iTeos Therapeutics, Inc.

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iTeos Therapeutics, Inc.

$ITOS

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Trade Date Insider Title Buy or Sell Quantity Security Type Price Proceeds Transaction Conviction Position Quantity Position Value Positon Conviction SEC Link Nature of Ownership
2020-07-28Capital, Llc Boxer-Buy2,943,568Common Stock$0.00$0.00  -2,943,568$0.00  -Form 4-
2020-07-28Capital, Llc Boxer-Buy48,691Common Stock$0.00$0.00  -48,691$0.00  -Form 4-
2020-07-28Capital, Llc Boxer-Buy1,401,448Common Stock$19.00-$26,627,512.00  -4,345,016$82,555,304.00  -Form 4-
2020-07-28Capital, Llc Boxer-Buy23,552Common Stock$19.00-$447,488.00  -72,243$1,372,617.00  -Form 4-
2020-07-28Mpm Bioventures 2014, L.p.-Buy1,269,230Common Stock$0.00$0.00  -1,269,230$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy84,655Common Stock$0.00$0.00  -84,655$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy43,687Common Stock$0.00$0.00  -43,687$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy801,619Common Stock$0.00$0.00  -801,619$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy42,605Common Stock$0.00$0.00  -42,605$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy15,820Common Stock$0.00$0.00  -15,820$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy724,702Common Stock$0.00$0.00  -1,993,932$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy48,336Common Stock$0.00$0.00  -132,991$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy24,944Common Stock$0.00$0.00  -68,381$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy457,706Common Stock$0.00$0.00  -1,259,325$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy24,326Common Stock$0.00$0.00  -66,931$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy9,033Common Stock$0.00$0.00  -24,853$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy89,955Common Stock$19.00-$1,709,145.00  -2,083,887$39,593,853.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy5,994Common Stock$19.00-$113,886.00  -138,985$2,640,715.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy3,096Common Stock$19.00-$58,824.00  -71,727$1,362,813.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy56,814Common Stock$19.00-$1,079,466.00  -1,316,139$25,006,641.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy3,020Common Stock$19.00-$57,380.00  -69,951$1,329,069.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy1,121Common Stock$19.00-$21,299.00  -25,974$493,506.00  -Form 4See Footnote
2020-07-28Ra Capital Management, L.p.-Buy2,992,259Common Stock$0.00$0.00  -2,992,259$0.00  -Form 4See footnote
2020-07-28Ra Capital Management, L.p.-Buy1,425,000Common Stock$19.00-$27,075,000.00  -4,417,259$83,927,921.00  -Form 4See footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy1,269,230Common Stock$0.00$0.00  -1,269,230$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy84,655Common Stock$0.00$0.00  -84,655$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy43,687Common Stock$0.00$0.00  -43,687$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy801,619Common Stock$0.00$0.00  -801,619$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy42,605Common Stock$0.00$0.00  -42,605$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy15,820Common Stock$0.00$0.00  -15,820$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy724,702Common Stock$0.00$0.00  -1,993,932$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy48,336Common Stock$0.00$0.00  -132,991$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy24,944Common Stock$0.00$0.00  -68,381$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy457,706Common Stock$0.00$0.00  -1,259,325$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy24,326Common Stock$0.00$0.00  -66,931$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy9,033Common Stock$0.00$0.00  -24,853$0.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy89,955Common Stock$19.00-$1,709,145.00  -2,083,887$39,593,853.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy5,994Common Stock$19.00-$113,886.00  -138,985$2,640,715.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy3,096Common Stock$19.00-$58,824.00  -71,727$1,362,813.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy56,814Common Stock$19.00-$1,079,466.00  -1,316,139$25,006,641.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy3,020Common Stock$19.00-$57,380.00  -69,951$1,329,069.00  -Form 4See Footnote
2020-07-28Mpm Bioventures 2014, L.p.-Buy1,121Common Stock$19.00-$21,299.00  -25,974$493,506.00  -Form 4See Footnote
2020-07-28Ansbert Gadicke-Buy1,269,230Common Stock$0.00$0.00  -1,269,230$0.00  379.61   [Very High]Form 4See Footnote
2020-07-28Ansbert Gadicke-Buy84,655Common Stock$0.00$0.00  -84,655$0.00  25.32    [High]Form 4See Footnote
2020-07-28Ansbert Gadicke-Buy43,687Common Stock$0.00$0.00  -43,687$0.00  13.07    [Average]Form 4See Footnote
2020-07-28Ansbert Gadicke-Buy801,619Common Stock$0.00$0.00  -801,619$0.00  239.75   [Very High]Form 4See Footnote
2020-07-28Ansbert Gadicke-Buy42,605Common Stock$0.00$0.00  -42,605$0.00  12.74    [Average]Form 4See Footnote
2020-07-28Ansbert Gadicke-Buy15,820Common Stock$0.00$0.00  -15,820$0.00  4.73     [Average]Form 4See Footnote
2020-07-28Ansbert Gadicke-Buy1,397,574Common Stock$0.00$0.00  -1,397,574$0.00  418.00   [Very High]Form 4See Footnote
2020-07-28Ansbert Gadicke-Buy724,702Common Stock$0.00$0.00  -1,993,932$0.00  596.36   [Very High]Form 4See Footnote
2020-07-28Ansbert Gadicke-Buy48,336Common Stock$0.00$0.00  -132,991$0.00  39.78    [High]Form 4See Footnote
2020-07-28Ansbert Gadicke-Buy24,944Common Stock$0.00$0.00  -68,381$0.00  20.45    [High]Form 4See Footnote
2020-07-28Ansbert Gadicke-Buy457,706Common Stock$0.00$0.00  -1,259,325$0.00  376.65   [Very High]Form 4See Footnote
2020-07-28Ansbert Gadicke-Buy24,326Common Stock$0.00$0.00  -66,931$0.00  20.02    [High]Form 4See Footnote
2020-07-28Ansbert Gadicke-Buy9,033Common Stock$0.00$0.00  -24,853$0.00  7.43     [Average]Form 4See Footnote
2020-07-28Ansbert Gadicke-Buy797,983Common Stock$0.00$0.00  -2,195,557$0.00  656.66   [Very High]Form 4See Footnote
2020-07-28Ansbert Gadicke-Buy89,955Common Stock$19.00-$1,709,145.00  26.90    [ Very High ]2,083,887$39,593,853.00  623.27   [Very High]Form 4See Footnote
2020-07-28Ansbert Gadicke-Buy5,994Common Stock$19.00-$113,886.00  1.79     [ High ]138,985$2,640,715.00  41.57    [High]Form 4See Footnote
2020-07-28Ansbert Gadicke-Buy3,096Common Stock$19.00-$58,824.00  0.93     [ High ]71,727$1,362,813.00  21.45    [High]Form 4See Footnote
2020-07-28Ansbert Gadicke-Buy56,814Common Stock$19.00-$1,079,466.00  16.99    [ Very High ]1,316,139$25,006,641.00  393.64   [Very High]Form 4See Footnote
2020-07-28Ansbert Gadicke-Buy3,020Common Stock$19.00-$57,380.00  0.90     [ High ]69,951$1,329,069.00  20.92    [High]Form 4See Footnote
2020-07-28Ansbert Gadicke-Buy1,121Common Stock$19.00-$21,299.00  0.34     [ Average ]25,974$493,506.00  7.77     [Average]Form 4See Footnote
2020-07-28Ansbert Gadicke-Buy160,000Common Stock$19.00-$3,040,000.00  47.85    [ Very High ]2,355,557$44,755,583.00  704.52   [Very High]Form 4See Footnote
2020-07-28Aaron I. Davis-Buy2,943,568Common Stock$0.00$0.00  -2,943,568$0.00  880.39   [Very High]Form 4See Footnote
2020-07-28Aaron I. Davis-Buy48,691Common Stock$0.00$0.00  -48,691$0.00  14.56    [Average]Form 4See Footnote
2020-07-28Aaron I. Davis-Buy1,401,448Common Stock$19.00-$26,627,512.00  419.16   [ Very High ]4,345,016$82,555,304.00  1,299.54 [Very High]Form 4See Footnotes
2020-07-28Aaron I. Davis-Buy23,552Common Stock$19.00-$447,488.00  7.04     [ Very High ]72,243$1,372,617.00  21.61    [High]Form 4See Footnotes
2021-04-01Ra Capital Management, L.p.-Buy289,843Common Stock$34.18-$9,906,833.74  82.58    [ Very High ]289,843$9,906,833.74  82.58    [Very High]Form 4See Footnote
2021-04-01Ra Capital Management, L.p.-Buy131,364Common Stock$34.18-$4,490,021.52  37.43    [ Very High ]3,155,667$107,860,698.06  899.08   [Very High]Form 4See Footnote
2021-04-09Ansbert Gadicke-Sell200Common Stock$29.99$5,998.00  0.06     [ Very Low ]6,004,368$180,070,996.32  1,710.69 [Very High]Form 4See Footnote
2021-04-09Mpm Bioventures 2014, L.p.-Sell119Common Stock$29.99$3,568.81  0.03     [ Very Low ]3,665,787$109,936,952.13  1,044.41 [Very High]Form 4See Footnote
2021-04-09Mpm Bioventures 2018, L.p.-Sell119Common Stock$29.99$3,568.81  0.03     [ Very Low ]3,665,787$109,936,952.13  1,044.41 [Very High]Form 4See Footnote
2021-05-17Yvonne McgrathVP, Research and DevelopmentBuy7,926Common Stock$4.23-$33,526.98  2.26     [ High ]7,926$33,526.98  2.26     [Low]Form 4-
2021-05-17Yvonne McgrathVP, Research and DevelopmentSell5,807Common Stock$24.41$141,748.87  1.65     [ High ]2,119$51,724.79  0.60     [Very Low]Form 4-
2021-05-17Yvonne McgrathVP, Research and DevelopmentSell2,029Common Stock$25.43$51,597.47  0.58     [ Average ]90$2,288.70  0.03     [Very Low]Form 4-
2021-05-17Yvonne McgrathVP, Research and DevelopmentSell90Common Stock$26.01$2,340.90  0.03     [ Very Low ]0$0.00  -Form 4-
2021-05-24Yvonne McgrathVP, Research and DevelopmentBuy7,927Common Stock$4.23-$33,531.21  2.26     [ High ]7,927$33,531.21  2.26     [Low]Form 4-
2021-05-24Yvonne McgrathVP, Research and DevelopmentSell7,927Common Stock$21.92$173,759.84  2.26     [ High ]0$0.00  -Form 4-
2021-06-01Yvonne McgrathVP, Research and DevelopmentBuy7,604Common Stock$4.23-$32,164.92  2.17     [ High ]7,604$32,164.92  2.17     [Low]Form 4-
2021-06-01Yvonne McgrathVP, Research and DevelopmentSell7,604Common Stock$20.18$153,448.72  2.17     [ High ]0$0.00  -Form 4-
2021-06-02Yvonne McgrathVP, Research and DevelopmentBuy323Common Stock$4.23-$1,366.29  0.09     [ Very Low ]323$1,366.29  0.09     [Very Low]Form 4-
2021-06-02Yvonne McgrathVP, Research and DevelopmentSell323Common Stock$20.00$6,460.00  0.09     [ Very Low ]0$0.00  -Form 4-
2021-06-08Yvonne McgrathVP, Research and DevelopmentBuy7,927Common Stock$4.23-$33,531.21  2.26     [ High ]7,927$33,531.21  2.26     [Low]Form 4-
2021-06-08Yvonne McgrathVP, Research and DevelopmentSell7,927Common Stock$20.00$158,540.00  2.26     [ High ]0$0.00  -Form 4-
2021-06-16Matthew GallChief Financial OfficerBuy5,000Common Stock$26.09-$130,450.00  1.42     [ High ]5,000$130,450.00  1.42     [Low]Form 4-
2021-06-14Michel DetheuxChief Executive OfficerSell25,063Common Stock$28.38$711,287.94  7.14     [ Very High ]152,874$4,338,564.12  43.55    [High]Form 4-
2021-06-14Michel DetheuxChief Executive OfficerSell3,937Common Stock$29.26$115,196.62  1.12     [ High ]148,937$4,357,896.62  42.43    [High]Form 4-
2021-07-30Matthew CallChief Operating OfficerBuy53,672Common Stock$2.95-$158,332.40  15.29    [ Very High ]53,672$158,332.40  15.29    [High]Form 4-
2021-08-23Michel DetheuxChief Executive OfficerSell7,499Common Stock$28.06$210,421.94  2.13     [ High ]141,438$3,968,750.28  40.17    [High]Form 4-
2021-08-24Michel DetheuxChief Executive OfficerSell225Common Stock$28.26$6,358.50  0.06     [ Very Low ]141,213$3,990,679.38  40.11    [High]Form 4-
2021-08-25Michel DetheuxChief Executive OfficerSell861Common Stock$28.00$24,108.00  0.24     [ Low ]140,352$3,929,856.00  39.86    [High]Form 4-
2021-08-27Michel DetheuxChief Executive OfficerSell8,248Common Stock$28.17$232,346.16  2.34     [ High ]132,104$3,721,369.68  37.52    [High]Form 4-
2021-08-30Michel DetheuxChief Executive OfficerSell2,322Common Stock$28.01$65,039.22  0.66     [ Average ]129,782$3,635,193.82  36.86    [High]Form 4-
2021-08-31Michel DetheuxChief Executive OfficerSell4,093Common Stock$28.12$115,095.16  1.16     [ High ]125,689$3,534,374.68  35.70    [High]Form 4-
2021-09-01Michel DetheuxChief Executive OfficerSell8,684Common Stock$28.30$245,757.20  2.47     [ High ]117,005$3,311,241.50  33.23    [High]Form 4-
2021-09-02Michel DetheuxChief Executive OfficerSell11,018Common Stock$28.91$318,530.38  3.13     [ Very High ]105,987$3,064,084.17  30.10    [High]Form 4-
2021-09-02Michel DetheuxChief Executive OfficerSell550Common Stock$29.49$16,219.50  0.16     [ Low ]105,437$3,109,337.13  29.95    [High]Form 4-
2021-09-07Ansbert Gadicke-Sell50,996Common Stock$29.18$1,488,063.28  14.48    [ Very High ]5,953,372$173,719,394.96  1,690.82 [Very High]Form 4See Footnote
2021-09-07Ansbert Gadicke-Sell31,340Common Stock$0.00$0.00  -5,922,032$0.00  1,681.92 [Very High]Form 4See Footnote
2021-09-08Ansbert Gadicke-Sell18,663Common Stock$28.61$533,948.43  5.30     [ Very High ]5,903,369$168,895,387.09  1,676.62 [Very High]Form 4See Footnote
2021-09-08Ansbert Gadicke-Sell1,573Common Stock$29.10$45,774.30  0.45     [ Average ]5,901,796$171,742,263.60  1,676.17 [Very High]Form 4See Footnote
2021-09-07Mpm Bioventures 2014, L.p.-Sell30,474Common Stock$29.18$889,231.32  8.65     [ Very High ]3,635,313$106,078,433.34  1,032.47 [Very High]Form 4See Footnote
2021-09-07Mpm Bioventures 2014, L.p.-Sell31,340Common Stock$0.00$0.00  -3,603,793$0.00  1,023.51 [Very High]Form 4See Footnote
2021-09-08Mpm Bioventures 2014, L.p.-Sell11,152Common Stock$28.61$319,058.72  3.17     [ Very High ]3,592,821$102,790,608.81  1,020.40 [Very High]Form 4See Footnote
2021-09-08Mpm Bioventures 2014, L.p.-Sell940Common Stock$29.10$27,354.00  0.27     [ Low ]3,591,881$104,523,737.10  1,020.13 [Very High]Form 4See Footnote
2021-09-07Mpm Bioventures 2018, L.p.-Sell30,474Common Stock$29.18$889,231.32  8.65     [ Very High ]3,635,313$106,078,433.34  1,032.47 [Very High]Form 4See Footnote
2021-09-07Mpm Bioventures 2018, L.p.-Sell31,340Common Stock$0.00$0.00  -3,603,793$0.00  1,023.51 [Very High]Form 4See Footnote
2021-09-08Mpm Bioventures 2018, L.p.-Sell11,152Common Stock$28.61$319,058.72  3.17     [ Very High ]3,592,821$102,790,608.81  1,020.40 [Very High]Form 4See Footnote
2021-09-08Mpm Bioventures 2018, L.p.-Sell940Common Stock$29.10$27,354.00  0.27     [ Low ]3,591,881$104,523,737.10  1,020.13 [Very High]Form 4See Footnote
2021-09-09Ansbert Gadicke-Sell38,028Common Stock$28.97$1,101,671.16  10.80    [ Very High ]5,863,768$169,873,358.96  1,665.37 [Very High]Form 4See Footnote
2021-09-10Ansbert Gadicke-Sell11,313Common Stock$27.86$315,180.18  3.21     [ Very High ]5,852,455$163,049,396.30  1,662.16 [Very High]Form 4See Footnote
2021-09-10Ansbert Gadicke-Sell11,330Common Stock$28.73$325,510.90  3.22     [ Very High ]5,841,125$167,815,521.25  1,658.94 [Very High]Form 4See Footnote
2021-09-13Ansbert Gadicke-Sell35,785Common Stock$27.64$989,097.40  10.16    [ Very High ]5,805,340$160,459,597.60  1,648.78 [Very High]Form 4See Footnote
2021-09-09Mpm Bioventures 2014, L.p.-Sell22,725Common Stock$28.97$658,343.25  6.45     [ Very High ]3,569,156$103,398,449.32  1,013.68 [Very High]Form 4See Footnote
2021-09-10Mpm Bioventures 2014, L.p.-Sell6,760Common Stock$27.86$188,333.60  1.92     [ High ]3,562,396$99,248,352.56  1,011.76 [Very High]Form 4See Footnote
2021-09-10Mpm Bioventures 2014, L.p.-Sell6,771Common Stock$28.73$194,530.83  1.92     [ High ]3,555,625$102,153,106.25  1,009.83 [Very High]Form 4See Footnote
2021-09-13Mpm Bioventures 2014, L.p.-Sell21,384Common Stock$27.64$591,053.76  6.07     [ Very High ]3,534,241$97,686,421.24  1,003.76 [Very High]Form 4See Footnote
2021-09-09Mpm Bioventures 2018, L.p.-Sell22,725Common Stock$28.97$658,343.25  6.45     [ Very High ]3,569,156$103,398,449.32  1,013.68 [Very High]Form 4See Footnote
2021-09-10Mpm Bioventures 2018, L.p.-Sell6,760Common Stock$27.86$188,333.60  1.92     [ High ]3,562,396$99,248,352.56  1,011.76 [Very High]Form 4See Footnote
2021-09-10Mpm Bioventures 2018, L.p.-Sell6,771Common Stock$28.73$194,530.83  1.92     [ High ]3,555,625$102,153,106.25  1,009.83 [Very High]Form 4See Footnote
2021-09-13Mpm Bioventures 2018, L.p.-Sell21,384Common Stock$27.64$591,053.76  6.07     [ Very High ]3,534,241$97,686,421.24  1,003.76 [Very High]Form 4See Footnote
2021-09-14Ansbert Gadicke-Sell30,018Common Stock$27.50$825,495.00  8.53     [ Very High ]5,775,322$158,821,355.00  1,640.25 [Very High]Form 4See Footnote
2021-09-14Ansbert Gadicke-Sell6,063Common Stock$27.99$169,703.37  1.72     [ High ]5,769,259$161,481,559.41  1,638.53 [Very High]Form 4See Footnote
2021-09-15Ansbert Gadicke-Sell38,677Common Stock$27.79$1,074,833.83  10.98    [ Very High ]5,730,582$159,252,873.78  1,627.54 [Very High]Form 4See Footnote
2021-09-15Ansbert Gadicke-Sell1,659Common Stock$28.15$46,700.85  0.47     [ Average ]5,728,923$161,269,182.45  1,627.07 [Very High]Form 4See Footnote
2021-09-14Mpm Bioventures 2014, L.p.-Sell17,938Common Stock$27.50$493,295.00  5.09     [ Very High ]3,516,303$96,698,332.50  998.67   [Very High]Form 4See Footnote
2021-09-14Mpm Bioventures 2014, L.p.-Sell3,623Common Stock$27.99$101,407.77  1.03     [ High ]3,512,680$98,319,913.20  997.64   [Very High]Form 4See Footnote
2021-09-15Mpm Bioventures 2014, L.p.-Sell23,113Common Stock$27.79$642,310.27  6.56     [ Very High ]3,489,567$96,975,066.93  991.07   [Very High]Form 4See Footnote
2021-09-15Mpm Bioventures 2014, L.p.-Sell991Common Stock$28.15$27,896.65  0.28     [ Low ]3,488,576$98,203,414.40  990.79   [Very High]Form 4See Footnote
2021-09-14Mpm Bioventures 2018, L.p.-Sell17,938Common Stock$27.50$493,295.00  5.09     [ Very High ]3,516,303$96,698,332.50  998.67   [Very High]Form 4See Footnote
2021-09-14Mpm Bioventures 2018, L.p.-Sell3,623Common Stock$27.99$101,407.77  1.03     [ High ]3,512,680$98,319,913.20  997.64   [Very High]Form 4See Footnote
2021-09-15Mpm Bioventures 2018, L.p.-Sell23,113Common Stock$27.79$642,310.27  6.56     [ Very High ]3,489,567$96,975,066.93  991.07   [Very High]Form 4See Footnote
2021-09-15Mpm Bioventures 2018, L.p.-Sell991Common Stock$28.15$27,896.65  0.28     [ Low ]3,488,576$98,203,414.40  990.79   [Very High]Form 4See Footnote
2021-09-16Ansbert Gadicke-Sell35,565Common Stock$28.47$1,012,535.55  10.10    [ Very High ]5,693,358$162,089,902.26  1,616.97 [Very High]Form 4See Footnote
2021-09-17Ansbert Gadicke-Sell76,473Common Stock$28.82$2,203,951.86  21.72    [ Very High ]5,616,885$161,878,625.70  1,595.25 [Very High]Form 4See Footnote
2021-09-20Ansbert Gadicke-Sell17,743Common Stock$27.03$479,593.29  5.04     [ Very High ]5,599,142$151,344,808.26  1,590.21 [Very High]Form 4See Footnote
2021-09-20Ansbert Gadicke-Sell22,930Common Stock$27.84$638,371.20  6.51     [ Very High ]5,576,212$155,241,742.08  1,583.70 [Very High]Form 4See Footnote
2021-09-16Mpm Bioventures 2014, L.p.-Sell21,253Common Stock$28.47$605,072.91  6.04     [ Very High ]3,467,323$98,714,685.81  984.76   [Very High]Form 4See Footnote
2021-09-17Mpm Bioventures 2014, L.p.-Sell45,698Common Stock$28.82$1,317,016.36  12.98    [ Very High ]3,421,625$98,611,232.50  971.78   [Very High]Form 4See Footnote
2021-09-20Mpm Bioventures 2014, L.p.-Sell10,602Common Stock$27.03$286,572.06  3.01     [ Very High ]3,411,023$92,199,951.69  968.77   [Very High]Form 4See Footnote
2021-09-20Mpm Bioventures 2014, L.p.-Sell13,701Common Stock$27.84$381,435.84  3.89     [ Very High ]3,397,322$94,581,444.48  964.87   [Very High]Form 4See Footnote
2021-09-16Mpm Bioventures 2018, L.p.-Sell21,253Common Stock$28.47$605,072.91  6.04     [ Very High ]3,467,323$98,714,685.81  984.76   [Very High]Form 4See Footnote
2021-09-17Mpm Bioventures 2018, L.p.-Sell45,698Common Stock$28.82$1,317,016.36  12.98    [ Very High ]3,421,625$98,611,232.50  971.78   [Very High]Form 4See Footnote
2021-09-20Mpm Bioventures 2018, L.p.-Sell10,602Common Stock$27.03$286,572.06  3.01     [ Very High ]3,411,023$92,199,951.69  968.77   [Very High]Form 4See Footnote
2021-09-20Mpm Bioventures 2018, L.p.-Sell13,701Common Stock$27.84$381,435.84  3.89     [ Very High ]3,397,322$94,581,444.48  964.87   [Very High]Form 4See Footnote
2021-09-21Ansbert Gadicke-Sell32,858Common Stock$27.47$902,609.26  9.33     [ Very High ]5,543,354$152,275,934.38  1,574.37 [Very High]Form 4See Footnote
2021-09-22Ansbert Gadicke-Sell23,921Common Stock$27.54$658,784.34  6.79     [ Very High ]5,519,433$152,005,184.82  1,567.58 [Very High]Form 4See Footnote
2021-09-21Mpm Bioventures 2014, L.p.-Sell19,635Common Stock$27.47$539,373.45  5.58     [ Very High ]3,377,687$92,785,061.89  959.30   [Very High]Form 4See Footnote
2021-09-22Mpm Bioventures 2014, L.p.-Sell14,294Common Stock$27.54$393,656.76  4.06     [ Very High ]3,363,393$92,627,843.22  955.24   [Very High]Form 4See Footnote
2021-09-21Mpm Bioventures 2018, L.p.-Sell19,635Common Stock$27.47$539,373.45  5.58     [ Very High ]3,377,687$92,785,061.89  959.30   [Very High]Form 4See Footnote
2021-09-22Mpm Bioventures 2018, L.p.-Sell14,294Common Stock$27.54$393,656.76  4.06     [ Very High ]3,363,393$92,627,843.22  955.24   [Very High]Form 4See Footnote
2021-09-23Ansbert Gadicke-Sell60,600Common Stock$27.96$1,694,376.00  17.21    [ Very High ]5,458,833$152,628,970.68  1,550.36 [Very High]Form 4See Footnote
2021-09-23Ansbert Gadicke-Sell1,200Common Stock$28.38$34,056.00  0.34     [ Average ]5,457,633$154,887,624.54  1,550.02 [Very High]Form 4See Footnote
2021-09-24Ansbert Gadicke-Sell8,221Common Stock$27.81$228,626.01  2.33     [ High ]5,449,412$151,548,147.72  1,547.69 [Very High]Form 4See Footnote
2021-09-27Ansbert Gadicke-Sell19,455Common Stock$27.09$527,035.95  5.53     [ Very High ]5,429,957$147,097,535.13  1,542.16 [Very High]Form 4See Footnote
2021-09-23Mpm Bioventures 2014, L.p.-Sell36,213Common Stock$27.96$1,012,515.48  10.28    [ Very High ]3,327,180$93,027,952.80  944.95   [Very High]Form 4See Footnote
2021-09-23Mpm Bioventures 2014, L.p.-Sell717Common Stock$28.38$20,348.46  0.20     [ Low ]3,326,463$94,405,019.94  944.75   [Very High]Form 4See Footnote
2021-09-24Mpm Bioventures 2014, L.p.-Sell4,913Common Stock$27.81$136,630.53  1.40     [ High ]3,321,550$92,372,305.50  943.35   [Very High]Form 4See Footnote
2021-09-27Mpm Bioventures 2014, L.p.-Sell11,625Common Stock$27.09$314,921.25  3.30     [ Very High ]3,309,925$89,665,868.25  940.05   [Very High]Form 4See Footnote
2021-09-23Mpm Bioventures 2018, L.p.-Sell36,213Common Stock$27.96$1,012,515.48  10.28    [ Very High ]3,327,180$93,027,952.80  944.95   [Very High]Form 4See Footnote
2021-09-23Mpm Bioventures 2018, L.p.-Sell717Common Stock$28.38$20,348.46  0.20     [ Low ]3,326,463$94,405,019.94  944.75   [Very High]Form 4See Footnote
2021-09-24Mpm Bioventures 2018, L.p.-Sell4,913Common Stock$27.81$136,630.53  1.40     [ High ]3,321,550$92,372,305.50  943.35   [Very High]Form 4See Footnote
2021-09-27Mpm Bioventures 2018, L.p.-Sell11,625Common Stock$27.09$314,921.25  3.30     [ Very High ]3,309,925$89,665,868.25  940.05   [Very High]Form 4See Footnote
2021-09-23Michel DetheuxChief Executive OfficerSell5,322Common Stock$28.16$149,867.52  1.51     [ High ]100,115$2,819,238.40  28.43    [High]Form 4-
2021-09-24Michel DetheuxChief Executive OfficerSell1,089Common Stock$28.02$30,513.78  0.31     [ Average ]99,026$2,774,708.52  28.12    [High]Form 4-
2021-09-28Ansbert Gadicke-Sell32,154Common Stock$27.00$868,158.00  9.13     [ Very High ]5,397,803$145,740,681.00  1,533.03 [Very High]Form 4See Footnote
2021-09-30Ansbert Gadicke-Sell3,836Common Stock$27.00$103,572.00  1.09     [ High ]5,393,967$145,637,109.00  1,531.94 [Very High]Form 4See Footnote
2021-09-28Mpm Bioventures 2014, L.p.-Sell19,214Common Stock$27.00$518,778.00  5.46     [ Very High ]3,290,711$88,849,197.00  934.60   [Very High]Form 4See Footnote
2021-09-30Mpm Bioventures 2014, L.p.-Sell2,292Common Stock$27.00$61,884.00  0.65     [ Average ]3,288,419$88,787,313.00  933.94   [Very High]Form 4See Footnote
2021-09-28Mpm Bioventures 2018, L.p.-Sell19,214Common Stock$27.00$518,778.00  5.46     [ Very High ]3,290,711$88,849,197.00  934.60   [Very High]Form 4See Footnote
2021-09-30Mpm Bioventures 2018, L.p.-Sell2,292Common Stock$27.00$61,884.00  0.65     [ Average ]3,288,419$88,787,313.00  933.94   [Very High]Form 4See Footnote
2021-10-01Ansbert Gadicke-Sell11,471Common Stock$27.00$309,717.00  3.26     [ Very High ]5,382,496$145,327,392.00  1,528.68 [Very High]Form 4See Footnote
2021-10-04Ansbert Gadicke-Sell34,659Common Stock$27.06$937,872.54  9.84     [ Very High ]5,347,837$144,712,469.22  1,518.84 [Very High]Form 4See Footnote
2021-10-01Mpm Bioventures 2014, L.p.-Sell6,855Common Stock$27.00$185,085.00  1.95     [ High ]3,281,564$88,602,228.00  932.00   [Very High]Form 4See Footnote
2021-10-04Mpm Bioventures 2014, L.p.-Sell20,711Common Stock$27.06$560,439.66  5.88     [ Very High ]3,260,853$88,238,682.18  926.12   [Very High]Form 4See Footnote
2021-10-01Mpm Bioventures 2018, L.p.-Sell6,855Common Stock$27.00$185,085.00  1.95     [ High ]3,281,564$88,602,228.00  932.00   [Very High]Form 4See Footnote
2021-10-04Mpm Bioventures 2018, L.p.-Sell20,711Common Stock$27.06$560,439.66  5.88     [ Very High ]3,260,853$88,238,682.18  926.12   [Very High]Form 4See Footnote
2021-10-07Ansbert Gadicke-Sell1,922Common Stock$27.00$51,894.00  0.55     [ Average ]5,345,915$144,339,705.00  1,518.29 [Very High]Form 4See Footnote
2021-10-08Ansbert Gadicke-Sell3,400Common Stock$27.01$91,834.00  0.97     [ High ]5,342,515$144,301,330.15  1,517.33 [Very High]Form 4See Footnote
2021-10-11Ansbert Gadicke-Sell81,684Common Stock$27.24$2,225,072.16  23.20    [ Very High ]5,260,831$143,305,036.44  1,494.13 [Very High]Form 4See Footnote
2021-10-07Mpm Bioventures 2014, L.p.-Sell1,149Common Stock$27.00$31,023.00  0.33     [ Average ]3,259,704$88,012,008.00  925.79   [Very High]Form 4See Footnote
2021-10-08Mpm Bioventures 2014, L.p.-Sell2,032Common Stock$27.01$54,884.32  0.58     [ Average ]3,257,672$87,989,720.72  925.21   [Very High]Form 4See Footnote
2021-10-11Mpm Bioventures 2014, L.p.-Sell48,812Common Stock$27.24$1,329,638.88  13.86    [ Very High ]3,208,860$87,409,346.40  911.35   [Very High]Form 4See Footnote
2021-10-07Mpm Bioventures 2018, L.p.-Sell1,149Common Stock$27.00$31,023.00  0.33     [ Average ]3,259,704$88,012,008.00  925.79   [Very High]Form 4See Footnote
2021-10-08Mpm Bioventures 2018, L.p.-Sell2,032Common Stock$27.01$54,884.32  0.58     [ Average ]3,257,672$87,989,720.72  925.21   [Very High]Form 4See Footnote
2021-10-11Mpm Bioventures 2018, L.p.-Sell48,812Common Stock$27.24$1,329,638.88  13.86    [ Very High ]3,208,860$87,409,346.40  911.35   [Very High]Form 4See Footnote
2021-10-11Matthew GallChief Financial OfficerBuy14,429Common Stock$6.16-$88,882.64  4.10     [ Very High ]19,429$119,682.64  5.52     [Average]Form 4-
2021-10-12Ansbert Gadicke-Sell14,260Common Stock$27.09$386,303.40  4.05     [ Very High ]5,246,571$142,129,608.39  1,490.08 [Very High]Form 4See Footnote
2021-10-13Ansbert Gadicke-Sell35,023Common Stock$27.13$950,173.99  9.95     [ Very High ]5,211,548$141,389,297.24  1,480.13 [Very High]Form 4See Footnote
2021-10-14Ansbert Gadicke-Sell45,719Common Stock$27.30$1,248,128.70  12.98    [ Very High ]5,165,829$141,027,131.70  1,467.15 [Very High]Form 4See Footnote
2021-10-12Mpm Bioventures 2014, L.p.-Sell8,521Common Stock$27.09$230,833.89  2.42     [ High ]3,200,339$86,697,183.51  908.93   [Very High]Form 4See Footnote
2021-10-13Mpm Bioventures 2014, L.p.-Sell20,929Common Stock$27.13$567,803.77  5.94     [ Very High ]3,179,410$86,257,393.30  902.98   [Very High]Form 4See Footnote
2021-10-14Mpm Bioventures 2014, L.p.-Sell27,320Common Stock$27.30$745,836.00  7.76     [ Very High ]3,152,090$86,052,057.00  895.23   [Very High]Form 4See Footnote
2021-10-12Mpm Bioventures 2018, L.p.-Sell8,521Common Stock$27.09$230,833.89  2.42     [ High ]3,200,339$86,697,183.51  908.93   [Very High]Form 4See Footnote
2021-10-13Mpm Bioventures 2018, L.p.-Sell20,929Common Stock$27.13$567,803.77  5.94     [ Very High ]3,179,410$86,257,393.30  902.98   [Very High]Form 4See Footnote
2021-10-14Mpm Bioventures 2018, L.p.-Sell27,320Common Stock$27.30$745,836.00  7.76     [ Very High ]3,152,090$86,052,057.00  895.23   [Very High]Form 4See Footnote
2021-10-15Ansbert Gadicke-Sell14,882Common Stock$27.53$409,701.46  4.23     [ Very High ]5,150,947$141,805,570.91  1,462.92 [Very High]Form 4See Footnote
2021-10-15Ansbert Gadicke-Sell3,413Common Stock$28.01$95,598.13  0.97     [ High ]5,147,534$144,182,427.34  1,461.95 [Very High]Form 4See Footnote
2021-10-18Ansbert Gadicke-Sell10,320Common Stock$27.14$280,084.80  2.93     [ Very High ]5,137,214$139,423,987.96  1,459.02 [Very High]Form 4See Footnote
2021-10-15Mpm Bioventures 2014, L.p.-Sell8,893Common Stock$27.53$244,824.29  2.53     [ Very High ]3,143,197$86,532,213.41  892.70   [Very High]Form 4See Footnote
2021-10-15Mpm Bioventures 2014, L.p.-Sell2,039Common Stock$28.01$57,112.39  0.58     [ Average ]3,141,158$87,983,835.58  892.12   [Very High]Form 4See Footnote
2021-10-18Mpm Bioventures 2014, L.p.-Sell6,167Common Stock$27.14$167,372.38  1.75     [ High ]3,134,991$85,083,655.74  890.37   [Very High]Form 4See Footnote
2021-10-15Mpm Bioventures 2018, L.p.-Sell8,893Common Stock$27.53$244,824.29  2.53     [ Very High ]3,143,197$86,532,213.41  892.70   [Very High]Form 4See Footnote
2021-10-15Mpm Bioventures 2018, L.p.-Sell2,039Common Stock$28.01$57,112.39  0.58     [ Average ]3,141,158$87,983,835.58  892.12   [Very High]Form 4See Footnote
2021-10-18Mpm Bioventures 2018, L.p.-Sell6,167Common Stock$27.14$167,372.38  1.75     [ High ]3,134,991$85,083,655.74  890.37   [Very High]Form 4See Footnote
2021-10-15Michel DetheuxChief Executive OfficerSell1,635Common Stock$28.01$45,796.35  0.46     [ Average ]97,391$2,727,921.91  27.66    [High]Form 4-
2021-10-19Michel DetheuxChief Executive OfficerSell201Common Stock$28.00$5,628.00  0.06     [ Very Low ]97,190$2,721,320.00  27.60    [High]Form 4-
2021-10-21Michel DetheuxChief Executive OfficerSell196Common Stock$28.00$5,488.00  0.06     [ Very Low ]96,994$2,715,832.00  27.55    [High]Form 4-
2021-11-01Michel DetheuxChief Executive OfficerSell81Common Stock$28.00$2,268.00  0.02     [ Very Low ]96,913$2,713,564.00  27.52    [High]Form 4-
2021-11-02Michel DetheuxChief Executive OfficerSell14,391Common Stock$28.41$408,848.31  4.09     [ Very High ]82,522$2,344,450.02  23.44    [High]Form 4-
2021-11-03Michel DetheuxChief Executive OfficerSell6,085Common Stock$28.89$175,795.65  1.73     [ High ]76,437$2,208,264.93  21.71    [High]Form 4-
2021-11-18Joanne Jenkins LagerChief Medical OfficerBuy28,000Common Stock$4.30-$120,400.00  7.94     [ Very High ]28,000$120,400.00  7.94     [Average]Form 4-
2021-11-18Joanne Jenkins LagerChief Medical OfficerSell28,000Common Stock$34.50$966,000.00  7.94     [ Very High ]0$0.00  -Form 4-
2021-11-17Ansbert Gadicke-Sell15,671Common Stock$0.00$0.00  -5,121,543$0.00  1,451.93 [Very High]Form 4See Footnote
2021-11-22Ansbert Gadicke-Sell15,575Common Stock$37.16$578,767.00  4.42     [ Very High ]5,105,986$189,738,439.76  1,447.52 [Very High]Form 4See Footnote
2021-11-22Ansbert Gadicke-Sell19,758Common Stock$37.81$747,049.98  5.60     [ Very High ]5,086,210$192,309,600.10  1,441.91 [Very High]Form 4See Footnote
2021-11-23Ansbert Gadicke-Sell32,876Common Stock$36.21$1,190,439.96  9.32     [ Very High ]5,053,334$182,981,224.14  1,432.59 [Very High]Form 4See Footnote
2021-11-23Ansbert Gadicke-Sell600Common Stock$36.50$21,900.00  0.17     [ Low ]5,052,734$184,424,791.00  1,432.42 [Very High]Form 4See Footnote
2021-11-24Ansbert Gadicke-Sell8,147Common Stock$35.20$286,774.40  2.31     [ High ]5,044,587$177,569,462.40  1,430.11 [Very High]Form 4See Footnote
2021-11-24Ansbert Gadicke-Sell30,696Common Stock$36.05$1,106,590.80  8.70     [ Very High ]5,013,891$180,750,770.55  1,421.41 [Very High]Form 4See Footnote
2021-11-24Ansbert Gadicke-Sell21,965Common Stock$37.02$813,144.30  6.23     [ Very High ]4,991,926$184,801,100.52  1,415.19 [Very High]Form 4See Footnote
2021-11-17Mpm Bioventures 2014, L.p.-Sell15,671Common Stock$0.00$0.00  -3,119,320$0.00  884.31   [Very High]Form 4See Footnote
2021-11-22Mpm Bioventures 2014, L.p.-Sell9,307Common Stock$37.16$345,848.12  2.64     [ Very High ]3,110,013$115,568,083.08  881.67   [Very High]Form 4See Footnote
2021-11-22Mpm Bioventures 2014, L.p.-Sell11,807Common Stock$37.81$446,422.67  3.35     [ Very High ]3,098,206$117,143,168.86  878.33   [Very High]Form 4See Footnote
2021-11-23Mpm Bioventures 2014, L.p.-Sell19,645Common Stock$36.21$711,345.45  5.57     [ Very High ]3,078,561$111,474,693.81  872.76   [Very High]Form 4See Footnote
2021-11-23Mpm Bioventures 2014, L.p.-Sell359Common Stock$36.50$13,103.50  0.10     [ Low ]3,078,202$112,354,373.00  872.65   [Very High]Form 4See Footnote
2021-11-24Mpm Bioventures 2014, L.p.-Sell4,868Common Stock$35.20$171,353.60  1.38     [ High ]3,073,334$108,181,356.80  871.27   [Very High]Form 4See Footnote
2021-11-24Mpm Bioventures 2014, L.p.-Sell18,343Common Stock$36.05$661,265.15  5.20     [ Very High ]3,054,991$110,132,425.55  866.07   [Very High]Form 4See Footnote
2021-11-24Mpm Bioventures 2014, L.p.-Sell13,126Common Stock$37.02$485,924.52  3.72     [ Very High ]3,041,865$112,609,842.30  862.35   [Very High]Form 4See Footnote
2021-11-17Mpm Bioventures 2018, L.p.-Sell15,671Common Stock$0.00$0.00  -3,119,320$0.00  884.31   [Very High]Form 4See Footnote
2021-11-22Mpm Bioventures 2018, L.p.-Sell9,307Common Stock$37.16$345,848.12  2.64     [ Very High ]3,110,013$115,568,083.08  881.67   [Very High]Form 4See Footnote
2021-11-22Mpm Bioventures 2018, L.p.-Sell11,807Common Stock$37.81$446,422.67  3.35     [ Very High ]3,098,206$117,143,168.86  878.33   [Very High]Form 4See Footnote
2021-11-23Mpm Bioventures 2018, L.p.-Sell19,645Common Stock$36.21$711,345.45  5.57     [ Very High ]3,078,561$111,474,693.81  872.76   [Very High]Form 4See Footnote
2021-11-23Mpm Bioventures 2018, L.p.-Sell359Common Stock$36.50$13,103.50  0.10     [ Low ]3,078,202$112,354,373.00  872.65   [Very High]Form 4See Footnote
2021-11-24Mpm Bioventures 2018, L.p.-Sell4,868Common Stock$35.20$171,353.60  1.38     [ High ]3,073,334$108,181,356.80  871.27   [Very High]Form 4See Footnote
2021-11-24Mpm Bioventures 2018, L.p.-Sell18,343Common Stock$36.05$661,265.15  5.20     [ Very High ]3,054,991$110,132,425.55  866.07   [Very High]Form 4See Footnote
2021-11-24Mpm Bioventures 2018, L.p.-Sell13,126Common Stock$37.02$485,924.52  3.72     [ Very High ]3,041,865$112,609,842.30  862.35   [Very High]Form 4See Footnote
2021-11-22Michel DetheuxChief Executive OfficerBuy16,263Common Stock$12.45-$202,474.35  4.61     [ Very High ]92,700$1,154,115.00  26.28    [High]Form 4-
2021-11-23Michel DetheuxChief Executive OfficerSell14,500Common Stock$36.08$523,160.00  4.11     [ Very High ]78,200$2,821,456.00  22.17    [High]Form 4-
2021-11-26Ansbert Gadicke-Sell10,952Common Stock$35.49$388,686.48  3.10     [ Very High ]4,980,974$176,774,767.26  1,412.08 [Very High]Form 4See Footnote
2021-11-26Ansbert Gadicke-Sell10,258Common Stock$36.03$369,595.74  2.91     [ Very High ]4,970,716$179,094,897.48  1,409.17 [Very High]Form 4See Footnote
2021-11-29Ansbert Gadicke-Sell16,856Common Stock$34.46$580,857.76  4.78     [ Very High ]4,953,860$170,710,015.60  1,404.39 [Very High]Form 4See Footnote
2021-11-29Ansbert Gadicke-Sell500Common Stock$35.37$17,685.00  0.14     [ Low ]4,953,360$175,200,343.20  1,404.25 [Very High]Form 4See Footnote
2021-11-26Mpm Bioventures 2014, L.p.-Sell6,545Common Stock$35.49$232,282.05  1.86     [ High ]3,035,320$107,723,506.80  860.50   [Very High]Form 4See Footnote
2021-11-26Mpm Bioventures 2014, L.p.-Sell6,129Common Stock$36.03$220,827.87  1.74     [ High ]3,029,191$109,141,751.73  858.76   [Very High]Form 4See Footnote
2021-11-29Mpm Bioventures 2014, L.p.-Sell10,073Common Stock$34.46$347,115.58  2.86     [ Very High ]3,019,118$104,038,806.28  855.90   [Very High]Form 4See Footnote
2021-11-29Mpm Bioventures 2014, L.p.-Sell298Common Stock$35.37$10,540.26  0.08     [ Very Low ]3,018,820$106,775,663.40  855.82   [Very High]Form 4See Footnote
2021-11-26Mpm Bioventures 2018, L.p.-Sell6,545Common Stock$35.49$232,282.05  1.86     [ High ]3,035,320$107,723,506.80  860.50   [Very High]Form 4See Footnote
2021-11-26Mpm Bioventures 2018, L.p.-Sell6,129Common Stock$36.03$220,827.87  1.74     [ High ]3,029,191$109,141,751.73  858.76   [Very High]Form 4See Footnote
2021-11-29Mpm Bioventures 2018, L.p.-Sell10,073Common Stock$34.46$347,115.58  2.86     [ Very High ]3,019,118$104,038,806.28  855.90   [Very High]Form 4See Footnote
2021-11-29Mpm Bioventures 2018, L.p.-Sell298Common Stock$35.37$10,540.26  0.08     [ Very Low ]3,018,820$106,775,663.40  855.82   [Very High]Form 4See Footnote
2021-11-30Ansbert Gadicke-Sell9,809Common Stock$34.62$339,587.58  2.78     [ Very High ]4,943,551$171,145,735.62  1,401.47 [Very High]Form 4See Footnote
2021-11-30Ansbert Gadicke-Sell46,992Common Stock$35.19$1,653,648.48  13.32    [ Very High ]4,896,559$172,309,911.21  1,388.15 [Very High]Form 4See Footnote
2021-12-01Ansbert Gadicke-Sell10,111Common Stock$33.82$341,954.02  2.87     [ Very High ]4,886,448$165,259,671.36  1,385.28 [Very High]Form 4See Footnote
2021-12-01Ansbert Gadicke-Sell9,131Common Stock$34.61$316,023.91  2.59     [ Very High ]4,877,317$168,803,941.37  1,382.69 [Very High]Form 4See Footnote
2021-12-01Ansbert Gadicke-Sell1,500Common Stock$35.34$53,010.00  0.43     [ Average ]4,875,817$172,311,372.78  1,382.27 [Very High]Form 4See Footnote
2021-12-02Ansbert Gadicke-Sell49,796Common Stock$33.74$1,680,117.04  14.12    [ Very High ]4,826,021$162,829,948.54  1,368.15 [Very High]Form 4See Footnote
2021-12-02Ansbert Gadicke-Sell12,434Common Stock$34.83$433,076.22  3.52     [ Very High ]4,813,587$167,657,235.21  1,364.63 [Very High]Form 4See Footnote
2021-11-30Mpm Bioventures 2014, L.p.-Sell5,861Common Stock$34.62$202,907.82  1.66     [ High ]3,012,959$104,308,640.58  854.16   [Very High]Form 4See Footnote
2021-11-30Mpm Bioventures 2014, L.p.-Sell28,076Common Stock$35.19$987,994.44  7.96     [ Very High ]2,984,883$105,038,032.77  846.20   [Very High]Form 4See Footnote
2021-12-01Mpm Bioventures 2014, L.p.-Sell6,042Common Stock$33.82$204,340.44  1.71     [ High ]2,978,841$100,744,402.62  844.49   [Very High]Form 4See Footnote
2021-12-01Mpm Bioventures 2014, L.p.-Sell5,457Common Stock$34.61$188,866.77  1.55     [ High ]2,973,384$102,908,820.24  842.94   [Very High]Form 4See Footnote
2021-12-01Mpm Bioventures 2014, L.p.-Sell896Common Stock$35.34$31,664.64  0.25     [ Low ]2,972,488$105,047,725.92  842.69   [Very High]Form 4See Footnote
2021-12-02Mpm Bioventures 2014, L.p.-Sell29,757Common Stock$33.74$1,004,001.18  8.44     [ Very High ]2,942,731$99,287,743.94  834.25   [Very High]Form 4See Footnote
2021-12-02Mpm Bioventures 2014, L.p.-Sell7,430Common Stock$34.83$258,786.90  2.11     [ High ]2,935,301$102,236,533.83  832.14   [Very High]Form 4See Fpotnote
2021-11-30Mpm Bioventures 2018, L.p.-Sell5,861Common Stock$34.62$202,907.82  1.66     [ High ]3,012,959$104,308,640.58  854.16   [Very High]Form 4See Footnote
2021-11-30Mpm Bioventures 2018, L.p.-Sell28,076Common Stock$35.19$987,994.44  7.96     [ Very High ]2,984,883$105,038,032.77  846.20   [Very High]Form 4See Footnote
2021-12-01Mpm Bioventures 2018, L.p.-Sell6,042Common Stock$33.82$204,340.44  1.71     [ High ]2,978,841$100,744,402.62  844.49   [Very High]Form 4See Footnote
2021-12-01Mpm Bioventures 2018, L.p.-Sell5,457Common Stock$34.61$188,866.77  1.55     [ High ]2,973,384$102,908,820.24  842.94   [Very High]Form 4See Footnote
2021-12-01Mpm Bioventures 2018, L.p.-Sell896Common Stock$35.34$31,664.64  0.25     [ Low ]2,972,488$105,047,725.92  842.69   [Very High]Form 4See Footnote
2021-12-02Mpm Bioventures 2018, L.p.-Sell29,757Common Stock$33.74$1,004,001.18  8.44     [ Very High ]2,942,731$99,287,743.94  834.25   [Very High]Form 4See Footnote
2021-12-02Mpm Bioventures 2018, L.p.-Sell7,430Common Stock$34.83$258,786.90  2.11     [ High ]2,935,301$102,236,533.83  832.14   [Very High]Form 4See Fpotnote