| Trade Date | Insider | Title | Buy or Sell | Quantity | Security Type | Price | Proceeds | Transaction Conviction | Position Quantity | Position Value | Positon Conviction | SEC Link | Nature of Ownership | 2020-07-06 | Robert I Blum | President & CEO | Buy | 5,000 | Common Stock | $6.00 | -$30,000.00 | 0.84 [ High ] | 309,868 | $1,859,208.00 | 52.10 [High] | Form 4 | - | 2020-07-06 | Robert I Blum | President & CEO | Sell | 5,000 | Common Stock | $24.85 | $124,250.00 | 0.84 [ High ] | 304,868 | $7,575,969.80 | 51.26 [High] | Form 4 | - | 2020-07-07 | Sandford D Smith | - | Buy | 5,232 | Common Stock | $6.21 | -$32,490.72 | 0.88 [ High ] | 5,232 | $32,490.72 | 0.88 [Very Low] | Form 4 | - | 2020-07-07 | Sandford D Smith | - | Sell | 5,232 | Common Stock | $27.00 | $141,264.00 | 0.88 [ High ] | 0 | $0.00 | - | Form 4 | - | 2020-07-07 | Sandford D Smith | - | Buy | 6,510 | Common Stock | $6.72 | -$43,747.20 | 1.09 [ High ] | 6,510 | $43,747.20 | 1.09 [Very Low] | Form 4 | - | 2020-07-07 | Sandford D Smith | - | Sell | 6,510 | Common Stock | $26.00 | $169,260.00 | 1.09 [ High ] | 0 | $0.00 | - | Form 4 | - | 2020-07-08 | Sandford D Smith | - | Buy | 1,434 | Common Stock | $6.21 | -$8,905.14 | 0.24 [ Low ] | 1,434 | $8,905.14 | 0.24 [Very Low] | Form 4 | - | 2020-07-08 | Sandford D Smith | - | Sell | 1,434 | Common Stock | $27.00 | $38,718.00 | 0.24 [ Low ] | 0 | $0.00 | - | Form 4 | - | 2020-07-09 | Fady Ibraham Malik | EVP Research & Development | Sell | 1,587 | Common Stock | $26.96 | $42,785.52 | 0.27 [ Average ] | 155,034 | $4,179,716.64 | 26.07 [High] | Form 4 | - | 2020-04-28 | Wendall Wierenga | - | Buy | 3,333 | Common Stock | $8.64 | -$28,797.12 | 0.56 [ Average ] | 3,333 | $28,797.12 | 0.56 [Very Low] | Form 4 | - | 2020-04-28 | Wendall Wierenga | - | Sell | 3,333 | Common Stock | $16.00 | $53,328.00 | 0.56 [ Average ] | 0 | $0.00 | - | Form 4 | - | 2020-04-28 | Wendall Wierenga | - | Buy | 6,666 | Common Stock | $11.04 | -$73,592.64 | 1.12 [ High ] | 6,666 | $73,592.64 | 1.12 [Very Low] | Form 4 | - | 2020-04-28 | Wendall Wierenga | - | Sell | 6,666 | Common Stock | $16.00 | $106,656.00 | 1.12 [ High ] | 0 | $0.00 | - | Form 4 | - | 2020-05-01 | Robert I Blum | President & CEO | Sell | 5,000 | Common Stock | $14.34 | $71,700.00 | 0.84 [ High ] | 304,444 | $4,365,726.96 | 51.19 [High] | Form 4 | - | 2020-05-05 | Santo J Costa | - | Buy | 4,166 | Common Stock | $6.78 | -$28,245.48 | 0.70 [ Average ] | 4,166 | $28,245.48 | 0.70 [Very Low] | Form 4 | - | 2020-05-05 | Santo J Costa | - | Sell | 4,166 | Common Stock | $17.00 | $70,822.00 | 0.70 [ Average ] | 0 | $0.00 | - | Form 4 | - | 2020-05-05 | Santo J Costa | - | Buy | 4,166 | Common Stock | $5.46 | -$22,746.36 | 0.70 [ Average ] | 4,166 | $22,746.36 | 0.70 [Very Low] | Form 4 | - | 2020-05-05 | Santo J Costa | - | Sell | 4,166 | Common Stock | $17.00 | $70,822.00 | 0.70 [ Average ] | 0 | $0.00 | - | Form 4 | - | 2020-05-18 | Robert I Blum | President & CEO | Sell | 811 | Common Stock | $22.10 | $17,923.10 | 0.14 [ Low ] | 303,633 | $6,710,289.30 | 51.06 [High] | Form 4 | - | 2020-05-18 | Robert I Blum | President & CEO | Buy | 4,189 | Common Stock | $6.30 | -$26,390.70 | 0.70 [ Average ] | 307,822 | $1,939,278.60 | 51.76 [High] | Form 4 | - | 2020-05-18 | Robert I Blum | President & CEO | Sell | 4,189 | Common Stock | $22.16 | $92,828.24 | 0.70 [ Average ] | 303,633 | $6,728,507.28 | 51.06 [High] | Form 4 | - | 2020-05-19 | John T Henderson | - | Buy | 3,333 | Common Stock | $16.86 | -$56,194.38 | 0.56 [ Average ] | 3,583 | $60,409.38 | 0.60 [Very Low] | Form 4 | - | 2020-05-19 | John T Henderson | - | Sell | 2,684 | Common Stock | $20.93 | $56,176.12 | 0.45 [ Average ] | 899 | $18,816.07 | 0.15 [Very Low] | Form 4 | - | 2020-05-18 | L Patrick Gage | - | Buy | 3,333 | Common Stock | $16.86 | -$56,194.38 | 0.56 [ Average ] | 23,333 | $393,394.38 | 3.92 [Low] | Form 4 | - | 2020-05-18 | L Patrick Gage | - | Sell | 2,529 | Common Stock | $22.22 | $56,194.38 | 0.43 [ Average ] | 20,804 | $462,264.88 | 3.50 [Low] | Form 4 | - | 2020-07-10 | Sandford D Smith | - | Buy | 6,667 | Common Stock | $6.21 | -$41,402.07 | 1.12 [ High ] | 6,667 | $41,402.07 | 1.12 [Very Low] | Form 4 | - | 2020-07-10 | Sandford D Smith | - | Sell | 6,667 | Common Stock | $28.00 | $186,676.00 | 1.12 [ High ] | 0 | $0.00 | - | Form 4 | - | 2020-05-11 | Santo J Costa | - | Buy | 20,000 | Common Stock | $6.21 | -$124,200.00 | 3.36 [ Very High ] | 20,000 | $124,200.00 | 3.36 [Low] | Form 4 | - | 2020-05-11 | Santo J Costa | - | Sell | 20,000 | Common Stock | $20.00 | $400,000.00 | 3.36 [ Very High ] | 0 | $0.00 | - | Form 4 | - | 2020-05-11 | Santo J Costa | - | Buy | 3,333 | Common Stock | $8.64 | -$28,797.12 | 0.56 [ Average ] | 3,333 | $28,797.12 | 0.56 [Very Low] | Form 4 | - | 2020-05-11 | Santo J Costa | - | Sell | 3,333 | Common Stock | $19.47 | $64,893.51 | 0.56 [ Average ] | 0 | $0.00 | - | Form 4 | - | 2020-05-11 | Santo J Costa | - | Buy | 6,666 | Common Stock | $15.24 | -$101,589.84 | 1.12 [ High ] | 6,666 | $101,589.84 | 1.12 [Very Low] | Form 4 | - | 2020-05-11 | Santo J Costa | - | Sell | 6,666 | Common Stock | $19.47 | $129,787.02 | 1.12 [ High ] | 0 | $0.00 | - | Form 4 | - | 2020-06-12 | Sandford D Smith | - | Buy | 10,879 | Common Stock | $4.02 | -$43,733.58 | - | 10,879 | $43,733.58 | - | Form 4 | - | 2020-06-12 | Sandford D Smith | - | Sell | 10,879 | Common Stock | $20.77 | $225,956.83 | - | 0 | $0.00 | - | Form 4 | - | 2020-06-12 | Sandford D Smith | - | Buy | 4,166 | Common Stock | $5.46 | -$22,746.36 | - | 4,166 | $22,746.36 | - | Form 4 | - | 2020-06-12 | Sandford D Smith | - | Sell | 4,166 | Common Stock | $21.10 | $87,902.60 | - | 0 | $0.00 | - | Form 4 | - | 2020-06-11 | Robert I Blum | President & CEO | Buy | 5,000 | Common Stock | $6.30 | -$31,500.00 | - | 309,868 | $1,952,168.40 | - | Form 4 | - | 2020-06-11 | Robert I Blum | President & CEO | Sell | 5,000 | Common Stock | $21.47 | $107,350.00 | - | 304,868 | $6,545,515.96 | - | Form 4 | - | 2020-06-15 | Sandford D Smith | - | Sell | 6,666 | Common Stock | $22.00 | $146,652.00 | 1.12 [ High ] | 0 | $0.00 | - | Form 4 | - | 2020-06-15 | Sandford D Smith | - | Buy | 6,666 | Common Stock | $6.30 | -$41,995.80 | 1.12 [ High ] | 6,666 | $41,995.80 | 1.12 [Very Low] | Form 4 | - | 2020-06-17 | Sandford D Smith | - | Buy | 4,166 | Common Stock | $6.78 | -$28,245.48 | - | 4,166 | $28,245.48 | - | Form 4 | - | 2020-06-17 | Sandford D Smith | - | Sell | 4,166 | Common Stock | $23.00 | $95,818.00 | - | 0 | $0.00 | - | Form 4 | - | 2020-06-17 | Sandford D Smith | - | Buy | 2,741 | Common Stock | $6.84 | -$18,748.44 | - | 2,741 | $18,748.44 | - | Form 4 | - | 2020-06-17 | Sandford D Smith | - | Sell | 2,741 | Common Stock | $23.00 | $63,043.00 | - | 0 | $0.00 | - | Form 4 | - | 2020-06-22 | Sandford D Smith | - | Sell | 5,000 | Common Stock | $24.00 | $120,000.00 | 0.84 [ High ] | 0 | $0.00 | - | Form 4 | - | 2020-06-22 | Sandford D Smith | - | Sell | 5,000 | Common Stock | $25.00 | $125,000.00 | 0.84 [ High ] | 0 | $0.00 | - | Form 4 | - | 2020-06-22 | Sandford D Smith | - | Buy | 5,000 | Common Stock | $4.44 | -$22,200.00 | 0.84 [ High ] | 5,000 | $22,200.00 | 0.84 [Very Low] | Form 4 | - | 2020-06-22 | B Lynne Parshall | - | Buy | 10,000 | Common Stock | $4.44 | -$44,400.00 | - | 10,000 | $44,400.00 | - | Form 4 | - | 2020-06-22 | B Lynne Parshall | - | Sell | 10,000 | Common Stock | $25.00 | $250,000.00 | - | 0 | $0.00 | - | Form 4 | - | 2020-06-22 | B Lynne Parshall | - | Buy | 6,510 | Common Stock | $6.72 | -$43,747.20 | - | 6,510 | $43,747.20 | - | Form 4 | - | 2020-06-22 | B Lynne Parshall | - | Sell | 6,510 | Common Stock | $25.00 | $162,750.00 | - | 0 | $0.00 | - | Form 4 | - | 2020-06-22 | Santo J Costa | - | Buy | 20,000 | Common Stock | $7.61 | -$152,200.00 | - | 20,000 | $152,200.00 | - | Form 4 | - | 2020-06-22 | Santo J Costa | - | Sell | 20,000 | Common Stock | $25.00 | $500,000.00 | - | 0 | $0.00 | - | Form 4 | - | 2020-06-24 | Robert I Blum | President & CEO | Buy | 3,821 | Common Stock | $6.00 | -$22,926.00 | - | 308,689 | $1,852,134.00 | - | Form 4 | - | 2020-06-24 | Robert I Blum | President & CEO | Sell | 3,821 | Common Stock | $23.86 | $91,169.06 | - | 304,868 | $7,274,150.48 | - | Form 4 | - | 2020-06-24 | Robert I Blum | President & CEO | Buy | 1,179 | Common Stock | $6.30 | -$7,427.70 | - | 306,047 | $1,928,096.10 | - | Form 4 | - | 2020-06-24 | Robert I Blum | President & CEO | Sell | 1,179 | Common Stock | $23.86 | $28,130.94 | - | 304,868 | $7,274,150.48 | - | Form 4 | - | 2020-07-15 | Sandford D Smith | - | Buy | 6,667 | Common Stock | $6.21 | -$41,402.07 | 1.12 [ High ] | 6,667 | $41,402.07 | 1.12 [Very Low] | Form 4 | - | 2020-07-15 | Sandford D Smith | - | Sell | 6,667 | Common Stock | $29.00 | $193,343.00 | 1.12 [ High ] | 0 | $0.00 | - | Form 4 | - | 2020-07-16 | Robert I Blum | President & CEO | Buy | 5,000 | Common Stock | $6.00 | -$30,000.00 | 0.84 [ High ] | 309,868 | $1,859,208.00 | 52.10 [High] | Form 4 | - | 2020-07-16 | Robert I Blum | President & CEO | Sell | 5,000 | Common Stock | $27.36 | $136,800.00 | 0.84 [ High ] | 304,868 | $8,341,188.48 | 51.26 [High] | Form 4 | - | 2020-07-28 | Robert I Blum | President & CEO | Buy | 5,000 | Common Stock | $6.00 | -$30,000.00 | 0.74 [ Average ] | 309,868 | $1,859,208.00 | 45.67 [High] | Form 4 | - | 2020-07-28 | Robert I Blum | President & CEO | Sell | 5,000 | Common Stock | $23.77 | $118,850.00 | 0.74 [ Average ] | 304,868 | $7,246,712.36 | 44.94 [High] | Form 4 | - | 2020-07-29 | Mark A Schlossberg | SVP - Legal & General Counsel | Buy | 10,000 | Common Stock | $7.03 | -$70,300.00 | 1.47 [ High ] | 40,000 | $281,200.00 | 5.90 [Average] | Form 4 | - | 2020-07-29 | Mark A Schlossberg | SVP - Legal & General Counsel | Sell | 10,000 | Common Stock | $23.07 | $230,700.00 | 1.47 [ High ] | 30,000 | $692,100.00 | 4.42 [Low] | Form 4 | - | 2020-08-05 | Robert I Blum | President & CEO | Buy | 5,000 | Common Stock | $6.00 | -$30,000.00 | 0.74 [ Average ] | 309,868 | $1,859,208.00 | 45.67 [High] | Form 4 | - | 2020-08-05 | Robert I Blum | President & CEO | Sell | 5,000 | Common Stock | $22.12 | $110,600.00 | 0.74 [ Average ] | 304,868 | $6,743,680.16 | 44.94 [High] | Form 4 | - | 2020-08-13 | Fady Ibraham Malik | EVP Research & Development | Sell | 599 | Common Stock | $21.85 | $13,088.15 | 0.08 [ Very Low ] | 154,435 | $3,374,404.75 | 21.90 [High] | Form 4 | - | 2020-08-18 | Robert I Blum | President & CEO | Buy | 5,000 | Common Stock | $6.00 | -$30,000.00 | 0.71 [ Average ] | 309,868 | $1,859,208.00 | 43.95 [High] | Form 4 | - | 2020-08-18 | Robert I Blum | President & CEO | Sell | 5,000 | Common Stock | $23.48 | $117,400.00 | 0.71 [ Average ] | 304,868 | $7,158,300.64 | 43.24 [High] | Form 4 | - | 2020-08-21 | Mark A Schlossberg | SVP - Legal & General Counsel | Buy | 10,000 | Common Stock | $7.03 | -$70,300.00 | 1.42 [ High ] | 40,000 | $281,200.00 | 5.67 [Average] | Form 4 | - | 2020-08-21 | Mark A Schlossberg | SVP - Legal & General Counsel | Sell | 10,000 | Common Stock | $25.00 | $250,000.00 | 1.42 [ High ] | 30,000 | $750,000.00 | 4.26 [Low] | Form 4 | - | 2020-08-21 | Ching Jaw | SVP Finance & CFO | Buy | 10,000 | Common Stock | $7.14 | -$71,400.00 | 1.42 [ High ] | 83,300 | $594,762.00 | 11.81 [Average] | Form 4 | - | 2020-08-21 | Ching Jaw | SVP Finance & CFO | Sell | 10,000 | Common Stock | $25.00 | $250,000.00 | 1.42 [ High ] | 73,300 | $1,832,500.00 | 10.40 [Average] | Form 4 | - | 2020-08-21 | Ching Jaw | SVP Finance & CFO | Buy | 15,000 | Common Stock | $7.80 | -$117,000.00 | 2.13 [ High ] | 88,300 | $688,740.00 | 12.52 [Average] | Form 4 | - | 2020-08-21 | Ching Jaw | SVP Finance & CFO | Sell | 15,000 | Common Stock | $25.00 | $375,000.00 | 2.13 [ High ] | 73,300 | $1,832,500.00 | 10.40 [Average] | Form 4 | - | 2020-09-04 | Robert I Blum | President & CEO | Buy | 5,000 | Common Stock | $6.00 | -$30,000.00 | 0.71 [ Average ] | 309,868 | $1,859,208.00 | 43.95 [High] | Form 4 | - | 2020-09-04 | Robert I Blum | President & CEO | Sell | 5,000 | Common Stock | $22.37 | $111,850.00 | 0.71 [ Average ] | 304,868 | $6,819,897.16 | 43.24 [High] | Form 4 | - | 2020-09-10 | Fady Ibraham Malik | EVP Research & Development | Sell | 995 | Common Stock | $22.85 | $22,735.75 | 0.14 [ Low ] | 153,440 | $3,506,104.00 | 21.76 [High] | Form 4 | - | 2020-09-11 | Robert I Blum | President & CEO | Buy | 5,000 | Common Stock | $6.00 | -$30,000.00 | 0.71 [ Average ] | 309,868 | $1,859,208.00 | 43.95 [High] | Form 4 | - | 2020-09-11 | Robert I Blum | President & CEO | Sell | 5,000 | Common Stock | $22.95 | $114,750.00 | 0.71 [ Average ] | 304,868 | $6,996,720.60 | 43.24 [High] | Form 4 | - | 2020-09-21 | Robert I Blum | President & CEO | Buy | 5,000 | Common Stock | $6.00 | -$30,000.00 | 0.71 [ Average ] | 309,868 | $1,859,208.00 | 43.95 [High] | Form 4 | - | 2020-09-21 | Robert I Blum | President & CEO | Sell | 5,000 | Common Stock | $20.97 | $104,850.00 | 0.71 [ Average ] | 304,868 | $6,393,081.96 | 43.24 [High] | Form 4 | - | 2020-10-02 | Robert I Blum | President & CEO | Buy | 5,000 | Common Stock | $6.00 | -$30,000.00 | 0.71 [ Average ] | 309,868 | $1,859,208.00 | 43.95 [High] | Form 4 | - | 2020-10-02 | Robert I Blum | President & CEO | Sell | 5,000 | Common Stock | $22.53 | $112,650.00 | 0.71 [ Average ] | 304,868 | $6,868,676.04 | 43.24 [High] | Form 4 | - | 2020-10-05 | Santo J Costa | - | Buy | 15,000 | Common Stock | $9.45 | -$141,750.00 | 2.13 [ High ] | 15,000 | $141,750.00 | 2.13 [Low] | Form 4 | - | 2020-10-05 | Santo J Costa | - | Sell | 15,000 | Common Stock | $30.00 | $450,000.00 | 2.13 [ High ] | 0 | $0.00 | - | Form 4 | - | 2020-10-05 | Ching Jaw | SVP Finance & CFO | Buy | 5,000 | Common Stock | $7.14 | -$35,700.00 | 0.71 [ Average ] | 78,300 | $559,062.00 | 11.11 [Average] | Form 4 | - | 2020-10-05 | Ching Jaw | SVP Finance & CFO | Sell | 5,000 | Common Stock | $30.00 | $150,000.00 | 0.71 [ Average ] | 73,300 | $2,199,000.00 | 10.40 [Average] | Form 4 | - | 2020-10-05 | Ching Jaw | SVP Finance & CFO | Buy | 7,500 | Common Stock | $7.80 | -$58,500.00 | 1.06 [ High ] | 80,800 | $630,240.00 | 11.46 [Average] | Form 4 | - | 2020-10-05 | Ching Jaw | SVP Finance & CFO | Sell | 7,500 | Common Stock | $30.00 | $225,000.00 | 1.06 [ High ] | 73,300 | $2,199,000.00 | 10.40 [Average] | Form 4 | - | 2020-10-05 | Ching Jaw | SVP Finance & CFO | Buy | 15,000 | Common Stock | $12.10 | -$181,500.00 | 2.13 [ High ] | 88,300 | $1,068,430.00 | 12.52 [Average] | Form 4 | - | 2020-10-05 | Ching Jaw | SVP Finance & CFO | Sell | 15,000 | Common Stock | $30.00 | $450,000.00 | 2.13 [ High ] | 73,300 | $2,199,000.00 | 10.40 [Average] | Form 4 | - | 2020-10-05 | Kaye Edward M. Md | - | Buy | 20,000 | Common Stock | $7.61 | -$152,200.00 | 2.84 [ Very High ] | 20,000 | $152,200.00 | 2.84 [Low] | Form 4 | - | 2020-10-05 | Kaye Edward M. Md | - | Sell | 20,000 | Common Stock | $30.00 | $600,000.00 | 2.84 [ Very High ] | 0 | $0.00 | - | Form 4 | - | 2020-10-05 | John T Henderson | - | Buy | 1,500 | Common Stock | $12.96 | -$19,440.00 | 0.21 [ Low ] | 2,399 | $31,091.04 | 0.34 [Very Low] | Form 4 | - | 2020-10-05 | John T Henderson | - | Sell | 1,500 | Common Stock | $30.00 | $45,000.00 | 0.21 [ Low ] | 899 | $26,970.00 | 0.13 [Very Low] | Form 4 | - | 2020-10-05 | John T Henderson | - | Sell | 1,500 | Common Stock | $28.00 | $42,000.00 | 0.21 [ Low ] | 899 | $25,172.00 | 0.13 [Very Low] | Form 4 | - | 2020-10-05 | Sandford D Smith | - | Buy | 5,936 | Common Stock | $7.37 | -$43,748.32 | 0.84 [ High ] | 5,936 | $43,748.32 | 0.84 [Very Low] | Form 4 | - | 2020-10-05 | Sandford D Smith | - | Sell | 5,936 | Common Stock | $30.00 | $178,080.00 | 0.84 [ High ] | 0 | $0.00 | - | Form 4 | - | 2020-10-05 | B Lynne Parshall | - | Buy | 20,000 | Common Stock | $7.61 | -$152,200.00 | 2.84 [ Very High ] | 20,000 | $152,200.00 | 2.84 [Low] | Form 4 | - | 2020-10-05 | B Lynne Parshall | - | Sell | 20,000 | Common Stock | $30.00 | $600,000.00 | 2.84 [ Very High ] | 0 | $0.00 | - | Form 4 | - | 2020-10-05 | B Lynne Parshall | - | Buy | 4,375 | Common Stock | $10.00 | -$43,750.00 | 0.62 [ Average ] | 4,375 | $43,750.00 | 0.62 [Very Low] | Form 4 | - | 2020-10-05 | B Lynne Parshall | - | Sell | 4,375 | Common Stock | $30.00 | $131,250.00 | 0.62 [ Average ] | 0 | $0.00 | - | Form 4 | - | 2020-10-05 | B Lynne Parshall | - | Buy | 20,000 | Common Stock | $6.21 | -$124,200.00 | 2.84 [ Very High ] | 20,000 | $124,200.00 | 2.84 [Low] | Form 4 | - | 2020-10-05 | B Lynne Parshall | - | Sell | 20,000 | Common Stock | $30.00 | $600,000.00 | 2.84 [ Very High ] | 0 | $0.00 | - | Form 4 | - | 2020-10-05 | B Lynne Parshall | - | Buy | 5,936 | Common Stock | $7.37 | -$43,748.32 | 0.84 [ High ] | 5,936 | $43,748.32 | 0.84 [Very Low] | Form 4 | - | 2020-10-05 | B Lynne Parshall | - | Sell | 5,936 | Common Stock | $30.00 | $178,080.00 | 0.84 [ High ] | 0 | $0.00 | - | Form 4 | - | 2020-10-08 | Fady Ibraham Malik | EVP Research & Development | Sell | 1,258 | Common Stock | $17.45 | $21,952.10 | 0.18 [ Low ] | 152,182 | $2,655,575.90 | 21.58 [High] | Form 4 | - | 2020-10-13 | Robert I Blum | President & CEO | Buy | 5,000 | Common Stock | $6.00 | -$30,000.00 | 0.71 [ Average ] | 309,868 | $1,859,208.00 | 43.95 [High] | Form 4 | - | 2020-10-13 | Robert I Blum | President & CEO | Sell | 5,000 | Common Stock | $15.94 | $79,700.00 | 0.71 [ Average ] | 304,868 | $4,859,595.92 | 43.24 [High] | Form 4 | - | 2020-10-29 | Robert I Blum | President & CEO | Buy | 5,000 | Common Stock | $6.00 | -$30,000.00 | 0.71 [ Average ] | 309,868 | $1,859,208.00 | 43.95 [High] | Form 4 | - | 2020-10-29 | Robert I Blum | President & CEO | Sell | 5,000 | Common Stock | $15.15 | $75,750.00 | 0.71 [ Average ] | 304,868 | $4,618,750.20 | 43.24 [High] | Form 4 | - | 2020-11-10 | Robert I Blum | President & CEO | Buy | 5,000 | Common Stock | $6.00 | -$30,000.00 | 0.71 [ Average ] | 309,868 | $1,859,208.00 | 43.78 [High] | Form 4 | - | 2020-11-10 | Robert I Blum | President & CEO | Sell | 5,000 | Common Stock | $16.50 | $82,500.00 | 0.71 [ Average ] | 304,868 | $5,030,322.00 | 43.07 [High] | Form 4 | - | 2020-11-12 | Fady Ibraham Malik | EVP Research & Development | Sell | 1,231 | Common Stock | $17.15 | $21,111.65 | 0.17 [ Low ] | 150,951 | $2,588,809.65 | 21.33 [High] | Form 4 | - | 2020-11-23 | Robert I Blum | President & CEO | Buy | 5,000 | Common Stock | $6.00 | -$30,000.00 | 0.71 [ Average ] | 309,868 | $1,859,208.00 | 43.78 [High] | Form 4 | - | 2020-11-23 | Robert I Blum | President & CEO | Sell | 5,000 | Common Stock | $15.73 | $78,650.00 | 0.71 [ Average ] | 304,868 | $4,795,573.64 | 43.07 [High] | Form 4 | - | 2020-12-10 | Fady Ibraham Malik | EVP Research & Development | Sell | 1,052 | Common Stock | $20.13 | $21,176.76 | 0.15 [ Low ] | 150,441 | $3,028,377.33 | 21.26 [High] | Form 4 | - | 2020-12-09 | Bvf Partners L P/il | - | Sell | 239,274 | Common Stock, $0.001 par value | $18.00 | $4,306,932.00 | 33.81 [ Very High ] | 3,811,271 | $68,602,878.00 | 538.47 [Very High] | Form 4 | - | 2020-12-09 | Bvf Partners L P/il | - | Sell | 166,194 | Common Stock, $0.001 par value | $18.00 | $2,991,492.00 | 23.48 [ Very High ] | 2,760,185 | $49,683,330.00 | 389.97 [Very High] | Form 4 | - | 2020-12-09 | Bvf Partners L P/il | - | Sell | 25,486 | Common Stock, $0.001 par value | $18.00 | $458,748.00 | 3.60 [ Very High ] | 463,244 | $8,338,392.00 | 65.45 [High] | Form 4 | - | 2020-12-15 | L Patrick Gage | - | Buy | 7,716 | Common Stock | $12.96 | -$99,999.36 | 1.09 [ High ] | 28,520 | $369,619.20 | 4.03 [Low] | Form 4 | - | 2020-12-15 | L Patrick Gage | - | Sell | 7,716 | Common Stock | $21.00 | $162,036.00 | 1.09 [ High ] | 20,804 | $436,884.00 | 2.94 [Low] | Form 4 | - | 2020-12-15 | David Cragg | SVP Human Resources | Buy | 7,423 | Common Stock | $9.42 | -$69,924.66 | 1.05 [ High ] | 147,639 | $1,390,759.38 | 20.86 [High] | Form 4 | - | 2020-12-15 | David Cragg | SVP Human Resources | Sell | 4,745 | Common Stock | $21.00 | $99,645.00 | 0.67 [ Average ] | 142,894 | $3,000,774.00 | 20.19 [High] | Form 4 | - | 2020-12-15 | David Cragg | SVP Human Resources | Buy | 9,243 | Common Stock | $9.42 | -$87,069.06 | 1.31 [ High ] | 152,137 | $1,433,130.54 | 21.49 [High] | Form 4 | - | 2020-12-15 | David Cragg | SVP Human Resources | Sell | 5,908 | Common Stock | $21.00 | $124,068.00 | 0.83 [ Average ] | 146,229 | $3,070,809.00 | 20.66 [High] | Form 4 | - | 2020-12-16 | Robert I Blum | President & CEO | Buy | 5,000 | Common Stock | $6.00 | -$30,000.00 | 0.71 [ Average ] | 310,589 | $1,863,534.00 | 43.88 [High] | Form 4 | - | 2020-12-16 | Robert I Blum | President & CEO | Sell | 5,000 | Common Stock | $20.51 | $102,550.00 | 0.71 [ Average ] | 305,589 | $6,267,630.39 | 43.18 [High] | Form 4 | - | 2020-12-31 | John T Henderson | - | Buy | 858 | Common Stock | $12.96 | -$11,119.68 | 0.12 [ Low ] | 1,757 | $22,770.72 | 0.25 [Very Low] | Form 4 | - | 2020-12-31 | John T Henderson | - | Sell | 858 | Common Stock | $20.31 | $17,425.98 | 0.12 [ Low ] | 899 | $18,258.69 | 0.13 [Very Low] | Form 4 | - | 2021-01-04 | Robert I Blum | President & CEO | Buy | 5,000 | Common Stock | $6.00 | -$30,000.00 | 0.71 [ Average ] | 310,589 | $1,863,534.00 | 43.88 [High] | Form 4 | - | 2021-01-04 | Robert I Blum | President & CEO | Sell | 5,000 | Common Stock | $20.23 | $101,150.00 | 0.71 [ Average ] | 305,589 | $6,182,065.47 | 43.18 [High] | Form 4 | - | 2021-01-04 | Robert Califf | - | Buy | 255 | Common Stock | $19.56 | -$4,987.80 | 0.04 [ Very Low ] | 255 | $4,987.80 | 0.04 [Very Low] | Form 4 | - | 2021-01-04 | L Patrick Gage | - | Buy | 958 | Common Stock | $19.56 | -$18,738.48 | 0.14 [ Low ] | 21,762 | $425,664.72 | 3.07 [Low] | Form 4 | - | 2021-01-04 | John T Henderson | - | Buy | 511 | Common Stock | $19.56 | -$9,995.16 | 0.07 [ Very Low ] | 1,410 | $27,579.60 | 0.20 [Very Low] | Form 4 | - | 2021-01-04 | Kaye Edward M. Md | - | Buy | 511 | Common Stock | $19.56 | -$9,995.16 | 0.07 [ Very Low ] | 511 | $9,995.16 | 0.07 [Very Low] | Form 4 | - | 2021-01-04 | Sandford D Smith | - | Buy | 511 | Common Stock | $19.56 | -$9,995.16 | 0.07 [ Very Low ] | 511 | $9,995.16 | 0.07 [Very Low] | Form 4 | - | 2021-01-04 | Wendall Wierenga | - | Buy | 511 | Common Stock | $19.56 | -$9,995.16 | 0.07 [ Very Low ] | 511 | $9,995.16 | 0.07 [Very Low] | Form 4 | - | 2021-01-04 | Nancy Wysenski | - | Buy | 255 | Common Stock | $19.56 | -$4,987.80 | 0.04 [ Very Low ] | 255 | $4,987.80 | 0.04 [Very Low] | Form 4 | - | 2021-01-14 | Fady Ibraham Malik | EVP Research & Development | Buy | 617 | Common Stock | $9.42 | -$5,812.14 | 0.09 [ Very Low ] | 151,058 | $1,422,966.36 | 21.34 [High] | Form 4 | - | 2021-01-14 | Fady Ibraham Malik | EVP Research & Development | Sell | 617 | Common Stock | $19.25 | $11,877.25 | 0.09 [ Very Low ] | 150,441 | $2,895,989.25 | 21.26 [High] | Form 4 | - | 2021-01-14 | Fady Ibraham Malik | EVP Research & Development | Buy | 11,883 | Common Stock | $9.42 | -$111,937.86 | 1.68 [ High ] | 162,324 | $1,529,092.08 | 22.93 [High] | Form 4 | - | 2021-01-14 | Fady Ibraham Malik | EVP Research & Development | Sell | 11,883 | Common Stock | $19.25 | $228,747.75 | 1.68 [ High ] | 150,441 | $2,895,989.25 | 21.26 [High] | Form 4 | - | 2021-01-20 | Robert I Blum | President & CEO | Buy | 5,000 | Common Stock | $6.00 | -$30,000.00 | 0.71 [ Average ] | 310,589 | $1,863,534.00 | 43.88 [High] | Form 4 | - | 2021-01-20 | Robert I Blum | President & CEO | Sell | 5,000 | Common Stock | $20.41 | $102,050.00 | 0.71 [ Average ] | 305,589 | $6,237,071.49 | 43.18 [High] | Form 4 | - | 2021-01-29 | Robert I Blum | President & CEO | Buy | 5,000 | Common Stock | $6.00 | -$30,000.00 | 0.71 [ Average ] | 310,589 | $1,863,534.00 | 43.88 [High] | Form 4 | - | 2021-01-29 | Robert I Blum | President & CEO | Sell | 5,000 | Common Stock | $20.34 | $101,700.00 | 0.71 [ Average ] | 305,589 | $6,215,680.26 | 43.18 [High] | Form 4 | - | 2021-02-10 | Robert I Blum | President & CEO | Buy | 5,000 | Common Stock | $6.00 | -$30,000.00 | 0.71 [ Average ] | 310,589 | $1,863,534.00 | 43.88 [High] | Form 4 | - | 2021-02-10 | Robert I Blum | President & CEO | Sell | 5,000 | Common Stock | $23.88 | $119,400.00 | 0.71 [ Average ] | 305,589 | $7,297,465.32 | 43.18 [High] | Form 4 | - | 2021-02-11 | Fady Ibraham Malik | EVP Research & Development | Sell | 1,632 | Common Stock | $23.34 | $38,090.88 | 0.23 [ Low ] | 148,809 | $3,473,202.06 | 21.02 [High] | Form 4 | - | 2021-02-18 | Robert I Blum | President & CEO | Buy | 10,409 | Common Stock | $9.42 | -$98,052.78 | 1.47 [ High ] | 315,998 | $2,976,701.16 | 44.65 [High] | Form 4 | - | 2021-02-18 | Robert I Blum | President & CEO | Sell | 6,652 | Common Stock | $21.01 | $139,758.52 | 0.94 [ High ] | 309,346 | $6,499,359.46 | 43.71 [High] | Form 4 | - | 2021-02-18 | Robert I Blum | President & CEO | Buy | 72,923 | Common Stock | $9.42 | -$686,934.66 | 10.30 [ Very High ] | 382,269 | $3,600,973.98 | 54.01 [High] | Form 4 | - | 2021-02-18 | Robert I Blum | President & CEO | Sell | 47,896 | Common Stock | $21.01 | $1,006,294.96 | 6.77 [ Very High ] | 334,373 | $7,025,176.73 | 47.24 [High] | Form 4 | - | 2021-02-26 | Robert I Blum | President & CEO | Buy | 5,000 | Common Stock | $6.00 | -$30,000.00 | 0.71 [ Average ] | 339,373 | $2,036,238.00 | 47.95 [High] | Form 4 | - | 2021-02-26 | Robert I Blum | President & CEO | Sell | 5,000 | Common Stock | $19.33 | $96,650.00 | 0.71 [ Average ] | 334,373 | $6,463,430.09 | 47.24 [High] | Form 4 | - | 2021-02-26 | Robert I Blum | President & CEO | Sell | 23,799 | Common Stock | $18.73 | $445,755.27 | 3.36 [ Very High ] | 310,574 | $5,817,051.02 | 43.88 [High] | Form 4 | - | 2021-02-26 | David Cragg | SVP Human Resources | Sell | 4,379 | Common Stock | $18.73 | $82,018.67 | 0.62 [ Average ] | 141,850 | $2,656,850.50 | 20.04 [High] | Form 4 | - | 2021-02-26 | Ching Jaw | SVP Finance & CFO | Sell | 4,353 | Common Stock | $18.73 | $81,531.69 | 0.62 [ Average ] | 69,026 | $1,292,856.98 | 9.75 [Average] | Form 4 | - | 2021-02-26 | Fady Ibraham Malik | EVP Research & Development | Sell | 7,060 | Common Stock | $18.73 | $132,233.80 | 1.00 [ High ] | 141,749 | $2,654,958.77 | 20.03 [High] | Form 4 | - | 2021-03-01 | Robert I Blum | President & CEO | Sell | 9,916 | Common Stock | $19.66 | $194,948.56 | 1.39 [ High ] | 300,658 | $5,910,936.28 | 42.28 [High] | Form 4 | - | 2021-03-01 | David Cragg | SVP Human Resources | Sell | 2,075 | Common Stock | $19.66 | $40,794.50 | 0.29 [ Average ] | 139,775 | $2,747,976.50 | 19.66 [High] | Form 4 | - | 2021-03-01 | Ching Jaw | SVP Finance & CFO | Sell | 1,384 | Common Stock | $19.66 | $27,209.44 | 0.19 [ Low ] | 67,642 | $1,329,841.72 | 9.51 [Average] | Form 4 | - | 2021-03-01 | Fady Ibraham Malik | EVP Research & Development | Sell | 2,767 | Common Stock | $19.66 | $54,399.22 | 0.39 [ Average ] | 138,982 | $2,732,386.12 | 19.54 [High] | Form 4 | - |
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