| Trade Date |
Insider |
Title |
Buy or Sell |
Quantity |
Security Type |
Price |
Proceeds |
Transaction Conviction |
Position Quantity |
Position Value |
Positon Conviction |
SEC Link |
Nature of Ownership |
2020-05-27 | Presidio Management Group X Llc | - | Buy | 2,307,142 | Common Stock | $0.00 | $0.00 | - | 2,307,142 | $0.00 | 491.40 [Very High] | Form 4 | Directly owned by USVP X | 2020-05-27 | Presidio Management Group X Llc | - | Buy | 2,899,876 | Common Stock | $0.00 | $0.00 | - | 5,207,018 | $0.00 | 1,109.06 [Very High] | Form 4 | Directly owned by USVP X | 2020-05-27 | Presidio Management Group X Llc | - | Buy | 2,278,331 | Common Stock | $0.00 | $0.00 | - | 7,485,349 | $0.00 | 1,594.32 [Very High] | Form 4 | Directly owned by USVP X | 2020-05-27 | Presidio Management Group X Llc | - | Buy | 73,809 | Common Stock | $0.00 | $0.00 | - | 73,809 | $0.00 | 15.72 [Average] | Form 4 | Directly owned by AFF X | 2020-05-27 | Presidio Management Group X Llc | - | Buy | 92,771 | Common Stock | $0.00 | $0.00 | - | 166,580 | $0.00 | 35.48 [High] | Form 4 | Directly owned by AFF X | 2020-05-27 | Presidio Management Group X Llc | - | Buy | 72,887 | Common Stock | $0.00 | $0.00 | - | 239,467 | $0.00 | 51.00 [High] | Form 4 | Directly owned by AFF X | 2020-05-27 | Presidio Management Group X Llc | - | Buy | 97,962 | Common Stock | $19.00 | -$1,861,278.00 | 20.87 [ Very High ] | 97,962 | $1,861,278.00 | 20.87 [High] | Form 4 | Directly owned by Casey Tansey | 2020-05-27 | Jonathan D Root | - | Buy | 251,795 | Common Stock | $19.00 | -$4,784,105.00 | 53.63 [ Very High ] | 251,795 | $4,784,105.00 | 53.63 [High] | Form 4 | - | 2020-05-27 | Jonathan D Root | - | Buy | 7,485,349 | Common Stock | $0.00 | $0.00 | - | 7,485,349 | $0.00 | 1,594.32 [Very High] | Form 4 | Directly Owned by USVP X | 2020-05-27 | Jonathan D Root | - | Buy | 239,467 | Common Stock | $0.00 | $0.00 | - | 239,467 | $0.00 | 51.00 [High] | Form 4 | Directly Owned by AFF X | 2020-05-27 | Donald B Milder | - | Buy | 239,841 | Common Stock | $19.00 | -$4,556,979.00 | 51.08 [ Very High ] | 239,841 | $4,556,979.00 | 51.08 [High] | Form 4 | - | 2020-05-27 | Donald B Milder | - | Buy | 5,033,614 | Common Stock | $0.00 | $0.00 | - | 5,033,614 | $0.00 | 1,072.12 [Very High] | Form 4 | Milder Community Property Trust | 2020-05-27 | William Hoffman | President and CEO | Buy | 13,095 | Common Stock | $19.00 | -$248,805.00 | 2.79 [ Very High ] | 1,232,283 | $23,413,377.00 | 262.47 [Very High] | Form 4 | - | 2020-05-27 | William Hoffman | President and CEO | Buy | 89,633 | Common Stock | $0.00 | $0.00 | - | 1,321,916 | $0.00 | 281.56 [Very High] | Form 4 | - | 2020-05-27 | Cynthia L Lucchese | - | Buy | 28,091 | Common Stock | $19.00 | -$533,729.00 | 5.98 [ Very High ] | 28,091 | $533,729.00 | 5.98 [Average] | Form 4 | - | 2020-05-27 | Cooperatieve Gilde Healthcare Iv U.a. | - | Buy | 342,329 | Common Stock | $19.00 | -$6,504,251.00 | 72.91 [ Very High ] | 342,329 | $6,504,251.00 | 72.91 [High] | Form 4 | See footnote | 2020-05-27 | Cooperatieve Gilde Healthcare Iv U.a. | - | Buy | 7,599,350 | Common Stock | $0.00 | $0.00 | - | 7,941,679 | $0.00 | 1,691.52 [Very High] | Form 4 | See footnote | 2020-05-27 | Catherine M. Szyman | - | Buy | 28,091 | Common Stock | $19.00 | -$533,729.00 | 5.98 [ Very High ] | 28,091 | $533,729.00 | 5.98 [Average] | Form 4 | - | 2020-05-27 | Versant Ventures Iv, Llc | - | Buy | 5,745,542 | Common Stock | $0.00 | $0.00 | - | 5,745,542 | $0.00 | 1,223.76 [Very High] | Form 4 | See footnote | 2020-05-27 | Kirk G. Nielsen | - | Buy | 5,745,542 | Common Stock | $0.00 | $0.00 | - | 5,745,542 | $0.00 | 1,223.76 [Very High] | Form 4 | See footnote | 2020-05-27 | Mitch C. Hill, | Chief Financial Officer | Buy | 7,500 | Common Stock | $19.00 | -$142,500.00 | 1.60 [ High ] | 7,500 | $142,500.00 | 1.60 [Low] | Form 4 | - | 2020-05-27 | Mitch C. Hill, | Chief Financial Officer | Buy | 1,600 | Common Stock | $19.00 | -$30,400.00 | 0.34 [ Average ] | 1,600 | $30,400.00 | 0.34 [Very Low] | Form 4 | By Spouse | 2020-05-27 | Andrew Hykes | Chief Commercial Officer | Buy | 13,570 | Common Stock | $0.00 | $0.00 | - | 314,941 | $0.00 | 67.08 [High] | Form 4 | - | 2020-05-27 | Andrew Hykes | Chief Commercial Officer | Buy | 1,000 | Common Stock | $19.00 | -$19,000.00 | 0.21 [ Low ] | 1,000 | $19,000.00 | 0.21 [Very Low] | Form 4 | By Spouse | 2020-05-27 | Andrew Hykes | Chief Commercial Officer | Buy | 1,550 | Common Stock | $19.00 | -$29,450.00 | 0.33 [ Average ] | 1,550 | $29,450.00 | 0.33 [Very Low] | Form 4 | By Child 1 | 2020-05-27 | Andrew Hykes | Chief Commercial Officer | Buy | 1,550 | Common Stock | $19.00 | -$29,450.00 | 0.33 [ Average ] | 1,550 | $29,450.00 | 0.33 [Very Low] | Form 4 | By Child 2 | 2020-05-27 | Andrew Hykes | Chief Commercial Officer | Buy | 1,550 | Common Stock | $19.00 | -$29,450.00 | 0.33 [ Average ] | 1,550 | $29,450.00 | 0.33 [Very Low] | Form 4 | By Child 3 | 2020-05-27 | Thomas Tu | Chief Medical Officer | Buy | 28,091 | Common Stock | $19.00 | -$533,729.00 | 5.98 [ Very High ] | 28,091 | $533,729.00 | 5.98 [Average] | Form 4 | - | 2020-11-27 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 13,956 | Common Stock | $66.99 | $934,912.44 | 2.87 [ Very High ] | 7,927,723 | $531,078,163.77 | 1,627.50 [Very High] | Form 4 | See footnote | 2020-11-27 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 11,200 | Common Stock | $68.28 | $764,736.00 | 2.30 [ High ] | 7,916,523 | $540,540,190.44 | 1,625.20 [Very High] | Form 4 | See footnote | 2020-11-27 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 53,484 | Common Stock | $68.94 | $3,687,186.96 | 10.98 [ Very High ] | 7,863,039 | $542,077,908.66 | 1,614.22 [Very High] | Form 4 | See footnote | 2020-11-30 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 14,770 | Common Stock | $65.81 | $972,013.70 | 3.03 [ Very High ] | 7,848,269 | $516,494,582.89 | 1,611.19 [Very High] | Form 4 | See footnote | 2020-11-30 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 65,795 | Common Stock | $66.94 | $4,404,317.30 | 13.51 [ Very High ] | 7,782,474 | $520,958,809.56 | 1,597.68 [Very High] | Form 4 | See footnote | 2020-11-30 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 78,696 | Common Stock | $67.74 | $5,330,867.04 | 16.16 [ Very High ] | 7,703,778 | $521,853,921.72 | 1,581.53 [Very High] | Form 4 | See footnote | 2020-11-30 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 39,955 | Common Stock | $68.81 | $2,749,303.55 | 8.20 [ Very High ] | 7,663,823 | $527,347,660.63 | 1,573.32 [Very High] | Form 4 | See footnote | 2020-12-01 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 88,435 | Common Stock | $67.06 | $5,930,451.10 | 18.16 [ Very High ] | 7,575,388 | $508,005,519.28 | 1,555.17 [Very High] | Form 4 | See footnote | 2020-12-01 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 73,435 | Common Stock | $67.93 | $4,988,439.55 | 15.08 [ Very High ] | 7,501,953 | $509,607,667.29 | 1,540.09 [Very High] | Form 4 | See footnote | 2020-12-01 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 2,818 | Common Stock | $69.07 | $194,639.26 | 0.58 [ Average ] | 7,499,135 | $517,965,254.45 | 1,539.52 [Very High] | Form 4 | See footnote | 2020-11-30 | Thomas Tu | Chief Medical Officer | Buy | 3,500 | Common Stock | $0.46 | -$1,610.00 | 0.72 [ Average ] | 31,591 | $14,531.86 | 6.49 [Average] | Form 4 | - | 2020-11-30 | Thomas Tu | Chief Medical Officer | Sell | 300 | Common Stock | $66.10 | $19,830.00 | 0.06 [ Very Low ] | 31,291 | $2,068,335.10 | 6.42 [Average] | Form 4 | - | 2020-11-30 | Thomas Tu | Chief Medical Officer | Sell | 1,900 | Common Stock | $67.44 | $128,136.00 | 0.39 [ Average ] | 29,391 | $1,982,129.04 | 6.03 [Average] | Form 4 | - | 2020-11-30 | Thomas Tu | Chief Medical Officer | Sell | 1,000 | Common Stock | $68.34 | $68,340.00 | 0.21 [ Low ] | 28,391 | $1,940,240.94 | 5.83 [Average] | Form 4 | - | 2020-11-30 | Thomas Tu | Chief Medical Officer | Sell | 300 | Common Stock | $69.07 | $20,721.00 | 0.06 [ Very Low ] | 28,091 | $1,940,245.37 | 5.77 [Average] | Form 4 | - | 2020-11-30 | Andrew Hykes | Chief Operating Officer | Sell | 1,400 | Common Stock | $65.69 | $91,966.00 | 0.29 [ Low ] | 313,541 | $20,596,508.29 | 64.37 [High] | Form 4 | - | 2020-11-30 | Andrew Hykes | Chief Operating Officer | Sell | 9,112 | Common Stock | $67.11 | $611,506.32 | 1.87 [ High ] | 304,429 | $20,430,230.19 | 62.50 [High] | Form 4 | - | 2020-11-30 | Andrew Hykes | Chief Operating Officer | Sell | 10,772 | Common Stock | $67.87 | $731,095.64 | 2.21 [ High ] | 293,657 | $19,930,500.59 | 60.29 [High] | Form 4 | - | 2020-11-30 | Andrew Hykes | Chief Operating Officer | Sell | 6,116 | Common Stock | $68.81 | $420,841.96 | 1.26 [ High ] | 287,541 | $19,785,696.21 | 59.03 [High] | Form 4 | - | 2020-12-04 | William Hoffman | President and CEO | Sell | 11,085 | Common Stock | $64.22 | $711,878.70 | 2.28 [ High ] | 1,310,831 | $84,181,566.82 | 269.10 [Very High] | Form 4 | - | 2020-12-04 | William Hoffman | President and CEO | Sell | 18,915 | Common Stock | $64.85 | $1,226,637.75 | 3.88 [ Very High ] | 1,291,916 | $83,780,752.60 | 265.22 [Very High] | Form 4 | - | 2020-12-03 | Mitch C. Hill, | Chief Financial Officer | Buy | 50,000 | Common Stock | $0.46 | -$23,000.00 | 10.26 [ Very High ] | 57,500 | $26,450.00 | 11.80 [Average] | Form 4 | - | 2020-12-07 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 70,939 | Common Stock | $65.10 | $4,618,128.90 | 14.56 [ Very High ] | 7,333,069 | $477,382,791.90 | 1,505.42 [Very High] | Form 4 | See footnote | 2020-12-08 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 28,677 | Common Stock | $65.35 | $1,874,041.95 | 5.89 [ Very High ] | 7,304,392 | $477,342,017.20 | 1,499.54 [Very High] | Form 4 | See footnote | 2020-12-09 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 36,715 | Common Stock | $65.88 | $2,418,784.20 | 7.54 [ Very High ] | 7,267,677 | $478,794,560.76 | 1,492.00 [Very High] | Form 4 | See footnote | 2020-12-09 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 112,780 | Common Stock | $66.75 | $7,528,065.00 | 23.15 [ Very High ] | 7,154,897 | $477,589,374.75 | 1,468.85 [Very High] | Form 4 | See footnote | 2020-12-09 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 5,729 | Common Stock | $67.33 | $385,733.57 | 1.18 [ High ] | 7,149,168 | $481,353,481.44 | 1,467.67 [Very High] | Form 4 | See footnote | 2020-12-08 | Mitch C. Hill, | Chief Financial Officer | Buy | 5,000 | Common Stock | $0.46 | -$2,300.00 | 1.03 [ High ] | 62,500 | $28,750.00 | 12.83 [Average] | Form 4 | - | 2020-12-08 | Mitch C. Hill, | Chief Financial Officer | Sell | 4,141 | Common Stock | $64.73 | $268,046.93 | 0.85 [ High ] | 58,359 | $3,777,578.07 | 11.98 [Average] | Form 4 | - | 2020-12-08 | Mitch C. Hill, | Chief Financial Officer | Sell | 859 | Common Stock | $65.49 | $56,255.91 | 0.18 [ Low ] | 57,500 | $3,765,675.00 | 11.80 [Average] | Form 4 | - | 2020-12-10 | Donald B Milder | - | Sell | 2,393 | Common Stock | $67.75 | $162,125.75 | 0.49 [ Average ] | 5,031,221 | $340,865,222.75 | 1,032.87 [Very High] | Form 4 | Milder Community Property Trust | 2020-12-10 | Donald B Milder | - | Sell | 4,607 | Common Stock | $68.26 | $314,473.82 | 0.95 [ High ] | 5,026,614 | $343,116,671.64 | 1,031.93 [Very High] | Form 4 | Milder Community Property Trust | 2020-12-10 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 8,419 | Common Stock | $67.04 | $564,409.76 | 1.73 [ High ] | 7,140,749 | $478,715,812.96 | 1,465.94 [Very High] | Form 4 | See footnote | 2020-12-10 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 29,444 | Common Stock | $67.81 | $1,996,597.64 | 6.04 [ Very High ] | 7,111,305 | $482,217,592.05 | 1,459.90 [Very High] | Form 4 | See footnote | 2020-12-10 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 98,180 | Common Stock | $68.22 | $6,697,839.60 | 20.16 [ Very High ] | 7,013,125 | $478,435,387.50 | 1,439.74 [Very High] | Form 4 | See footnote | 2020-12-11 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 66,371 | Common Stock | $66.60 | $4,420,308.60 | 13.63 [ Very High ] | 6,946,754 | $462,653,816.40 | 1,426.12 [Very High] | Form 4 | See footnote | 2020-12-11 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 5,075 | Common Stock | $67.39 | $342,004.25 | 1.04 [ High ] | 6,941,679 | $467,799,747.81 | 1,425.07 [Very High] | Form 4 | See footnote | 2020-12-18 | Andrew Hykes | Chief Operating Officer | Sell | 4,169 | Common Stock | $72.13 | $300,709.97 | 0.86 [ High ] | 283,372 | $20,439,622.36 | 58.17 [High] | Form 4 | - | 2020-12-18 | Andrew Hykes | Chief Operating Officer | Sell | 12,202 | Common Stock | $71.41 | $871,344.82 | 2.50 [ High ] | 271,170 | $19,364,249.70 | 55.67 [High] | Form 4 | - | 2020-12-18 | Andrew Hykes | Chief Operating Officer | Sell | 3,859 | Common Stock | $70.47 | $271,943.73 | 0.79 [ Average ] | 267,311 | $18,837,406.17 | 54.88 [High] | Form 4 | - | 2020-12-18 | Andrew Hykes | Chief Operating Officer | Sell | 7,170 | Common Stock | $69.35 | $497,239.50 | 1.47 [ High ] | 260,141 | $18,040,778.35 | 53.40 [High] | Form 4 | - | 2020-12-18 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 63,840 | Common Stock | $70.52 | $4,501,996.80 | 13.11 [ Very High ] | 6,877,839 | $485,025,206.28 | 1,411.97 [Very High] | Form 4 | See footnote | 2020-12-18 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 110,474 | Common Stock | $71.53 | $7,902,205.22 | 22.68 [ Very High ] | 6,767,365 | $484,069,618.45 | 1,389.29 [Very High] | Form 4 | See footnote | 2020-12-18 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 41,878 | Common Stock | $72.16 | $3,021,916.48 | 8.60 [ Very High ] | 6,725,487 | $485,311,141.92 | 1,380.69 [Very High] | Form 4 | See footnote | 2020-12-21 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 11,885 | Common Stock | $70.41 | $836,822.85 | 2.44 [ High ] | 6,713,602 | $472,704,716.82 | 1,378.25 [Very High] | Form 4 | See footnote | 2020-12-21 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 13,125 | Common Stock | $71.73 | $941,456.25 | 2.69 [ Very High ] | 6,700,477 | $480,625,215.21 | 1,375.56 [Very High] | Form 4 | See footnote | 2020-12-21 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 54,257 | Common Stock | $72.47 | $3,932,004.79 | 11.14 [ Very High ] | 6,646,220 | $481,651,563.40 | 1,364.42 [Very High] | Form 4 | See footnote | 2020-12-21 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 71,415 | Common Stock | $73.47 | $5,246,860.05 | 14.66 [ Very High ] | 6,574,805 | $483,050,923.35 | 1,349.76 [Very High] | Form 4 | See footnote | 2020-12-21 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 44,268 | Common Stock | $74.53 | $3,299,294.04 | 9.09 [ Very High ] | 6,530,537 | $486,720,922.61 | 1,340.67 [Very High] | Form 4 | See footnote | 2020-12-22 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 20,754 | Common Stock | $76.11 | $1,579,586.94 | 4.26 [ Very High ] | 6,509,783 | $495,459,584.13 | 1,336.41 [Very High] | Form 4 | See footnote | 2020-12-22 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 71,340 | Common Stock | $77.22 | $5,508,874.80 | 14.65 [ Very High ] | 6,438,443 | $497,176,568.46 | 1,321.76 [Very High] | Form 4 | See footnote | 2020-12-22 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 98,190 | Common Stock | $78.21 | $7,679,439.90 | 20.16 [ Very High ] | 6,340,253 | $495,871,187.13 | 1,301.61 [Very High] | Form 4 | See footnote | 2020-12-22 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 4,880 | Common Stock | $78.57 | $383,421.60 | 1.00 [ High ] | 6,335,373 | $497,770,256.61 | 1,300.60 [Very High] | Form 4 | See footnote | 2020-12-22 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 4,714 | Common Stock | $74.48 | $351,098.72 | 0.97 [ High ] | 6,330,659 | $471,507,482.32 | 1,299.64 [Very High] | Form 4 | See footnote | 2020-12-22 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 5,287 | Common Stock | $76.12 | $402,446.44 | 1.09 [ High ] | 6,325,372 | $481,487,316.64 | 1,298.55 [Very High] | Form 4 | See footnote | 2020-12-22 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 43,841 | Common Stock | $77.22 | $3,385,402.02 | 9.00 [ Very High ] | 6,281,531 | $485,059,823.82 | 1,289.55 [Very High] | Form 4 | See footnote | 2020-12-22 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 6,316 | Common Stock | $77.79 | $491,321.64 | 1.30 [ High ] | 6,275,215 | $488,148,974.85 | 1,288.25 [Very High] | Form 4 | See footnote | 2020-12-22 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 28,700 | Common Stock | $78.31 | $2,247,497.00 | 5.89 [ Very High ] | 6,246,515 | $489,164,589.65 | 1,282.36 [Very High] | Form 4 | See footnote | 2020-12-21 | Thomas Tu | Chief Medical Officer | Buy | 1,500 | Common Stock | $0.46 | -$690.00 | 0.31 [ Average ] | 29,591 | $13,611.86 | 6.07 [Average] | Form 4 | - | 2020-12-21 | Thomas Tu | Chief Medical Officer | Sell | 1,500 | Common Stock | $74.00 | $111,000.00 | 0.31 [ Average ] | 28,091 | $2,078,734.00 | 5.77 [Average] | Form 4 | - | 2020-12-23 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 46,365 | Common Stock | $79.51 | $3,686,481.15 | 9.52 [ Very High ] | 6,200,150 | $492,973,926.50 | 1,272.84 [Very High] | Form 4 | See footnote | 2020-12-23 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 164,392 | Common Stock | $80.45 | $13,225,336.40 | 33.75 [ Very High ] | 6,035,758 | $485,576,731.10 | 1,239.10 [Very High] | Form 4 | See footnote | 2020-12-23 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 42,643 | Common Stock | $81.36 | $3,469,434.48 | 8.75 [ Very High ] | 5,993,115 | $487,599,836.40 | 1,230.34 [Very High] | Form 4 | See footnote | 2020-12-23 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 8,926 | Common Stock | $82.04 | $732,289.04 | 1.83 [ High ] | 5,984,189 | $490,942,865.56 | 1,228.51 [Very High] | Form 4 | See footnote | 2020-12-23 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 2,234 | Common Stock | $83.40 | $186,315.60 | 0.46 [ Average ] | 5,981,955 | $498,895,047.00 | 1,228.05 [Very High] | Form 4 | See footnote | 2020-12-23 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 1,208 | Common Stock | $84.27 | $101,798.16 | 0.25 [ Low ] | 5,980,747 | $503,997,549.69 | 1,227.80 [Very High] | Form 4 | See footnote | 2020-12-24 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 5,852 | Common Stock | $80.79 | $472,783.08 | 1.20 [ High ] | 5,974,895 | $482,711,767.05 | 1,226.60 [Very High] | Form 4 | See footnote | 2020-12-24 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 22,439 | Common Stock | $81.73 | $1,833,939.47 | 4.61 [ Very High ] | 5,952,456 | $486,494,228.88 | 1,221.99 [Very High] | Form 4 | See footnote | 2020-12-24 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 8,830 | Common Stock | $82.64 | $729,711.20 | 1.81 [ High ] | 5,943,626 | $491,181,252.64 | 1,220.18 [Very High] | Form 4 | See footnote | 2020-12-24 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 1,947 | Common Stock | $83.47 | $162,516.09 | 0.40 [ Average ] | 5,941,679 | $495,951,946.13 | 1,219.78 [Very High] | Form 4 | See footnote | 2021-01-04 | William Hoffman | President and CEO | Sell | 40,118 | Common Stock | $83.86 | $3,364,295.48 | 8.24 [ Very High ] | 1,251,798 | $104,975,780.28 | 256.98 [Very High] | Form 4 | - | 2021-01-04 | William Hoffman | President and CEO | Sell | 49,783 | Common Stock | $84.45 | $4,204,174.35 | 10.22 [ Very High ] | 1,202,015 | $101,510,166.75 | 246.76 [Very High] | Form 4 | - | 2021-01-04 | William Hoffman | President and CEO | Sell | 8,811 | Common Stock | $85.62 | $754,397.82 | 1.81 [ High ] | 1,193,204 | $102,162,126.48 | 244.96 [Very High] | Form 4 | - | 2021-01-04 | William Hoffman | President and CEO | Sell | 1,288 | Common Stock | $86.73 | $111,708.24 | 0.26 [ Low ] | 1,191,916 | $103,374,874.68 | 244.69 [Very High] | Form 4 | - | 2021-01-04 | Kirk G. Nielsen | - | Sell | 856,437 | Common Stock | $0.00 | $0.00 | - | 1,427,394 | $0.00 | 293.03 [Very High] | Form 4 | See footnote | 2021-01-04 | Kirk G. Nielsen | - | Buy | 220,530 | Common Stock | $0.00 | $0.00 | - | 220,530 | $0.00 | 45.27 [High] | Form 4 | See footnote | 2021-01-04 | Kirk G. Nielsen | - | Sell | 220,530 | Common Stock | $0.00 | $0.00 | - | 0 | $0.00 | - | Form 4 | See footnote | 2021-01-04 | Kirk G. Nielsen | - | Buy | 11,932 | Common Stock | $0.00 | $0.00 | - | 26,638 | $0.00 | 5.47 [Average] | Form 4 | - | 2021-01-04 | Kirk G. Nielsen | - | Sell | 5,395 | Common Stock | $0.00 | $0.00 | - | 8,991 | $0.00 | 1.85 [Low] | Form 4 | See footnote | 2021-01-05 | Andrew Hykes | Chief Operating Officer | Sell | 6,486 | Common Stock | $77.86 | $504,999.96 | 1.33 [ High ] | 253,655 | $19,749,578.30 | 52.07 [High] | Form 4 | - | 2021-01-05 | Andrew Hykes | Chief Operating Officer | Sell | 8,514 | Common Stock | $78.81 | $670,988.34 | 1.75 [ High ] | 245,141 | $19,319,562.21 | 50.33 [High] | Form 4 | - | 2021-01-05 | Andrew Hykes | Chief Operating Officer | Sell | 4,600 | Common Stock | $80.07 | $368,322.00 | 0.94 [ High ] | 240,541 | $19,260,117.87 | 49.38 [High] | Form 4 | - | 2021-01-05 | Andrew Hykes | Chief Operating Officer | Sell | 3,175 | Common Stock | $81.23 | $257,905.25 | 0.65 [ Average ] | 237,366 | $19,281,240.18 | 48.73 [High] | Form 4 | - | 2021-01-05 | Andrew Hykes | Chief Operating Officer | Sell | 4,215 | Common Stock | $81.86 | $345,039.90 | 0.87 [ High ] | 233,151 | $19,085,740.86 | 47.86 [High] | Form 4 | - | 2021-01-05 | Andrew Hykes | Chief Operating Officer | Sell | 610 | Common Stock | $82.78 | $50,495.80 | 0.13 [ Low ] | 232,541 | $19,249,743.98 | 47.74 [High] | Form 4 | - | 2020-12-08 | Mitch C. Hill, | Chief Financial Officer | Buy | 5,000 | Common Stock | $0.46 | -$2,300.00 | 1.03 [ High ] | 62,500 | $28,750.00 | 12.83 [Average] | Form 4 | - | 2021-01-08 | Mitch C. Hill, | Chief Financial Officer | Sell | 1,700 | Common Stock | $81.98 | $139,366.00 | 0.35 [ Average ] | 60,800 | $4,984,384.00 | 12.48 [Average] | Form 4 | - | 2021-01-08 | Mitch C. Hill, | Chief Financial Officer | Sell | 1,857 | Common Stock | $82.83 | $153,815.31 | 0.38 [ Average ] | 58,943 | $4,882,248.69 | 12.10 [Average] | Form 4 | - | 2021-01-08 | Mitch C. Hill, | Chief Financial Officer | Sell | 1,443 | Common Stock | $83.80 | $120,923.40 | 0.30 [ Average ] | 57,500 | $4,818,500.00 | 11.80 [Average] | Form 4 | - | 2021-01-11 | Donald B Milder | - | Sell | 799 | Common Stock | $83.29 | $66,548.71 | 0.16 [ Low ] | 5,025,815 | $418,600,131.35 | 1,031.76 [Very High] | Form 4 | Milder Community Property Trust | 2021-01-11 | Donald B Milder | - | Sell | 1,411 | Common Stock | $84.38 | $119,060.18 | 0.29 [ Low ] | 5,024,404 | $423,959,209.52 | 1,031.47 [Very High] | Form 4 | Milder Community Property Trust | 2021-01-11 | Donald B Milder | - | Sell | 4,790 | Common Stock | $84.88 | $406,575.20 | 0.98 [ High ] | 5,019,614 | $426,064,836.32 | 1,030.49 [Very High] | Form 4 | Milder Community Property Trust | 2021-01-13 | William Hoffman | President and CEO | Sell | 21,821 | Common Stock | $90.26 | $1,969,563.46 | 4.48 [ Very High ] | 1,170,095 | $105,612,774.70 | 240.21 [Very High] | Form 4 | - | 2021-01-13 | William Hoffman | President and CEO | Sell | 6,681 | Common Stock | $91.39 | $610,576.59 | 1.37 [ High ] | 1,163,414 | $106,324,405.46 | 238.84 [Very High] | Form 4 | - | 2021-01-13 | William Hoffman | President and CEO | Sell | 1,498 | Common Stock | $92.02 | $137,845.96 | 0.31 [ Average ] | 1,161,916 | $106,919,510.32 | 238.53 [Very High] | Form 4 | - | 2021-01-13 | Kirk G. Nielsen | - | Sell | 856,437 | Common Stock | $0.00 | $0.00 | - | 570,957 | $0.00 | 117.21 [Very High] | Form 4 | See footnote | 2021-01-13 | Kirk G. Nielsen | - | Buy | 220,532 | Common Stock | $0.00 | $0.00 | - | 220,532 | $0.00 | 45.27 [High] | Form 4 | See footnote | 2021-01-13 | Kirk G. Nielsen | - | Sell | 220,532 | Common Stock | $0.00 | $0.00 | - | 0 | $0.00 | - | Form 4 | See footnote | 2021-01-13 | Kirk G. Nielsen | - | Buy | 11,933 | Common Stock | $0.00 | $0.00 | - | 38,571 | $0.00 | 7.92 [Average] | Form 4 | - | 2021-01-13 | Kirk G. Nielsen | - | Sell | 5,395 | Common Stock | $0.00 | $0.00 | - | 3,596 | $0.00 | 0.74 [Very Low] | Form 4 | See footnote | 2021-01-13 | Andrew Hykes | Chief Operating Officer | Sell | 8,045 | Common Stock | $93.70 | $753,816.50 | 1.65 [ High ] | 224,496 | $21,035,275.20 | 46.09 [High] | Form 4 | - | 2021-01-13 | Andrew Hykes | Chief Operating Officer | Sell | 6,547 | Common Stock | $94.70 | $620,000.90 | 1.34 [ High ] | 217,949 | $20,639,770.30 | 44.74 [High] | Form 4 | - | 2021-01-13 | Andrew Hykes | Chief Operating Officer | Sell | 9,007 | Common Stock | $95.76 | $862,510.32 | 1.85 [ High ] | 208,942 | $20,008,285.92 | 42.89 [High] | Form 4 | - | 2021-01-13 | Andrew Hykes | Chief Operating Officer | Sell | 3,701 | Common Stock | $96.63 | $357,627.63 | 0.76 [ Average ] | 205,241 | $19,832,437.83 | 42.13 [High] | Form 4 | - | 2021-01-13 | Andrew Hykes | Chief Operating Officer | Sell | 300 | Common Stock | $97.49 | $29,247.00 | 0.06 [ Very Low ] | 204,941 | $19,979,698.09 | 42.07 [High] | Form 4 | - | 2021-01-13 | Mitch C. Hill, | Chief Financial Officer | Buy | 36,000 | Common Stock | $0.46 | -$16,560.00 | 7.39 [ Very High ] | 93,500 | $43,010.00 | 19.19 [High] | Form 4 | - | 2021-01-13 | Mitch C. Hill, | Chief Financial Officer | Sell | 27,313 | Common Stock | $90.29 | $2,466,090.77 | 5.61 [ Very High ] | 66,187 | $5,976,024.23 | 13.59 [Average] | Form 4 | - | 2021-01-13 | Mitch C. Hill, | Chief Financial Officer | Sell | 7,489 | Common Stock | $91.38 | $684,344.82 | 1.54 [ High ] | 58,698 | $5,363,823.24 | 12.05 [Average] | Form 4 | - | 2021-01-13 | Mitch C. Hill, | Chief Financial Officer | Sell | 1,198 | Common Stock | $92.01 | $110,227.98 | 0.25 [ Low ] | 57,500 | $5,290,575.00 | 11.80 [Average] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 300 | Common Stock | $94.21 | $28,263.00 | 0.06 [ Very Low ] | 204,641 | $19,279,228.61 | 42.01 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 900 | Common Stock | $95.38 | $85,842.00 | 0.18 [ Low ] | 203,741 | $19,432,816.58 | 41.83 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 600 | Common Stock | $96.69 | $58,014.00 | 0.12 [ Low ] | 203,141 | $19,641,703.29 | 41.70 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 600 | Common Stock | $97.94 | $58,764.00 | 0.12 [ Low ] | 202,541 | $19,836,865.54 | 41.58 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 600 | Common Stock | $98.72 | $59,232.00 | 0.12 [ Low ] | 201,941 | $19,935,615.52 | 41.46 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 400 | Common Stock | $94.32 | $37,728.00 | 0.08 [ Very Low ] | 201,541 | $19,009,347.12 | 41.37 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 800 | Common Stock | $95.23 | $76,184.00 | 0.16 [ Low ] | 200,741 | $19,116,565.43 | 41.21 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 600 | Common Stock | $96.69 | $58,014.00 | 0.12 [ Low ] | 200,141 | $19,351,633.29 | 41.09 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 599 | Common Stock | $97.97 | $58,684.03 | 0.12 [ Low ] | 199,542 | $19,549,129.74 | 40.96 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 601 | Common Stock | $98.71 | $59,324.71 | 0.12 [ Low ] | 198,941 | $19,637,466.11 | 40.84 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 400 | Common Stock | $94.32 | $37,728.00 | 0.08 [ Very Low ] | 198,541 | $18,726,387.12 | 40.76 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 700 | Common Stock | $95.24 | $66,668.00 | 0.14 [ Low ] | 197,841 | $18,842,376.84 | 40.62 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 666 | Common Stock | $96.64 | $64,362.24 | 0.14 [ Low ] | 197,175 | $19,054,992.00 | 40.48 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 923 | Common Stock | $98.16 | $90,601.68 | 0.19 [ Low ] | 196,252 | $19,264,096.32 | 40.29 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 311 | Common Stock | $98.75 | $30,711.25 | 0.06 [ Very Low ] | 195,941 | $19,349,173.75 | 40.23 [High] | Form 4 | - | 2021-01-20 | William Hoffman | President and CEO | Sell | 14,900 | Common Stock | $100.32 | $1,494,768.00 | 3.06 [ Very High ] | 1,147,016 | $115,068,645.12 | 235.47 [Very High] | Form 4 | - | 2021-01-20 | William Hoffman | President and CEO | Sell | 3,500 | Common Stock | $101.53 | $355,355.00 | 0.72 [ Average ] | 1,143,516 | $116,101,179.48 | 234.76 [Very High] | Form 4 | - | 2021-01-20 | William Hoffman | President and CEO | Sell | 1,600 | Common Stock | $102.15 | $163,440.00 | 0.33 [ Average ] | 1,141,916 | $116,646,719.40 | 234.43 [Very High] | Form 4 | - | 2021-01-20 | Thomas Tu | Chief Medical Officer | Buy | 12,000 | Common Stock | $0.46 | -$5,520.00 | 2.46 [ High ] | 40,091 | $18,441.86 | 8.23 [Average] | Form 4 | - | 2021-01-20 | Thomas Tu | Chief Medical Officer | Sell | 11,100 | Common Stock | $100.33 | $1,113,663.00 | 2.28 [ High ] | 28,991 | $2,908,667.03 | 5.95 [Average] | Form 4 | - | 2021-01-20 | Thomas Tu | Chief Medical Officer | Sell | 900 | Common Stock | $101.52 | $91,368.00 | 0.18 [ Low ] | 28,091 | $2,851,798.32 | 5.77 [Average] | Form 4 | - |
