Insider Analysis

Insider Transactions

Edgewise Therapeutics, Inc.

$EWTX

Search Table

Pages

Trade Date	Insider	Title	Buy or Sell	Quantity	Security Type	Price	Proceeds	Transaction Conviction	Position Quantity	Position Value	Positon Conviction	SEC Link	Nature of Ownership
2021-03-30	James E Flynn	-	Buy	1,572,960	Common Stock	$0.00	$0.00	-	1,572,960	$0.00	330.56 [Very High]	Form 4	Through Deerfield Private Design Fund IV, L.P.
2021-03-30	James E Flynn	-	Buy	1,301,626	Common Stock	$0.00	$0.00	-	2,874,586	$0.00	604.11 [Very High]	Form 4	Through Deerfield Private Design Fund IV, L.P.
2021-03-30	James E Flynn	-	Buy	433,551	Common Stock	$0.00	$0.00	-	3,308,137	$0.00	695.22 [Very High]	Form 4	Through Deerfield Private Design Fund IV, L.P.
2021-03-30	James E Flynn	-	Buy	625,000	Common Stock	$16.00	-$10,000,000.00	131.35 [ Very High ]	3,933,137	$62,930,192.00	826.57 [Very High]	Form 4	Through Deerfield Private Design Fund IV, L.P.
2021-03-30	Wellington Biomedical Innovation Master Investors (cayman) I L.p.	-	Buy	681,812	Common Stock	$0.00	$0.00	-	681,812	$0.00	143.29 [Very High]	Form 4	-
2021-09-23	Alan J Russell	Chief Scientific Officer	Sell	21,763	Common Stock	$18.34	$399,133.42	4.42 [ Very High ]	242,337	$4,444,460.58	49.19 [High]	Form 4	-
2021-09-23	Alan J Russell	Chief Scientific Officer	Sell	5,072	Common Stock	$19.42	$98,498.24	1.03 [ High ]	237,265	$4,607,686.30	48.16 [High]	Form 4	-
2021-09-24	Alan J Russell	Chief Scientific Officer	Sell	20,100	Common Stock	$18.16	$365,016.00	4.08 [ Very High ]	217,165	$3,943,716.40	44.08 [High]	Form 4	-
2021-09-27	Alan J Russell	Chief Scientific Officer	Sell	11,594	Common Stock	$17.98	$208,460.12	2.35 [ High ]	205,571	$3,696,166.58	41.73 [High]	Form 4	-
2021-09-27	Alan J Russell	Chief Scientific Officer	Sell	17	Common Stock	$18.48	$314.16	-	205,554	$3,798,637.92	41.73 [High]	Form 4	-
2021-09-28	Alan J Russell	Chief Scientific Officer	Sell	14,610	Common Stock	$17.30	$252,753.00	2.97 [ Very High ]	190,944	$3,303,331.20	38.76 [High]	Form 4	-
2021-09-29	Alan J Russell	Chief Scientific Officer	Sell	11,226	Common Stock	$16.83	$188,933.58	2.28 [ High ]	179,718	$3,024,653.94	36.48 [High]	Form 4	-
2021-09-29	Alan J Russell	Chief Scientific Officer	Sell	618	Common Stock	$17.47	$10,796.46	0.13 [ Low ]	179,100	$3,128,877.00	36.36 [High]	Form 4	-
2021-10-01	Alan J Russell	Chief Scientific Officer	Sell	274	Common Stock	$18.00	$4,932.00	0.06 [ Very Low ]	178,826	$3,218,868.00	36.30 [High]	Form 4	-
2021-10-04	Alan J Russell	Chief Scientific Officer	Sell	100	Common Stock	$18.00	$1,800.00	0.02 [ Very Low ]	178,726	$3,217,068.00	36.28 [High]	Form 4	-
2021-10-05	Alan J Russell	Chief Scientific Officer	Sell	5,404	Common Stock	$18.26	$98,677.04	1.10 [ High ]	173,322	$3,164,859.72	35.18 [High]	Form 4	-
2021-10-06	Alan J Russell	Chief Scientific Officer	Sell	2,108	Common Stock	$18.03	$38,007.24	0.43 [ Average ]	171,214	$3,086,988.42	34.76 [High]	Form 4	-
2021-10-07	Alan J Russell	Chief Scientific Officer	Sell	13,018	Common Stock	$18.56	$241,614.08	2.64 [ Very High ]	158,196	$2,936,117.76	32.11 [High]	Form 4	-
2021-10-08	Alan J Russell	Chief Scientific Officer	Sell	5,902	Common Stock	$18.15	$107,121.30	1.20 [ High ]	152,294	$2,764,136.10	30.92 [High]	Form 4	-
2021-10-11	Alan J Russell	Chief Scientific Officer	Sell	1,270	Common Stock	$18.02	$22,885.40	0.26 [ Low ]	151,024	$2,721,452.48	30.66 [High]	Form 4	-
2021-10-14	Alan J Russell	Chief Scientific Officer	Sell	5,749	Common Stock	$18.18	$104,516.82	1.17 [ High ]	145,275	$2,641,099.50	29.49 [High]	Form 4	-
2021-10-15	Alan J Russell	Chief Scientific Officer	Sell	1,307	Common Stock	$18.13	$23,695.91	0.27 [ Low ]	143,968	$2,610,139.84	29.22 [High]	Form 4	-
2021-10-15	Alan J Russell	Chief Scientific Officer	Sell	126	Common Stock	$18.00	$2,268.00	0.03 [ Very Low ]	143,842	$2,589,156.00	29.20 [High]	Form 4	-
2021-11-01	Alan J Russell	Chief Scientific Officer	Sell	469	Common Stock	$18.02	$8,451.38	0.10 [ Low ]	143,373	$2,583,581.46	29.10 [High]	Form 4	-
2021-11-02	Alan J Russell	Chief Scientific Officer	Sell	17,519	Common Stock	$17.43	$305,356.17	3.56 [ Very High ]	125,854	$2,193,635.22	25.55 [High]	Form 4	-
2021-11-03	Alan J Russell	Chief Scientific Officer	Sell	20,822	Common Stock	$17.98	$374,379.56	4.23 [ Very High ]	105,032	$1,888,475.36	21.32 [High]	Form 4	-
2021-11-03	Alan J Russell	Chief Scientific Officer	Sell	4,243	Common Stock	$18.84	$79,938.12	0.86 [ High ]	100,789	$1,898,864.76	20.46 [High]	Form 4	-
2021-11-03	Alan J Russell	Chief Scientific Officer	Sell	1,119	Common Stock	$19.42	$21,730.98	0.23 [ Low ]	99,670	$1,935,591.40	20.23 [High]	Form 4	-
2021-11-04	Alan J Russell	Chief Scientific Officer	Sell	7,392	Common Stock	$19.76	$146,065.92	1.50 [ High ]	92,278	$1,823,413.28	18.73 [High]	Form 4	-
2021-11-05	Alan J Russell	Chief Scientific Officer	Sell	6	Common Stock	$20.70	$124.20	-	92,272	$1,910,030.40	18.73 [High]	Form 4	-
2021-11-05	Alan J Russell	Chief Scientific Officer	Sell	13,036	Common Stock	$19.62	$255,766.32	2.65 [ Very High ]	79,236	$1,554,610.32	16.08 [High]	Form 4	-
2021-11-08	Alan J Russell	Chief Scientific Officer	Sell	9,017	Common Stock	$20.16	$181,782.72	1.83 [ High ]	70,219	$1,415,615.04	14.25 [Average]	Form 4	-
2021-11-09	Alan J Russell	Chief Scientific Officer	Sell	16,864	Common Stock	$19.94	$336,268.16	3.42 [ Very High ]	53,355	$1,063,898.70	10.82 [Average]	Form 4	-
2021-11-09	Alan J Russell	Chief Scientific Officer	Sell	12,712	Common Stock	$20.30	$258,053.60	2.58 [ Very High ]	40,643	$825,052.90	8.24 [Average]	Form 4	-
2021-11-10	Alan J Russell	Chief Scientific Officer	Sell	11,746	Common Stock	$19.70	$231,396.20	2.38 [ High ]	28,897	$569,270.90	5.86 [Average]	Form 4	-
2021-11-10	Alan J Russell	Chief Scientific Officer	Sell	580	Common Stock	$20.21	$11,721.80	0.12 [ Low ]	28,317	$572,286.57	5.74 [Average]	Form 4	-
2021-11-11	Alan J Russell	Chief Scientific Officer	Sell	15,595	Common Stock	$19.82	$309,092.90	3.16 [ Very High ]	12,722	$252,150.04	2.58 [Low]	Form 4	-
2021-11-11	Alan J Russell	Chief Scientific Officer	Sell	3,681	Common Stock	$20.43	$75,202.83	0.75 [ Average ]	9,041	$184,707.63	1.83 [Low]	Form 4	-
2021-11-12	Alan J Russell	Chief Scientific Officer	Sell	8,562	Common Stock	$19.51	$167,044.62	1.74 [ High ]	479	$9,345.29	0.10 [Very Low]	Form 4	-
2021-11-15	Alan J Russell	Chief Scientific Officer	Sell	441	Common Stock	$19.07	$8,409.87	0.09 [ Very Low ]	38	$724.66	-	Form 4	-
2021-11-15	Alan J Russell	Chief Scientific Officer	Sell	38	Common Stock	$19.61	$745.18	-	0	$0.00	-	Form 4	-
2021-11-30	Alan J Russell	Chief Scientific Officer	Buy	147,585	Common Stock	$0.18	-$26,565.30	29.94 [ Very High ]	147,585	$26,565.30	29.94 [High]	Form 4	-
2021-11-30	Alan J Russell	Chief Scientific Officer	Buy	25,000	Common Stock	$0.45	-$11,250.00	5.07 [ Very High ]	172,585	$77,663.25	35.01 [High]	Form 4	-
2021-12-28	John R Moore	General Counsel	Buy	5,400	Common Stock	$0.71	-$3,834.00	1.10 [ High ]	6,962	$4,943.02	1.41 [Low]	Form 4	-
2022-01-21	John R Moore	General Counsel	Buy	5,400	Common Stock	$0.71	-$3,834.00	1.10 [ High ]	12,362	$8,777.02	2.51 [Low]	Form 4	-
2022-02-25	Jonathan D Root	-	Sell	3,473,543	Common Stock	$0.00	$0.00	-	0	$0.00	-	Form 4	Directly owned by USVP XI
2022-05-16	John R Moore	General Counsel	Sell	10,800	Common Stock	$7.42	$80,136.00	2.18 [ High ]	3,000	$22,260.00	0.61 [Very Low]	Form 4	-
2022-05-18	Advisors Llc Orbimed	-	Buy	138,000	Common Stock	$7.21	-$994,980.00	27.84 [ Very High ]	13,497,456	$97,316,657.76	2,722.58 [Very High]	Form 4	See Footnotes
2022-05-18	Peter A. Thompson	-	Buy	138,000	Common Stock	$7.21	-$994,980.00	27.84 [ Very High ]	13,497,456	$97,316,657.76	2,722.58 [Very High]	Form 4	See Footnotes
2022-05-23	R Michael Carruthers	Chief Financial Officer	Buy	9,000	Common Stock	$0.71	-$6,390.00	1.82 [ High ]	12,000	$8,520.00	2.42 [Low]	Form 4	-
2022-06-03	John R Moore	General Counsel	Buy	15,230	Common Stock	$1.93	-$29,393.90	3.07 [ Very High ]	18,230	$35,183.90	3.68 [Low]	Form 4	-
2022-06-03	John R Moore	General Counsel	Sell	15,230	Common Stock	$6.05	$92,141.50	3.07 [ Very High ]	3,000	$18,150.00	0.61 [Very Low]	Form 4	-
2022-06-06	John R Moore	General Counsel	Buy	13,934	Common Stock	$1.93	-$26,892.62	2.81 [ Very High ]	16,934	$32,682.62	3.42 [Low]	Form 4	-
2022-06-06	John R Moore	General Counsel	Sell	13,934	Common Stock	$6.03	$84,022.02	2.81 [ Very High ]	3,000	$18,090.00	0.61 [Very Low]	Form 4	-
2022-06-07	John R Moore	General Counsel	Buy	973	Common Stock	$1.93	-$1,877.89	0.20 [ Low ]	3,973	$7,667.89	0.80 [Very Low]	Form 4	-
2022-06-07	John R Moore	General Counsel	Sell	973	Common Stock	$6.61	$6,431.53	0.20 [ Low ]	3,000	$19,830.00	0.61 [Very Low]	Form 4	-
2022-06-07	John R Moore	General Counsel	Buy	17,150	Common Stock	$0.71	-$12,176.50	3.46 [ Very High ]	20,150	$14,306.50	4.06 [Low]	Form 4	-
2022-06-07	John R Moore	General Counsel	Sell	17,150	Common Stock	$6.61	$113,361.50	3.46 [ Very High ]	3,000	$19,830.00	0.61 [Very Low]	Form 4	-
2022-06-08	John R Moore	General Counsel	Buy	12,566	Common Stock	$0.71	-$8,921.86	2.53 [ Very High ]	15,566	$11,051.86	3.14 [Low]	Form 4	-
2022-06-08	John R Moore	General Counsel	Sell	12,566	Common Stock	$6.63	$83,312.58	2.53 [ Very High ]	3,000	$19,890.00	0.61 [Very Low]	Form 4	-
2022-06-09	John R Moore	General Counsel	Buy	7,615	Common Stock	$0.71	-$5,406.65	1.54 [ High ]	10,615	$7,536.65	2.14 [Low]	Form 4	-
2022-06-09	John R Moore	General Counsel	Sell	7,615	Common Stock	$6.49	$49,421.35	1.54 [ High ]	3,000	$19,470.00	0.61 [Very Low]	Form 4	-
2022-06-10	John R Moore	General Counsel	Buy	7,125	Common Stock	$0.71	-$5,058.75	1.44 [ High ]	10,125	$7,188.75	2.04 [Low]	Form 4	-
2022-06-10	John R Moore	General Counsel	Sell	7,125	Common Stock	$6.05	$43,106.25	1.44 [ High ]	3,000	$18,150.00	0.61 [Very Low]	Form 4	-
2022-06-13	John R Moore	General Counsel	Buy	4,093	Common Stock	$0.71	-$2,906.03	0.83 [ High ]	7,093	$5,036.03	1.43 [Low]	Form 4	-
2022-06-13	John R Moore	General Counsel	Sell	4,093	Common Stock	$6.01	$24,598.93	0.83 [ High ]	3,000	$18,030.00	0.61 [Very Low]	Form 4	-
2022-06-14	John R Moore	General Counsel	Buy	3,628	Common Stock	$0.71	-$2,575.88	0.73 [ Average ]	6,628	$4,705.88	1.34 [Low]	Form 4	-
2022-06-14	John R Moore	General Counsel	Sell	3,628	Common Stock	$6.02	$21,840.56	0.73 [ Average ]	3,000	$18,060.00	0.61 [Very Low]	Form 4	-
2022-06-15	John R Moore	General Counsel	Buy	18,075	Common Stock	$0.71	-$12,833.25	3.65 [ Very High ]	21,075	$14,963.25	4.25 [Low]	Form 4	-
2022-06-15	John R Moore	General Counsel	Buy	585	Common Stock	$1.93	-$1,129.05	0.12 [ Low ]	21,660	$41,803.80	4.37 [Low]	Form 4	-
2022-06-15	John R Moore	General Counsel	Sell	585	Common Stock	$6.11	$3,574.35	0.12 [ Low ]	21,075	$128,768.25	4.25 [Low]	Form 4	-
2022-06-15	John R Moore	General Counsel	Sell	18,075	Common Stock	$6.11	$110,438.25	3.65 [ Very High ]	3,000	$18,330.00	0.61 [Very Low]	Form 4	-
2022-06-16	John R Moore	General Counsel	Buy	14,722	Common Stock	$1.93	-$28,413.46	2.97 [ Very High ]	17,722	$34,203.46	3.57 [Low]	Form 4	-
2022-06-16	John R Moore	General Counsel	Sell	14,722	Common Stock	$6.17	$90,834.74	2.97 [ Very High ]	3,000	$18,510.00	0.61 [Very Low]	Form 4	-
2022-06-17	John R Moore	General Counsel	Buy	22,127	Common Stock	$1.93	-$42,705.11	4.46 [ Very High ]	25,127	$48,495.11	5.07 [Average]	Form 4	-
2022-06-17	John R Moore	General Counsel	Sell	22,127	Common Stock	$6.62	$146,480.74	4.46 [ Very High ]	3,000	$19,860.00	0.61 [Very Low]	Form 4	-
2022-06-21	John R Moore	General Counsel	Buy	13,508	Common Stock	$0.71	-$9,590.68	2.72 [ Very High ]	16,508	$11,720.68	3.33 [Low]	Form 4	-
2022-06-21	John R Moore	General Counsel	Buy	17,570	Common Stock	$1.93	-$33,910.10	3.54 [ Very High ]	34,078	$65,770.54	6.87 [Average]	Form 4	-
2022-06-21	John R Moore	General Counsel	Sell	31,078	Common Stock	$7.29	$226,558.62	6.27 [ Very High ]	3,000	$21,870.00	0.61 [Very Low]	Form 4	-

Trade Date

Insider

Title

Buy or Sell

Quantity

Security Type

Price

Proceeds

Transaction Conviction

Position Quantity

Position Value

Positon Conviction

SEC Link

Nature of Ownership

2021-03-30

James E Flynn

Buy

1,572,960

Common Stock

$0.00

1,572,960

$0.00

330.56 [Very High]

Form 4

Through Deerfield Private Design Fund IV, L.P.

2021-03-30

James E Flynn

Buy

1,301,626

Common Stock

$0.00

2,874,586

$0.00

604.11 [Very High]

Form 4

Through Deerfield Private Design Fund IV, L.P.

2021-03-30

James E Flynn

Buy

433,551

Common Stock

$0.00

3,308,137

$0.00

695.22 [Very High]

Form 4

Through Deerfield Private Design Fund IV, L.P.

2021-03-30

James E Flynn

Buy

625,000

Common Stock

$16.00

-$10,000,000.00

131.35 [ Very High ]

3,933,137

$62,930,192.00

826.57 [Very High]

Form 4

Through Deerfield Private Design Fund IV, L.P.

2021-03-30

Wellington Biomedical Innovation Master Investors (cayman) I L.p.

Buy

681,812

Common Stock

$0.00

681,812

$0.00

143.29 [Very High]

Form 4

2021-09-23

Alan J Russell

Chief Scientific Officer

Sell

21,763

Common Stock

$18.34

$399,133.42

4.42 [ Very High ]

242,337

$4,444,460.58

49.19 [High]

Form 4

2021-09-23

Alan J Russell

Chief Scientific Officer

Sell

5,072

Common Stock

$19.42

$98,498.24

1.03 [ High ]

237,265

$4,607,686.30

48.16 [High]

Form 4

2021-09-24

Alan J Russell

Chief Scientific Officer

Sell

20,100

Common Stock

$18.16

$365,016.00

4.08 [ Very High ]

217,165

$3,943,716.40

44.08 [High]

Form 4

2021-09-27

Alan J Russell

Chief Scientific Officer

Sell

11,594

Common Stock

$17.98

$208,460.12

2.35 [ High ]

205,571

$3,696,166.58

41.73 [High]

Form 4

2021-09-27

Alan J Russell

Chief Scientific Officer

Sell

Common Stock

$18.48

$314.16

205,554

$3,798,637.92

41.73 [High]

Form 4

2021-09-28

Alan J Russell

Chief Scientific Officer

Sell

14,610

Common Stock

$17.30

$252,753.00

2.97 [ Very High ]

190,944

$3,303,331.20

38.76 [High]

Form 4

2021-09-29

Alan J Russell

Chief Scientific Officer

Sell

11,226

Common Stock

$16.83

$188,933.58

2.28 [ High ]

179,718

$3,024,653.94

36.48 [High]

Form 4

2021-09-29

Alan J Russell

Chief Scientific Officer

Sell

618

Common Stock

$17.47

$10,796.46

0.13 [ Low ]

179,100

$3,128,877.00

36.36 [High]

Form 4

2021-10-01

Alan J Russell

Chief Scientific Officer

Sell

274

Common Stock

$18.00

$4,932.00

0.06 [ Very Low ]

178,826

$3,218,868.00

36.30 [High]

Form 4

2021-10-04

Alan J Russell

Chief Scientific Officer

Sell

100

Common Stock

$18.00

$1,800.00

0.02 [ Very Low ]

178,726

$3,217,068.00

36.28 [High]

Form 4

2021-10-05

Alan J Russell

Chief Scientific Officer

Sell

5,404

Common Stock

$18.26

$98,677.04

1.10 [ High ]

173,322

$3,164,859.72

35.18 [High]

Form 4

2021-10-06

Alan J Russell

Chief Scientific Officer

Sell

2,108

Common Stock

$18.03

$38,007.24

0.43 [ Average ]

171,214

$3,086,988.42

34.76 [High]

Form 4

2021-10-07

Alan J Russell

Chief Scientific Officer

Sell

13,018

Common Stock

$18.56

$241,614.08

2.64 [ Very High ]

158,196

$2,936,117.76

32.11 [High]

Form 4

2021-10-08

Alan J Russell

Chief Scientific Officer

Sell

5,902

Common Stock

$18.15

$107,121.30

1.20 [ High ]

152,294

$2,764,136.10

30.92 [High]

Form 4

2021-10-11

Alan J Russell

Chief Scientific Officer

Sell

1,270

Common Stock

$18.02

$22,885.40

0.26 [ Low ]

151,024

$2,721,452.48

30.66 [High]

Form 4

2021-10-14

Alan J Russell

Chief Scientific Officer

Sell

5,749

Common Stock

$18.18

$104,516.82

1.17 [ High ]

145,275

$2,641,099.50

29.49 [High]

Form 4

2021-10-15

Alan J Russell

Chief Scientific Officer

Sell

1,307

Common Stock

$18.13

$23,695.91

0.27 [ Low ]

143,968

$2,610,139.84

29.22 [High]

Form 4

2021-10-15

Alan J Russell

Chief Scientific Officer

Sell

126

Common Stock

$18.00

$2,268.00

0.03 [ Very Low ]

143,842

$2,589,156.00

29.20 [High]

Form 4

2021-11-01

Alan J Russell

Chief Scientific Officer

Sell

469

Common Stock

$18.02

$8,451.38

0.10 [ Low ]

143,373

$2,583,581.46

29.10 [High]

Form 4

2021-11-02

Alan J Russell

Chief Scientific Officer

Sell

17,519

Common Stock

$17.43

$305,356.17

3.56 [ Very High ]

125,854

$2,193,635.22

25.55 [High]

Form 4

2021-11-03

Alan J Russell

Chief Scientific Officer

Sell

20,822

Common Stock

$17.98

$374,379.56

4.23 [ Very High ]

105,032

$1,888,475.36

21.32 [High]

Form 4

2021-11-03

Alan J Russell

Chief Scientific Officer

Sell

4,243

Common Stock

$18.84

$79,938.12

0.86 [ High ]

100,789

$1,898,864.76

20.46 [High]

Form 4

2021-11-03

Alan J Russell

Chief Scientific Officer

Sell

1,119

Common Stock

$19.42

$21,730.98

0.23 [ Low ]

99,670

$1,935,591.40

20.23 [High]

Form 4

2021-11-04

Alan J Russell

Chief Scientific Officer

Sell

7,392

Common Stock

$19.76

$146,065.92

1.50 [ High ]

92,278

$1,823,413.28

18.73 [High]

Form 4

2021-11-05

Alan J Russell

Chief Scientific Officer

Sell

Common Stock

$20.70

$124.20

92,272

$1,910,030.40

18.73 [High]

Form 4

2021-11-05

Alan J Russell

Chief Scientific Officer

Sell

13,036

Common Stock

$19.62

$255,766.32

2.65 [ Very High ]

79,236

$1,554,610.32

16.08 [High]

Form 4

2021-11-08

Alan J Russell

Chief Scientific Officer

Sell

9,017

Common Stock

$20.16

$181,782.72

1.83 [ High ]

70,219

$1,415,615.04

14.25 [Average]

Form 4

2021-11-09

Alan J Russell

Chief Scientific Officer

Sell

16,864

Common Stock

$19.94

$336,268.16

3.42 [ Very High ]

53,355

$1,063,898.70

10.82 [Average]

Form 4

2021-11-09

Alan J Russell

Chief Scientific Officer

Sell

12,712

Common Stock

$20.30

$258,053.60

2.58 [ Very High ]

40,643

$825,052.90

8.24 [Average]

Form 4

2021-11-10

Alan J Russell

Chief Scientific Officer

Sell

11,746

Common Stock

$19.70

$231,396.20

2.38 [ High ]

28,897

$569,270.90

5.86 [Average]

Form 4

2021-11-10

Alan J Russell

Chief Scientific Officer

Sell

580

Common Stock

$20.21

$11,721.80

0.12 [ Low ]

28,317

$572,286.57

5.74 [Average]

Form 4

2021-11-11

Alan J Russell

Chief Scientific Officer

Sell

15,595

Common Stock

$19.82

$309,092.90

3.16 [ Very High ]

12,722

$252,150.04

2.58 [Low]

Form 4

2021-11-11

Alan J Russell

Chief Scientific Officer

Sell

3,681

Common Stock

$20.43

$75,202.83

0.75 [ Average ]

9,041

$184,707.63

1.83 [Low]

Form 4

2021-11-12

Alan J Russell

Chief Scientific Officer

Sell

8,562

Common Stock

$19.51

$167,044.62

1.74 [ High ]

479

$9,345.29

0.10 [Very Low]

Form 4

2021-11-15

Alan J Russell

Chief Scientific Officer

Sell

441

Common Stock

$19.07

$8,409.87

0.09 [ Very Low ]

$724.66

Form 4

2021-11-15

Alan J Russell

Chief Scientific Officer

Sell

Common Stock

$19.61

$745.18

$0.00

Form 4

2021-11-30

Alan J Russell

Chief Scientific Officer

Buy

147,585

Common Stock

$0.18

-$26,565.30

29.94 [ Very High ]

147,585

$26,565.30

29.94 [High]

Form 4

2021-11-30

Alan J Russell

Chief Scientific Officer

Buy

25,000

Common Stock

$0.45

-$11,250.00

5.07 [ Very High ]

172,585

$77,663.25

35.01 [High]

Form 4

2021-12-28

John R Moore

General Counsel

Buy

5,400

Common Stock

$0.71

-$3,834.00

1.10 [ High ]

6,962

$4,943.02

1.41 [Low]

Form 4

2022-01-21

John R Moore

General Counsel

Buy

5,400

Common Stock

$0.71

-$3,834.00

1.10 [ High ]

12,362

$8,777.02

2.51 [Low]

Form 4

2022-02-25

Jonathan D Root

Sell

3,473,543

Common Stock

$0.00

Form 4

Directly owned by USVP XI

2022-05-16

John R Moore

General Counsel

Sell

10,800

Common Stock

$7.42

$80,136.00

2.18 [ High ]

3,000

$22,260.00

0.61 [Very Low]

Form 4

2022-05-18

Advisors Llc Orbimed

Buy

138,000

Common Stock

$7.21

-$994,980.00

27.84 [ Very High ]

13,497,456

$97,316,657.76

2,722.58 [Very High]

Form 4

See Footnotes

2022-05-18

Peter A. Thompson

Buy

138,000

Common Stock

$7.21

-$994,980.00

27.84 [ Very High ]

13,497,456

$97,316,657.76

2,722.58 [Very High]

Form 4

See Footnotes

2022-05-23

R Michael Carruthers

Chief Financial Officer

Buy

9,000

Common Stock

$0.71

-$6,390.00

1.82 [ High ]

12,000

$8,520.00

2.42 [Low]

Form 4

2022-06-03

John R Moore

General Counsel

Buy

15,230

Common Stock

$1.93

-$29,393.90

3.07 [ Very High ]

18,230

$35,183.90

3.68 [Low]

Form 4

2022-06-03

John R Moore

General Counsel

Sell

15,230

Common Stock

$6.05

$92,141.50

3.07 [ Very High ]

3,000

$18,150.00

0.61 [Very Low]

Form 4

2022-06-06

John R Moore

General Counsel

Buy

13,934

Common Stock

$1.93

-$26,892.62

2.81 [ Very High ]

16,934

$32,682.62

3.42 [Low]

Form 4

2022-06-06

John R Moore

General Counsel

Sell

13,934

Common Stock

$6.03

$84,022.02

2.81 [ Very High ]

3,000

$18,090.00

0.61 [Very Low]

Form 4

2022-06-07

John R Moore

General Counsel

Buy

973

Common Stock

$1.93

-$1,877.89

0.20 [ Low ]

3,973

$7,667.89

0.80 [Very Low]

Form 4

2022-06-07

John R Moore

General Counsel

Sell

973

Common Stock

$6.61

$6,431.53

0.20 [ Low ]

3,000

$19,830.00

0.61 [Very Low]

Form 4

2022-06-07

John R Moore

General Counsel

Buy

17,150

Common Stock

$0.71

-$12,176.50

3.46 [ Very High ]

20,150

$14,306.50

4.06 [Low]

Form 4

2022-06-07

John R Moore

General Counsel

Sell

17,150

Common Stock

$6.61

$113,361.50

3.46 [ Very High ]

3,000

$19,830.00

0.61 [Very Low]

Form 4

2022-06-08

John R Moore

General Counsel

Buy

12,566

Common Stock

$0.71

-$8,921.86

2.53 [ Very High ]

15,566

$11,051.86

3.14 [Low]

Form 4

2022-06-08

John R Moore

General Counsel

Sell

12,566

Common Stock

$6.63

$83,312.58

2.53 [ Very High ]

3,000

$19,890.00

0.61 [Very Low]

Form 4

2022-06-09

John R Moore

General Counsel

Buy

7,615

Common Stock

$0.71

-$5,406.65

1.54 [ High ]

10,615

$7,536.65

2.14 [Low]

Form 4

2022-06-09

John R Moore

General Counsel

Sell

7,615

Common Stock

$6.49

$49,421.35

1.54 [ High ]

3,000

$19,470.00

0.61 [Very Low]

Form 4

2022-06-10

John R Moore

General Counsel

Buy

7,125

Common Stock

$0.71

-$5,058.75

1.44 [ High ]

10,125

$7,188.75

2.04 [Low]

Form 4

2022-06-10

John R Moore

General Counsel

Sell

7,125

Common Stock

$6.05

$43,106.25

1.44 [ High ]

3,000

$18,150.00

0.61 [Very Low]

Form 4

2022-06-13

John R Moore

General Counsel

Buy

4,093

Common Stock

$0.71

-$2,906.03

0.83 [ High ]

7,093

$5,036.03

1.43 [Low]

Form 4

2022-06-13

John R Moore

General Counsel

Sell

4,093

Common Stock

$6.01

$24,598.93

0.83 [ High ]

3,000

$18,030.00

0.61 [Very Low]

Form 4

2022-06-14

John R Moore

General Counsel

Buy

3,628

Common Stock

$0.71

-$2,575.88

0.73 [ Average ]

6,628

$4,705.88

1.34 [Low]

Form 4

2022-06-14

John R Moore

General Counsel

Sell

3,628

Common Stock

$6.02

$21,840.56

0.73 [ Average ]

3,000

$18,060.00

0.61 [Very Low]

Form 4

2022-06-15

John R Moore

General Counsel

Buy

18,075

Common Stock

$0.71

-$12,833.25

3.65 [ Very High ]

21,075

$14,963.25

4.25 [Low]

Form 4

2022-06-15

John R Moore

General Counsel

Buy

585

Common Stock

$1.93

-$1,129.05

0.12 [ Low ]

21,660

$41,803.80

4.37 [Low]

Form 4

2022-06-15

John R Moore

General Counsel

Sell

585

Common Stock

$6.11

$3,574.35

0.12 [ Low ]

21,075

$128,768.25

4.25 [Low]

Form 4

2022-06-15

John R Moore

General Counsel

Sell

18,075

Common Stock

$6.11

$110,438.25

3.65 [ Very High ]

3,000

$18,330.00

0.61 [Very Low]

Form 4

2022-06-16

John R Moore

General Counsel

Buy

14,722

Common Stock

$1.93

-$28,413.46

2.97 [ Very High ]

17,722

$34,203.46

3.57 [Low]

Form 4

2022-06-16

John R Moore

General Counsel

Sell

14,722

Common Stock

$6.17

$90,834.74

2.97 [ Very High ]

3,000

$18,510.00

0.61 [Very Low]

Form 4

2022-06-17

John R Moore

General Counsel

Buy

22,127

Common Stock

$1.93

-$42,705.11

4.46 [ Very High ]

25,127

$48,495.11

5.07 [Average]

Form 4

2022-06-17

John R Moore

General Counsel

Sell

22,127

Common Stock

$6.62

$146,480.74

4.46 [ Very High ]

3,000

$19,860.00

0.61 [Very Low]

Form 4

2022-06-21

John R Moore

General Counsel

Buy

13,508

Common Stock

$0.71

-$9,590.68

2.72 [ Very High ]

16,508

$11,720.68

3.33 [Low]

Form 4

2022-06-21

John R Moore

General Counsel

Buy

17,570

Common Stock

$1.93

-$33,910.10

3.54 [ Very High ]

34,078

$65,770.54

6.87 [Average]

Form 4

2022-06-21

John R Moore

General Counsel

Sell

31,078

Common Stock

$7.29

$226,558.62

6.27 [ Very High ]

3,000

$21,870.00

0.61 [Very Low]

Form 4

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