Trade Date | Insider | Title | Buy or Sell | Quantity | Security Type | Price | Proceeds | Transaction Conviction | Position Quantity | Position Value | Positon Conviction | SEC Link | Nature of Ownership | 2020-04-01 | Ra Capital Management, L.p. | - | Buy | 117,600 | Common Stock | $24.86 | -$2,923,536.00 | 40.60 [ Very High ] | 3,825,008 | $95,089,698.88 | 1,320.56 [Very High] | Form 4 | See Footnote | 2020-06-12 | Frazier Life Sciences Ix, L.p. | - | Sell | 1,456,854 | Common Stock | $0.00 | $0.00 | - | 5,827,415 | $0.00 | 2,011.88 [Very High] | Form 4 | - | 2020-06-25 | Azmi Nabulsi | Chief Operating Officer | Sell | 867,200 | Common Stock | $0.00 | $0.00 | - | 0 | $0.00 | - | Form 4 | - | 2020-06-25 | Azmi Nabulsi | Chief Operating Officer | Buy | 867,200 | Common Stock | $0.00 | $0.00 | - | 867,200 | $0.00 | 299.40 [Very High] | Form 4 | By Trust | 2020-11-02 | Azmi Nabulsi | Chief Operating Officer | Sell | 14,500 | Common Stock | $36.83 | $534,035.00 | 5.01 [ Very High ] | 852,700 | $31,404,941.00 | 294.39 [Very High] | Form 4 | By Trust | 2020-11-09 | David A Socks | - | Sell | 5,207 | Common Stock | $41.95 | $218,433.65 | 1.80 [ High ] | 1,682,139 | $70,565,731.05 | 580.75 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-11-09 | David A Socks | - | Sell | 5,477 | Common Stock | $42.67 | $233,703.59 | 1.89 [ High ] | 1,676,662 | $71,543,167.54 | 578.86 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-11-09 | David A Socks | - | Sell | 100 | Common Stock | $44.00 | $4,400.00 | 0.03 [ Very Low ] | 1,676,562 | $73,768,728.00 | 578.82 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-11-10 | David A Socks | - | Sell | 7,880 | Common Stock | $41.29 | $325,365.20 | 2.72 [ Very High ] | 1,668,682 | $68,899,879.78 | 576.10 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-11-10 | David A Socks | - | Sell | 4,601 | Common Stock | $42.31 | $194,668.31 | 1.59 [ High ] | 1,664,081 | $70,407,267.11 | 574.51 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-11-10 | David A Socks | - | Sell | 200 | Common Stock | $43.07 | $8,614.00 | 0.07 [ Very Low ] | 1,659,480 | $71,473,803.60 | 572.93 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-11-11 | David A Socks | - | Sell | 2,620 | Common Stock | $38.17 | $100,005.40 | 0.90 [ High ] | 1,656,860 | $63,242,346.20 | 572.02 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-11-11 | David A Socks | - | Sell | 3,354 | Common Stock | $39.22 | $131,543.88 | 1.16 [ High ] | 1,653,506 | $64,850,505.32 | 570.86 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-11-11 | David A Socks | - | Sell | 903 | Common Stock | $40.36 | $36,445.08 | 0.31 [ Average ] | 1,652,603 | $66,699,057.08 | 570.55 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-12-01 | Azmi Nabulsi | Chief Operating Officer | Sell | 5,370 | Common Stock | $43.99 | $236,226.30 | 1.85 [ High ] | 847,330 | $37,274,046.70 | 292.54 [Very High] | Form 4 | By Trust | 2020-12-01 | Azmi Nabulsi | Chief Operating Officer | Sell | 1,828 | Common Stock | $44.83 | $81,949.24 | 0.63 [ Average ] | 845,502 | $37,903,854.66 | 291.90 [Very High] | Form 4 | By Trust | 2020-12-02 | Azmi Nabulsi | Chief Operating Officer | Sell | 4,307 | Common Stock | $45.05 | $194,030.35 | 1.49 [ High ] | 841,195 | $37,895,834.75 | 290.42 [Very High] | Form 4 | By Trust | 2020-12-02 | Azmi Nabulsi | Chief Operating Officer | Sell | 2,995 | Common Stock | $45.57 | $136,482.15 | 1.03 [ High ] | 838,200 | $38,196,774.00 | 289.38 [Very High] | Form 4 | By Trust | 2020-12-16 | David A Socks | - | Sell | 5,000 | Common Stock | $46.22 | $231,100.00 | 1.73 [ High ] | 1,647,603 | $76,152,210.66 | 568.83 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-12-16 | David A Socks | - | Sell | 13,292 | Common Stock | $47.35 | $629,376.20 | 4.59 [ Very High ] | 1,634,311 | $77,384,625.85 | 564.24 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-12-16 | David A Socks | - | Sell | 12,954 | Common Stock | $48.19 | $624,253.26 | 4.47 [ Very High ] | 1,621,357 | $78,133,193.83 | 559.76 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-12-16 | David A Socks | - | Sell | 200 | Common Stock | $48.99 | $9,798.00 | 0.07 [ Very Low ] | 1,621,157 | $79,420,481.43 | 559.70 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-12-17 | David A Socks | - | Sell | 35,197 | Common Stock | $40.49 | $1,425,126.53 | 12.15 [ Very High ] | 1,585,960 | $64,215,520.40 | 547.54 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-12-17 | David A Socks | - | Sell | 12,915 | Common Stock | $41.43 | $535,068.45 | 4.46 [ Very High ] | 1,573,045 | $65,171,254.35 | 543.08 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-12-17 | David A Socks | - | Sell | 100 | Common Stock | $42.00 | $4,200.00 | 0.03 [ Very Low ] | 1,572,945 | $66,063,690.00 | 543.05 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2020-01-04 | Azmi Nabulsi | Chief Operating Officer | Sell | 4,932 | Common Stock | $33.02 | $162,854.64 | 1.58 [ High ] | 833,268 | $27,514,509.36 | 266.94 [Very High] | Form 4 | By Trust | 2020-01-04 | Azmi Nabulsi | Chief Operating Officer | Sell | 7,614 | Common Stock | $33.93 | $258,343.02 | 2.44 [ High ] | 825,654 | $28,014,440.22 | 264.51 [Very High] | Form 4 | By Trust | 2020-01-04 | Azmi Nabulsi | Chief Operating Officer | Sell | 100 | Common Stock | $34.57 | $3,457.00 | 0.03 [ Very Low ] | 825,554 | $28,539,401.78 | 264.47 [Very High] | Form 4 | By Trust | 2020-01-05 | Azmi Nabulsi | Chief Operating Officer | Sell | 1,854 | Common Stock | $33.77 | $62,609.58 | 0.59 [ Average ] | 823,700 | $27,816,349.00 | 263.88 [Very High] | Form 4 | By Trust | 2021-01-11 | David A Socks | - | Sell | 12,835 | Common Stock | $34.92 | $448,198.20 | 4.11 [ Very High ] | 1,560,110 | $54,479,041.20 | 499.79 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-01-12 | David A Socks | - | Sell | 7,074 | Common Stock | $35.74 | $252,824.76 | 2.27 [ High ] | 1,553,036 | $55,505,506.64 | 497.53 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust | 2021-01-12 | David A Socks | - | Sell | 20,091 | Common Stock | $36.18 | $726,892.38 | 6.44 [ Very High ] | 1,532,945 | $55,461,950.10 | 491.09 [Very High] | Form 4 | David A. Socks 2013 Revocable Trust |
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