chief Operating Officer | Buy | 2,500 | Common Stock | $2.50 | -$6,250.00 | 0.87 [ High ] | 51,056 | $127,640.00 | 17.69 [High] | Form 4 | - | 2020-05-18 | Vincent R Anicetti | Chief Operating Officer | Sell | 2,500 | Common Stock | $17.17 | $42,925.00 | 0.87 [ High ] | 48,556 | $833,706.52 | 16.83 [High] | Form 4 | - | 2020-05-20 | Jean-frederic Viret | Chief Financial Officer | Sell | 1,278 | Common Stock, $0.0001 par value | $17.66 | $22,569.48 | 0.18 [ Low ] | 46,567 | $822,373.22 | 6.57 [Average] | Form 4 | - | 2020-06-17 | Mats Wahlstrom | - | Sell | 200,000 | Common Stock, $0.0001 par value | $17.15 | $3,430,000.00 | - | 0 | $0.00 | - | Form 4 | See Footnote | 2020-06-17 | Vincent R Anicetti | Chief Operating Officer | Buy | 2,500 | Common Stock | $2.50 | -$6,250.00 | - | 51,056 | $127,640.00 | - | Form 4 | - | 2020-06-17 | Vincent R Anicetti | Chief Operating Officer | Sell | 2,500 | Common Stock | $17.22 | $43,050.00 | - | 48,556 | $836,134.32 | - | Form 4 | - | 2020-06-22 | Mary T Szela | - | Buy | 14,997 | Common Stock, $0.0001 par value | $2.50 | -$37,492.50 | - | 14,997 | $37,492.50 | - | Form 4 | - | 2020-06-22 | Mary T Szela | - | Buy | 20,000 | Common Stock, $0.0001 par value | $10.05 | -$201,000.00 | - | 34,997 | $351,719.85 | - | Form 4 | - | 2020-06-22 | Mary T Szela | - | Buy | 20,000 | Common Stock, $0.0001 par value | $12.37 | -$247,400.00 | - | 54,997 | $680,312.89 | - | Form 4 | - | 2020-06-22 | Mary T Szela | - | Sell | 54,997 | Common Stock, $0.0001 par value | $17.58 | $966,847.26 | - | 0 | $0.00 | - | Form 4 | - | 2020-07-17 | Vincent R Anicetti | Chief Operating Officer | Buy | 2,500 | Common Stock | $2.50 | -$6,250.00 | 0.35 [ Average ] | 51,056 | $127,640.00 | 7.20 [Average] | Form 4 | - | 2020-07-17 | Vincent R Anicetti | Chief Operating Officer | Buy | 12,500 | Common Stock | $12.70 | -$158,750.00 | 1.76 [ High ] | 63,556 | $807,161.20 | 8.96 [Average] | Form 4 | - | 2020-07-17 | Vincent R Anicetti | Chief Operating Officer | Sell | 15,000 | Common Stock | $18.25 | $273,750.00 | 2.12 [ High ] | 48,556 | $886,147.00 | 6.85 [Average] | Form 4 | - | 2020-08-17 | Vincent R Anicetti | Chief Operating Officer | Buy | 2,500 | Common Stock | $2.50 | -$6,250.00 | 0.35 [ Average ] | 51,056 | $127,640.00 | 7.14 [Average] | Form 4 | - | 2020-08-17 | Vincent R Anicetti | Chief Operating Officer | Buy | 2,500 | Common Stock | $12.70 | -$31,750.00 | 0.35 [ Average ] | 53,556 | $680,161.20 | 7.49 [Average] | Form 4 | - | 2020-08-17 | Vincent R Anicetti | Chief Operating Officer | Sell | 5,000 | Common Stock | $19.37 | $96,850.00 | 0.70 [ Average ] | 48,556 | $940,529.72 | 6.79 [Average] | Form 4 | - | 2020-08-28 | James Healy | - | Sell | 983,221 | Common Stock, $0.0001 par value | $0.00 | $0.00 | - | 950,000 | $0.00 | 132.92 [Very High] | Form 4 | See Footnote | 2020-08-28 | James Healy | - | Buy | 221,009 | Common Stock, $0.0001 par value | $0.00 | $0.00 | - | 221,009 | $0.00 | 30.92 [High] | Form 4 | See Footnote | 2020-09-17 | Vincent R Anicetti | Chief Operating Officer | Buy | 2,500 | Common Stock | $2.50 | -$6,250.00 | 0.35 [ Average ] | 51,056 | $127,640.00 | 7.14 [Average] | Form 4 | - | 2020-09-17 | Vincent R Anicetti | Chief Operating Officer | Buy | 2,500 | Common Stock | $12.70 | -$31,750.00 | 0.35 [ Average ] | 53,556 | $680,161.20 | 7.49 [Average] | Form 4 | - | 2020-09-17 | Vincent R Anicetti | Chief Operating Officer | Sell | 5,000 | Common Stock | $18.84 | $94,200.00 | 0.70 [ Average ] | 48,556 | $914,795.04 | 6.79 [Average] | Form 4 | - | 2020-09-29 | James Healy | - | Sell | 950,000 | Common Stock, $0.0001 par value | $0.00 | $0.00 | - | 0 | $0.00 | - | Form 4 | See Footnote | 2020-09-29 | James Healy | - | Buy | 213,546 | Common Stock, $0.0001 par value | $0.00 | $0.00 | - | 434,555 | $0.00 | 60.80 [High] | Form 4 | See Footnote | 2020-10-14 | Jean-frederic Viret | Chief Financial Officer | Sell | 6,144 | Common Stock, $0.0001 par value | $19.00 | $116,736.00 | 0.86 [ High ] | 40,423 | $768,037.00 | 5.66 [Average] | Form 4 | - | 2020-10-19 | Vincent R Anicetti | Chief Operating Officer | Buy | 2,500 | Common Stock | $2.50 | -$6,250.00 | 0.35 [ Average ] | 51,056 | $127,640.00 | 7.14 [Average] | Form 4 | - | 2020-10-19 | Vincent R Anicetti | Chief Operating Officer | Buy | 717 | Common Stock | $12.70 | -$9,105.90 | 0.10 [ Low ] | 51,773 | $657,517.10 | 7.24 [Average] | Form 4 | - | 2020-10-19 | Vincent R Anicetti | Chief Operating Officer | Sell | 3,217 | Common Stock | $17.89 | $57,552.13 | 0.45 [ Average ] | 48,556 | $868,666.84 | 6.79 [Average] | Form 4 | - | 2020-12-03 | Vincent R Anicetti | Chief Operating Officer | Buy | 36,736 | Common Stock | $17.17 | -$630,757.12 | 5.10 [ Very High ] | 69,305 | $1,189,966.85 | 9.62 [Average] | Form 4 | - | 2020-12-03 | Vincent R Anicetti | Chief Operating Officer | Buy | 13,020 | Common Stock | $17.73 | -$230,844.60 | 1.81 [ High ] | 82,325 | $1,459,622.25 | 11.43 [Average] | Form 4 | - | 2020-12-03 | Vincent R Anicetti | Chief Operating Officer | Sell | 49,756 | Common Stock | $18.67 | $928,944.52 | 6.91 [ Very High ] | 32,569 | $608,063.23 | 4.52 [Low] | Form 4 | - | 2020-12-04 | Vincent R Anicetti | Chief Operating Officer | Buy | 32,291 | Common Stock | $16.75 | -$540,874.25 | 4.48 [ Very High ] | 64,860 | $1,086,405.00 | 9.00 [Average] | Form 4 | - | 2020-12-04 | Vincent R Anicetti | Chief Operating Officer | Buy | 16,709 | Common Stock | $12.70 | -$212,204.30 | 2.32 [ High ] | 81,569 | $1,035,926.30 | 11.32 [Average] | Form 4 | - | 2020-12-04 | Vincent R Anicetti | Chief Operating Officer | Sell | 49,000 | Common Stock | $18.85 | $923,650.00 | 6.80 [ Very High ] | 32,569 | $613,925.65 | 4.52 [Low] | Form 4 | - | 2020-12-07 | Vincent R Anicetti | Chief Operating Officer | Buy | 3,000 | Common Stock | $12.37 | -$37,110.00 | 0.42 [ Average ] | 35,569 | $439,988.53 | 4.94 [Low] | Form 4 | - | 2020-12-07 | Vincent R Anicetti | Chief Operating Officer | Buy | 5,791 | Common Stock | $12.70 | -$73,545.70 | 0.80 [ Average ] | 41,360 | $525,272.00 | 5.74 [Average] | Form 4 | - | 2020-12-07 | Vincent R Anicetti | Chief Operating Officer | Sell | 8,791 | Common Stock | $18.42 | $161,930.22 | 1.22 [ High ] | 32,569 | $599,920.98 | 4.52 [Low] | Form 4 | - | 2020-12-09 | Vladimir Vexler | Chief Scientific Officer | Buy | 30,000 | Common Stock | $2.08 | -$62,400.00 | 4.16 [ Very High ] | 86,185 | $179,264.80 | 11.96 [Average] | Form 4 | - | 2020-12-09 | Vladimir Vexler | Chief Scientific Officer | Sell | 49,512 | Common Stock | $18.24 | $903,098.88 | 6.87 [ Very High ] | 36,673 | $668,915.52 | 5.09 [Average] | Form 4 | - | 2020-12-10 | Vladimir Vexler | Chief Scientific Officer | Buy | 17,626 | Common Stock | $2.08 | -$36,662.08 | 2.45 [ High ] | 54,299 | $112,941.92 | 7.54 [Average] | Form 4 | - | 2020-12-10 | Vladimir Vexler | Chief Scientific Officer | Sell | 17,626 | Common Stock | $18.05 | $318,149.30 | 2.45 [ High ] | 36,673 | $661,947.65 | 5.09 [Average] | Form 4 | - | 2020-12-17 | Vincent R Anicetti | Chief Operating Officer | Buy | 2,500 | Common Stock | $2.50 | -$6,250.00 | 0.35 [ Average ] | 35,069 | $87,672.50 | 4.87 [Low] | Form 4 | - | 2020-12-17 | Vincent R Anicetti | Chief Operating Officer | Sell | 2,500 | Common Stock | $17.51 | $43,775.00 | 0.35 [ Average ] | 32,569 | $570,283.19 | 4.52 [Low] | Form 4 | - | 2021-01-10 | Jean-frederic Viret | Chief Financial Officer | Sell | 4,080 | Common Stock | $18.18 | $74,174.40 | 0.57 [ Average ] | 36,189 | $657,916.02 | 5.02 [Low] | Form 4 | - | 2021-01-10 | Vincent R Anicetti | Chief Operating Officer | Sell | 4,080 | Common Stock | $18.18 | $74,174.40 | 0.57 [ Average ] | 28,489 | $517,930.02 | 3.95 [Low] | Form 4 | - | 2021-01-10 | Vladimir Vexler | Chief Scientific Officer | Sell | 4,080 | Common Stock | $18.18 | $74,174.40 | 0.57 [ Average ] | 33,896 | $616,229.28 | 4.70 [Low] | Form 4 | - | 2021-01-11 | Jean-frederic Viret | Chief Financial Officer | Buy | 31,250 | Common Stock | $0.00 | $0.00 | - | 67,439 | $0.00 | 9.36 [Average] | Form 4 | - | 2021-01-11 | Vincent R Anicetti | Chief Operating Officer | Buy | 31,250 | Common Stock | $0.00 | $0.00 | - | 59,739 | $0.00 | 8.29 [Average] | Form 4 | - | 2021-01-11 | Vladimir Vexler | Chief Scientific Officer | Buy | 31,250 | Common Stock | $0.00 | $0.00 | - | 65,146 | $0.00 | 9.04 [Average] | Form 4 | - | 2021-01-19 | Vincent R Anicetti | Chief Operating Officer | Buy | 2,500 | Common Stock | $2.50 | -$6,250.00 | 0.35 [ Average ] | 62,239 | $155,597.50 | 8.64 [Average] | Form 4 | - | 2021-01-19 | Vincent R Anicetti | Chief Operating Officer | Sell | 2,500 | Common Stock | $17.94 | $44,850.00 | 0.35 [ Average ] | 59,739 | $1,071,717.66 | 8.29 [Average] | Form 4 | - |
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