| Trade Date | Insider | Title | Buy or Sell | Quantity | Security Type | Price | Proceeds | Transaction Conviction | Position Quantity | Position Value | Positon Conviction | SEC Link | Nature of Ownership | 2020-07-07 | Jonathan C Fox | See Remarks | Sell | 5,000 | Common Stock | $50.00 | $250,000.00 | 1.30 [ High ] | 387,673 | $19,383,650.00 | 100.60 [High] | Form 4 | See footnote | 2020-06-29 | Jonathan C Fox | See Remarks | Buy | 1,088 | Common Stock | $0.00 | $0.00 | - | 392,673 | $0.00 | - | Form 4 | See footnote | 2020-04-20 | Franco Valle | Senior Vice President, Finance | Buy | 2,000 | Common Stock | $7.24 | -$14,480.00 | 0.52 [ Average ] | 2,000 | $14,480.00 | 0.52 [Very Low] | Form 4 | - | 2020-04-20 | Franco Valle | Senior Vice President, Finance | Sell | 2,000 | Common Stock | $49.79 | $99,580.00 | 0.52 [ Average ] | 0 | $0.00 | - | Form 4 | - | 2020-04-23 | Jonathan C Fox | See Remarks | Sell | 2,847 | Common Stock | $50.00 | $142,350.00 | 0.74 [ High ] | 405,778 | $20,288,900.00 | 105.30 [Very High] | Form 4 | See footnote | 2020-04-24 | Jonathan C Fox | See Remarks | Sell | 2,153 | Common Stock | $50.00 | $107,650.00 | 0.56 [ Average ] | 403,625 | $20,181,250.00 | 104.74 [Very High] | Form 4 | See footnote | 2020-05-01 | Cameron Turtle | Chief Business Officer | Buy | 5,000 | Common Stock | $13.20 | -$66,000.00 | 1.30 [ High ] | 85,155 | $1,124,046.00 | 22.10 [High] | Form 4 | - | 2020-05-01 | Cameron Turtle | Chief Business Officer | Sell | 7,750 | Common Stock | $40.52 | $314,030.00 | 2.01 [ High ] | 77,405 | $3,136,450.60 | 20.09 [High] | Form 4 | - | 2020-05-01 | Cameron Turtle | Chief Business Officer | Sell | 1,050 | Common Stock | $41.23 | $43,291.50 | 0.27 [ Average ] | 76,355 | $3,148,116.65 | 19.81 [High] | Form 4 | - | 2020-05-01 | Cameron Turtle | Chief Business Officer | Sell | 1,180 | Common Stock | $42.56 | $50,220.80 | 0.31 [ Average ] | 75,175 | $3,199,448.00 | 19.51 [High] | Form 4 | - | 2020-05-01 | Cameron Turtle | Chief Business Officer | Sell | 20 | Common Stock | $43.26 | $865.20 | - | 75,155 | $3,251,205.30 | 19.50 [High] | Form 4 | - | 2020-05-26 | Cameron Turtle | Chief Business Officer | Buy | 2,500 | Common Stock | $17.00 | -$42,500.00 | 0.65 [ Average ] | 77,655 | $1,320,135.00 | 20.15 [High] | Form 4 | - | 2020-05-26 | Cameron Turtle | Chief Business Officer | Sell | 2,500 | Common Stock | $47.00 | $117,500.00 | 0.65 [ Average ] | 75,155 | $3,532,285.00 | 19.50 [High] | Form 4 | - | 2020-05-28 | Jonathan C Fox | See Remarks | Sell | 5,000 | Common Stock | $50.00 | $250,000.00 | - | 398,625 | $19,931,250.00 | - | Form 4 | See footnote | 2020-05-31 | Jonathan C Fox | See Remarks | Buy | 444 | Common Stock | $41.57 | -$18,457.08 | - | 3,294 | $136,931.58 | - | Form 4 | - | 2020-06-01 | Jonathan C Fox | See Remarks | Sell | 1,020 | Common Stock | $0.00 | $0.00 | - | 397,605 | $0.00 | - | Form 4 | See footnote | 2020-06-02 | Jonathan C Fox | See Remarks | Sell | 1,020 | Common Stock | $0.00 | $0.00 | - | 396,585 | $0.00 | - | Form 4 | See footnote | 2020-06-03 | Jonathan C Fox | See Remarks | Sell | 5,000 | Common Stock | $50.00 | $250,000.00 | - | 391,585 | $19,579,250.00 | - | Form 4 | See footnote | 2020-05-31 | Franco Valle | Senior Vice President, Finance | Buy | 444 | Common Stock | $41.57 | -$18,457.08 | - | 444 | $18,457.08 | - | Form 4 | - | 2020-05-31 | Uma Sinha | Chief Scientific Officer | Buy | 444 | Common Stock | $41.57 | -$18,457.08 | - | 331,525 | $13,781,494.25 | - | Form 4 | - | 2020-05-31 | Cameron Turtle | Chief Business Officer | Buy | 376 | Common Stock | $41.57 | -$15,630.32 | - | 75,531 | $3,139,823.67 | - | Form 4 | - | 2020-08-03 | Cameron Turtle | Chief Business Officer | Buy | 5,000 | Common Stock | $13.20 | -$66,000.00 | 1.30 [ High ] | 80,531 | $1,063,009.20 | 20.90 [High] | Form 4 | - | 2020-08-03 | Cameron Turtle | Chief Business Officer | Sell | 2,800 | Common Stock | $39.05 | $109,340.00 | 0.73 [ Average ] | 77,731 | $3,035,395.55 | 20.17 [High] | Form 4 | - | 2020-08-03 | Cameron Turtle | Chief Business Officer | Sell | 6,700 | Common Stock | $40.25 | $269,675.00 | 1.74 [ High ] | 71,031 | $2,858,997.75 | 18.43 [High] | Form 4 | - | 2020-08-03 | Cameron Turtle | Chief Business Officer | Sell | 500 | Common Stock | $40.89 | $20,445.00 | 0.13 [ Low ] | 70,531 | $2,884,012.59 | 18.30 [High] | Form 4 | - | 2020-09-10 | Cameron Turtle | Chief Business Officer | Buy | 2,500 | Common Stock | $17.00 | -$42,500.00 | 0.65 [ Average ] | 73,031 | $1,241,527.00 | 18.93 [High] | Form 4 | - | 2020-09-10 | Cameron Turtle | Chief Business Officer | Sell | 2,500 | Common Stock | $47.00 | $117,500.00 | 0.65 [ Average ] | 70,531 | $3,314,957.00 | 18.29 [High] | Form 4 | - | 2020-09-14 | Jonathan C Fox | See Remarks | Sell | 111 | Common Stock | $50.00 | $5,550.00 | 0.03 [ Very Low ] | 387,562 | $19,378,100.00 | 100.48 [Very High] | Form 4 | See footnote | 2020-09-15 | Jonathan C Fox | See Remarks | Sell | 1,000 | Common Stock | $50.06 | $50,060.00 | 0.26 [ Low ] | 386,562 | $19,351,293.72 | 100.22 [Very High] | Form 4 | See footnote | 2020-09-16 | Jonathan C Fox | See Remarks | Sell | 3,122 | Common Stock | $50.16 | $156,599.52 | 0.81 [ High ] | 383,440 | $19,233,350.40 | 99.41 [Very High] | Form 4 | See footnote | 2020-09-17 | Jonathan C Fox | See Remarks | Sell | 5,767 | Common Stock | $50.16 | $289,272.72 | 1.50 [ High ] | 377,673 | $18,944,077.68 | 97.92 [Very High] | Form 4 | See footnote | 2020-09-30 | Uma Sinha | Chief Scientific Officer | Sell | 69 | Common Stock | $52.08 | $3,593.52 | 0.02 [ Very Low ] | 331,456 | $17,262,228.48 | 85.93 [Very High] | Form 4 | - | 2020-09-30 | Uma Sinha | Chief Scientific Officer | Sell | 100 | Common Stock | $52.00 | $5,200.00 | 0.03 [ Very Low ] | 331,356 | $17,230,512.00 | 85.91 [Very High] | Form 4 | - | 2020-10-01 | Uma Sinha | Chief Scientific Officer | Sell | 4,831 | Common Stock | $52.35 | $252,902.85 | 1.25 [ High ] | 326,525 | $17,093,583.75 | 84.66 [Very High] | Form 4 | - | 2020-10-07 | Franco Valle | Senior Vice President, Finance | Buy | 5,000 | Common Stock | $7.24 | -$36,200.00 | 1.30 [ High ] | 5,444 | $39,414.56 | 1.41 [Low] | Form 4 | - | 2020-10-07 | Franco Valle | Senior Vice President, Finance | Sell | 5,444 | Common Stock | $75.08 | $408,735.52 | 1.41 [ High ] | 0 | $0.00 | - | Form 4 | - | 2020-10-08 | Franco Valle | Senior Vice President, Finance | Buy | 5,199 | Common Stock | $7.24 | -$37,640.76 | 1.35 [ High ] | 5,199 | $37,640.76 | 1.35 [Low] | Form 4 | - | 2020-10-08 | Franco Valle | Senior Vice President, Finance | Sell | 5,199 | Common Stock | $74.85 | $389,145.15 | 1.35 [ High ] | 0 | $0.00 | - | Form 4 | - | 2020-10-29 | Uma Sinha | Chief Scientific Officer | Sell | 1,300 | Common Stock | $71.90 | $93,470.00 | 0.34 [ Average ] | 325,225 | $23,383,677.50 | 84.27 [High] | Form 4 | - | 2020-10-29 | Uma Sinha | Chief Scientific Officer | Sell | 3,700 | Common Stock | $72.60 | $268,620.00 | 0.96 [ High ] | 321,525 | $23,342,715.00 | 83.31 [High] | Form 4 | - | 2020-11-02 | Cameron Turtle | Chief Business Officer | Buy | 5,000 | Common Stock | $13.20 | -$66,000.00 | 1.29 [ High ] | 75,531 | $997,009.20 | 19.54 [High] | Form 4 | - | 2020-11-02 | Cameron Turtle | Chief Business Officer | Buy | 2,500 | Common Stock | $17.00 | -$42,500.00 | 0.65 [ Average ] | 78,031 | $1,326,527.00 | 20.18 [High] | Form 4 | - | 2020-11-02 | Cameron Turtle | Chief Business Officer | Sell | 9,145 | Common Stock | $70.44 | $644,173.80 | 2.37 [ High ] | 68,886 | $4,852,329.84 | 17.82 [High] | Form 4 | - | 2020-11-02 | Cameron Turtle | Chief Business Officer | Sell | 3,146 | Common Stock | $71.42 | $224,687.32 | 0.81 [ High ] | 65,740 | $4,695,150.80 | 17.00 [High] | Form 4 | - | 2020-11-02 | Cameron Turtle | Chief Business Officer | Sell | 209 | Common Stock | $72.10 | $15,068.90 | 0.05 [ Very Low ] | 65,531 | $4,724,785.10 | 16.95 [High] | Form 4 | - | 2020-11-09 | Franco Valle | Senior Vice President, Finance | Buy | 1,623 | Common Stock | $7.24 | -$11,750.52 | 0.42 [ Average ] | 1,623 | $11,750.52 | 0.42 [Very Low] | Form 4 | - | 2020-11-09 | Franco Valle | Senior Vice President, Finance | Sell | 1,623 | Common Stock | $74.93 | $121,611.39 | 0.42 [ Average ] | 0 | $0.00 | - | Form 4 | - | 2020-11-11 | Cameron Turtle | Chief Business Officer | Sell | 3,005 | Common Stock | $73.56 | $221,047.80 | 0.78 [ Average ] | 62,526 | $4,599,412.56 | 16.17 [Average] | Form 4 | - | 2020-11-11 | Cameron Turtle | Chief Business Officer | Sell | 9,497 | Common Stock | $74.75 | $709,900.75 | 2.46 [ High ] | 53,029 | $3,963,917.75 | 13.72 [Average] | Form 4 | - | 2020-11-11 | Cameron Turtle | Chief Business Officer | Sell | 908 | Common Stock | $75.23 | $68,308.84 | 0.23 [ Low ] | 52,121 | $3,921,062.83 | 13.48 [Average] | Form 4 | - | 2020-11-11 | Cameron Turtle | Chief Business Officer | Sell | 1,500 | Common Stock | $0.00 | $0.00 | - | 50,621 | $0.00 | 13.09 [Average] | Form 4 | - | 2020-12-15 | Cameron Turtle | Chief Business Officer | Buy | 4,451 | Common Stock | $17.00 | -$75,667.00 | 1.15 [ High ] | 55,072 | $936,224.00 | 14.17 [Average] | Form 4 | - | 2020-12-15 | Cameron Turtle | Chief Business Officer | Buy | 21,843 | Common Stock | $13.20 | -$288,327.60 | 5.62 [ Very High ] | 76,915 | $1,015,278.00 | 19.79 [High] | Form 4 | - | 2020-12-15 | Cameron Turtle | Chief Business Officer | Sell | 3,756 | Common Stock | $110.29 | $414,249.24 | 0.97 [ High ] | 73,159 | $8,068,706.11 | 18.83 [High] | Form 4 | - | 2020-12-15 | Cameron Turtle | Chief Business Officer | Sell | 7,600 | Common Stock | $111.31 | $845,956.00 | 1.96 [ High ] | 65,559 | $7,297,372.29 | 16.87 [High] | Form 4 | - | 2020-12-15 | Cameron Turtle | Chief Business Officer | Sell | 11,445 | Common Stock | $112.19 | $1,284,014.55 | 2.95 [ Very High ] | 54,114 | $6,071,049.66 | 13.92 [Average] | Form 4 | - | 2020-12-15 | Cameron Turtle | Chief Business Officer | Sell | 3,493 | Common Stock | $112.97 | $394,604.21 | 0.90 [ High ] | 50,621 | $5,718,654.37 | 13.03 [Average] | Form 4 | - | 2021-01-11 | Franco Valle | Senior Vice President, Finance | Buy | 1,500 | Common Stock | $7.24 | -$10,860.00 | 0.39 [ Average ] | 1,500 | $10,860.00 | 0.39 [Very Low] | Form 4 | - | 2021-01-11 | Franco Valle | Senior Vice President, Finance | Sell | 1,500 | Common Stock | $125.61 | $188,415.00 | 0.39 [ Average ] | 0 | $0.00 | - | Form 4 | - | 2021-01-12 | Franco Valle | Senior Vice President, Finance | Buy | 1,747 | Common Stock | $7.24 | -$12,648.28 | 0.45 [ Average ] | 1,747 | $12,648.28 | 0.45 [Very Low] | Form 4 | - | 2021-01-12 | Franco Valle | Senior Vice President, Finance | Sell | 1,747 | Common Stock | $125.44 | $219,143.68 | 0.45 [ Average ] | 0 | $0.00 | - | Form 4 | - | 2021-01-13 | Uma Sinha | Chief Scientific Officer | Sell | 696 | Common Stock | $121.11 | $84,292.56 | 0.18 [ Low ] | 315,829 | $38,250,050.19 | 81.27 [High] | Form 4 | - | 2021-01-13 | Uma Sinha | Chief Scientific Officer | Sell | 572 | Common Stock | $122.27 | $69,938.44 | 0.15 [ Low ] | 315,257 | $38,546,473.39 | 81.12 [High] | Form 4 | - | 2021-01-13 | Uma Sinha | Chief Scientific Officer | Sell | 1,498 | Common Stock | $123.48 | $184,973.04 | 0.39 [ Average ] | 313,759 | $38,742,961.32 | 80.74 [High] | Form 4 | - | 2021-01-13 | Uma Sinha | Chief Scientific Officer | Sell | 4,934 | Common Stock | $124.72 | $615,368.48 | 1.27 [ High ] | 308,825 | $38,516,654.00 | 79.47 [High] | Form 4 | - | 2021-01-13 | Uma Sinha | Chief Scientific Officer | Sell | 2,000 | Common Stock | $125.35 | $250,700.00 | 0.51 [ Average ] | 306,825 | $38,460,513.75 | 78.95 [High] | Form 4 | - | 2021-01-13 | Uma Sinha | Chief Scientific Officer | Sell | 300 | Common Stock | $126.39 | $37,917.00 | 0.08 [ Very Low ] | 306,525 | $38,741,694.75 | 78.88 [High] | Form 4 | - |
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