Trade Date | Insider | Title | Buy or Sell | Quantity | Security Type | Price | Proceeds | Transaction Conviction | Position Quantity | Position Value | Positon Conviction | SEC Link | Nature of Ownership | 2021-03-30 | James E Flynn | - | Buy | 1,572,960 | Common Stock | $0.00 | $0.00 | - | 1,572,960 | $0.00 | 330.56 [Very High] | Form 4 | Through Deerfield Private Design Fund IV, L.P. | 2021-03-30 | James E Flynn | - | Buy | 1,301,626 | Common Stock | $0.00 | $0.00 | - | 2,874,586 | $0.00 | 604.11 [Very High] | Form 4 | Through Deerfield Private Design Fund IV, L.P. | 2021-03-30 | James E Flynn | - | Buy | 433,551 | Common Stock | $0.00 | $0.00 | - | 3,308,137 | $0.00 | 695.22 [Very High] | Form 4 | Through Deerfield Private Design Fund IV, L.P. | 2021-03-30 | James E Flynn | - | Buy | 625,000 | Common Stock | $16.00 | -$10,000,000.00 | 131.35 [ Very High ] | 3,933,137 | $62,930,192.00 | 826.57 [Very High] | Form 4 | Through Deerfield Private Design Fund IV, L.P. | 2021-03-30 | Wellington Biomedical Innovation Master Investors (cayman) I L.p. | - | Buy | 681,812 | Common Stock | $0.00 | $0.00 | - | 681,812 | $0.00 | 143.29 [Very High] | Form 4 | - | 2021-09-23 | Alan J Russell | Chief Scientific Officer | Sell | 21,763 | Common Stock | $18.34 | $399,133.42 | 4.42 [ Very High ] | 242,337 | $4,444,460.58 | 49.19 [High] | Form 4 | - | 2021-09-23 | Alan J Russell | Chief Scientific Officer | Sell | 5,072 | Common Stock | $19.42 | $98,498.24 | 1.03 [ High ] | 237,265 | $4,607,686.30 | 48.16 [High] | Form 4 | - | 2021-09-24 | Alan J Russell | Chief Scientific Officer | Sell | 20,100 | Common Stock | $18.16 | $365,016.00 | 4.08 [ Very High ] | 217,165 | $3,943,716.40 | 44.08 [High] | Form 4 | - | 2021-09-27 | Alan J Russell | Chief Scientific Officer | Sell | 11,594 | Common Stock | $17.98 | $208,460.12 | 2.35 [ High ] | 205,571 | $3,696,166.58 | 41.73 [High] | Form 4 | - | 2021-09-27 | Alan J Russell | Chief Scientific Officer | Sell | 17 | Common Stock | $18.48 | $314.16 | - | 205,554 | $3,798,637.92 | 41.73 [High] | Form 4 | - | 2021-09-28 | Alan J Russell | Chief Scientific Officer | Sell | 14,610 | Common Stock | $17.30 | $252,753.00 | 2.97 [ Very High ] | 190,944 | $3,303,331.20 | 38.76 [High] | Form 4 | - | 2021-09-29 | Alan J Russell | Chief Scientific Officer | Sell | 11,226 | Common Stock | $16.83 | $188,933.58 | 2.28 [ High ] | 179,718 | $3,024,653.94 | 36.48 [High] | Form 4 | - | 2021-09-29 | Alan J Russell | Chief Scientific Officer | Sell | 618 | Common Stock | $17.47 | $10,796.46 | 0.13 [ Low ] | 179,100 | $3,128,877.00 | 36.36 [High] | Form 4 | - | 2021-10-01 | Alan J Russell | Chief Scientific Officer | Sell | 274 | Common Stock | $18.00 | $4,932.00 | 0.06 [ Very Low ] | 178,826 | $3,218,868.00 | 36.30 [High] | Form 4 | - | 2021-10-04 | Alan J Russell | Chief Scientific Officer | Sell | 100 | Common Stock | $18.00 | $1,800.00 | 0.02 [ Very Low ] | 178,726 | $3,217,068.00 | 36.28 [High] | Form 4 | - | 2021-10-05 | Alan J Russell | Chief Scientific Officer | Sell | 5,404 | Common Stock | $18.26 | $98,677.04 | 1.10 [ High ] | 173,322 | $3,164,859.72 | 35.18 [High] | Form 4 | - | 2021-10-06 | Alan J Russell | Chief Scientific Officer | Sell | 2,108 | Common Stock | $18.03 | $38,007.24 | 0.43 [ Average ] | 171,214 | $3,086,988.42 | 34.76 [High] | Form 4 | - | 2021-10-07 | Alan J Russell | Chief Scientific Officer | Sell | 13,018 | Common Stock | $18.56 | $241,614.08 | 2.64 [ Very High ] | 158,196 | $2,936,117.76 | 32.11 [High] | Form 4 | - | 2021-10-08 | Alan J Russell | Chief Scientific Officer | Sell | 5,902 | Common Stock | $18.15 | $107,121.30 | 1.20 [ High ] | 152,294 | $2,764,136.10 | 30.92 [High] | Form 4 | - | 2021-10-11 | Alan J Russell | Chief Scientific Officer | Sell | 1,270 | Common Stock | $18.02 | $22,885.40 | 0.26 [ Low ] | 151,024 | $2,721,452.48 | 30.66 [High] | Form 4 | - | 2021-10-14 | Alan J Russell | Chief Scientific Officer | Sell | 5,749 | Common Stock | $18.18 | $104,516.82 | 1.17 [ High ] | 145,275 | $2,641,099.50 | 29.49 [High] | Form 4 | - | 2021-10-15 | Alan J Russell | Chief Scientific Officer | Sell | 1,307 | Common Stock | $18.13 | $23,695.91 | 0.27 [ Low ] | 143,968 | $2,610,139.84 | 29.22 [High] | Form 4 | - | 2021-10-15 | Alan J Russell | Chief Scientific Officer | Sell | 126 | Common Stock | $18.00 | $2,268.00 | 0.03 [ Very Low ] | 143,842 | $2,589,156.00 | 29.20 [High] | Form 4 | - | 2021-11-01 | Alan J Russell | Chief Scientific Officer | Sell | 469 | Common Stock | $18.02 | $8,451.38 | 0.10 [ Low ] | 143,373 | $2,583,581.46 | 29.10 [High] | Form 4 | - | 2021-11-02 | Alan J Russell | Chief Scientific Officer | Sell | 17,519 | Common Stock | $17.43 | $305,356.17 | 3.56 [ Very High ] | 125,854 | $2,193,635.22 | 25.55 [High] | Form 4 | - | 2021-11-03 | Alan J Russell | Chief Scientific Officer | Sell | 20,822 | Common Stock | $17.98 | $374,379.56 | 4.23 [ Very High ] | 105,032 | $1,888,475.36 | 21.32 [High] | Form 4 | - | 2021-11-03 | Alan J Russell | Chief Scientific Officer | Sell | 4,243 | Common Stock | $18.84 | $79,938.12 | 0.86 [ High ] | 100,789 | $1,898,864.76 | 20.46 [High] | Form 4 | - | 2021-11-03 | Alan J Russell | Chief Scientific Officer | Sell | 1,119 | Common Stock | $19.42 | $21,730.98 | 0.23 [ Low ] | 99,670 | $1,935,591.40 | 20.23 [High] | Form 4 | - | 2021-11-04 | Alan J Russell | Chief Scientific Officer | Sell | 7,392 | Common Stock | $19.76 | $146,065.92 | 1.50 [ High ] | 92,278 | $1,823,413.28 | 18.73 [High] | Form 4 | - | 2021-11-05 | Alan J Russell | Chief Scientific Officer | Sell | 6 | Common Stock | $20.70 | $124.20 | - | 92,272 | $1,910,030.40 | 18.73 [High] | Form 4 | - | 2021-11-05 | Alan J Russell | Chief Scientific Officer | Sell | 13,036 | Common Stock | $19.62 | $255,766.32 | 2.65 [ Very High ] | 79,236 | $1,554,610.32 | 16.08 [High] | Form 4 | - | 2021-11-08 | Alan J Russell | Chief Scientific Officer | Sell | 9,017 | Common Stock | $20.16 | $181,782.72 | 1.83 [ High ] | 70,219 | $1,415,615.04 | 14.25 [Average] | Form 4 | - | 2021-11-09 | Alan J Russell | Chief Scientific Officer | Sell | 16,864 | Common Stock | $19.94 | $336,268.16 | 3.42 [ Very High ] | 53,355 | $1,063,898.70 | 10.82 [Average] | Form 4 | - | 2021-11-09 | Alan J Russell | Chief Scientific Officer | Sell | 12,712 | Common Stock | $20.30 | $258,053.60 | 2.58 [ Very High ] | 40,643 | $825,052.90 | 8.24 [Average] | Form 4 | - | 2021-11-10 | Alan J Russell | Chief Scientific Officer | Sell | 11,746 | Common Stock | $19.70 | $231,396.20 | 2.38 [ High ] | 28,897 | $569,270.90 | 5.86 [Average] | Form 4 | - | 2021-11-10 | Alan J Russell | Chief Scientific Officer | Sell | 580 | Common Stock | $20.21 | $11,721.80 | 0.12 [ Low ] | 28,317 | $572,286.57 | 5.74 [Average] | Form 4 | - | 2021-11-11 | Alan J Russell | Chief Scientific Officer | Sell | 15,595 | Common Stock | $19.82 | $309,092.90 | 3.16 [ Very High ] | 12,722 | $252,150.04 | 2.58 [Low] | Form 4 | - | 2021-11-11 | Alan J Russell | Chief Scientific Officer | Sell | 3,681 | Common Stock | $20.43 | $75,202.83 | 0.75 [ Average ] | 9,041 | $184,707.63 | 1.83 [Low] | Form 4 | - | 2021-11-12 | Alan J Russell | Chief Scientific Officer | Sell | 8,562 | Common Stock | $19.51 | $167,044.62 | 1.74 [ High ] | 479 | $9,345.29 | 0.10 [Very Low] | Form 4 | - | 2021-11-15 | Alan J Russell | Chief Scientific Officer | Sell | 441 | Common Stock | $19.07 | $8,409.87 | 0.09 [ Very Low ] | 38 | $724.66 | - | Form 4 | - | 2021-11-15 | Alan J Russell | Chief Scientific Officer | Sell | 38 | Common Stock | $19.61 | $745.18 | - | 0 | $0.00 | - | Form 4 | - | 2021-11-30 | Alan J Russell | Chief Scientific Officer | Buy | 147,585 | Common Stock | $0.18 | -$26,565.30 | 29.94 [ Very High ] | 147,585 | $26,565.30 | 29.94 [High] | Form 4 | - | 2021-11-30 | Alan J Russell | Chief Scientific Officer | Buy | 25,000 | Common Stock | $0.45 | -$11,250.00 | 5.07 [ Very High ] | 172,585 | $77,663.25 | 35.01 [High] | Form 4 | - | 2021-12-28 | John R Moore | General Counsel | Buy | 5,400 | Common Stock | $0.71 | -$3,834.00 | 1.10 [ High ] | 6,962 | $4,943.02 | 1.41 [Low] | Form 4 | - | 2022-01-21 | John R Moore | General Counsel | Buy | 5,400 | Common Stock | $0.71 | -$3,834.00 | 1.10 [ High ] | 12,362 | $8,777.02 | 2.51 [Low] | Form 4 | - | 2022-02-25 | Jonathan D Root | - | Sell | 3,473,543 | Common Stock | $0.00 | $0.00 | - | 0 | $0.00 | - | Form 4 | Directly owned by USVP XI | 2022-05-16 | John R Moore | General Counsel | Sell | 10,800 | Common Stock | $7.42 | $80,136.00 | 2.18 [ High ] | 3,000 | $22,260.00 | 0.61 [Very Low] | Form 4 | - | 2022-05-18 | Advisors Llc Orbimed | - | Buy | 138,000 | Common Stock | $7.21 | -$994,980.00 | 27.84 [ Very High ] | 13,497,456 | $97,316,657.76 | 2,722.58 [Very High] | Form 4 | See Footnotes | 2022-05-18 | Peter A. Thompson | - | Buy | 138,000 | Common Stock | $7.21 | -$994,980.00 | 27.84 [ Very High ] | 13,497,456 | $97,316,657.76 | 2,722.58 [Very High] | Form 4 | See Footnotes | 2022-05-23 | R Michael Carruthers | Chief Financial Officer | Buy | 9,000 | Common Stock | $0.71 | -$6,390.00 | 1.82 [ High ] | 12,000 | $8,520.00 | 2.42 [Low] | Form 4 | - | 2022-06-03 | John R Moore | General Counsel | Buy | 15,230 | Common Stock | $1.93 | -$29,393.90 | 3.07 [ Very High ] | 18,230 | $35,183.90 | 3.68 [Low] | Form 4 | - | 2022-06-03 | John R Moore | General Counsel | Sell | 15,230 | Common Stock | $6.05 | $92,141.50 | 3.07 [ Very High ] | 3,000 | $18,150.00 | 0.61 [Very Low] | Form 4 | - | 2022-06-06 | John R Moore | General Counsel | Buy | 13,934 | Common Stock | $1.93 | -$26,892.62 | 2.81 [ Very High ] | 16,934 | $32,682.62 | 3.42 [Low] | Form 4 | - | 2022-06-06 | John R Moore | General Counsel | Sell | 13,934 | Common Stock | $6.03 | $84,022.02 | 2.81 [ Very High ] | 3,000 | $18,090.00 | 0.61 [Very Low] | Form 4 | - | 2022-06-07 | John R Moore | General Counsel | Buy | 973 | Common Stock | $1.93 | -$1,877.89 | 0.20 [ Low ] | 3,973 | $7,667.89 | 0.80 [Very Low] | Form 4 | - | 2022-06-07 | John R Moore | General Counsel | Sell | 973 | Common Stock | $6.61 | $6,431.53 | 0.20 [ Low ] | 3,000 | $19,830.00 | 0.61 [Very Low] | Form 4 | - | 2022-06-07 | John R Moore | General Counsel | Buy | 17,150 | Common Stock | $0.71 | -$12,176.50 | 3.46 [ Very High ] | 20,150 | $14,306.50 | 4.06 [Low] | Form 4 | - | 2022-06-07 | John R Moore | General Counsel | Sell | 17,150 | Common Stock | $6.61 | $113,361.50 | 3.46 [ Very High ] | 3,000 | $19,830.00 | 0.61 [Very Low] | Form 4 | - | 2022-06-08 | John R Moore | General Counsel | Buy | 12,566 | Common Stock | $0.71 | -$8,921.86 | 2.53 [ Very High ] | 15,566 | $11,051.86 | 3.14 [Low] | Form 4 | - | 2022-06-08 | John R Moore | General Counsel | Sell | 12,566 | Common Stock | $6.63 | $83,312.58 | 2.53 [ Very High ] | 3,000 | $19,890.00 | 0.61 [Very Low] | Form 4 | - | 2022-06-09 | John R Moore | General Counsel | Buy | 7,615 | Common Stock | $0.71 | -$5,406.65 | 1.54 [ High ] | 10,615 | $7,536.65 | 2.14 [Low] | Form 4 | - | 2022-06-09 | John R Moore | General Counsel | Sell | 7,615 | Common Stock | $6.49 | $49,421.35 | 1.54 [ High ] | 3,000 | $19,470.00 | 0.61 [Very Low] | Form 4 | - | 2022-06-10 | John R Moore | General Counsel | Buy | 7,125 | Common Stock | $0.71 | -$5,058.75 | 1.44 [ High ] | 10,125 | $7,188.75 | 2.04 [Low] | Form 4 | - | 2022-06-10 | John R Moore | General Counsel | Sell | 7,125 | Common Stock | $6.05 | $43,106.25 | 1.44 [ High ] | 3,000 | $18,150.00 | 0.61 [Very Low] | Form 4 | - | 2022-06-13 | John R Moore | General Counsel | Buy | 4,093 | Common Stock | $0.71 | -$2,906.03 | 0.83 [ High ] | 7,093 | $5,036.03 | 1.43 [Low] | Form 4 | - | 2022-06-13 | John R Moore | General Counsel | Sell | 4,093 | Common Stock | $6.01 | $24,598.93 | 0.83 [ High ] | 3,000 | $18,030.00 | 0.61 [Very Low] | Form 4 | - | 2022-06-14 | John R Moore | General Counsel | Buy | 3,628 | Common Stock | $0.71 | -$2,575.88 | 0.73 [ Average ] | 6,628 | $4,705.88 | 1.34 [Low] | Form 4 | - | 2022-06-14 | John R Moore | General Counsel | Sell | 3,628 | Common Stock | $6.02 | $21,840.56 | 0.73 [ Average ] | 3,000 | $18,060.00 | 0.61 [Very Low] | Form 4 | - | 2022-06-15 | John R Moore | General Counsel | Buy | 18,075 | Common Stock | $0.71 | -$12,833.25 | 3.65 [ Very High ] | 21,075 | $14,963.25 | 4.25 [Low] | Form 4 | - | 2022-06-15 | John R Moore | General Counsel | Buy | 585 | Common Stock | $1.93 | -$1,129.05 | 0.12 [ Low ] | 21,660 | $41,803.80 | 4.37 [Low] | Form 4 | - | 2022-06-15 | John R Moore | General Counsel | Sell | 585 | Common Stock | $6.11 | $3,574.35 | 0.12 [ Low ] | 21,075 | $128,768.25 | 4.25 [Low] | Form 4 | - | 2022-06-15 | John R Moore | General Counsel | Sell | 18,075 | Common Stock | $6.11 | $110,438.25 | 3.65 [ Very High ] | 3,000 | $18,330.00 | 0.61 [Very Low] | Form 4 | - | 2022-06-16 | John R Moore | General Counsel | Buy | 14,722 | Common Stock | $1.93 | -$28,413.46 | 2.97 [ Very High ] | 17,722 | $34,203.46 | 3.57 [Low] | Form 4 | - | 2022-06-16 | John R Moore | General Counsel | Sell | 14,722 | Common Stock | $6.17 | $90,834.74 | 2.97 [ Very High ] | 3,000 | $18,510.00 | 0.61 [Very Low] | Form 4 | - | 2022-06-17 | John R Moore | General Counsel | Buy | 22,127 | Common Stock | $1.93 | -$42,705.11 | 4.46 [ Very High ] | 25,127 | $48,495.11 | 5.07 [Average] | Form 4 | - | 2022-06-17 | John R Moore | General Counsel | Sell | 22,127 | Common Stock | $6.62 | $146,480.74 | 4.46 [ Very High ] | 3,000 | $19,860.00 | 0.61 [Very Low] | Form 4 | - | 2022-06-21 | John R Moore | General Counsel | Buy | 13,508 | Common Stock | $0.71 | -$9,590.68 | 2.72 [ Very High ] | 16,508 | $11,720.68 | 3.33 [Low] | Form 4 | - | 2022-06-21 | John R Moore | General Counsel | Buy | 17,570 | Common Stock | $1.93 | -$33,910.10 | 3.54 [ Very High ] | 34,078 | $65,770.54 | 6.87 [Average] | Form 4 | - | 2022-06-21 | John R Moore | General Counsel | Sell | 31,078 | Common Stock | $7.29 | $226,558.62 | 6.27 [ Very High ] | 3,000 | $21,870.00 | 0.61 [Very Low] | Form 4 | - |
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