| Trade Date |
Insider |
Title |
Buy or Sell |
Quantity |
Security Type |
Price |
Proceeds |
Transaction Conviction |
Position Quantity |
Position Value |
Positon Conviction |
SEC Link |
Nature of Ownership |
2020-04-01 | Ra Capital Management, L.p. | - | Buy | 117,600 | Common Stock | $24.86 | -$2,923,536.00 | 40.60 [ Very High ] | 3,825,008 | $95,089,698.88 | 1,320.56 [Very High] | Form 4 | See Footnote | 2020-06-12 | Frazier Life Sciences Ix, L.p. | - | Sell | 1,456,854 | Common Stock | $0.00 | $0.00 | - | 5,827,415 | $0.00 | 2,011.88 [Very High] | Form 4 | - | 2020-06-25 | Azmi Nabulsi | Chief Operating Officer | Sell | 867,200 | Common Stock | $0.00 | $0.00 | - | 0 | $0.00 | - | Form 4 | - | 2020-06-25 | Azmi Nabulsi | Chief Operating Officer | Buy | 867,200 | Common Stock | $0.00 | $0.00 | - | 867,200 | $0.00 | 299.40 [Very High] | Form 4 | By Trust | 2020-11-02 | Azmi Nabulsi | Chief Operating Officer | Sell | 14,500 | Common Stock | $36.83 | $534,035.00 | 5.01 [ Very High ] | 852,700 | $31,404,941.00 | 294.39 [Very High] | Form 4 | By Trust | 2020-11-09 | David A Socks | - | Sell | 5,207 | Common Stock | $41.95 | $218,433.65 | 1.80 [ High ] | 1,682,139 | $70,565,731.05 | 580.75 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-11-09 | David A Socks | - | Sell | 5,477 | Common Stock | $42.67 | $233,703.59 | 1.89 [ High ] | 1,676,662 | $71,543,167.54 | 578.86 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-11-09 | David A Socks | - | Sell | 100 | Common Stock | $44.00 | $4,400.00 | 0.03 [ Very Low ] | 1,676,562 | $73,768,728.00 | 578.82 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-11-10 | David A Socks | - | Sell | 7,880 | Common Stock | $41.29 | $325,365.20 | 2.72 [ Very High ] | 1,668,682 | $68,899,879.78 | 576.10 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-11-10 | David A Socks | - | Sell | 4,601 | Common Stock | $42.31 | $194,668.31 | 1.59 [ High ] | 1,664,081 | $70,407,267.11 | 574.51 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-11-10 | David A Socks | - | Sell | 200 | Common Stock | $43.07 | $8,614.00 | 0.07 [ Very Low ] | 1,659,480 | $71,473,803.60 | 572.93 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-11-11 | David A Socks | - | Sell | 2,620 | Common Stock | $38.17 | $100,005.40 | 0.90 [ High ] | 1,656,860 | $63,242,346.20 | 572.02 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-11-11 | David A Socks | - | Sell | 3,354 | Common Stock | $39.22 | $131,543.88 | 1.16 [ High ] | 1,653,506 | $64,850,505.32 | 570.86 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-11-11 | David A Socks | - | Sell | 903 | Common Stock | $40.36 | $36,445.08 | 0.31 [ Average ] | 1,652,603 | $66,699,057.08 | 570.55 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-12-01 | Azmi Nabulsi | Chief Operating Officer | Sell | 5,370 | Common Stock | $43.99 | $236,226.30 | 1.85 [ High ] | 847,330 | $37,274,046.70 | 292.54 [Very High] | Form 4 | By Trust | 2020-12-01 | Azmi Nabulsi | Chief Operating Officer | Sell | 1,828 | Common Stock | $44.83 | $81,949.24 | 0.63 [ Average ] | 845,502 | $37,903,854.66 | 291.90 [Very High] | Form 4 | By Trust | 2020-12-02 | Azmi Nabulsi | Chief Operating Officer | Sell | 4,307 | Common Stock | $45.05 | $194,030.35 | 1.49 [ High ] | 841,195 | $37,895,834.75 | 290.42 [Very High] | Form 4 | By Trust | 2020-12-02 | Azmi Nabulsi | Chief Operating Officer | Sell | 2,995 | Common Stock | $45.57 | $136,482.15 | 1.03 [ High ] | 838,200 | $38,196,774.00 | 289.38 [Very High] | Form 4 | By Trust | 2020-12-16 | David A Socks | - | Sell | 5,000 | Common Stock | $46.22 | $231,100.00 | 1.73 [ High ] | 1,647,603 | $76,152,210.66 | 568.83 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-12-16 | David A Socks | - | Sell | 13,292 | Common Stock | $47.35 | $629,376.20 | 4.59 [ Very High ] | 1,634,311 | $77,384,625.85 | 564.24 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-12-16 | David A Socks | - | Sell | 12,954 | Common Stock | $48.19 | $624,253.26 | 4.47 [ Very High ] | 1,621,357 | $78,133,193.83 | 559.76 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-12-16 | David A Socks | - | Sell | 200 | Common Stock | $48.99 | $9,798.00 | 0.07 [ Very Low ] | 1,621,157 | $79,420,481.43 | 559.70 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-12-17 | David A Socks | - | Sell | 35,197 | Common Stock | $40.49 | $1,425,126.53 | 12.15 [ Very High ] | 1,585,960 | $64,215,520.40 | 547.54 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-12-17 | David A Socks | - | Sell | 12,915 | Common Stock | $41.43 | $535,068.45 | 4.46 [ Very High ] | 1,573,045 | $65,171,254.35 | 543.08 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-12-17 | David A Socks | - | Sell | 100 | Common Stock | $42.00 | $4,200.00 | 0.03 [ Very Low ] | 1,572,945 | $66,063,690.00 | 543.05 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-01-04 | Azmi Nabulsi | Chief Operating Officer | Sell | 4,932 | Common Stock | $33.02 | $162,854.64 | 1.58 [ High ] | 833,268 | $27,514,509.36 | 266.94 [Very High] | Form 4 | By Trust | 2020-01-04 | Azmi Nabulsi | Chief Operating Officer | Sell | 7,614 | Common Stock | $33.93 | $258,343.02 | 2.44 [ High ] | 825,654 | $28,014,440.22 | 264.51 [Very High] | Form 4 | By Trust | 2020-01-04 | Azmi Nabulsi | Chief Operating Officer | Sell | 100 | Common Stock | $34.57 | $3,457.00 | 0.03 [ Very Low ] | 825,554 | $28,539,401.78 | 264.47 [Very High] | Form 4 | By Trust | 2020-01-05 | Azmi Nabulsi | Chief Operating Officer | Sell | 1,854 | Common Stock | $33.77 | $62,609.58 | 0.59 [ Average ] | 823,700 | $27,816,349.00 | 263.88 [Very High] | Form 4 | By Trust | 2021-01-11 | David A Socks | - | Sell | 12,835 | Common Stock | $34.92 | $448,198.20 | 4.11 [ Very High ] | 1,560,110 | $54,479,041.20 | 499.79 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-01-12 | David A Socks | - | Sell | 7,074 | Common Stock | $35.74 | $252,824.76 | 2.27 [ High ] | 1,553,036 | $55,505,506.64 | 497.53 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-01-12 | David A Socks | - | Sell | 20,091 | Common Stock | $36.18 | $726,892.38 | 6.44 [ Very High ] | 1,532,945 | $55,461,950.10 | 491.09 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-02-01 | Azmi Nabulsi | Chief Operating Officer | Sell | 5,416 | Common Stock | $38.09 | $206,295.44 | 1.74 [ High ] | 818,284 | $31,168,437.56 | 262.14 [Very High] | Form 4 | By Trust | 2021-02-02 | Azmi Nabulsi | Chief Operating Officer | Sell | 2,700 | Common Stock | $40.51 | $109,377.00 | 0.86 [ High ] | 815,584 | $33,039,307.84 | 261.28 [Very High] | Form 4 | By Trust | 2021-02-02 | Azmi Nabulsi | Chief Operating Officer | Sell | 6,384 | Common Stock | $41.16 | $262,765.44 | 2.05 [ High ] | 809,200 | $33,306,672.00 | 259.23 [Very High] | Form 4 | By Trust | 2021-02-19 | David A Socks | - | Sell | 5,200 | Common Stock | $46.02 | $239,304.00 | 1.67 [ High ] | 1,500,745 | $69,064,284.90 | 480.78 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-02-19 | David A Socks | - | Sell | 21,360 | Common Stock | $47.08 | $1,005,628.80 | 6.84 [ Very High ] | 1,479,385 | $69,649,445.80 | 473.93 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-02-19 | David A Socks | - | Sell | 18,316 | Common Stock | $47.61 | $872,024.76 | 5.87 [ Very High ] | 1,461,069 | $69,561,495.09 | 468.07 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-02-22 | David A Socks | - | Sell | 11,482 | Common Stock | $45.27 | $519,790.14 | 3.68 [ Very High ] | 1,449,587 | $65,622,803.49 | 464.39 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-02-22 | David A Socks | - | Sell | 7,241 | Common Stock | $46.02 | $333,230.82 | 2.32 [ High ] | 1,442,346 | $66,376,762.92 | 462.07 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-02-22 | David A Socks | - | Sell | 1,417 | Common Stock | $46.99 | $66,584.83 | 0.45 [ Average ] | 1,440,929 | $67,709,253.71 | 461.61 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-02-23 | David A Socks | - | Sell | 1,019 | Common Stock | $42.50 | $43,307.50 | 0.33 [ Average ] | 1,439,910 | $61,196,175.00 | 461.29 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-02-23 | David A Socks | - | Sell | 1,881 | Common Stock | $43.35 | $81,541.35 | 0.60 [ Average ] | 1,438,029 | $62,338,557.15 | 460.69 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-02-23 | David A Socks | - | Sell | 2,084 | Common Stock | $44.70 | $93,154.80 | 0.67 [ Average ] | 1,435,945 | $64,186,741.50 | 460.02 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-03-01 | Azmi Nabulsi | Chief Operating Officer | Sell | 3,825 | Common Stock | $45.77 | $175,070.25 | 1.23 [ High ] | 805,375 | $36,862,013.75 | 258.01 [Very High] | Form 4 | By Trust | 2021-03-01 | Azmi Nabulsi | Chief Operating Officer | Sell | 1,548 | Common Stock | $46.05 | $71,285.40 | 0.50 [ Average ] | 803,827 | $37,016,233.35 | 257.51 [Very High] | Form 4 | By Trust | 2021-03-02 | Azmi Nabulsi | Chief Operating Officer | Sell | 600 | Common Stock | $44.59 | $26,754.00 | 0.19 [ Low ] | 803,227 | $35,815,891.93 | 257.32 [Very High] | Form 4 | By Trust | 2021-03-02 | Azmi Nabulsi | Chief Operating Officer | Sell | 4,833 | Common Stock | $46.16 | $223,091.28 | 1.55 [ High ] | 798,394 | $36,853,867.04 | 255.77 [Very High] | Form 4 | By Trust | 2021-03-02 | Azmi Nabulsi | Chief Operating Officer | Sell | 24 | Common Stock | $46.73 | $1,121.52 | - | 798,370 | $37,307,830.10 | 255.76 [Very High] | Form 4 | By Trust | 2021-03-02 | Azmi Nabulsi | Chief Operating Officer | Sell | 1,600 | Common Stock | $45.17 | $72,272.00 | 0.51 [ Average ] | 796,770 | $35,990,100.90 | 255.25 [Very High] | Form 4 | By Trust | 2021-03-02 | Azmi Nabulsi | Chief Operating Officer | Sell | 2,070 | Common Stock | $46.23 | $95,696.10 | 0.66 [ Average ] | 794,700 | $36,738,981.00 | 254.59 [Very High] | Form 4 | By Trust | 2021-03-10 | David A Socks | - | Sell | 2,425 | Common Stock | $48.32 | $117,176.00 | 0.78 [ High ] | 1,433,520 | $69,267,686.40 | 459.24 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-03-10 | David A Socks | - | Sell | 7,844 | Common Stock | $49.02 | $384,512.88 | 2.51 [ Very High ] | 1,425,676 | $69,886,637.52 | 456.73 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-03-10 | David A Socks | - | Sell | 1,802 | Common Stock | $49.93 | $89,973.86 | 0.58 [ Average ] | 1,423,874 | $71,094,028.82 | 456.15 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-03-11 | David A Socks | - | Sell | 41,698 | Common Stock | $47.18 | $1,967,311.64 | 13.36 [ Very High ] | 1,382,176 | $65,211,063.68 | 442.79 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-03-11 | David A Socks | - | Sell | 731 | Common Stock | $47.54 | $34,751.74 | 0.23 [ Low ] | 1,381,445 | $65,673,895.30 | 442.56 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-03-12 | David A Socks | - | Sell | 500 | Common Stock | $46.67 | $23,335.00 | 0.16 [ Low ] | 1,380,945 | $64,448,703.15 | 442.40 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-03-11 | Ra Capital Management, L.p. | - | Sell | 710,000 | Common Stock | $43.75 | $31,062,500.00 | 227.45 [ Very High ] | 3,115,008 | $136,281,600.00 | 997.92 [Very High] | Form 4 | See Footnote | 2021-03-22 | Terrie Curran | President and Chief Executive | Buy | 11,513 | Common Stock | $6.95 | -$80,015.35 | 3.69 [ Very High ] | 11,513 | $80,015.35 | 3.69 [Low] | Form 4 | - | 2021-03-22 | Terrie Curran | President and Chief Executive | Sell | 10,373 | Common Stock | $43.24 | $448,528.52 | 3.32 [ Very High ] | 1,140 | $49,293.60 | 0.37 [Very Low] | Form 4 | - | 2021-03-22 | Terrie Curran | President and Chief Executive | Sell | 1,140 | Common Stock | $44.08 | $50,251.20 | 0.37 [ Average ] | 0 | $0.00 | - | Form 4 | - | 2021-04-01 | Azmi Nabulsi | Chief Operating Officer | Sell | 3,405 | Common Stock | $37.28 | $126,938.40 | 1.09 [ High ] | 791,295 | $29,499,477.60 | 253.50 [Very High] | Form 4 | By Trust | 2021-04-01 | Azmi Nabulsi | Chief Operating Officer | Sell | 1,742 | Common Stock | $38.14 | $66,439.88 | 0.56 [ Average ] | 789,553 | $30,113,551.42 | 252.94 [Very High] | Form 4 | By Trust | 2021-04-05 | Azmi Nabulsi | Chief Operating Officer | Sell | 4,252 | Common Stock | $35.66 | $151,626.32 | 1.36 [ High ] | 785,301 | $28,003,833.66 | 251.58 [Very High] | Form 4 | By Trust | 2021-04-05 | Azmi Nabulsi | Chief Operating Officer | Sell | 4,316 | Common Stock | $36.37 | $156,972.92 | 1.38 [ High ] | 780,985 | $28,404,424.45 | 250.20 [Very High] | Form 4 | By Trust | 2021-04-05 | Azmi Nabulsi | Chief Operating Officer | Sell | 785 | Common Stock | $37.11 | $29,131.35 | 0.25 [ Low ] | 780,200 | $28,953,222.00 | 249.94 [Very High] | Form 4 | By Trust | 2021-04-05 | David A Socks | - | Sell | 12,619 | Common Stock | $35.69 | $450,372.11 | 4.04 [ Very High ] | 1,368,326 | $48,835,554.94 | 438.36 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-04-05 | David A Socks | - | Sell | 7,769 | Common Stock | $36.40 | $282,791.60 | 2.49 [ Very High ] | 1,360,557 | $49,524,274.80 | 435.87 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-04-05 | David A Socks | - | Sell | 1,730 | Common Stock | $37.15 | $64,269.50 | 0.55 [ Average ] | 1,358,827 | $50,480,423.05 | 435.31 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-04-06 | David A Socks | - | Sell | 1,400 | Common Stock | $34.96 | $48,944.00 | 0.45 [ Average ] | 1,357,427 | $47,455,647.92 | 434.86 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-04-06 | David A Socks | - | Sell | 3,359 | Common Stock | $35.97 | $120,823.23 | 1.08 [ High ] | 1,354,068 | $48,705,825.96 | 433.79 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-04-06 | David A Socks | - | Sell | 6,328 | Common Stock | $37.37 | $236,477.36 | 2.03 [ High ] | 1,347,740 | $50,365,043.80 | 431.76 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-04-06 | David A Socks | - | Sell | 6,795 | Common Stock | $38.03 | $258,413.85 | 2.18 [ High ] | 1,340,945 | $50,996,138.35 | 429.58 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust |
