Morphic Holding, Inc.

Pages

Morphic Holding, Inc.

$MORF

Search Table
Pages

Trade Date Insider Title Buy or Sell Quantity Security Type Price Proceeds Transaction Conviction Position Quantity Position Value Positon Conviction SEC Link Nature of Ownership
2020-07-01William DevaulGeneral Counsel and SecretaryBuy2,283Common Stock$4.32-$9,862.56  -4,783$20,662.56  -Form 4-
2020-07-01William DevaulGeneral Counsel and SecretarySell1,448Common Stock$26.15$37,865.20  -3,335$87,210.25  -Form 4-
2020-07-01William DevaulGeneral Counsel and SecretarySell835Common Stock$27.14$22,661.90  -2,500$67,850.00  -Form 4-
2020-07-02William DevaulGeneral Counsel and SecretaryBuy5,400Common Stock$4.32-$23,328.00  -7,900$34,128.00  -Form 4-
2020-07-02William DevaulGeneral Counsel and SecretarySell5,400Common Stock$26.51$143,154.00  -2,500$66,275.00  -Form 4-
2020-07-06William DevaulGeneral Counsel and SecretaryBuy2,200Common Stock$4.32-$9,504.00  -4,700$20,304.00  -Form 4-
2020-07-06William DevaulGeneral Counsel and SecretarySell2,200Common Stock$25.88$56,936.00  -2,500$64,700.00  -Form 4-
2020-07-01Alexey LugovskoyChief Development OfficerSell2,807Common Stock$26.18$73,487.26  -130,441$3,414,945.38  -Form 4-
2020-07-01Alexey LugovskoyChief Development OfficerSell1,706Common Stock$27.15$46,317.90  -128,735$3,495,155.25  -Form 4-
2020-07-02Alexey LugovskoyChief Development OfficerSell9,939Common Stock$26.47$263,085.33  -118,796$3,144,530.12  -Form 4-
2020-07-02Alexey LugovskoyChief Development OfficerSell100Common Stock$26.83$2,683.00  -118,696$3,184,613.68  -Form 4-
2020-07-06Alexey LugovskoyChief Development OfficerSell4,304Common Stock$25.87$111,344.48  -114,392$2,959,321.04  -Form 4-
2020-07-07William DevaulGeneral Counsel and SecretaryBuy1,261Common Stock$4.32-$5,447.52  0.41     [ Average ]3,761$16,247.52  1.23     [Very Low]Form 4-
2020-07-07William DevaulGeneral Counsel and SecretarySell1,161Common Stock$25.89$30,058.29  0.38     [ Average ]2,600$67,314.00  0.85     [Very Low]Form 4-
2020-07-07William DevaulGeneral Counsel and SecretarySell100Common Stock$26.65$2,665.00  0.03     [ Very Low ]2,500$66,625.00  0.82     [Very Low]Form 4-
2020-07-08William DevaulGeneral Counsel and SecretaryBuy856Common Stock$4.32-$3,697.92  0.28     [ Average ]3,356$14,497.92  1.10     [Very Low]Form 4-
2020-07-08William DevaulGeneral Counsel and SecretarySell794Common Stock$24.77$19,667.38  0.26     [ Low ]2,562$63,460.74  0.84     [Very Low]Form 4-
2020-07-08William DevaulGeneral Counsel and SecretarySell62Common Stock$25.75$1,596.50  0.02     [ Very Low ]2,500$64,375.00  0.82     [Very Low]Form 4-
2020-07-07Alexey LugovskoyChief Development OfficerSell4,396Common Stock$25.74$113,153.04  1.43     [ High ]109,996$2,831,297.04  35.89    [High]Form 4-
2020-07-07Alexey LugovskoyChief Development OfficerSell605Common Stock$26.65$16,123.25  0.20     [ Low ]109,391$2,915,270.15  35.69    [High]Form 4-
2020-07-08Alexey LugovskoyChief Development OfficerSell3,430Common Stock$24.82$85,132.60  1.12     [ High ]105,961$2,629,952.02  34.57    [High]Form 4-
2020-07-08Alexey LugovskoyChief Development OfficerSell200Common Stock$25.80$5,160.00  0.07     [ Very Low ]105,761$2,728,633.80  34.51    [High]Form 4-
2020-07-09Alexey LugovskoyChief Development OfficerSell513Common Stock$24.99$12,819.87  0.17     [ Low ]105,248$2,630,147.52  34.34    [High]Form 4-
2020-05-29Farrell Robert E JrSVP Finance and CAOSell13,319Common Stock$20.17$268,644.23  -84,615$1,706,684.55  -Form 4-
2020-06-01Farrell Robert E JrSVP Finance and CAOSell6,681Common Stock$20.35$135,958.35  -77,934$1,585,956.90  -Form 4-
2020-06-10Bruce RogersChief Scientific OfficerSell21,301Common Stock$23.18$493,757.18  -157,018$3,639,677.24  -Form 4-
2020-06-10Bruce RogersChief Scientific OfficerSell3,699Common Stock$24.19$89,478.81  -153,319$3,708,786.61  -Form 4-
2020-08-13William DevaulGeneral Counsel and SecretaryBuy1,104Common Stock$4.32-$4,769.28  0.36     [ Average ]3,604$15,569.28  1.18     [Very Low]Form 4-
2020-08-13William DevaulGeneral Counsel and SecretarySell1,104Common Stock$30.13$33,263.52  0.36     [ Average ]2,500$75,325.00  0.82     [Very Low]Form 4-
2020-08-14William DevaulGeneral Counsel and SecretaryBuy1,201Common Stock$4.32-$5,188.32  0.39     [ Average ]3,701$15,988.32  1.21     [Very Low]Form 4-
2020-08-14William DevaulGeneral Counsel and SecretarySell1,201Common Stock$30.34$36,438.34  0.39     [ Average ]2,500$75,850.00  0.82     [Very Low]Form 4-
2020-10-01Farrell Robert E JrSVP Finance and CAOSell3,279Common Stock$27.61$90,533.19  1.07     [ High ]74,655$2,061,224.55  24.35    [High]Form 4-
2020-10-02Farrell Robert E JrSVP Finance and CAOSell1,029Common Stock$25.76$26,507.04  0.34     [ Average ]73,626$1,896,605.76  24.02    [High]Form 4-
2020-10-02Farrell Robert E JrSVP Finance and CAOSell813Common Stock$26.64$21,658.32  0.27     [ Low ]72,813$1,939,738.32  23.75    [High]Form 4-
2020-10-05Farrell Robert E JrSVP Finance and CAOSell2,000Common Stock$26.56$53,120.00  0.65     [ Average ]70,813$1,880,793.28  23.10    [High]Form 4-
2020-10-01Alexey LugovskoyChief Development OfficerSell1,627Common Stock$27.60$44,905.20  0.53     [ Average ]103,621$2,859,939.60  33.80    [High]Form 4-
2020-10-02Alexey LugovskoyChief Development OfficerSell600Common Stock$25.84$15,504.00  0.20     [ Low ]103,021$2,662,062.64  33.60    [High]Form 4-
2020-10-02Alexey LugovskoyChief Development OfficerSell300Common Stock$26.65$7,995.00  0.10     [ Low ]102,721$2,737,514.65  33.51    [High]Form 4-
2020-10-05Alexey LugovskoyChief Development OfficerSell1,000Common Stock$26.50$26,500.00  0.33     [ Average ]101,721$2,695,606.50  33.18    [High]Form 4-
2020-10-06Farrell Robert E JrSVP Finance and CAOSell1,215Common Stock$26.32$31,978.80  0.40     [ Average ]69,598$1,831,819.36  22.70    [High]Form 4-
2020-10-06Farrell Robert E JrSVP Finance and CAOSell100Common Stock$26.93$2,693.00  0.03     [ Very Low ]69,498$1,871,581.14  22.67    [High]Form 4-
2020-10-07Farrell Robert E JrSVP Finance and CAOSell4,026Common Stock$25.69$103,427.94  1.31     [ High ]65,472$1,681,975.68  21.36    [High]Form 4-
2020-10-07Farrell Robert E JrSVP Finance and CAOSell2,558Common Stock$26.69$68,273.02  0.83     [ High ]62,914$1,679,174.66  20.52    [High]Form 4-
2020-10-08Farrell Robert E JrSVP Finance and CAOSell1,915Common Stock$26.71$51,149.65  0.62     [ Average ]60,999$1,629,283.29  19.90    [High]Form 4-
2020-10-06Alexey LugovskoyChief Development OfficerSell537Common Stock$26.33$14,139.21  0.18     [ Low ]101,184$2,664,174.72  33.00    [High]Form 4-
2020-10-06Alexey LugovskoyChief Development OfficerSell100Common Stock$26.93$2,693.00  0.03     [ Very Low ]101,084$2,722,192.12  32.97    [High]Form 4-
2020-10-07Alexey LugovskoyChief Development OfficerSell2,200Common Stock$25.73$56,606.00  0.72     [ Average ]98,884$2,544,285.32  32.25    [High]Form 4-
2020-10-07Alexey LugovskoyChief Development OfficerSell1,013Common Stock$26.80$27,148.40  0.33     [ Average ]97,871$2,622,942.80  31.92    [High]Form 4-
2020-10-08Alexey LugovskoyChief Development OfficerSell500Common Stock$26.49$13,245.00  0.16     [ Low ]97,371$2,579,357.79  31.76    [High]Form 4-
2020-10-08Alexey LugovskoyChief Development OfficerSell405Common Stock$26.97$10,922.85  0.13     [ Low ]96,966$2,615,173.02  31.63    [High]Form 4-
2020-10-09Farrell Robert E JrSVP Finance and CAOSell1,916Common Stock$26.75$51,253.00  0.62     [ Average ]59,083$1,580,470.25  19.27    [High]Form 4-
2020-10-12Farrell Robert E JrSVP Finance and CAOSell1,149Common Stock$27.02$31,045.98  0.37     [ Average ]57,934$1,565,376.68  18.90    [High]Form 4-
2020-10-09Alexey LugovskoyChief Development OfficerSell1,000Common Stock$26.80$26,800.00  0.33     [ Average ]95,966$2,571,888.80  31.30    [High]Form 4-
2020-10-12Alexey LugovskoyChief Development OfficerSell718Common Stock$27.03$19,407.54  0.23     [ Low ]95,248$2,574,553.44  31.07    [High]Form 4-
2020-10-19Farrell Robert E JrSVP Finance and CAOSell100Common Stock$28.05$2,805.00  0.03     [ Very Low ]57,834$1,622,243.70  18.86    [High]Form 4-
2020-10-19Alexey LugovskoyChief Development OfficerSell100Common Stock$28.22$2,822.00  0.03     [ Very Low ]95,148$2,685,076.56  31.04    [High]Form 4-
2020-10-23Farrell Robert E JrSVP Finance and CAOSell2,300Common Stock$28.31$65,113.00  0.75     [ Average ]55,534$1,572,167.54  18.11    [High]Form 4-
2020-10-26Farrell Robert E JrSVP Finance and CAOSell1,660Common Stock$28.16$46,745.60  0.54     [ Average ]53,874$1,517,091.84  17.57    [High]Form 4-
2020-10-26Farrell Robert E JrSVP Finance and CAOSell100Common Stock$29.31$2,931.00  0.03     [ Very Low ]53,774$1,576,115.94  17.54    [High]Form 4-
2020-10-23Alexey LugovskoyChief Development OfficerSell2,318Common Stock$28.31$65,622.58  0.76     [ Average ]92,830$2,628,017.30  30.28    [High]Form 4-
2020-10-26Alexey LugovskoyChief Development OfficerSell1,267Common Stock$28.25$35,792.75  0.41     [ Average ]91,563$2,586,654.75  29.87    [High]Form 4-
2020-10-26Alexey LugovskoyChief Development OfficerSell100Common Stock$29.31$2,931.00  0.03     [ Very Low ]91,463$2,680,780.53  29.83    [High]Form 4-
2020-11-02Praveen P. TipirneniPresident and CEOBuy7,777Common Stock$4.32-$33,596.64  2.54     [ Very High ]11,063$47,792.16  3.61     [Low]Form 4-
2020-11-02Praveen P. TipirneniPresident and CEOSell6,845Common Stock$25.57$175,026.65  2.23     [ High ]4,218$107,854.26  1.38     [Low]Form 4-
2020-11-02Praveen P. TipirneniPresident and CEOSell932Common Stock$26.14$24,362.48  0.30     [ Average ]3,286$85,896.04  1.07     [Very Low]Form 4-
2020-11-02Praveen P. TipirneniPresident and CEOSell6,936Common Stock$25.60$177,561.60  2.26     [ High ]669,538$17,140,172.80  218.39   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2020-11-02Praveen P. TipirneniPresident and CEOSell800Common Stock$26.14$20,912.00  0.26     [ Low ]668,738$17,480,811.32  218.13   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2020-11-03Praveen P. TipirneniPresident and CEOBuy2,605Common Stock$4.32-$11,253.60  0.85     [ High ]5,891$25,449.12  1.92     [Low]Form 4-
2020-11-03Praveen P. TipirneniPresident and CEOSell1,700Common Stock$25.86$43,962.00  0.55     [ Average ]4,191$108,379.26  1.37     [Low]Form 4-
2020-11-03Praveen P. TipirneniPresident and CEOSell905Common Stock$26.25$23,756.25  0.30     [ Average ]3,286$86,257.50  1.07     [Very Low]Form 4-
2020-11-03Praveen P. TipirneniPresident and CEOSell2,375Common Stock$25.96$61,655.00  0.77     [ Average ]666,363$17,298,783.48  217.35   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2020-11-03Praveen P. TipirneniPresident and CEOSell200Common Stock$26.41$5,282.00  0.07     [ Very Low ]666,163$17,593,364.83  217.29   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2020-11-04Praveen P. TipirneniPresident and CEOBuy6,100Common Stock$4.32-$26,352.00  1.99     [ High ]9,386$40,547.52  3.06     [Low]Form 4-
2020-11-04Praveen P. TipirneniPresident and CEOSell6,100Common Stock$26.58$162,138.00  1.99     [ High ]3,286$87,341.88  1.07     [Very Low]Form 4-
2020-11-04Praveen P. TipirneniPresident and CEOSell6,238Common Stock$26.58$165,806.04  2.03     [ High ]659,925$17,540,806.50  215.25   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2020-11-05Praveen P. TipirneniPresident and CEOBuy6,643Common Stock$4.32-$28,697.76  2.17     [ High ]9,929$42,893.28  3.24     [Low]Form 4-
2020-11-05Praveen P. TipirneniPresident and CEOSell6,643Common Stock$26.85$178,364.55  2.17     [ High ]3,286$88,229.10  1.07     [Very Low]Form 4-
2020-11-05Praveen P. TipirneniPresident and CEOSell6,525Common Stock$26.85$175,196.25  2.13     [ High ]653,400$17,543,790.00  213.13   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2020-11-06Praveen P. TipirneniPresident and CEOBuy4,367Common Stock$4.32-$18,865.44  1.42     [ High ]7,653$33,060.96  2.50     [Low]Form 4-
2020-11-06Praveen P. TipirneniPresident and CEOSell4,367Common Stock$26.14$114,153.38  1.42     [ High ]3,286$85,896.04  1.07     [Very Low]Form 4-
2020-11-06Praveen P. TipirneniPresident and CEOSell4,331Common Stock$26.13$113,169.03  1.41     [ High ]649,069$16,960,172.97  211.71   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2020-11-09Praveen P. TipirneniPresident and CEOBuy2,508Common Stock$4.32-$10,834.56  0.82     [ High ]5,794$25,030.08  1.89     [Low]Form 4-
2020-11-09Praveen P. TipirneniPresident and CEOSell2,508Common Stock$27.61$69,245.88  0.82     [ High ]3,286$90,726.46  1.07     [Very Low]Form 4-
2020-11-09Praveen P. TipirneniPresident and CEOSell2,595Common Stock$27.66$71,777.70  0.85     [ High ]646,474$17,881,470.84  210.87   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2020-11-09Farrell Robert E JrSVP Finance and CAOSell800Common Stock$28.00$22,400.00  0.26     [ Low ]52,974$1,483,272.00  17.02    [High]Form 4-
2020-11-10Farrell Robert E JrSVP Finance and CAOSell5,040Common Stock$28.12$141,724.80  1.62     [ High ]47,934$1,347,904.08  15.40    [Average]Form 4-
2020-11-09Alexey LugovskoyChief Development OfficerSell900Common Stock$28.00$25,200.00  0.29     [ Average ]90,563$2,535,764.00  29.10    [High]Form 4-
2020-11-10Alexey LugovskoyChief Development OfficerSell5,315Common Stock$28.13$149,510.95  1.71     [ High ]85,248$2,398,026.24  27.39    [High]Form 4-
2020-11-12William DevaulGeneral Counsel and SecretaryBuy390Common Stock$4.32-$1,684.80  0.13     [ Low ]3,676$15,880.32  1.18     [Very Low]Form 4-
2020-11-12William DevaulGeneral Counsel and SecretarySell390Common Stock$30.00$11,700.00  0.13     [ Low ]3,286$98,580.00  1.06     [Very Low]Form 4-
2020-11-13William DevaulGeneral Counsel and SecretaryBuy530Common Stock$4.32-$2,289.60  0.17     [ Low ]3,816$16,485.12  1.23     [Very Low]Form 4-
2020-11-13William DevaulGeneral Counsel and SecretarySell530Common Stock$30.00$15,900.00  0.17     [ Low ]3,286$98,580.00  1.06     [Very Low]Form 4-
2020-11-16William DevaulGeneral Counsel and SecretaryBuy500Common Stock$4.32-$2,160.00  0.16     [ Low ]3,786$16,355.52  1.22     [Very Low]Form 4-
2020-11-16William DevaulGeneral Counsel and SecretarySell500Common Stock$30.05$15,025.00  0.16     [ Low ]3,286$98,744.30  1.06     [Very Low]Form 4-
2020-11-12Praveen P. TipirneniPresident and CEOBuy460Common Stock$4.32-$1,987.20  0.15     [ Low ]3,746$16,182.72  1.20     [Very Low]Form 4-
2020-11-12Praveen P. TipirneniPresident and CEOSell460Common Stock$30.00$13,800.00  0.15     [ Low ]3,286$98,580.00  1.06     [Very Low]Form 4-
2020-11-12Praveen P. TipirneniPresident and CEOSell400Common Stock$30.00$12,000.00  0.13     [ Low ]646,074$19,382,220.00  207.57   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2020-11-13Praveen P. TipirneniPresident and CEOBuy300Common Stock$4.32-$1,296.00  0.10     [ Low ]3,586$15,491.52  1.15     [Very Low]Form 4-
2020-11-16Praveen P. TipirneniPresident and CEOSell300Common Stock$30.00$9,000.00  0.10     [ Low ]3,286$98,580.00  1.06     [Very Low]Form 4-
2020-11-13Praveen P. TipirneniPresident and CEOSell341Common Stock$30.02$10,236.82  0.11     [ Low ]645,733$19,384,904.66  207.46   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2020-11-16Praveen P. TipirneniPresident and CEOBuy200Common Stock$4.32-$864.00  0.06     [ Very Low ]3,486$15,059.52  1.12     [Very Low]Form 4-
2020-11-16Praveen P. TipirneniPresident and CEOSell200Common Stock$30.05$6,010.00  0.06     [ Very Low ]3,286$98,744.30  1.06     [Very Low]Form 4-
2020-11-16Praveen P. TipirneniPresident and CEOSell200Common Stock$30.05$6,010.00  0.06     [ Very Low ]645,533$19,398,266.65  207.40   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2020-12-01Praveen P. TipirneniPresident and CEOBuy4,000Common Stock$4.32-$17,280.00  1.29     [ High ]7,813$33,752.16  2.51     [Low]Form 4-
2020-12-01Praveen P. TipirneniPresident and CEOSell4,000Common Stock$31.24$124,960.00  1.29     [ High ]3,813$119,118.12  1.23     [Very Low]Form 4-
2020-12-01Praveen P. TipirneniPresident and CEOSell4,000Common Stock$31.24$124,960.00  1.29     [ High ]638,474$19,945,927.76  205.13   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2020-12-10Praveen P. TipirneniPresident and CEOBuy600Common Stock$4.32-$2,592.00  0.19     [ Low ]4,413$19,064.16  1.42     [Low]Form 4-
2020-12-10Praveen P. TipirneniPresident and CEOSell600Common Stock$35.49$21,294.00  0.19     [ Low ]3,813$135,323.37  1.23     [Very Low]Form 4-
2020-12-10Praveen P. TipirneniPresident and CEOSell6,427Common Stock$35.41$227,580.07  2.06     [ High ]632,047$22,380,784.27  203.07   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2020-12-16Praveen P. TipirneniPresident and CEOBuy1,000Common Stock$4.32-$4,320.00  0.32     [ Average ]4,813$20,792.16  1.55     [Low]Form 4-
2020-12-16Praveen P. TipirneniPresident and CEOSell1,000Common Stock$35.20$35,200.00  0.32     [ Average ]3,813$134,217.60  1.23     [Very Low]Form 4-
2020-12-16Praveen P. TipirneniPresident and CEOSell1,259Common Stock$35.13$44,228.67  0.40     [ Average ]630,788$22,159,582.44  202.66   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2020-12-21Praveen P. TipirneniPresident and CEOBuy200Common Stock$4.32-$864.00  0.06     [ Very Low ]4,013$17,336.16  1.29     [Very Low]Form 4-
2020-12-21Praveen P. TipirneniPresident and CEOSell200Common Stock$35.01$7,002.00  0.06     [ Very Low ]3,813$133,493.13  1.23     [Very Low]Form 4-
2020-12-21Praveen P. TipirneniPresident and CEOSell240Common Stock$35.01$8,402.40  0.08     [ Very Low ]630,548$22,075,485.48  202.59   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2020-12-22Praveen P. TipirneniPresident and CEOSell74Common Stock$35.00$2,590.00  0.02     [ Very Low ]630,474$22,066,590.00  202.56   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2020-12-22Praveen P. TipirneniPresident and CEOBuy2,268Common Stock$4.32-$9,797.76  0.73     [ Average ]6,081$26,269.92  1.95     [Low]Form 4-
2020-12-22Praveen P. TipirneniPresident and CEOSell2,268Common Stock$35.05$79,493.40  0.73     [ Average ]3,813$133,645.65  1.23     [Very Low]Form 4-
2020-12-23Omega Fund V, L.p.-Sell8,692Common Stock$33.34$289,791.28  2.79     [ Very High ]2,969,140$98,991,127.60  953.94   [Very High]Form 4-
2020-12-23Omega Fund V, L.p.-Sell313Common Stock$33.81$10,582.53  0.10     [ Very Low ]2,968,827$100,376,040.87  953.84   [Very High]Form 4-
2020-12-23Omega Fund V, L.p.-Sell137Common Stock$34.95$4,788.15  0.04     [ Very Low ]2,968,690$103,755,715.50  953.80   [Very High]Form 4-
2020-12-24Omega Fund V, L.p.-Sell2,130Common Stock$32.48$69,182.40  0.68     [ Average ]2,966,560$96,353,868.80  953.11   [Very High]Form 4-
2020-12-24Omega Fund V, L.p.-Sell753Common Stock$33.25$25,037.25  0.24     [ Low ]2,965,807$98,613,082.75  952.87   [Very High]Form 4-
2020-12-28Omega Fund V, L.p.-Sell9,317Common Stock$32.34$301,311.78  2.99     [ Very High ]2,956,490$95,612,886.60  949.88   [Very High]Form 4-
2020-12-28Omega Fund V, L.p.-Sell149Common Stock$33.25$4,954.25  0.05     [ Very Low ]2,956,341$98,298,338.25  949.83   [Very High]Form 4-
2020-12-29Omega Fund V, L.p.-Sell10,374Common Stock$31.75$329,374.50  3.33     [ Very High ]2,945,967$93,534,452.25  946.50   [Very High]Form 4-
2020-12-29Omega Fund V, L.p.-Sell54Common Stock$32.87$1,774.98  0.02     [ Very Low ]2,945,913$96,832,160.31  946.48   [Very High]Form 4-
2020-12-28Farrell Robert E JrSVP Finance and CAOSell12,231Common Stock$32.28$394,816.68  3.93     [ Very High ]35,703$1,152,492.84  11.47    [Average]Form 4-
2020-12-28Farrell Robert E JrSVP Finance and CAOSell405Common Stock$33.12$13,413.60  0.13     [ Low ]35,298$1,169,069.76  11.34    [Average]Form 4-
2020-12-30Farrell Robert E JrSVP Finance and CAOSell7,364Common Stock$32.56$239,771.84  2.37     [ High ]27,934$909,531.04  8.97     [Average]Form 4-
2020-12-30Omega Fund V, L.p.-Sell7,730Common Stock$32.42$250,606.60  2.48     [ High ]2,938,183$95,255,892.86  943.99   [Very High]Form 4-
2020-12-30Omega Fund V, L.p.-Sell3,769Common Stock$33.23$125,243.87  1.21     [ High ]2,934,414$97,510,577.22  942.78   [Very High]Form 4-
2020-12-30Omega Fund V, L.p.-Sell486Common Stock$33.75$16,402.50  0.16     [ Low ]2,933,928$99,020,070.00  942.63   [Very High]Form 4-
2020-12-31Omega Fund V, L.p.-Sell3,756Common Stock$33.84$127,103.04  1.21     [ High ]2,930,172$99,157,020.48  941.42   [Very High]Form 4-
2020-12-31Omega Fund V, L.p.-Sell151Common Stock$34.55$5,217.05  0.05     [ Very Low ]2,930,021$101,232,225.55  941.37   [Very High]Form 4-
2021-01-04Omega Fund V, L.p.-Sell10,463Common Stock$32.57$340,779.91  3.36     [ Very High ]2,919,558$95,090,004.06  938.01   [Very High]Form 4-
2021-01-04Omega Fund V, L.p.-Sell1,655Common Stock$33.55$55,525.25  0.53     [ Average ]2,917,903$97,895,645.65  937.48   [Very High]Form 4-
2021-01-05Omega Fund V, L.p.-Sell11,168Common Stock$30.89$344,979.52  3.59     [ Very High ]2,906,735$89,789,044.15  933.89   [Very High]Form 4-
2021-01-05Omega Fund V, L.p.-Sell2,017Common Stock$32.00$64,544.00  0.65     [ Average ]2,904,718$92,950,976.00  933.24   [Very High]Form 4-
2021-01-05Omega Fund V, L.p.-Sell139Common Stock$32.84$4,564.76  0.04     [ Very Low ]2,904,579$95,386,374.36  933.20   [Very High]Form 4-
2020-11-27Bruce RogersChief Scientific OfficerSell5,000Common Stock$0.00$0.00  -149,195$0.00  47.93    [High]Form 4-
2021-01-04Bruce RogersChief Scientific OfficerSell9,308Common Stock$32.51$302,603.08  2.99     [ Very High ]139,797$4,544,800.47  44.91    [High]Form 4-
2021-01-04Bruce RogersChief Scientific OfficerSell2,640Common Stock$33.46$88,334.40  0.85     [ High ]137,157$4,589,273.22  44.07    [High]Form 4-
2021-01-04Bruce RogersChief Scientific OfficerSell2Common Stock$34.18$68.36  -137,155$4,687,957.90  44.07    [High]Form 4-
2021-01-05Bruce RogersChief Scientific OfficerSell12,332Common Stock$30.86$380,565.52  3.96     [ Very High ]124,823$3,852,037.78  40.10    [High]Form 4-
2021-01-05Bruce RogersChief Scientific OfficerSell1,801Common Stock$30.90$55,650.90  0.58     [ Average ]123,022$3,801,379.80  39.53    [High]Form 4-
2021-01-05Bruce RogersChief Scientific OfficerSell318Common Stock$32.71$10,401.78  0.10     [ Very Low ]122,704$4,013,647.84  39.42    [High]Form 4-
2021-01-06Bruce RogersChief Scientific OfficerSell10,840Common Stock$30.15$326,826.00  3.48     [ Very High ]111,864$3,372,699.60  35.94    [High]Form 4-
2021-01-06Bruce RogersChief Scientific OfficerSell400Common Stock$31.32$12,528.00  0.13     [ Low ]111,464$3,491,052.48  35.81    [High]Form 4-
2021-01-04Praveen P. TipirneniPresident and CEOBuy2,347Common Stock$4.32-$10,139.04  0.75     [ Average ]6,160$26,611.20  1.98     [Low]Form 4-
2021-01-04Praveen P. TipirneniPresident and CEOSell1,947Common Stock$32.52$63,316.44  0.63     [ Average ]4,213$137,006.76  1.35     [Low]Form 4-
2021-01-04Praveen P. TipirneniPresident and CEOSell400Common Stock$33.70$13,480.00  0.13     [ Low ]3,813$128,498.10  1.23     [Very Low]Form 4-
2021-01-04Praveen P. TipirneniPresident and CEOSell1,796Common Stock$32.54$58,441.84  0.58     [ Average ]628,678$20,457,182.12  201.98   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2021-01-04Praveen P. TipirneniPresident and CEOSell600Common Stock$33.46$20,076.00  0.19     [ Low ]628,078$21,015,489.88  201.79   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2021-01-05Praveen P. TipirneniPresident and CEOBuy1,653Common Stock$4.32-$7,140.96  0.53     [ Average ]5,466$23,613.12  1.76     [Low]Form 4-
2021-01-05Praveen P. TipirneniPresident and CEOSell1,353Common Stock$30.96$41,888.88  0.43     [ Average ]4,113$127,338.48  1.32     [Very Low]Form 4-
2021-01-05Praveen P. TipirneniPresident and CEOSell300Common Stock$32.06$9,618.00  0.10     [ Very Low ]3,813$122,244.78  1.23     [Very Low]Form 4-
2021-01-05Praveen P. TipirneniPresident and CEOSell1,304Common Stock$30.94$40,345.76  0.42     [ Average ]626,774$19,392,387.56  201.37   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2021-01-05Praveen P. TipirneniPresident and CEOSell300Common Stock$32.03$9,609.00  0.10     [ Very Low ]626,474$20,065,962.22  201.28   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2021-01-06Omega Fund V, L.p.-Sell11,929Common Stock$30.09$358,943.61  3.83     [ Very High ]2,892,650$87,039,838.50  929.37   [Very High]Form 4-
2021-01-06Omega Fund V, L.p.-Sell95Common Stock$31.36$2,979.20  0.03     [ Very Low ]2,892,555$90,710,524.80  929.33   [Very High]Form 4-
2021-01-07Omega Fund V, L.p.-Sell16,141Common Stock$29.98$483,907.18  5.19     [ Very High ]2,876,414$86,234,891.72  924.15   [Very High]Form 4-
2021-01-07Bruce RogersChief Scientific OfficerSell2,359Common Stock$30.10$71,005.90  0.76     [ Average ]109,105$3,284,060.50  35.05    [High]Form 4-
2021-01-08Omega Fund V, L.p.-Sell9,027Common Stock$30.13$271,983.51  2.90     [ Very High ]2,867,387$86,394,370.31  921.25   [Very High]Form 4-
2021-01-11Omega Fund V, L.p.-Sell3,382Common Stock$30.15$101,967.30  1.09     [ High ]2,864,005$86,349,750.75  920.16   [Very High]Form 4-
2021-01-12Omega Fund V, L.p.-Sell5,758Common Stock$30.10$173,315.80  1.85     [ High ]2,858,247$86,033,234.70  918.31   [Very High]Form 4-
2021-01-13Omega Fund V, L.p.-Sell6,740Common Stock$30.11$202,941.40  2.17     [ High ]2,851,507$85,858,875.77  916.15   [Very High]Form 4-
2021-01-14Omega Fund V, L.p.-Sell5,337Common Stock$30.27$161,550.99  1.71     [ High ]2,848,170$86,214,105.90  915.07   [Very High]Form 4-
2021-01-14Omega Fund V, L.p.-Sell3,904Common Stock$31.06$121,258.24  1.25     [ High ]2,842,266$88,280,781.96  913.18   [Very High]Form 4-
2021-01-15Omega Fund V, L.p.-Sell14,289Common Stock$30.49$435,671.61  4.59     [ Very High ]2,827,977$86,225,018.73  908.59   [Very High]Form 4-
2021-01-19Omega Fund V, L.p.-Sell10,732Common Stock$30.10$323,033.20  3.45     [ Very High ]2,817,245$84,799,074.50  905.14   [Very High]Form 4-
2021-01-19Omega Fund V, L.p.-Sell6,506Common Stock$29.95$194,854.70  2.09     [ High ]2,810,739$84,181,633.05  903.05   [Very High]Form 4-
2021-01-21Omega Fund V, L.p.-Sell264Common Stock$29.98$7,914.72  0.08     [ Very Low ]2,810,475$84,258,040.50  902.96   [Very High]Form 4-
2021-01-22Omega Fund V, L.p.-Sell7,303Common Stock$30.64$223,763.92  2.35     [ High ]2,803,172$85,889,190.08  900.62   [Very High]Form 4-
2021-01-22Omega Fund V, L.p.-Sell2,438Common Stock$31.11$75,846.18  0.78     [ Average ]2,800,734$87,130,834.74  899.83   [Very High]Form 4-
2021-01-25Omega Fund V, L.p.-Sell5,119Common Stock$30.88$158,074.72  1.64     [ High ]2,795,615$86,328,591.20  898.19   [Very High]Form 4-
2021-01-25Omega Fund V, L.p.-Sell1,504Common Stock$31.48$47,345.92  0.48     [ Average ]2,794,111$87,958,614.28  897.71   [Very High]Form 4-
2021-01-26Omega Fund V, L.p.-Sell6,848Common Stock$32.25$220,848.00  2.20     [ High ]2,787,263$89,889,231.75  895.51   [Very High]Form 4-
2021-01-26Omega Fund V, L.p.-Sell2,438Common Stock$32.91$80,234.58  0.78     [ Average ]2,784,723$91,645,233.93  894.69   [Very High]Form 4-
2021-01-27Omega Fund V, L.p.-Sell6,534Common Stock$31.78$207,650.52  2.10     [ High ]2,778,189$88,290,846.42  892.59   [Very High]Form 4-
2021-01-27Omega Fund V, L.p.-Sell2,941Common Stock$32.37$95,200.17  0.94     [ High ]2,775,248$89,834,777.76  891.65   [Very High]Form 4-
2021-01-28Omega Fund V, L.p.-Sell4,274Common Stock$33.09$141,426.66  1.37     [ High ]2,770,974$91,691,529.66  890.27   [Very High]Form 4-
2021-01-28Omega Fund V, L.p.-Sell6,987Common Stock$33.67$235,252.29  2.24     [ High ]2,763,987$93,063,442.29  888.03   [Very High]Form 4-
2021-01-29Omega Fund V, L.p.-Sell9,885Common Stock$33.41$330,257.85  3.18     [ Very High ]2,754,102$92,014,547.82  884.85   [Very High]Form 4-
2021-01-29Omega Fund V, L.p.-Sell449Common Stock$34.00$15,266.00  0.14     [ Low ]2,753,653$93,624,202.00  884.71   [Very High]Form 4-
2021-02-01Omega Fund V, L.p.-Sell3,883Common Stock$33.31$129,342.73  1.25     [ High ]2,749,770$91,594,838.70  883.46   [Very High]Form 4-
2021-02-01Omega Fund V, L.p.-Sell5,166Common Stock$34.38$177,607.08  1.66     [ High ]2,744,604$94,359,485.52  881.80   [Very High]Form 4-
2021-02-01Omega Fund V, L.p.-Sell1,160Common Stock$34.87$40,449.20  0.37     [ Average ]2,743,444$95,663,892.28  881.43   [Very High]Form 4-
2021-02-02Farrell Robert E JrSVP Finance and CAOSell5,918Common Stock$35.51$210,148.18  1.90     [ High ]22,016$781,788.16  7.07     [Average]Form 4-
2021-02-02Farrell Robert E JrSVP Finance and CAOSell3,683Common Stock$36.59$134,760.97  1.18     [ High ]18,333$670,804.47  5.89     [Average]Form 4-
2021-02-02Farrell Robert E JrSVP Finance and CAOSell399Common Stock$37.11$14,806.89  0.13     [ Low ]17,934$665,530.74  5.76     [Average]Form 4-
2021-02-03Farrell Robert E JrSVP Finance and CAOBuy15,000Common Stock$4.32-$64,800.00  4.82     [ Very High ]32,934$142,274.88  10.58    [Average]Form 4-
2021-02-03Farrell Robert E JrSVP Finance and CAOSell12,046Common Stock$38.04$458,229.84  3.87     [ Very High ]20,888$794,579.52  6.71     [Average]Form 4-
2021-02-03Farrell Robert E JrSVP Finance and CAOSell2,954Common Stock$38.59$113,994.86  0.95     [ High ]17,934$692,073.06  5.76     [Average]Form 4-
2021-02-01Praveen P. TipirneniPresident and CEOBuy4,000Common Stock$4.32-$17,280.00  1.29     [ High ]7,286$31,475.52  2.34     [Low]Form 4-
2021-02-01Praveen P. TipirneniPresident and CEOSell2,201Common Stock$33.49$73,711.49  0.71     [ Average ]5,085$170,296.65  1.63     [Low]Form 4-
2021-02-01Praveen P. TipirneniPresident and CEOSell1,799Common Stock$34.43$61,939.57  0.58     [ Average ]3,286$113,136.98  1.06     [Very Low]Form 4-
2021-02-01Praveen P. TipirneniPresident and CEOSell2,100Common Stock$33.48$70,308.00  0.67     [ Average ]624,374$20,904,041.52  200.60   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2021-02-01Praveen P. TipirneniPresident and CEOSell1,900Common Stock$34.41$65,379.00  0.61     [ Average ]622,474$21,419,330.34  199.99   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2021-02-02Praveen P. TipirneniPresident and CEOBuy11,932Common Stock$4.32-$51,546.24  3.83     [ Very High ]15,218$65,741.76  4.89     [Low]Form 4-
2021-02-02Praveen P. TipirneniPresident and CEOSell7,729Common Stock$35.55$274,765.95  2.48     [ High ]7,489$266,233.95  2.41     [Low]Form 4-
2021-02-02Praveen P. TipirneniPresident and CEOSell4,203Common Stock$36.70$154,250.10  1.35     [ High ]3,286$120,596.20  1.06     [Very Low]Form 4-
2021-02-02Praveen P. TipirneniPresident and CEOSell5,128Common Stock$35.57$182,402.96  1.65     [ High ]617,346$21,958,997.22  198.34   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2021-02-02Praveen P. TipirneniPresident and CEOSell2,772Common Stock$36.70$101,732.40  0.89     [ High ]614,574$22,554,865.80  197.45   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2021-02-02Praveen P. TipirneniPresident and CEOSell100Common Stock$37.09$3,709.00  0.03     [ Very Low ]614,474$22,790,840.66  197.42   [Very High]Form 4By The Praveen P. Tipirneni Irrevocable Trust of 2019
2021-02-02Omega Fund V, L.p.-Sell19,935Common Stock$35.61$709,885.35  6.40     [ Very High ]2,723,509$96,984,155.49  875.02   [Very High]Form 4-
2021-02-02Omega Fund V, L.p.-Sell7,362Common Stock$36.74$270,479.88  2.37     [ High ]2,716,147$99,791,240.78  872.66   [Very High]Form 4-
2021-02-02Omega Fund V, L.p.-Sell669Common Stock$37.16$24,860.04  0.21     [ Low ]2,715,478$100,907,162.48  872.44   [Very High]Form 4-
2021-02-03Omega Fund V, L.p.-Sell17,572Common Stock$38.05$668,614.60  5.65     [ Very High ]2,697,906$102,655,323.30  866.80   [Very High]Form 4-
2021-02-03Omega Fund V, L.p.-Sell8,586Common Stock$38.63$331,677.18  2.76     [ Very High ]2,689,320$103,888,431.60  864.04   [Very High]Form 4-
2021-02-04Omega Fund V, L.p.-Sell4,574Common Stock$37.95$173,583.30  1.47     [ High ]2,684,746$101,886,110.70  862.57   [Very High]Form 4-
2021-02-04Omega Fund V, L.p.-Sell4,963Common Stock$38.55$191,323.65  1.59     [ High ]2,679,783$103,305,634.65  860.97   [Very High]Form 4-
2021-02-05Omega Fund V, L.p.-Sell5,734Common Stock$37.78$216,630.52  1.84     [ High ]2,674,049$101,025,571.22  859.13   [Very High]Form 4-
2021-02-05Omega Fund V, L.p.-Sell147Common Stock$38.40$5,644.80  0.05     [ Very Low ]2,673,902$102,677,836.80  859.08   [Very High]Form 4-
2021-02-08Omega Fund V, L.p.-Sell4,068Common Stock$38.80$157,838.40  1.31     [ High ]2,661,584$103,269,459.20  855.13   [Very High]Form 4-
2021-02-08Omega Fund V, L.p.-Sell12,554Common Stock$39.83$500,025.82  4.03     [ Very High ]2,649,030$105,510,864.90  851.09   [Very High]Form 4-
2021-02-09Omega Fund V, L.p.-Sell4,313Common Stock$39.76$171,484.88  1.39     [ High ]2,644,717$105,153,947.92  849.71   [Very High]Form 4-
2021-02-09Omega Fund V, L.p.-Sell1,148Common Stock$40.37$46,344.76  0.37     [ Average ]2,643,569$106,720,880.53  849.34   [Very High]Form 4-
2021-02-08Bruce RogersChief Scientific OfficerSell4,654Common Stock$40.03$186,299.62  1.50     [ High ]104,451$4,181,173.53  33.56    [High]Form 4-
2021-02-09Bruce RogersChief Scientific OfficerSell6,837Common Stock$40.21$274,915.77  2.20     [ High ]97,614$3,925,058.94  31.36    [High]Form 4-
2021-02-10Omega Fund V, L.p.-Sell5,022Common Stock$37.34$187,521.48  1.61     [ High ]2,638,547$98,523,344.98  847.73   [Very High]Form 4-
2021-02-10Omega Fund V, L.p.-Sell1,046Common Stock$38.49$40,260.54  0.34     [ Average ]2,637,501$101,517,413.49  847.39   [Very High]Form 4-
2021-02-11Omega Fund V, L.p.-Sell3,988Common Stock$37.76$150,586.88  1.28     [ High ]2,633,513$99,441,450.88  846.11   [Very High]Form 4-
2021-02-11Omega Fund V, L.p.-Sell17Common Stock$38.08$647.36  -2,633,496$100,283,527.68  846.10   [Very High]Form 4-
2021-02-12Omega Fund V, L.p.-Sell1,588Common Stock$37.47$59,502.36  0.51     [ Average ]2,631,908$98,617,592.76  845.59   [Very High]Form 4-
2021-02-12Omega Fund V, L.p.-Sell776Common Stock$38.21$29,650.96  0.25     [ Low ]2,631,132$100,535,553.72  845.34   [Very High]Form 4-
2021-02-16Omega Fund V, L.p.-Sell4,863Common Stock$36.42$177,110.46  1.56     [ High ]2,626,269$95,648,716.98  843.78   [Very High]Form 4-
2021-02-16Omega Fund V, L.p.-Sell1,162Common Stock$37.25$43,284.50  0.37     [ Average ]2,625,107$97,785,235.75  843.41   [Very High]Form 4-
2021-02-17Omega Fund V, L.p.-Sell7,262Common Stock$35.93$260,923.66  2.33     [ High ]2,617,845$94,059,170.85  841.07   [Very High]Form 4-
2021-02-18Omega Fund V, L.p.-Sell7,966Common Stock$34.83$277,455.78  2.56     [ Very High ]2,609,879$90,902,085.57  838.52   [Very High]Form 4-
2021-02-18Omega Fund V, L.p.-Sell928Common Stock$35.76$33,185.28  0.30     [ Average ]2,608,951$93,296,087.76  838.22   [Very High]Form 4-
2021-02-19Omega Fund V, L.p.-Sell2,025Common Stock$34.82$70,510.50  0.65     [ Average ]2,606,926$90,773,163.32  837.57   [Very High]Form 4-
2021-02-19Omega Fund V, L.p.-Sell1,871Common Stock$36.12$67,580.52  0.60     [ Average ]2,605,055$94,094,586.60  836.97   [Very High]Form 4-
2021-02-19Omega Fund V, L.p.-Sell540Common Stock$36.50$19,710.00  0.17     [ Low ]2,604,515$95,064,797.50  836.79   [Very High]Form 4-
2021-02-22Omega Fund V, L.p.-Sell5,638Common Stock$34.80$196,202.40  1.81     [ High ]2,598,877$90,440,919.60  834.98   [Very High]Form 4-
2021-02-22Omega Fund V, L.p.-Sell785Common Stock$35.72$28,040.20  0.25     [ Low ]2,598,092$92,803,846.24  834.73   [Very High]Form 4-
2021-02-23Omega Fund V, L.p.-Sell5,498Common Stock$33.75$185,557.50  1.77     [ High ]2,592,594$87,500,047.50  832.96   [Very High]Form 4-
2021-02-23Omega Fund V, L.p.-Sell2,052Common Stock$34.36$70,506.72  0.66     [ Average ]2,590,542$89,011,023.12  832.30   [Very High]Form 4-
2021-02-24Omega Fund V, L.p.-Sell567Common Stock$34.27$19,431.09  0.18     [ Low ]2,589,975$88,758,443.25  832.12   [Very High]Form 4-
2021-02-24Omega Fund V, L.p.-Sell2,431Common Stock$34.89$84,817.59  0.78     [ High ]2,587,544$90,279,410.16  831.34   [Very High]Form 4-
2021-02-25Omega Fund V, L.p.-Sell7,424Common Stock$33.46$248,407.04  2.39     [ High ]2,580,120$86,330,815.20  828.95   [Very High]Form 4-
2021-02-25Omega Fund V, L.p.-Sell2,013Common Stock$34.39$69,227.07  0.65     [ Average ]2,578,107$88,661,099.73  828.31   [Very High]Form 4-
2021-02-25Omega Fund V, L.p.-Sell242Common Stock$35.32$8,547.44  0.08     [ Very Low ]2,577,865$91,050,191.80  828.23   [Very High]Form 4-
2021-02-26Omega Fund V, L.p.-Sell2,376Common Stock$32.87$78,099.12  0.76     [ Average ]2,575,489$84,656,323.43  827.47   [Very High]Form 4-
2021-02-26Omega Fund V, L.p.-Sell5,458Common Stock$34.28$187,100.24  1.75     [ High ]2,570,031$88,100,662.68  825.71   [Very High]Form 4-
2021-02-26Omega Fund V, L.p.-Sell7,808Common Stock$35.27$275,388.16  2.51     [ Very High ]2,562,223$90,369,605.21  823.20   [Very High]Form 4-
2021-02-26Omega Fund V, L.p.-Sell3,604Common Stock$35.93$129,491.72  1.16     [ High ]2,558,619$91,931,180.67  822.05   [Very High]Form 4-
2021-03-01Omega Fund V, L.p.-Sell3,772Common Stock$45.49$171,588.28  1.21     [ High ]2,554,847$116,219,990.03  820.83   [Very High]Form 4-
2021-03-01Omega Fund V, L.p.-Sell2,692Common Stock$46.28$124,585.76  0.86     [ High ]2,552,155$118,113,733.40  819.97   [Very High]Form 4-
2021-03-01Omega Fund V, L.p.-Sell600Common Stock$47.12$28,272.00  0.19     [ Low ]2,551,555$120,229,271.60  819.78   [Very High]Form 4-
2021-03-05Timothy A Springer-Buy100,000Common Stock$70.00-$7,000,000.00  27.82    [ Very High ]475,019$33,251,330.00  132.13   [Very High]Form 4By TAS Partners LLC
2021-03-05Vikas Goyal-Buy1,000Common Stock$70.00-$70,000.00  0.28     [ Average ]1,000$70,000.00  0.28     [Very Low]Form 4-
2021-03-08Marc SchegerinCFO and COOBuy3,000Common Stock$63.50-$190,500.00  0.83     [ High ]6,379$405,066.50  1.77     [Low]Form 4-
2021-03-15Omega Fund V, L.p.-Sell10,341Common Stock$63.97$661,513.77  2.88     [ Very High ]2,541,214$162,561,459.58  706.87   [Very High]Form 4-
2021-03-15Omega Fund V, L.p.-Sell4,004Common Stock$64.78$259,379.12  1.11     [ High ]2,537,210$164,360,463.80  705.76   [Very High]Form 4-
2021-03-15Omega Fund V, L.p.-Sell6,620Common Stock$66.06$437,317.20  1.84     [ High ]2,530,590$167,170,775.40  703.92   [Very High]Form 4-
2021-03-15Omega Fund V, L.p.-Sell10,825Common Stock$66.94$724,625.50  3.01     [ Very High ]2,519,765$168,673,069.10  700.91   [Very High]Form 4-
2021-03-15Omega Fund V, L.p.-Sell2,630Common Stock$67.96$178,734.80  0.73     [ Average ]2,517,125$171,063,815.00  700.17   [Very High]Form 4-
2021-03-15Omega Fund V, L.p.-Sell2,112Common Stock$69.13$146,002.56  0.59     [ Average ]2,515,023$173,863,539.99  699.59   [Very High]Form 4-
2021-03-16Omega Fund V, L.p.-Sell4,316Common Stock$62.52$269,836.32  1.20     [ High ]2,510,707$156,969,401.64  698.39   [Very High]Form 4-
2021-03-16Omega Fund V, L.p.-Sell14,777Common Stock$63.72$941,590.44  4.11     [ Very High ]2,495,930$159,040,659.60  694.28   [Very High]Form 4-
2021-03-16Omega Fund V, L.p.-Sell6,483Common Stock$64.44$417,764.52  1.80     [ High ]2,489,447$160,419,964.68  692.47   [Very High]Form 4-
2021-03-16Omega Fund V, L.p.-Sell692Common Stock$65.55$45,360.60  0.19     [ Low ]2,488,755$163,137,890.25  692.28   [Very High]Form 4-
2021-03-16Omega Fund V, L.p.-Sell197Common Stock$66.47$13,094.59  0.05     [ Very Low ]2,488,558$165,414,450.26  692.23   [Very High]Form 4-
2021-03-16Omega Fund V, L.p.-Sell1,394Common Stock$68.33$95,252.02  0.39     [ Average ]2,487,164$169,947,916.12  691.84   [Very High]Form 4-
2021-03-15William DevaulGeneral Counsel and SecretaryBuy45,973Common Stock$4.32-$198,603.36  12.79    [ Very High ]50,179$216,773.28  13.96    [Average]Form 4-
2021-03-15William DevaulGeneral Counsel and SecretarySell12,674Common Stock$63.84$809,108.16  3.53     [ Very High ]37,505$2,394,319.20  10.43    [Average]Form 4-
2021-03-15William DevaulGeneral Counsel and SecretarySell5,396Common Stock$64.70$349,121.20  1.50     [ High ]32,109$2,077,452.30  8.93     [Average]Form 4-
2021-03-15William DevaulGeneral Counsel and SecretarySell7,916Common Stock$66.04$522,772.64  2.20     [ High ]24,193$1,597,705.72  6.73     [Average]Form 4-
2021-03-15William DevaulGeneral Counsel and SecretarySell15,068Common Stock$66.85$1,007,295.80  4.19     [ Very High ]9,125$610,006.25  2.54     [Low]Form 4-
2021-03-15William DevaulGeneral Counsel and SecretarySell3,410Common Stock$67.86$231,402.60  0.95     [ High ]5,715$387,819.90  1.59     [Low]Form 4-
2021-03-15William DevaulGeneral Counsel and SecretarySell1,509Common Stock$69.06$104,211.54  0.42     [ Average ]4,206$290,466.36  1.17     [Very Low]Form 4-
2021-03-16William DevaulGeneral Counsel and SecretaryBuy14,027Common Stock$4.32-$60,596.64  3.90     [ Very High ]18,233$78,766.56  5.07     [Average]Form 4-
2021-03-16William DevaulGeneral Counsel and SecretarySell9,429Common Stock$63.57$599,401.53  2.62     [ Very High ]8,804$559,670.28  2.45     [Low]Form 4-
2021-03-16William DevaulGeneral Counsel and SecretarySell3,498Common Stock$64.19$224,536.62  0.97     [ High ]5,306$340,592.14  1.48     [Low]Form 4-
2021-03-16William DevaulGeneral Counsel and SecretarySell500Common Stock$65.43$32,715.00  0.14     [ Low ]4,806$314,456.58  1.34     [Low]Form 4-
2021-03-16William DevaulGeneral Counsel and SecretarySell600Common Stock$68.38$41,028.00  0.17     [ Low ]4,206$287,606.28  1.17     [Very Low]Form 4-
2021-03-16Peter LindeChief Medical OfficerBuy11,365Common Stock$0.00$0.00  -12,222$0.00  3.40     [Low]Form 4-
2021-03-16Peter LindeChief Medical OfficerBuy10,378Common Stock$0.00$0.00  -22,600$0.00  6.29     [Average]Form 4-
2021-03-16Peter LindeChief Medical OfficerSell9,558Common Stock$63.65$608,366.70  2.66     [ Very High ]13,042$830,123.30  3.63     [Low]Form 4-
2021-03-16Peter LindeChief Medical OfficerSell1,561Common Stock$64.49$100,668.89  0.43     [ Average ]11,481$740,409.69  3.19     [Low]Form 4-
2021-03-16Peter LindeChief Medical OfficerSell381Common Stock$65.49$24,951.69  0.11     [ Low ]11,100$726,939.00  3.09     [Low]Form 4-
2021-03-16Peter LindeChief Medical OfficerSell500Common Stock$68.38$34,190.00  0.14     [ Low ]10,600$724,828.00  2.95     [Low]Form 4-
2021-03-15Bruce RogersChief Scientific OfficerSell2,900Common Stock$63.97$185,513.00  0.81     [ High ]95,458$6,106,448.26  26.55    [High]Form 4-
2021-03-15Bruce RogersChief Scientific OfficerSell1,345Common Stock$64.83$87,196.35  0.37     [ Average ]94,113$6,101,345.79  26.18    [High]Form 4-
2021-03-15Bruce RogersChief Scientific OfficerSell1,341Common Stock$66.04$88,559.64  0.37     [ Average ]92,772$6,126,662.88  25.81    [High]Form 4-
2021-03-15Bruce RogersChief Scientific OfficerSell1,693Common Stock$66.86$113,193.98  0.47     [ Average ]91,079$6,089,541.94  25.33    [High]Form 4-
2021-03-15Bruce RogersChief Scientific OfficerSell1,030Common Stock$67.85$69,885.50  0.29     [ Average ]90,049$6,109,824.65  25.05    [High]Form 4-
2021-03-15Bruce RogersChief Scientific OfficerSell200Common Stock$69.21$13,842.00  0.06     [ Very Low ]89,849$6,218,449.29  24.99    [High]Form 4-
2021-03-17Omega Fund V, L.p.-Sell7,301Common Stock$63.72$465,219.72  2.03     [ High ]2,479,863$158,016,870.36  689.81   [Very High]Form 4-
2021-03-17Omega Fund V, L.p.-Sell8,087Common Stock$64.59$522,339.33  2.25     [ High ]2,471,776$159,652,011.84  687.56   [Very High]Form 4-
2021-03-17Omega Fund V, L.p.-Sell993Common Stock$65.26$64,803.18  0.28     [ Average ]2,470,843$161,247,214.18  687.30   [Very High]Form 4-
2021-03-18Omega Fund V, L.p.-Sell3,235Common Stock$63.00$203,805.00  0.90     [ High ]2,467,608$155,459,304.00  686.40   [Very High]Form 4-
2021-03-18Omega Fund V, L.p.-Sell15,154Common Stock$64.02$970,159.08  4.22     [ Very High ]2,452,454$157,006,105.08  682.18   [Very High]Form 4-
2021-03-18Omega Fund V, L.p.-Sell1,083Common Stock$64.58$69,940.14  0.30     [ Average ]2,451,371$158,309,539.18  681.88   [Very High]Form 4-
2021-03-19Omega Fund V, L.p.-Sell2,919Common Stock$61.92$180,744.48  0.81     [ High ]2,448,452$151,608,147.84  681.07   [Very High]Form 4-
2021-03-19Omega Fund V, L.p.-Sell5,026Common Stock$63.01$316,688.26  1.40     [ High ]2,443,426$153,960,272.26  679.67   [Very High]Form 4-
2021-03-19Omega Fund V, L.p.-Sell5,836Common Stock$64.00$373,504.00  1.62     [ High ]2,437,590$156,005,760.00  678.05   [Very High]Form 4-
2021-03-19Omega Fund V, L.p.-Sell2,848Common Stock$64.69$184,237.12  0.79     [ High ]2,434,742$157,503,459.98  677.26   [Very High]Form 4-
2021-03-22Omega Fund V, L.p.-Sell1,751Common Stock$63.98$112,028.98  0.49     [ Average ]2,432,991$155,662,764.18  676.77   [Very High]Form 4-
2021-03-22Omega Fund V, L.p.-Sell5,996Common Stock$64.99$389,680.04  1.67     [ High ]2,426,995$157,730,405.05  675.10   [Very High]Form 4-
2021-03-22Omega Fund V, L.p.-Sell1,406Common Stock$65.51$92,107.06  0.39     [ Average ]2,425,589$158,900,335.39  674.71   [Very High]Form 4-
2021-03-23Omega Fund V, L.p.-Sell1,751Common Stock$60.81$106,478.31  0.49     [ Average ]2,423,838$147,393,588.78  674.22   [Very High]Form 4-
2021-03-23Omega Fund V, L.p.-Sell9,236Common Stock$61.94$572,077.84  2.57     [ Very High ]2,414,602$149,560,447.88  671.66   [Very High]Form 4-
2021-03-23Omega Fund V, L.p.-Sell6,912Common Stock$62.70$433,382.40  1.92     [ High ]2,407,690$150,962,163.00  669.73   [Very High]Form 4-
2021-03-23Omega Fund V, L.p.-Sell1,444Common Stock$63.66$91,925.04  0.40     [ Average ]2,406,246$153,181,620.36  669.33   [Very High]Form 4-
2021-03-24Omega Fund V, L.p.-Sell6,255Common Stock$57.05$356,847.75  1.74     [ High ]2,399,991$136,919,486.55  667.59   [Very High]Form 4-
2021-03-24Omega Fund V, L.p.-Sell8,280Common Stock$58.18$481,730.40  2.30     [ High ]2,391,711$139,149,745.98  665.29   [Very High]Form 4-
2021-03-24Omega Fund V, L.p.-Sell4,736Common Stock$59.38$281,223.68  1.32     [ High ]2,386,975$141,738,575.50  663.97   [Very High]Form 4-
2021-03-24Omega Fund V, L.p.-Sell4,289Common Stock$60.38$258,969.82  1.19     [ High ]2,382,686$143,866,580.68  662.78   [Very High]Form 4-
2021-03-24Omega Fund V, L.p.-Sell5,043Common Stock$61.52$310,245.36  1.40     [ High ]2,377,643$146,272,597.36  661.37   [Very High]Form 4-
2021-03-24Omega Fund V, L.p.-Sell4,368Common Stock$62.54$273,174.72  1.22     [ High ]2,373,275$148,424,618.50  660.16   [Very High]Form 4-
2021-03-25Omega Fund V, L.p.-Sell4,004Common Stock$56.28$225,345.12  1.11     [ High ]2,369,271$133,342,571.88  659.05   [Very High]Form 4-
2021-03-25Omega Fund V, L.p.-Sell8,820Common Stock$57.24$504,856.80  2.45     [ Very High ]2,360,451$135,112,215.24  656.59   [Very High]Form 4-
2021-03-25Omega Fund V, L.p.-Sell11,257Common Stock$58.21$655,269.97  3.13     [ Very High ]2,349,194$136,746,582.74  653.46   [Very High]Form 4-
2021-03-25Omega Fund V, L.p.-Sell4,087Common Stock$59.02$241,214.74  1.14     [ High ]2,345,107$138,408,215.14  652.32   [Very High]Form 4-
2021-03-25Omega Fund V, L.p.-Sell6,372Common Stock$60.43$385,059.96  1.77     [ High ]2,338,735$141,329,756.05  650.55   [Very High]Form 4-
2021-03-25Omega Fund V, L.p.-Sell416Common Stock$60.86$25,317.76  0.12     [ Low ]2,338,319$142,310,094.34  650.44   [Very High]Form 4-
2021-03-26Omega Fund V, L.p.-Sell7,003Common Stock$59.22$414,717.66  1.95     [ High ]2,331,316$138,060,533.52  648.49   [Very High]Form 4-
2021-03-26Omega Fund V, L.p.-Sell4,572Common Stock$60.10$274,777.20  1.27     [ High ]2,326,744$139,837,314.40  647.22   [Very High]Form 4-
2021-03-26Omega Fund V, L.p.-Sell1,406Common Stock$61.14$85,962.84  0.39     [ Average ]2,325,338$142,171,165.32  646.83   [Very High]Form 4-
2021-04-05Omega Fund V, L.p.-Sell3,079Common Stock$61.05$187,972.95  0.86     [ High ]2,255,778$137,715,246.90  627.48   [Very High]Form 4-
2021-04-05Omega Fund V, L.p.-Sell3,918Common Stock$61.79$242,093.22  1.09     [ High ]2,251,860$139,142,429.40  626.39   [Very High]Form 4-
2021-04-05Omega Fund V, L.p.-Sell1,354Common Stock$63.13$85,478.02  0.38     [ Average ]2,250,506$142,074,443.78  626.01   [Very High]Form 4-
2021-04-05Omega Fund V, L.p.-Sell1,192Common Stock$64.71$77,134.32  0.33     [ Average ]2,249,314$145,553,108.94  625.68   [Very High]Form 4-
2021-04-06Omega Fund V, L.p.-Sell7,273Common Stock$60.93$443,143.89  2.02     [ High ]2,242,041$136,607,558.13  623.66   [Very High]Form 4-
2021-04-06Omega Fund V, L.p.-Sell3,543Common Stock$61.48$217,823.64  0.99     [ High ]2,238,498$137,622,857.04  622.67   [Very High]Form 4-
2021-04-06Omega Fund V, L.p.-Sell65Common Stock$62.21$4,043.65  0.02     [ Very Low ]2,238,433$139,252,916.93  622.65   [Very High]Form 4-
2021-04-09Omega Fund V, L.p.-Sell3,126Common Stock$58.13$181,714.38  0.87     [ High ]2,208,622$128,387,196.86  614.36   [Very High]Form 4-
2021-04-09Omega Fund V, L.p.-Sell5,229Common Stock$59.19$309,504.51  1.45     [ High ]2,203,393$130,418,831.67  612.90   [Very High]Form 4-
2021-04-09Omega Fund V, L.p.-Sell1,830Common Stock$60.05$109,891.50  0.51     [ Average ]2,201,563$132,203,858.15  612.40   [Very High]Form 4-
2021-04-09Omega Fund V, L.p.-Sell35Common Stock$61.41$2,149.35  -2,201,528$135,195,834.48  612.39   [Very High]Form 4-
2021-04-12Omega Fund V, L.p.-Sell6,149Common Stock$56.84$349,509.16  1.71     [ High ]2,195,379$124,785,342.36  610.68   [Very High]Form 4-
2021-04-12Omega Fund V, L.p.-Sell7,735Common Stock$57.46$444,453.10  2.15     [ High ]2,187,644$125,702,024.24  608.52   [Very High]Form 4-
2021-04-12Omega Fund V, L.p.-Sell708Common Stock$59.07$41,821.56  0.20     [ Low ]2,186,936$129,182,309.52  608.33   [Very High]Form 4-
2021-04-13Omega Fund V, L.p.-Sell1,758Common Stock$56.70$99,678.60  0.49     [ Average ]2,185,178$123,899,592.60  607.84   [Very High]Form 4-
2021-04-13Omega Fund V, L.p.-Sell4,879Common Stock$57.61$281,079.19  1.36     [ High ]2,180,299$125,607,025.39  606.48   [Very High]Form 4-
2021-04-13Omega Fund V, L.p.-Sell367Common Stock$58.25$21,377.75  0.10     [ Low ]2,179,932$126,981,039.00  606.38   [Very High]Form 4-
2021-04-14Omega Fund V, L.p.-Sell4,097Common Stock$55.88$228,940.36  1.14     [ High ]2,175,835$121,585,659.80  605.24   [Very High]Form 4-
2021-04-14Omega Fund V, L.p.-Sell2,055Common Stock$56.95$117,032.25  0.57     [ Average ]2,173,780$123,796,771.00  604.67   [Very High]Form 4-
2021-04-14Omega Fund V, L.p.-Sell3,716Common Stock$58.08$215,825.28  1.03     [ High ]2,170,064$126,037,317.12  603.63   [Very High]Form 4-
2021-04-14Omega Fund V, L.p.-Sell4,064Common Stock$58.95$239,572.80  1.13     [ High ]2,166,000$127,685,700.00  602.50   [Very High]Form 4-
2021-04-15Omega Fund V, L.p.-Sell3,667Common Stock$55.16$202,271.72  1.02     [ High ]2,162,333$119,274,288.28  601.48   [Very High]Form 4-
2021-04-15Omega Fund V, L.p.-Sell4,331Common Stock$56.10$242,969.10  1.20     [ High ]2,158,002$121,063,912.20  600.28   [Very High]Form 4-
2021-04-15Omega Fund V, L.p.-Sell2,828Common Stock$57.15$161,620.20  0.79     [ High ]2,155,174$123,168,194.10  599.49   [Very High]Form 4-
2021-04-15Omega Fund V, L.p.-Sell355Common Stock$58.11$20,629.05  0.10     [ Low ]2,154,819$125,216,532.09  599.39   [Very High]Form 4-
2021-04-16Omega Fund V, L.p.-Sell3,846Common Stock$54.37$209,107.02  1.07     [ High ]2,150,973$116,948,402.01  598.32   [Very High]Form 4-
2021-04-16Omega Fund V, L.p.-Sell2,719Common Stock$55.36$150,523.84  0.76     [ High ]2,148,254$118,927,341.44  597.57   [Very High]Form 4-