| Trade Date | Insider | Title | Buy or Sell | Quantity | Security Type | Price | Proceeds | Transaction Conviction | Position Quantity | Position Value | Positon Conviction | SEC Link | Nature of Ownership | 2021-06-01 | Daniel J. Becker | - | Buy | 5,000 | Common Stock | $16.00 | -$80,000.00 | 0.83 [ High ] | 5,000 | $80,000.00 | 0.83 [Very Low] | Form 4 | - | 2021-06-01 | John A. Josey | - | Buy | 7,000 | Common Stock | $16.00 | -$112,000.00 | 1.16 [ High ] | 72,292 | $1,156,672.00 | 11.96 [Average] | Form 4 | - | 2021-06-01 | Papanek Julie Grant | - | Buy | 7,328,497 | Common Stock | $0.00 | $0.00 | - | 10,574,366 | $0.00 | 1,749.88 [Very High] | Form 4 | By Canaan XI, L.P. | 2021-06-01 | Papanek Julie Grant | - | Buy | 148,279 | Common Stock | $0.00 | $0.00 | - | 10,722,645 | $0.00 | 1,774.42 [Very High] | Form 4 | By Canaan XI, L.P. | 2021-06-01 | Papanek Julie Grant | - | Buy | 13,000 | Common Stock | $16.00 | -$208,000.00 | 2.15 [ High ] | 10,735,645 | $171,770,320.00 | 1,776.57 [Very High] | Form 4 | By Canaan XI, L.P. | 2021-06-01 | Atlas Venture Fund Xi, L.p. | - | Buy | 7,761,380 | Common Stock | $0.00 | $0.00 | - | 7,761,380 | $0.00 | 1,284.38 [Very High] | Form 4 | See Footnote | 2021-06-01 | Atlas Venture Fund Xi, L.p. | - | Buy | 741,396 | Common Stock | $0.00 | $0.00 | - | 741,396 | $0.00 | 122.69 [Very High] | Form 4 | See Footnote | 2021-06-01 | Atlas Venture Fund Xi, L.p. | - | Buy | 250,000 | Common Stock | $16.00 | -$4,000,000.00 | 41.37 [ Very High ] | 250,000 | $4,000,000.00 | 41.37 [High] | Form 4 | See Footnote | 2021-06-01 | Atlas Venture Fund Xi, L.p. | - | Buy | 250,000 | Common Stock | $16.00 | -$4,000,000.00 | 41.37 [ Very High ] | 250,000 | $4,000,000.00 | 41.37 [High] | Form 4 | See Footnote | 2021-06-01 | Xi L.p. Canaan | - | Buy | 7,328,497 | Common Stock | $0.00 | $0.00 | - | 10,574,366 | $0.00 | 1,749.88 [Very High] | Form 4 | - | 2021-06-01 | Xi L.p. Canaan | - | Buy | 148,279 | Common Stock | $0.00 | $0.00 | - | 10,722,645 | $0.00 | 1,774.42 [Very High] | Form 4 | - | 2021-06-01 | Xi L.p. Canaan | - | Buy | 13,000 | Common Stock | $16.00 | -$208,000.00 | 2.15 [ High ] | 10,735,645 | $171,770,320.00 | 1,776.57 [Very High] | Form 4 | - | 2021-06-01 | Ai Day 1 Llc | - | Buy | 8,502,776 | Common Stock | $0.00 | $0.00 | - | 8,502,776 | $0.00 | 1,407.07 [Very High] | Form 4 | - | 2021-06-01 | Ai Day 1 Llc | - | Buy | 875,000 | Common Stock | $16.00 | -$14,000,000.00 | 144.80 [ Very High ] | 9,377,776 | $150,044,416.00 | 1,551.87 [Very High] | Form 4 | - | 2021-11-24 | Takeda Pharmaceutical Co Ltd | - | Buy | 57,224 | Common Stock | $0.00 | $0.00 | - | 6,527,606 | $0.00 | 1,054.05 [Very High] | Form 4 | See Explanation of Responses | 2021-11-24 | Atlas Venture Fund Xi, L.p. | - | Sell | 801,138 | Common Stock | $0.00 | $0.00 | - | 7,210,242 | $0.00 | 1,164.28 [Very High] | Form 4 | - | 2021-12-03 | Takeda Pharmaceutical Co Ltd | - | Sell | 12,517 | Common Stock | $18.47 | $231,188.99 | 2.02 [ High ] | 6,515,089 | $120,333,693.83 | 1,052.03 [Very High] | Form 4 | See Explanation of Responses | 2021-12-06 | Takeda Pharmaceutical Co Ltd | - | Sell | 97,692 | Common Stock | $18.05 | $1,763,340.60 | 15.77 [ Very High ] | 6,417,397 | $115,834,015.85 | 1,036.25 [Very High] | Form 4 | See Explanation of Responses | 2021-12-07 | Takeda Pharmaceutical Co Ltd | - | Sell | 128,745 | Common Stock | $18.43 | $2,372,770.35 | 20.79 [ Very High ] | 6,288,652 | $115,899,856.36 | 1,015.46 [Very High] | Form 4 | See Explanation of Responses | 2021-12-07 | Takeda Pharmaceutical Co Ltd | - | Sell | 58,190 | Common Stock | $19.50 | $1,134,705.00 | 9.40 [ Very High ] | 6,230,462 | $121,494,009.00 | 1,006.07 [Very High] | Form 4 | See Explanation of Responses | 2021-12-08 | Takeda Pharmaceutical Co Ltd | - | Sell | 110,338 | Common Stock | $18.03 | $1,989,394.14 | 17.82 [ Very High ] | 6,120,124 | $110,345,835.72 | 988.25 [Very High] | Form 4 | See Explanation of Responses | 2021-12-08 | Xi L.p. Canaan | - | Sell | 536,000 | Common Stock | $0.00 | $0.00 | - | 10,199,645 | $0.00 | 1,646.99 [Very High] | Form 4 | - | 2021-12-21 | Xi L.p. Canaan | - | Sell | 536,000 | Common Stock | $0.00 | $0.00 | - | 9,663,645 | $0.00 | 1,560.44 [Very High] | Form 4 | - | 2022-01-03 | Samuel C. Blackman | Chief Medical Officer | Sell | 6,672 | Common Stock | $16.95 | $113,090.40 | 1.08 [ High ] | 1,370,046 | $23,222,279.70 | 221.23 [Very High] | Form 4 | - | 2022-01-03 | Samuel C. Blackman | Chief Medical Officer | Sell | 3,328 | Common Stock | $17.41 | $57,940.48 | 0.54 [ Average ] | 1,366,718 | $23,794,560.38 | 220.69 [Very High] | Form 4 | - | 2022-01-18 | Day1 Llc Ai | - | Buy | 43,429 | Common Stock | $14.26 | -$619,297.54 | 7.01 [ Very High ] | 9,421,205 | $134,346,383.30 | 1,521.29 [Very High] | Form 4 | - | 2022-01-19 | Day1 Llc Ai | - | Buy | 58,818 | Common Stock | $14.70 | -$864,624.60 | 9.50 [ Very High ] | 9,480,023 | $139,356,338.10 | 1,530.79 [Very High] | Form 4 | - | 2022-01-20 | Day1 Llc Ai | - | Buy | 4,615 | Common Stock | $14.73 | -$67,978.95 | 0.75 [ Average ] | 9,484,638 | $139,708,717.74 | 1,531.53 [Very High] | Form 4 | - | 2022-06-15 | Samuel C. Blackman | Chief Medical Officer | Sell | 50,000 | Common Stock | $16.26 | $813,000.00 | 8.08 [ Very High ] | 1,316,718 | $21,409,834.68 | 212.68 [Very High] | Form 4 | - | 2022-06-17 | Day1 Llc Ai | - | Buy | 1,200,000 | Common Stock | $15.00 | -$18,000,000.00 | 193.82 [ Very High ] | 10,684,638 | $160,269,570.00 | 1,725.78 [Very High] | Form 4 | - | 2022-06-17 | Atlas Venture Opportunity Fund Ii, L.p. | - | Buy | 766,667 | Common Stock | $15.00 | -$11,500,005.00 | 106.61 [ Very High ] | 766,667 | $11,500,005.00 | 106.61 [Very High] | Form 4 | - | 2022-06-17 | Michael Gladstone | - | Buy | 766,667 | Common Stock | $15.00 | -$11,500,005.00 | 106.61 [ Very High ] | 766,667 | $11,500,005.00 | 106.61 [Very High] | Form 4 | See Footnote |
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