| Trade Date |
Insider |
Title |
Buy or Sell |
Quantity |
Security Type |
Price |
Proceeds |
Transaction Conviction |
Position Quantity |
Position Value |
Positon Conviction |
SEC Link |
Nature of Ownership |
2020-05-27 | Presidio Management Group X Llc | - | Buy | 2,307,142 | Common Stock | $0.00 | $0.00 | - | 2,307,142 | $0.00 | 491.40 [Very High] | Form 4 | Directly owned by USVP X | 2020-05-27 | Presidio Management Group X Llc | - | Buy | 2,899,876 | Common Stock | $0.00 | $0.00 | - | 5,207,018 | $0.00 | 1,109.06 [Very High] | Form 4 | Directly owned by USVP X | 2020-05-27 | Presidio Management Group X Llc | - | Buy | 2,278,331 | Common Stock | $0.00 | $0.00 | - | 7,485,349 | $0.00 | 1,594.32 [Very High] | Form 4 | Directly owned by USVP X | 2020-05-27 | Presidio Management Group X Llc | - | Buy | 73,809 | Common Stock | $0.00 | $0.00 | - | 73,809 | $0.00 | 15.72 [Average] | Form 4 | Directly owned by AFF X | 2020-05-27 | Presidio Management Group X Llc | - | Buy | 92,771 | Common Stock | $0.00 | $0.00 | - | 166,580 | $0.00 | 35.48 [High] | Form 4 | Directly owned by AFF X | 2020-05-27 | Presidio Management Group X Llc | - | Buy | 72,887 | Common Stock | $0.00 | $0.00 | - | 239,467 | $0.00 | 51.00 [High] | Form 4 | Directly owned by AFF X | 2020-05-27 | Presidio Management Group X Llc | - | Buy | 97,962 | Common Stock | $19.00 | -$1,861,278.00 | 20.87 [ Very High ] | 97,962 | $1,861,278.00 | 20.87 [High] | Form 4 | Directly owned by Casey Tansey | 2020-05-27 | Jonathan D Root | - | Buy | 251,795 | Common Stock | $19.00 | -$4,784,105.00 | 53.63 [ Very High ] | 251,795 | $4,784,105.00 | 53.63 [High] | Form 4 | - | 2020-05-27 | Jonathan D Root | - | Buy | 7,485,349 | Common Stock | $0.00 | $0.00 | - | 7,485,349 | $0.00 | 1,594.32 [Very High] | Form 4 | Directly Owned by USVP X | 2020-05-27 | Jonathan D Root | - | Buy | 239,467 | Common Stock | $0.00 | $0.00 | - | 239,467 | $0.00 | 51.00 [High] | Form 4 | Directly Owned by AFF X | 2020-05-27 | Donald B Milder | - | Buy | 239,841 | Common Stock | $19.00 | -$4,556,979.00 | 51.08 [ Very High ] | 239,841 | $4,556,979.00 | 51.08 [High] | Form 4 | - | 2020-05-27 | Donald B Milder | - | Buy | 5,033,614 | Common Stock | $0.00 | $0.00 | - | 5,033,614 | $0.00 | 1,072.12 [Very High] | Form 4 | Milder Community Property Trust | 2020-05-27 | William Hoffman | President and CEO | Buy | 13,095 | Common Stock | $19.00 | -$248,805.00 | 2.79 [ Very High ] | 1,232,283 | $23,413,377.00 | 262.47 [Very High] | Form 4 | - | 2020-05-27 | William Hoffman | President and CEO | Buy | 89,633 | Common Stock | $0.00 | $0.00 | - | 1,321,916 | $0.00 | 281.56 [Very High] | Form 4 | - | 2020-05-27 | Cynthia L Lucchese | - | Buy | 28,091 | Common Stock | $19.00 | -$533,729.00 | 5.98 [ Very High ] | 28,091 | $533,729.00 | 5.98 [Average] | Form 4 | - | 2020-05-27 | Cooperatieve Gilde Healthcare Iv U.a. | - | Buy | 342,329 | Common Stock | $19.00 | -$6,504,251.00 | 72.91 [ Very High ] | 342,329 | $6,504,251.00 | 72.91 [High] | Form 4 | See footnote | 2020-05-27 | Cooperatieve Gilde Healthcare Iv U.a. | - | Buy | 7,599,350 | Common Stock | $0.00 | $0.00 | - | 7,941,679 | $0.00 | 1,691.52 [Very High] | Form 4 | See footnote | 2020-05-27 | Catherine M. Szyman | - | Buy | 28,091 | Common Stock | $19.00 | -$533,729.00 | 5.98 [ Very High ] | 28,091 | $533,729.00 | 5.98 [Average] | Form 4 | - | 2020-05-27 | Versant Ventures Iv, Llc | - | Buy | 5,745,542 | Common Stock | $0.00 | $0.00 | - | 5,745,542 | $0.00 | 1,223.76 [Very High] | Form 4 | See footnote | 2020-05-27 | Kirk G. Nielsen | - | Buy | 5,745,542 | Common Stock | $0.00 | $0.00 | - | 5,745,542 | $0.00 | 1,223.76 [Very High] | Form 4 | See footnote | 2020-05-27 | Mitch C. Hill, | Chief Financial Officer | Buy | 7,500 | Common Stock | $19.00 | -$142,500.00 | 1.60 [ High ] | 7,500 | $142,500.00 | 1.60 [Low] | Form 4 | - | 2020-05-27 | Mitch C. Hill, | Chief Financial Officer | Buy | 1,600 | Common Stock | $19.00 | -$30,400.00 | 0.34 [ Average ] | 1,600 | $30,400.00 | 0.34 [Very Low] | Form 4 | By Spouse | 2020-05-27 | Andrew Hykes | Chief Commercial Officer | Buy | 13,570 | Common Stock | $0.00 | $0.00 | - | 314,941 | $0.00 | 67.08 [High] | Form 4 | - | 2020-05-27 | Andrew Hykes | Chief Commercial Officer | Buy | 1,000 | Common Stock | $19.00 | -$19,000.00 | 0.21 [ Low ] | 1,000 | $19,000.00 | 0.21 [Very Low] | Form 4 | By Spouse | 2020-05-27 | Andrew Hykes | Chief Commercial Officer | Buy | 1,550 | Common Stock | $19.00 | -$29,450.00 | 0.33 [ Average ] | 1,550 | $29,450.00 | 0.33 [Very Low] | Form 4 | By Child 1 | 2020-05-27 | Andrew Hykes | Chief Commercial Officer | Buy | 1,550 | Common Stock | $19.00 | -$29,450.00 | 0.33 [ Average ] | 1,550 | $29,450.00 | 0.33 [Very Low] | Form 4 | By Child 2 | 2020-05-27 | Andrew Hykes | Chief Commercial Officer | Buy | 1,550 | Common Stock | $19.00 | -$29,450.00 | 0.33 [ Average ] | 1,550 | $29,450.00 | 0.33 [Very Low] | Form 4 | By Child 3 | 2020-05-27 | Thomas Tu | Chief Medical Officer | Buy | 28,091 | Common Stock | $19.00 | -$533,729.00 | 5.98 [ Very High ] | 28,091 | $533,729.00 | 5.98 [Average] | Form 4 | - | 2020-11-27 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 13,956 | Common Stock | $66.99 | $934,912.44 | 2.87 [ Very High ] | 7,927,723 | $531,078,163.77 | 1,627.50 [Very High] | Form 4 | See footnote | 2020-11-27 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 11,200 | Common Stock | $68.28 | $764,736.00 | 2.30 [ High ] | 7,916,523 | $540,540,190.44 | 1,625.20 [Very High] | Form 4 | See footnote | 2020-11-27 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 53,484 | Common Stock | $68.94 | $3,687,186.96 | 10.98 [ Very High ] | 7,863,039 | $542,077,908.66 | 1,614.22 [Very High] | Form 4 | See footnote | 2020-11-30 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 14,770 | Common Stock | $65.81 | $972,013.70 | 3.03 [ Very High ] | 7,848,269 | $516,494,582.89 | 1,611.19 [Very High] | Form 4 | See footnote | 2020-11-30 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 65,795 | Common Stock | $66.94 | $4,404,317.30 | 13.51 [ Very High ] | 7,782,474 | $520,958,809.56 | 1,597.68 [Very High] | Form 4 | See footnote | 2020-11-30 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 78,696 | Common Stock | $67.74 | $5,330,867.04 | 16.16 [ Very High ] | 7,703,778 | $521,853,921.72 | 1,581.53 [Very High] | Form 4 | See footnote | 2020-11-30 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 39,955 | Common Stock | $68.81 | $2,749,303.55 | 8.20 [ Very High ] | 7,663,823 | $527,347,660.63 | 1,573.32 [Very High] | Form 4 | See footnote | 2020-12-01 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 88,435 | Common Stock | $67.06 | $5,930,451.10 | 18.16 [ Very High ] | 7,575,388 | $508,005,519.28 | 1,555.17 [Very High] | Form 4 | See footnote | 2020-12-01 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 73,435 | Common Stock | $67.93 | $4,988,439.55 | 15.08 [ Very High ] | 7,501,953 | $509,607,667.29 | 1,540.09 [Very High] | Form 4 | See footnote | 2020-12-01 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 2,818 | Common Stock | $69.07 | $194,639.26 | 0.58 [ Average ] | 7,499,135 | $517,965,254.45 | 1,539.52 [Very High] | Form 4 | See footnote | 2020-11-30 | Thomas Tu | Chief Medical Officer | Buy | 3,500 | Common Stock | $0.46 | -$1,610.00 | 0.72 [ Average ] | 31,591 | $14,531.86 | 6.49 [Average] | Form 4 | - | 2020-11-30 | Thomas Tu | Chief Medical Officer | Sell | 300 | Common Stock | $66.10 | $19,830.00 | 0.06 [ Very Low ] | 31,291 | $2,068,335.10 | 6.42 [Average] | Form 4 | - | 2020-11-30 | Thomas Tu | Chief Medical Officer | Sell | 1,900 | Common Stock | $67.44 | $128,136.00 | 0.39 [ Average ] | 29,391 | $1,982,129.04 | 6.03 [Average] | Form 4 | - | 2020-11-30 | Thomas Tu | Chief Medical Officer | Sell | 1,000 | Common Stock | $68.34 | $68,340.00 | 0.21 [ Low ] | 28,391 | $1,940,240.94 | 5.83 [Average] | Form 4 | - | 2020-11-30 | Thomas Tu | Chief Medical Officer | Sell | 300 | Common Stock | $69.07 | $20,721.00 | 0.06 [ Very Low ] | 28,091 | $1,940,245.37 | 5.77 [Average] | Form 4 | - | 2020-11-30 | Andrew Hykes | Chief Operating Officer | Sell | 1,400 | Common Stock | $65.69 | $91,966.00 | 0.29 [ Low ] | 313,541 | $20,596,508.29 | 64.37 [High] | Form 4 | - | 2020-11-30 | Andrew Hykes | Chief Operating Officer | Sell | 9,112 | Common Stock | $67.11 | $611,506.32 | 1.87 [ High ] | 304,429 | $20,430,230.19 | 62.50 [High] | Form 4 | - | 2020-11-30 | Andrew Hykes | Chief Operating Officer | Sell | 10,772 | Common Stock | $67.87 | $731,095.64 | 2.21 [ High ] | 293,657 | $19,930,500.59 | 60.29 [High] | Form 4 | - | 2020-11-30 | Andrew Hykes | Chief Operating Officer | Sell | 6,116 | Common Stock | $68.81 | $420,841.96 | 1.26 [ High ] | 287,541 | $19,785,696.21 | 59.03 [High] | Form 4 | - | 2020-12-04 | William Hoffman | President and CEO | Sell | 11,085 | Common Stock | $64.22 | $711,878.70 | 2.28 [ High ] | 1,310,831 | $84,181,566.82 | 269.10 [Very High] | Form 4 | - | 2020-12-04 | William Hoffman | President and CEO | Sell | 18,915 | Common Stock | $64.85 | $1,226,637.75 | 3.88 [ Very High ] | 1,291,916 | $83,780,752.60 | 265.22 [Very High] | Form 4 | - | 2020-12-03 | Mitch C. Hill, | Chief Financial Officer | Buy | 50,000 | Common Stock | $0.46 | -$23,000.00 | 10.26 [ Very High ] | 57,500 | $26,450.00 | 11.80 [Average] | Form 4 | - | 2020-12-07 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 70,939 | Common Stock | $65.10 | $4,618,128.90 | 14.56 [ Very High ] | 7,333,069 | $477,382,791.90 | 1,505.42 [Very High] | Form 4 | See footnote | 2020-12-08 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 28,677 | Common Stock | $65.35 | $1,874,041.95 | 5.89 [ Very High ] | 7,304,392 | $477,342,017.20 | 1,499.54 [Very High] | Form 4 | See footnote | 2020-12-09 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 36,715 | Common Stock | $65.88 | $2,418,784.20 | 7.54 [ Very High ] | 7,267,677 | $478,794,560.76 | 1,492.00 [Very High] | Form 4 | See footnote | 2020-12-09 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 112,780 | Common Stock | $66.75 | $7,528,065.00 | 23.15 [ Very High ] | 7,154,897 | $477,589,374.75 | 1,468.85 [Very High] | Form 4 | See footnote | 2020-12-09 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 5,729 | Common Stock | $67.33 | $385,733.57 | 1.18 [ High ] | 7,149,168 | $481,353,481.44 | 1,467.67 [Very High] | Form 4 | See footnote | 2020-12-08 | Mitch C. Hill, | Chief Financial Officer | Buy | 5,000 | Common Stock | $0.46 | -$2,300.00 | 1.03 [ High ] | 62,500 | $28,750.00 | 12.83 [Average] | Form 4 | - | 2020-12-08 | Mitch C. Hill, | Chief Financial Officer | Sell | 4,141 | Common Stock | $64.73 | $268,046.93 | 0.85 [ High ] | 58,359 | $3,777,578.07 | 11.98 [Average] | Form 4 | - | 2020-12-08 | Mitch C. Hill, | Chief Financial Officer | Sell | 859 | Common Stock | $65.49 | $56,255.91 | 0.18 [ Low ] | 57,500 | $3,765,675.00 | 11.80 [Average] | Form 4 | - | 2020-12-10 | Donald B Milder | - | Sell | 2,393 | Common Stock | $67.75 | $162,125.75 | 0.49 [ Average ] | 5,031,221 | $340,865,222.75 | 1,032.87 [Very High] | Form 4 | Milder Community Property Trust | 2020-12-10 | Donald B Milder | - | Sell | 4,607 | Common Stock | $68.26 | $314,473.82 | 0.95 [ High ] | 5,026,614 | $343,116,671.64 | 1,031.93 [Very High] | Form 4 | Milder Community Property Trust | 2020-12-10 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 8,419 | Common Stock | $67.04 | $564,409.76 | 1.73 [ High ] | 7,140,749 | $478,715,812.96 | 1,465.94 [Very High] | Form 4 | See footnote | 2020-12-10 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 29,444 | Common Stock | $67.81 | $1,996,597.64 | 6.04 [ Very High ] | 7,111,305 | $482,217,592.05 | 1,459.90 [Very High] | Form 4 | See footnote | 2020-12-10 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 98,180 | Common Stock | $68.22 | $6,697,839.60 | 20.16 [ Very High ] | 7,013,125 | $478,435,387.50 | 1,439.74 [Very High] | Form 4 | See footnote | 2020-12-11 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 66,371 | Common Stock | $66.60 | $4,420,308.60 | 13.63 [ Very High ] | 6,946,754 | $462,653,816.40 | 1,426.12 [Very High] | Form 4 | See footnote | 2020-12-11 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 5,075 | Common Stock | $67.39 | $342,004.25 | 1.04 [ High ] | 6,941,679 | $467,799,747.81 | 1,425.07 [Very High] | Form 4 | See footnote | 2020-12-18 | Andrew Hykes | Chief Operating Officer | Sell | 4,169 | Common Stock | $72.13 | $300,709.97 | 0.86 [ High ] | 283,372 | $20,439,622.36 | 58.17 [High] | Form 4 | - | 2020-12-18 | Andrew Hykes | Chief Operating Officer | Sell | 12,202 | Common Stock | $71.41 | $871,344.82 | 2.50 [ High ] | 271,170 | $19,364,249.70 | 55.67 [High] | Form 4 | - | 2020-12-18 | Andrew Hykes | Chief Operating Officer | Sell | 3,859 | Common Stock | $70.47 | $271,943.73 | 0.79 [ Average ] | 267,311 | $18,837,406.17 | 54.88 [High] | Form 4 | - | 2020-12-18 | Andrew Hykes | Chief Operating Officer | Sell | 7,170 | Common Stock | $69.35 | $497,239.50 | 1.47 [ High ] | 260,141 | $18,040,778.35 | 53.40 [High] | Form 4 | - | 2020-12-18 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 63,840 | Common Stock | $70.52 | $4,501,996.80 | 13.11 [ Very High ] | 6,877,839 | $485,025,206.28 | 1,411.97 [Very High] | Form 4 | See footnote | 2020-12-18 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 110,474 | Common Stock | $71.53 | $7,902,205.22 | 22.68 [ Very High ] | 6,767,365 | $484,069,618.45 | 1,389.29 [Very High] | Form 4 | See footnote | 2020-12-18 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 41,878 | Common Stock | $72.16 | $3,021,916.48 | 8.60 [ Very High ] | 6,725,487 | $485,311,141.92 | 1,380.69 [Very High] | Form 4 | See footnote | 2020-12-21 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 11,885 | Common Stock | $70.41 | $836,822.85 | 2.44 [ High ] | 6,713,602 | $472,704,716.82 | 1,378.25 [Very High] | Form 4 | See footnote | 2020-12-21 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 13,125 | Common Stock | $71.73 | $941,456.25 | 2.69 [ Very High ] | 6,700,477 | $480,625,215.21 | 1,375.56 [Very High] | Form 4 | See footnote | 2020-12-21 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 54,257 | Common Stock | $72.47 | $3,932,004.79 | 11.14 [ Very High ] | 6,646,220 | $481,651,563.40 | 1,364.42 [Very High] | Form 4 | See footnote | 2020-12-21 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 71,415 | Common Stock | $73.47 | $5,246,860.05 | 14.66 [ Very High ] | 6,574,805 | $483,050,923.35 | 1,349.76 [Very High] | Form 4 | See footnote | 2020-12-21 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 44,268 | Common Stock | $74.53 | $3,299,294.04 | 9.09 [ Very High ] | 6,530,537 | $486,720,922.61 | 1,340.67 [Very High] | Form 4 | See footnote | 2020-12-22 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 20,754 | Common Stock | $76.11 | $1,579,586.94 | 4.26 [ Very High ] | 6,509,783 | $495,459,584.13 | 1,336.41 [Very High] | Form 4 | See footnote | 2020-12-22 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 71,340 | Common Stock | $77.22 | $5,508,874.80 | 14.65 [ Very High ] | 6,438,443 | $497,176,568.46 | 1,321.76 [Very High] | Form 4 | See footnote | 2020-12-22 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 98,190 | Common Stock | $78.21 | $7,679,439.90 | 20.16 [ Very High ] | 6,340,253 | $495,871,187.13 | 1,301.61 [Very High] | Form 4 | See footnote | 2020-12-22 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 4,880 | Common Stock | $78.57 | $383,421.60 | 1.00 [ High ] | 6,335,373 | $497,770,256.61 | 1,300.60 [Very High] | Form 4 | See footnote | 2020-12-22 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 4,714 | Common Stock | $74.48 | $351,098.72 | 0.97 [ High ] | 6,330,659 | $471,507,482.32 | 1,299.64 [Very High] | Form 4 | See footnote | 2020-12-22 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 5,287 | Common Stock | $76.12 | $402,446.44 | 1.09 [ High ] | 6,325,372 | $481,487,316.64 | 1,298.55 [Very High] | Form 4 | See footnote | 2020-12-22 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 43,841 | Common Stock | $77.22 | $3,385,402.02 | 9.00 [ Very High ] | 6,281,531 | $485,059,823.82 | 1,289.55 [Very High] | Form 4 | See footnote | 2020-12-22 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 6,316 | Common Stock | $77.79 | $491,321.64 | 1.30 [ High ] | 6,275,215 | $488,148,974.85 | 1,288.25 [Very High] | Form 4 | See footnote | 2020-12-22 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 28,700 | Common Stock | $78.31 | $2,247,497.00 | 5.89 [ Very High ] | 6,246,515 | $489,164,589.65 | 1,282.36 [Very High] | Form 4 | See footnote | 2020-12-21 | Thomas Tu | Chief Medical Officer | Buy | 1,500 | Common Stock | $0.46 | -$690.00 | 0.31 [ Average ] | 29,591 | $13,611.86 | 6.07 [Average] | Form 4 | - | 2020-12-21 | Thomas Tu | Chief Medical Officer | Sell | 1,500 | Common Stock | $74.00 | $111,000.00 | 0.31 [ Average ] | 28,091 | $2,078,734.00 | 5.77 [Average] | Form 4 | - | 2020-12-23 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 46,365 | Common Stock | $79.51 | $3,686,481.15 | 9.52 [ Very High ] | 6,200,150 | $492,973,926.50 | 1,272.84 [Very High] | Form 4 | See footnote | 2020-12-23 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 164,392 | Common Stock | $80.45 | $13,225,336.40 | 33.75 [ Very High ] | 6,035,758 | $485,576,731.10 | 1,239.10 [Very High] | Form 4 | See footnote | 2020-12-23 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 42,643 | Common Stock | $81.36 | $3,469,434.48 | 8.75 [ Very High ] | 5,993,115 | $487,599,836.40 | 1,230.34 [Very High] | Form 4 | See footnote | 2020-12-23 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 8,926 | Common Stock | $82.04 | $732,289.04 | 1.83 [ High ] | 5,984,189 | $490,942,865.56 | 1,228.51 [Very High] | Form 4 | See footnote | 2020-12-23 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 2,234 | Common Stock | $83.40 | $186,315.60 | 0.46 [ Average ] | 5,981,955 | $498,895,047.00 | 1,228.05 [Very High] | Form 4 | See footnote | 2020-12-23 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 1,208 | Common Stock | $84.27 | $101,798.16 | 0.25 [ Low ] | 5,980,747 | $503,997,549.69 | 1,227.80 [Very High] | Form 4 | See footnote | 2020-12-24 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 5,852 | Common Stock | $80.79 | $472,783.08 | 1.20 [ High ] | 5,974,895 | $482,711,767.05 | 1,226.60 [Very High] | Form 4 | See footnote | 2020-12-24 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 22,439 | Common Stock | $81.73 | $1,833,939.47 | 4.61 [ Very High ] | 5,952,456 | $486,494,228.88 | 1,221.99 [Very High] | Form 4 | See footnote | 2020-12-24 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 8,830 | Common Stock | $82.64 | $729,711.20 | 1.81 [ High ] | 5,943,626 | $491,181,252.64 | 1,220.18 [Very High] | Form 4 | See footnote | 2020-12-24 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 1,947 | Common Stock | $83.47 | $162,516.09 | 0.40 [ Average ] | 5,941,679 | $495,951,946.13 | 1,219.78 [Very High] | Form 4 | See footnote | 2021-01-04 | William Hoffman | President and CEO | Sell | 40,118 | Common Stock | $83.86 | $3,364,295.48 | 8.24 [ Very High ] | 1,251,798 | $104,975,780.28 | 256.98 [Very High] | Form 4 | - | 2021-01-04 | William Hoffman | President and CEO | Sell | 49,783 | Common Stock | $84.45 | $4,204,174.35 | 10.22 [ Very High ] | 1,202,015 | $101,510,166.75 | 246.76 [Very High] | Form 4 | - | 2021-01-04 | William Hoffman | President and CEO | Sell | 8,811 | Common Stock | $85.62 | $754,397.82 | 1.81 [ High ] | 1,193,204 | $102,162,126.48 | 244.96 [Very High] | Form 4 | - | 2021-01-04 | William Hoffman | President and CEO | Sell | 1,288 | Common Stock | $86.73 | $111,708.24 | 0.26 [ Low ] | 1,191,916 | $103,374,874.68 | 244.69 [Very High] | Form 4 | - | 2021-01-04 | Kirk G. Nielsen | - | Sell | 856,437 | Common Stock | $0.00 | $0.00 | - | 1,427,394 | $0.00 | 293.03 [Very High] | Form 4 | See footnote | 2021-01-04 | Kirk G. Nielsen | - | Buy | 220,530 | Common Stock | $0.00 | $0.00 | - | 220,530 | $0.00 | 45.27 [High] | Form 4 | See footnote | 2021-01-04 | Kirk G. Nielsen | - | Sell | 220,530 | Common Stock | $0.00 | $0.00 | - | 0 | $0.00 | - | Form 4 | See footnote | 2021-01-04 | Kirk G. Nielsen | - | Buy | 11,932 | Common Stock | $0.00 | $0.00 | - | 26,638 | $0.00 | 5.47 [Average] | Form 4 | - | 2021-01-04 | Kirk G. Nielsen | - | Sell | 5,395 | Common Stock | $0.00 | $0.00 | - | 8,991 | $0.00 | 1.85 [Low] | Form 4 | See footnote | 2021-01-05 | Andrew Hykes | Chief Operating Officer | Sell | 6,486 | Common Stock | $77.86 | $504,999.96 | 1.33 [ High ] | 253,655 | $19,749,578.30 | 52.07 [High] | Form 4 | - | 2021-01-05 | Andrew Hykes | Chief Operating Officer | Sell | 8,514 | Common Stock | $78.81 | $670,988.34 | 1.75 [ High ] | 245,141 | $19,319,562.21 | 50.33 [High] | Form 4 | - | 2021-01-05 | Andrew Hykes | Chief Operating Officer | Sell | 4,600 | Common Stock | $80.07 | $368,322.00 | 0.94 [ High ] | 240,541 | $19,260,117.87 | 49.38 [High] | Form 4 | - | 2021-01-05 | Andrew Hykes | Chief Operating Officer | Sell | 3,175 | Common Stock | $81.23 | $257,905.25 | 0.65 [ Average ] | 237,366 | $19,281,240.18 | 48.73 [High] | Form 4 | - | 2021-01-05 | Andrew Hykes | Chief Operating Officer | Sell | 4,215 | Common Stock | $81.86 | $345,039.90 | 0.87 [ High ] | 233,151 | $19,085,740.86 | 47.86 [High] | Form 4 | - | 2021-01-05 | Andrew Hykes | Chief Operating Officer | Sell | 610 | Common Stock | $82.78 | $50,495.80 | 0.13 [ Low ] | 232,541 | $19,249,743.98 | 47.74 [High] | Form 4 | - | 2020-12-08 | Mitch C. Hill, | Chief Financial Officer | Buy | 5,000 | Common Stock | $0.46 | -$2,300.00 | 1.03 [ High ] | 62,500 | $28,750.00 | 12.83 [Average] | Form 4 | - | 2021-01-08 | Mitch C. Hill, | Chief Financial Officer | Sell | 1,700 | Common Stock | $81.98 | $139,366.00 | 0.35 [ Average ] | 60,800 | $4,984,384.00 | 12.48 [Average] | Form 4 | - | 2021-01-08 | Mitch C. Hill, | Chief Financial Officer | Sell | 1,857 | Common Stock | $82.83 | $153,815.31 | 0.38 [ Average ] | 58,943 | $4,882,248.69 | 12.10 [Average] | Form 4 | - | 2021-01-08 | Mitch C. Hill, | Chief Financial Officer | Sell | 1,443 | Common Stock | $83.80 | $120,923.40 | 0.30 [ Average ] | 57,500 | $4,818,500.00 | 11.80 [Average] | Form 4 | - | 2021-01-11 | Donald B Milder | - | Sell | 799 | Common Stock | $83.29 | $66,548.71 | 0.16 [ Low ] | 5,025,815 | $418,600,131.35 | 1,031.76 [Very High] | Form 4 | Milder Community Property Trust | 2021-01-11 | Donald B Milder | - | Sell | 1,411 | Common Stock | $84.38 | $119,060.18 | 0.29 [ Low ] | 5,024,404 | $423,959,209.52 | 1,031.47 [Very High] | Form 4 | Milder Community Property Trust | 2021-01-11 | Donald B Milder | - | Sell | 4,790 | Common Stock | $84.88 | $406,575.20 | 0.98 [ High ] | 5,019,614 | $426,064,836.32 | 1,030.49 [Very High] | Form 4 | Milder Community Property Trust | 2021-01-13 | William Hoffman | President and CEO | Sell | 21,821 | Common Stock | $90.26 | $1,969,563.46 | 4.48 [ Very High ] | 1,170,095 | $105,612,774.70 | 240.21 [Very High] | Form 4 | - | 2021-01-13 | William Hoffman | President and CEO | Sell | 6,681 | Common Stock | $91.39 | $610,576.59 | 1.37 [ High ] | 1,163,414 | $106,324,405.46 | 238.84 [Very High] | Form 4 | - | 2021-01-13 | William Hoffman | President and CEO | Sell | 1,498 | Common Stock | $92.02 | $137,845.96 | 0.31 [ Average ] | 1,161,916 | $106,919,510.32 | 238.53 [Very High] | Form 4 | - | 2021-01-13 | Kirk G. Nielsen | - | Sell | 856,437 | Common Stock | $0.00 | $0.00 | - | 570,957 | $0.00 | 117.21 [Very High] | Form 4 | See footnote | 2021-01-13 | Kirk G. Nielsen | - | Buy | 220,532 | Common Stock | $0.00 | $0.00 | - | 220,532 | $0.00 | 45.27 [High] | Form 4 | See footnote | 2021-01-13 | Kirk G. Nielsen | - | Sell | 220,532 | Common Stock | $0.00 | $0.00 | - | 0 | $0.00 | - | Form 4 | See footnote | 2021-01-13 | Kirk G. Nielsen | - | Buy | 11,933 | Common Stock | $0.00 | $0.00 | - | 38,571 | $0.00 | 7.92 [Average] | Form 4 | - | 2021-01-13 | Kirk G. Nielsen | - | Sell | 5,395 | Common Stock | $0.00 | $0.00 | - | 3,596 | $0.00 | 0.74 [Very Low] | Form 4 | See footnote | 2021-01-13 | Andrew Hykes | Chief Operating Officer | Sell | 8,045 | Common Stock | $93.70 | $753,816.50 | 1.65 [ High ] | 224,496 | $21,035,275.20 | 46.09 [High] | Form 4 | - | 2021-01-13 | Andrew Hykes | Chief Operating Officer | Sell | 6,547 | Common Stock | $94.70 | $620,000.90 | 1.34 [ High ] | 217,949 | $20,639,770.30 | 44.74 [High] | Form 4 | - | 2021-01-13 | Andrew Hykes | Chief Operating Officer | Sell | 9,007 | Common Stock | $95.76 | $862,510.32 | 1.85 [ High ] | 208,942 | $20,008,285.92 | 42.89 [High] | Form 4 | - | 2021-01-13 | Andrew Hykes | Chief Operating Officer | Sell | 3,701 | Common Stock | $96.63 | $357,627.63 | 0.76 [ Average ] | 205,241 | $19,832,437.83 | 42.13 [High] | Form 4 | - | 2021-01-13 | Andrew Hykes | Chief Operating Officer | Sell | 300 | Common Stock | $97.49 | $29,247.00 | 0.06 [ Very Low ] | 204,941 | $19,979,698.09 | 42.07 [High] | Form 4 | - | 2021-01-13 | Mitch C. Hill, | Chief Financial Officer | Buy | 36,000 | Common Stock | $0.46 | -$16,560.00 | 7.39 [ Very High ] | 93,500 | $43,010.00 | 19.19 [High] | Form 4 | - | 2021-01-13 | Mitch C. Hill, | Chief Financial Officer | Sell | 27,313 | Common Stock | $90.29 | $2,466,090.77 | 5.61 [ Very High ] | 66,187 | $5,976,024.23 | 13.59 [Average] | Form 4 | - | 2021-01-13 | Mitch C. Hill, | Chief Financial Officer | Sell | 7,489 | Common Stock | $91.38 | $684,344.82 | 1.54 [ High ] | 58,698 | $5,363,823.24 | 12.05 [Average] | Form 4 | - | 2021-01-13 | Mitch C. Hill, | Chief Financial Officer | Sell | 1,198 | Common Stock | $92.01 | $110,227.98 | 0.25 [ Low ] | 57,500 | $5,290,575.00 | 11.80 [Average] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 300 | Common Stock | $94.21 | $28,263.00 | 0.06 [ Very Low ] | 204,641 | $19,279,228.61 | 42.01 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 900 | Common Stock | $95.38 | $85,842.00 | 0.18 [ Low ] | 203,741 | $19,432,816.58 | 41.83 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 600 | Common Stock | $96.69 | $58,014.00 | 0.12 [ Low ] | 203,141 | $19,641,703.29 | 41.70 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 600 | Common Stock | $97.94 | $58,764.00 | 0.12 [ Low ] | 202,541 | $19,836,865.54 | 41.58 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 600 | Common Stock | $98.72 | $59,232.00 | 0.12 [ Low ] | 201,941 | $19,935,615.52 | 41.46 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 400 | Common Stock | $94.32 | $37,728.00 | 0.08 [ Very Low ] | 201,541 | $19,009,347.12 | 41.37 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 800 | Common Stock | $95.23 | $76,184.00 | 0.16 [ Low ] | 200,741 | $19,116,565.43 | 41.21 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 600 | Common Stock | $96.69 | $58,014.00 | 0.12 [ Low ] | 200,141 | $19,351,633.29 | 41.09 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 599 | Common Stock | $97.97 | $58,684.03 | 0.12 [ Low ] | 199,542 | $19,549,129.74 | 40.96 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 601 | Common Stock | $98.71 | $59,324.71 | 0.12 [ Low ] | 198,941 | $19,637,466.11 | 40.84 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 400 | Common Stock | $94.32 | $37,728.00 | 0.08 [ Very Low ] | 198,541 | $18,726,387.12 | 40.76 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 700 | Common Stock | $95.24 | $66,668.00 | 0.14 [ Low ] | 197,841 | $18,842,376.84 | 40.62 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 666 | Common Stock | $96.64 | $64,362.24 | 0.14 [ Low ] | 197,175 | $19,054,992.00 | 40.48 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 923 | Common Stock | $98.16 | $90,601.68 | 0.19 [ Low ] | 196,252 | $19,264,096.32 | 40.29 [High] | Form 4 | - | 2021-01-19 | Andrew Hykes | Chief Operating Officer | Sell | 311 | Common Stock | $98.75 | $30,711.25 | 0.06 [ Very Low ] | 195,941 | $19,349,173.75 | 40.23 [High] | Form 4 | - | 2021-01-20 | William Hoffman | President and CEO | Sell | 14,900 | Common Stock | $100.32 | $1,494,768.00 | 3.06 [ Very High ] | 1,147,016 | $115,068,645.12 | 235.47 [Very High] | Form 4 | - | 2021-01-20 | William Hoffman | President and CEO | Sell | 3,500 | Common Stock | $101.53 | $355,355.00 | 0.72 [ Average ] | 1,143,516 | $116,101,179.48 | 234.76 [Very High] | Form 4 | - | 2021-01-20 | William Hoffman | President and CEO | Sell | 1,600 | Common Stock | $102.15 | $163,440.00 | 0.33 [ Average ] | 1,141,916 | $116,646,719.40 | 234.43 [Very High] | Form 4 | - | 2021-01-20 | Thomas Tu | Chief Medical Officer | Buy | 12,000 | Common Stock | $0.46 | -$5,520.00 | 2.46 [ High ] | 40,091 | $18,441.86 | 8.23 [Average] | Form 4 | - | 2021-01-20 | Thomas Tu | Chief Medical Officer | Sell | 11,100 | Common Stock | $100.33 | $1,113,663.00 | 2.28 [ High ] | 28,991 | $2,908,667.03 | 5.95 [Average] | Form 4 | - | 2021-01-20 | Thomas Tu | Chief Medical Officer | Sell | 900 | Common Stock | $101.52 | $91,368.00 | 0.18 [ Low ] | 28,091 | $2,851,798.32 | 5.77 [Average] | Form 4 | - | 2021-01-27 | Thomas Tu | Chief Medical Officer | Buy | 5,000 | Common Stock | $0.46 | -$2,300.00 | 1.03 [ High ] | 33,091 | $15,221.86 | 6.79 [Average] | Form 4 | - | 2021-01-27 | Thomas Tu | Chief Medical Officer | Sell | 1,055 | Common Stock | $92.32 | $97,397.60 | 0.22 [ Low ] | 32,036 | $2,957,563.52 | 6.58 [Average] | Form 4 | - | 2021-01-27 | Thomas Tu | Chief Medical Officer | Sell | 345 | Common Stock | $93.46 | $32,243.70 | 0.07 [ Very Low ] | 31,691 | $2,961,840.86 | 6.51 [Average] | Form 4 | - | 2021-01-27 | Thomas Tu | Chief Medical Officer | Sell | 600 | Common Stock | $95.77 | $57,462.00 | 0.12 [ Low ] | 31,091 | $2,977,585.07 | 6.38 [Average] | Form 4 | - | 2021-01-27 | Thomas Tu | Chief Medical Officer | Sell | 400 | Common Stock | $97.33 | $38,932.00 | 0.08 [ Very Low ] | 30,691 | $2,987,155.03 | 6.30 [Average] | Form 4 | - | 2021-01-27 | Thomas Tu | Chief Medical Officer | Sell | 400 | Common Stock | $98.56 | $39,424.00 | 0.08 [ Very Low ] | 30,291 | $2,985,480.96 | 6.22 [Average] | Form 4 | - | 2021-01-27 | Thomas Tu | Chief Medical Officer | Sell | 600 | Common Stock | $99.58 | $59,748.00 | 0.12 [ Low ] | 29,691 | $2,956,629.78 | 6.10 [Average] | Form 4 | - | 2021-01-27 | Thomas Tu | Chief Medical Officer | Sell | 300 | Common Stock | $101.92 | $30,576.00 | 0.06 [ Very Low ] | 29,391 | $2,995,530.72 | 6.03 [Average] | Form 4 | - | 2021-01-27 | Thomas Tu | Chief Medical Officer | Sell | 700 | Common Stock | $103.29 | $72,303.00 | 0.14 [ Low ] | 28,691 | $2,963,493.39 | 5.89 [Average] | Form 4 | - | 2021-01-27 | Thomas Tu | Chief Medical Officer | Sell | 300 | Common Stock | $106.40 | $31,920.00 | 0.06 [ Very Low ] | 28,391 | $3,020,802.40 | 5.83 [Average] | Form 4 | - | 2021-01-27 | Thomas Tu | Chief Medical Officer | Sell | 300 | Common Stock | $108.17 | $32,451.00 | 0.06 [ Very Low ] | 28,091 | $3,038,603.47 | 5.77 [Average] | Form 4 | - | 2021-02-05 | William Hoffman | President and CEO | Sell | 1,600 | Common Stock | $107.05 | $171,280.00 | 0.33 [ Average ] | 1,140,316 | $122,070,827.80 | 234.10 [Very High] | Form 4 | - | 2021-02-05 | William Hoffman | President and CEO | Sell | 2,000 | Common Stock | $108.04 | $216,080.00 | 0.41 [ Average ] | 1,138,316 | $122,983,660.64 | 233.69 [Very High] | Form 4 | - | 2021-02-05 | William Hoffman | President and CEO | Sell | 5,792 | Common Stock | $110.36 | $639,205.12 | 1.19 [ High ] | 1,132,524 | $124,985,348.64 | 232.50 [Very High] | Form 4 | - | 2021-02-05 | William Hoffman | President and CEO | Sell | 16,005 | Common Stock | $111.32 | $1,781,676.60 | 3.29 [ Very High ] | 1,116,519 | $124,290,895.08 | 229.21 [Very High] | Form 4 | - | 2021-02-05 | William Hoffman | President and CEO | Sell | 3,503 | Common Stock | $111.95 | $392,160.85 | 0.72 [ Average ] | 1,113,016 | $124,602,141.20 | 228.49 [Very High] | Form 4 | - | 2021-02-05 | William Hoffman | President and CEO | Sell | 1,100 | Common Stock | $122.97 | $135,267.00 | 0.23 [ Low ] | 1,111,916 | $136,732,310.52 | 228.27 [Very High] | Form 4 | - | 2021-02-09 | Mitch C. Hill, | Chief Financial Officer | Buy | 5,000 | Common Stock | $0.46 | -$2,300.00 | 1.03 [ High ] | 62,500 | $28,750.00 | 12.83 [Average] | Form 4 | - | 2021-02-09 | Mitch C. Hill, | Chief Financial Officer | Sell | 2,377 | Common Stock | $112.53 | $267,483.81 | 0.49 [ Average ] | 60,123 | $6,765,641.19 | 12.34 [Average] | Form 4 | - | 2021-02-09 | Mitch C. Hill, | Chief Financial Officer | Sell | 1,823 | Common Stock | $113.10 | $206,181.30 | 0.37 [ Average ] | 58,300 | $6,593,730.00 | 11.97 [Average] | Form 4 | - | 2021-02-09 | Mitch C. Hill, | Chief Financial Officer | Sell | 400 | Common Stock | $114.45 | $45,780.00 | 0.08 [ Very Low ] | 57,900 | $6,626,655.00 | 11.89 [Average] | Form 4 | - | 2021-02-09 | Mitch C. Hill, | Chief Financial Officer | Sell | 300 | Common Stock | $115.88 | $34,764.00 | 0.06 [ Very Low ] | 57,600 | $6,674,688.00 | 11.82 [Average] | Form 4 | - | 2021-02-09 | Mitch C. Hill, | Chief Financial Officer | Sell | 100 | Common Stock | $116.93 | $11,693.00 | 0.02 [ Very Low ] | 57,500 | $6,723,475.00 | 11.80 [Average] | Form 4 | - | 2021-02-10 | Donald B Milder | - | Sell | 3,207 | Common Stock | $112.37 | $360,370.59 | 0.66 [ Average ] | 5,016,407 | $563,693,654.59 | 1,029.83 [Very High] | Form 4 | Milder Community Property Trust | 2021-02-10 | Donald B Milder | - | Sell | 3,148 | Common Stock | $113.16 | $356,227.68 | 0.65 [ Average ] | 5,013,259 | $567,300,388.44 | 1,029.18 [Very High] | Form 4 | Milder Community Property Trust | 2021-02-10 | Donald B Milder | - | Sell | 100 | Common Stock | $113.82 | $11,382.00 | 0.02 [ Very Low ] | 5,013,159 | $570,597,757.38 | 1,029.16 [Very High] | Form 4 | Milder Community Property Trust | 2021-02-10 | Donald B Milder | - | Sell | 300 | Common Stock | $116.02 | $34,806.00 | 0.06 [ Very Low ] | 5,012,859 | $581,591,901.18 | 1,029.10 [Very High] | Form 4 | Milder Community Property Trust | 2021-02-10 | Donald B Milder | - | Sell | 245 | Common Stock | $117.53 | $28,794.85 | 0.05 [ Very Low ] | 5,012,614 | $589,132,523.42 | 1,029.05 [Very High] | Form 4 | Milder Community Property Trust | 2021-02-11 | Andrew Hykes | Chief Operating Officer | Buy | 16,030 | Common Stock | $0.00 | $0.00 | - | 211,971 | $0.00 | 43.52 [High] | Form 4 | - | 2021-02-19 | Andrew Hykes | Chief Operating Officer | Sell | 300 | Common Stock | $115.04 | $34,512.00 | 0.06 [ Very Low ] | 211,671 | $24,350,631.84 | 43.45 [High] | Form 4 | - | 2021-02-19 | Andrew Hykes | Chief Operating Officer | Sell | 1,501 | Common Stock | $116.48 | $174,836.48 | 0.31 [ Average ] | 210,170 | $24,480,601.60 | 43.15 [High] | Form 4 | - | 2021-02-19 | Andrew Hykes | Chief Operating Officer | Sell | 4,672 | Common Stock | $117.67 | $549,754.24 | 0.96 [ High ] | 205,498 | $24,180,949.66 | 42.19 [High] | Form 4 | - | 2021-02-19 | Andrew Hykes | Chief Operating Officer | Sell | 1,507 | Common Stock | $118.62 | $178,760.34 | 0.31 [ Average ] | 203,991 | $24,197,412.42 | 41.88 [High] | Form 4 | - | 2021-02-19 | Andrew Hykes | Chief Operating Officer | Sell | 1,020 | Common Stock | $119.38 | $121,767.60 | 0.21 [ Low ] | 202,971 | $24,230,677.98 | 41.67 [High] | Form 4 | - | 2021-02-11 | William Hoffman | President and CEO | Buy | 21,380 | Common Stock | $0.00 | $0.00 | - | 1,133,296 | $0.00 | 232.66 [Very High] | Form 4 | - | 2021-02-11 | Mitch C. Hill, | Chief Financial Officer | Buy | 10,690 | Common Stock | $0.00 | $0.00 | - | 68,190 | $0.00 | 14.00 [Average] | Form 4 | - | 2021-02-11 | Thomas Tu | Chief Medical Officer | Buy | 10,690 | Common Stock | $0.00 | $0.00 | - | 38,781 | $0.00 | 7.96 [Average] | Form 4 | - | 2021-02-26 | Thomas Tu | Chief Medical Officer | Buy | 5,000 | Common Stock | $0.46 | -$2,300.00 | 1.03 [ High ] | 44,344 | $20,398.24 | 9.10 [Average] | Form 4 | - | 2021-02-26 | Thomas Tu | Chief Medical Officer | Sell | 400 | Common Stock | $101.40 | $40,560.00 | 0.08 [ Very Low ] | 43,944 | $4,455,921.60 | 9.02 [Average] | Form 4 | - | 2021-02-26 | Thomas Tu | Chief Medical Officer | Sell | 800 | Common Stock | $102.73 | $82,184.00 | 0.16 [ Low ] | 43,144 | $4,432,183.12 | 8.86 [Average] | Form 4 | - | 2021-02-26 | Thomas Tu | Chief Medical Officer | Sell | 2,024 | Common Stock | $103.84 | $210,172.16 | 0.42 [ Average ] | 41,120 | $4,269,900.80 | 8.44 [Average] | Form 4 | - | 2021-02-26 | Thomas Tu | Chief Medical Officer | Sell | 1,776 | Common Stock | $104.67 | $185,893.92 | 0.36 [ Average ] | 39,344 | $4,118,136.48 | 8.08 [Average] | Form 4 | - | 2021-03-05 | William Hoffman | President and CEO | Sell | 3,300 | Common Stock | $88.93 | $293,469.00 | 0.68 [ Average ] | 1,130,382 | $100,524,871.26 | 232.06 [Very High] | Form 4 | - | 2021-03-05 | William Hoffman | President and CEO | Sell | 3,100 | Common Stock | $89.96 | $278,876.00 | 0.64 [ Average ] | 1,127,282 | $101,410,288.72 | 231.42 [Very High] | Form 4 | - | 2021-03-05 | William Hoffman | President and CEO | Sell | 2,100 | Common Stock | $91.31 | $191,751.00 | 0.43 [ Average ] | 1,125,182 | $102,740,368.42 | 230.99 [Very High] | Form 4 | - | 2021-03-05 | William Hoffman | President and CEO | Sell | 7,150 | Common Stock | $92.53 | $661,589.50 | 1.47 [ High ] | 1,118,032 | $103,451,500.96 | 229.52 [Very High] | Form 4 | - | 2021-03-05 | William Hoffman | President and CEO | Sell | 10,997 | Common Stock | $93.69 | $1,030,308.93 | 2.26 [ High ] | 1,107,035 | $103,718,109.15 | 227.27 [Very High] | Form 4 | - | 2021-03-05 | William Hoffman | President and CEO | Sell | 2,508 | Common Stock | $94.45 | $236,880.60 | 0.51 [ Average ] | 1,104,527 | $104,322,575.15 | 226.75 [Very High] | Form 4 | - | 2021-03-05 | William Hoffman | President and CEO | Sell | 445 | Common Stock | $95.66 | $42,568.70 | 0.09 [ Very Low ] | 1,104,082 | $105,616,484.12 | 226.66 [Very High] | Form 4 | - | 2021-03-05 | William Hoffman | President and CEO | Sell | 400 | Common Stock | $96.52 | $38,608.00 | 0.08 [ Very Low ] | 1,103,682 | $106,527,386.64 | 226.58 [Very High] | Form 4 | - | 2021-03-09 | Mitch C. Hill, | Chief Financial Officer | Buy | 5,000 | Common Stock | $0.46 | -$2,300.00 | 1.01 [ High ] | 73,190 | $33,667.40 | 14.79 [High] | Form 4 | - | 2021-03-09 | Mitch C. Hill, | Chief Financial Officer | Sell | 100 | Common Stock | $94.05 | $9,405.00 | 0.02 [ Very Low ] | 73,090 | $6,874,114.50 | 14.77 [High] | Form 4 | - | 2021-03-09 | Mitch C. Hill, | Chief Financial Officer | Sell | 400 | Common Stock | $95.53 | $38,212.00 | 0.08 [ Very Low ] | 72,690 | $6,944,075.70 | 14.68 [High] | Form 4 | - | 2021-03-09 | Mitch C. Hill, | Chief Financial Officer | Sell | 1,500 | Common Stock | $97.44 | $146,160.00 | 0.30 [ Average ] | 71,190 | $6,936,753.60 | 14.38 [High] | Form 4 | - | 2021-03-09 | Mitch C. Hill, | Chief Financial Officer | Sell | 2,058 | Common Stock | $98.39 | $202,486.62 | 0.42 [ Average ] | 69,132 | $6,801,897.48 | 13.97 [Average] | Form 4 | - | 2021-03-09 | Mitch C. Hill, | Chief Financial Officer | Sell | 942 | Common Stock | $99.28 | $93,521.76 | 0.19 [ Low ] | 68,190 | $6,769,903.20 | 13.78 [Average] | Form 4 | - | 2021-03-10 | Donald B Milder | - | Sell | 300 | Common Stock | $113.51 | $34,053.00 | 0.06 [ Very Low ] | 5,012,314 | $568,947,762.14 | 1,012.57 [Very High] | Form 4 | Milder Community Property Trust | 2021-03-10 | Donald B Milder | - | Sell | 1,000 | Common Stock | $114.39 | $114,390.00 | 0.20 [ Low ] | 5,011,314 | $573,244,208.46 | 1,012.37 [Very High] | Form 4 | Milder Community Property Trust | 2021-03-10 | Donald B Milder | - | Sell | 1,500 | Common Stock | $115.55 | $173,325.00 | 0.30 [ Average ] | 5,009,814 | $578,884,007.70 | 1,012.06 [Very High] | Form 4 | Milder Community Property Trust | 2021-03-10 | Donald B Milder | - | Sell | 900 | Common Stock | $116.70 | $105,030.00 | 0.18 [ Low ] | 5,008,914 | $584,540,263.80 | 1,011.88 [Very High] | Form 4 | Milder Community Property Trust | 2021-03-10 | Donald B Milder | - | Sell | 2,100 | Common Stock | $117.51 | $246,771.00 | 0.42 [ Average ] | 5,006,814 | $588,350,713.14 | 1,011.46 [Very High] | Form 4 | Milder Community Property Trust | 2021-03-10 | Donald B Milder | - | Sell | 1,000 | Common Stock | $119.00 | $119,000.00 | 0.20 [ Low ] | 5,005,814 | $595,691,866.00 | 1,011.26 [Very High] | Form 4 | Milder Community Property Trust | 2021-03-10 | Donald B Milder | - | Sell | 200 | Common Stock | $119.63 | $23,926.00 | 0.04 [ Very Low ] | 5,005,614 | $598,821,602.82 | 1,011.21 [Very High] | Form 4 | Milder Community Property Trust | 2021-03-11 | Kirk G. Nielsen | - | Sell | 570,957 | Common Stock | $0.00 | $0.00 | - | 0 | $0.00 | - | Form 4 | See footnote | 2021-03-11 | Kirk G. Nielsen | - | Buy | 147,021 | Common Stock | $0.00 | $0.00 | - | 147,021 | $0.00 | 29.70 [High] | Form 4 | See footnote | 2021-03-11 | Kirk G. Nielsen | - | Sell | 147,021 | Common Stock | $0.00 | $0.00 | - | 0 | $0.00 | - | Form 4 | See footnote | 2021-03-11 | Kirk G. Nielsen | - | Buy | 7,955 | Common Stock | $0.00 | $0.00 | - | 46,526 | $0.00 | 9.40 [Average] | Form 4 | - | 2021-03-11 | Kirk G. Nielsen | - | Sell | 3,596 | Common Stock | $0.00 | $0.00 | - | 0 | $0.00 | - | Form 4 | See footnote | 2021-03-12 | Kirk G. Nielsen | - | Sell | 206 | Common Stock | $120.00 | $24,720.00 | 0.04 [ Very Low ] | 46,320 | $5,558,400.00 | 9.36 [Average] | Form 4 | - | 2021-03-12 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 47,935 | Common Stock | $115.15 | $5,519,715.25 | 9.68 [ Very High ] | 5,893,744 | $678,664,621.60 | 1,190.63 [Very High] | Form 4 | See footnote | 2021-03-12 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 113,990 | Common Stock | $115.84 | $13,204,601.60 | 23.03 [ Very High ] | 5,779,754 | $669,526,703.36 | 1,167.60 [Very High] | Form 4 | See footnote | 2021-03-12 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 32,926 | Common Stock | $116.92 | $3,849,707.92 | 6.65 [ Very High ] | 5,746,828 | $671,919,129.76 | 1,160.95 [Very High] | Form 4 | See footnote | 2021-03-12 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 18,700 | Common Stock | $117.86 | $2,203,982.00 | 3.78 [ Very High ] | 5,728,128 | $675,117,166.08 | 1,157.17 [Very High] | Form 4 | See footnote | 2021-03-12 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 24,689 | Common Stock | $119.01 | $2,938,237.89 | 4.99 [ Very High ] | 5,703,439 | $678,766,275.39 | 1,152.19 [Very High] | Form 4 | See footnote | 2021-03-12 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 11,760 | Common Stock | $119.81 | $1,408,965.60 | 2.38 [ High ] | 5,691,679 | $681,920,060.99 | 1,149.81 [Very High] | Form 4 | See footnote | 2021-03-15 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 4,707 | Common Stock | $113.21 | $532,879.47 | 0.95 [ High ] | 5,686,972 | $643,822,100.12 | 1,148.86 [Very High] | Form 4 | See footnote | 2021-03-15 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 89,169 | Common Stock | $114.22 | $10,184,883.18 | 18.01 [ Very High ] | 5,597,803 | $639,381,058.66 | 1,130.85 [Very High] | Form 4 | See footnote | 2021-03-15 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 49,316 | Common Stock | $115.15 | $5,678,737.40 | 9.96 [ Very High ] | 5,548,487 | $638,908,278.05 | 1,120.88 [Very High] | Form 4 | See footnote | 2021-03-15 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 33,799 | Common Stock | $116.17 | $3,926,429.83 | 6.83 [ Very High ] | 5,514,688 | $640,641,304.96 | 1,114.06 [Very High] | Form 4 | See footnote | 2021-03-15 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 20,663 | Common Stock | $116.96 | $2,416,744.48 | 4.17 [ Very High ] | 5,494,025 | $642,581,164.00 | 1,109.88 [Very High] | Form 4 | See footnote | 2021-03-15 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 2,346 | Common Stock | $117.98 | $276,781.08 | 0.47 [ Average ] | 5,491,679 | $647,908,288.42 | 1,109.41 [Very High] | Form 4 | See footnote | 2021-03-15 | Cooperatieve Gilde Healthcare Iv U.a. | - | Sell | 1,000,000 | Common Stock | $111.50 | $111,500,000.00 | 202.02 [ Very High ] | 4,491,679 | $500,822,208.50 | 907.39 [Very High] | Form 4 | See footnote | 2021-03-16 | Jonathan D Root | - | Sell | 2,619,872 | Common Stock | $0.00 | $0.00 | - | 2,619,872 | $0.00 | 529.26 [Very High] | Form 4 | Directly owned by USVP X | 2021-03-16 | Jonathan D Root | - | Sell | 83,814 | Common Stock | $0.00 | $0.00 | - | 83,813 | $0.00 | 16.93 [High] | Form 4 | Directly owned by AFF X | 2021-03-16 | Jonathan D Root | - | Buy | 685,827 | Common Stock | $0.00 | $0.00 | - | 685,827 | $0.00 | 138.55 [Very High] | Form 4 | Directly owned by PMG X | 2021-03-16 | Jonathan D Root | - | Sell | 685,827 | Common Stock | $0.00 | $0.00 | - | 0 | $0.00 | - | Form 4 | Directly owned by PMG X | 2021-03-16 | Jonathan D Root | - | Buy | 94,101 | Common Stock | $0.00 | $0.00 | - | 427,892 | $0.00 | 86.44 [Very High] | Form 4 | - | 2021-03-16 | Presidio Management Group X Llc | - | Sell | 2,619,872 | Common Stock | $0.00 | $0.00 | - | 2,619,872 | $0.00 | 529.26 [Very High] | Form 4 | Directly owned by USVP X | 2021-03-16 | Presidio Management Group X Llc | - | Sell | 83,814 | Common Stock | $0.00 | $0.00 | - | 83,813 | $0.00 | 16.93 [High] | Form 4 | Directly owned by AFF X | 2021-03-16 | Presidio Management Group X Llc | - | Buy | 685,827 | Common Stock | $0.00 | $0.00 | - | 685,827 | $0.00 | 138.55 [Very High] | Form 4 | Directly owned by PMG X. | 2021-03-16 | Presidio Management Group X Llc | - | Sell | 685,827 | Common Stock | $0.00 | $0.00 | - | 0 | $0.00 | - | Form 4 | Directly owned by PMG X. | 2021-03-16 | Presidio Management Group X Llc | - | Buy | 77,296 | Common Stock | $0.00 | $0.00 | - | 242,988 | $0.00 | 49.09 [High] | Form 4 | Directly owned by Tansey | 2021-03-17 | Andrew Hykes | Chief Operating Officer | Buy | 20,000 | Common Stock | $0.43 | -$8,600.00 | 4.04 [ Very High ] | 222,971 | $95,877.53 | 45.04 [High] | Form 4 | - | 2021-03-19 | Andrew Hykes | Chief Operating Officer | Sell | 1,400 | Common Stock | $106.89 | $149,646.00 | 0.28 [ Average ] | 221,571 | $23,683,724.19 | 44.76 [High] | Form 4 | - | 2021-03-19 | Andrew Hykes | Chief Operating Officer | Sell | 2,143 | Common Stock | $108.43 | $232,365.49 | 0.43 [ Average ] | 219,428 | $23,792,578.04 | 44.33 [High] | Form 4 | - | 2021-03-19 | Andrew Hykes | Chief Operating Officer | Sell | 2,400 | Common Stock | $109.56 | $262,944.00 | 0.48 [ Average ] | 217,028 | $23,777,587.68 | 43.84 [High] | Form 4 | - | 2021-03-19 | Andrew Hykes | Chief Operating Officer | Sell | 2,485 | Common Stock | $110.55 | $274,716.75 | 0.50 [ Average ] | 214,543 | $23,717,728.65 | 43.34 [High] | Form 4 | - | 2021-03-19 | Andrew Hykes | Chief Operating Officer | Sell | 572 | Common Stock | $111.07 | $63,532.04 | 0.12 [ Low ] | 213,971 | $23,765,758.97 | 43.23 [High] | Form 4 | - | 2021-03-26 | Thomas Tu | Chief Medical Officer | Buy | 5,000 | Common Stock | $0.46 | -$2,300.00 | 1.01 [ High ] | 44,344 | $20,398.24 | 8.96 [Average] | Form 4 | - | 2021-03-26 | Thomas Tu | Chief Medical Officer | Sell | 1,092 | Common Stock | $100.40 | $109,636.80 | 0.22 [ Low ] | 43,252 | $4,342,500.80 | 8.74 [Average] | Form 4 | - | 2021-03-26 | Thomas Tu | Chief Medical Officer | Sell | 100 | Common Stock | $100.94 | $10,094.00 | 0.02 [ Very Low ] | 43,152 | $4,355,762.88 | 8.72 [Average] | Form 4 | - | 2021-03-26 | Thomas Tu | Chief Medical Officer | Sell | 1,109 | Common Stock | $102.92 | $114,138.28 | 0.22 [ Low ] | 42,043 | $4,327,065.56 | 8.49 [Average] | Form 4 | - | 2021-03-26 | Thomas Tu | Chief Medical Officer | Sell | 709 | Common Stock | $103.88 | $73,650.92 | 0.14 [ Low ] | 41,334 | $4,293,775.92 | 8.35 [Average] | Form 4 | - | 2021-03-26 | Thomas Tu | Chief Medical Officer | Sell | 1,390 | Common Stock | $104.67 | $145,491.30 | 0.28 [ Average ] | 39,944 | $4,180,938.48 | 8.07 [Average] | Form 4 | - | 2021-03-26 | Thomas Tu | Chief Medical Officer | Sell | 600 | Common Stock | $105.94 | $63,564.00 | 0.12 [ Low ] | 39,344 | $4,168,103.36 | 7.95 [Average] | Form 4 | - | 2021-04-01 | William Hoffman | President and CEO | Sell | 459 | Common Stock | $109.21 | $50,127.39 | 0.09 [ Very Low ] | 1,103,223 | $120,482,983.83 | 222.87 [Very High] | Form 4 | - | 2021-04-01 | Thomas Tu | Chief Medical Officer | Sell | 252 | Common Stock | $109.21 | $27,520.92 | 0.05 [ Very Low ] | 39,092 | $4,269,237.32 | 7.90 [Average] | Form 4 | - | 2021-04-01 | Andrew Hykes | Chief Operating Officer | Sell | 360 | Common Stock | $109.21 | $39,315.60 | 0.07 [ Very Low ] | 213,611 | $23,328,457.31 | 43.15 [High] | Form 4 | - | 2021-04-01 | Mitch C. Hill, | Chief Financial Officer | Sell | 253 | Common Stock | $109.21 | $27,630.13 | 0.05 [ Very Low ] | 67,937 | $7,419,399.77 | 13.72 [Average] | Form 4 | - | 2020-12-03 | Donald B Milder | - | Sell | 210,000 | Common Stock | $0.00 | $0.00 | - | 4,795,614 | $0.00 | 968.79 [Very High] | Form 4 | Milder Community Property Trust | 2021-03-16 | Donald B Milder | - | Sell | 210,000 | Common Stock | $0.00 | $0.00 | - | 4,585,614 | $0.00 | 926.37 [Very High] | Form 4 | Milder Community Property Trust | 2021-04-05 | William Hoffman | President and CEO | Sell | 53,745 | Common Stock | $105.70 | $5,680,846.50 | 10.86 [ Very High ] | 1,049,478 | $110,929,824.60 | 212.01 [Very High] | Form 4 | - | 2021-04-05 | William Hoffman | President and CEO | Sell | 72,233 | Common Stock | $106.27 | $7,676,200.91 | 14.59 [ Very High ] | 977,245 | $103,851,826.15 | 197.42 [Very High] | Form 4 | - | 2021-04-05 | William Hoffman | President and CEO | Sell | 5,821 | Common Stock | $107.41 | $625,233.61 | 1.18 [ High ] | 971,424 | $104,340,651.84 | 196.24 [Very High] | Form 4 | - | 2021-04-05 | William Hoffman | President and CEO | Sell | 13,521 | Common Stock | $108.35 | $1,465,000.35 | 2.73 [ Very High ] | 957,903 | $103,788,790.05 | 193.51 [Very High] | Form 4 | - | 2021-04-05 | William Hoffman | President and CEO | Sell | 3,680 | Common Stock | $109.27 | $402,113.60 | 0.74 [ Average ] | 954,223 | $104,267,947.21 | 192.77 [Very High] | Form 4 | - | 2021-04-05 | William Hoffman | President and CEO | Sell | 1,000 | Common Stock | $110.79 | $110,790.00 | 0.20 [ Low ] | 953,223 | $105,607,576.17 | 192.57 [Very High] | Form 4 | - | 2021-03-15 | William Hoffman | President and CEO | Sell | 2,165 | Common Stock | $0.00 | $0.00 | - | 951,058 | $0.00 | 192.13 [Very High] | Form 4 | - |
