| Trade Date | Insider | Title | Buy or Sell | Quantity | Security Type | Price | Proceeds | Transaction Conviction | Position Quantity | Position Value | Positon Conviction | SEC Link | Nature of Ownership | 2020-08-17 | Gene G. Kinney | President and CEO | Buy | 10,000 | Ordinary Shares, par value $0.01 per share | $6.41 | -$64,100.00 | 2.51 [ Very High ] | 12,793 | $82,003.13 | 3.21 [Low] | Form 4 | - | 2021-02-12 | Wagner M. Zago | Chief Scientific Officer | Buy | 7,560 | Ordinary Shares, par value $0.01 per share | $6.41 | -$48,459.60 | 1.89 [ High ] | 7,560 | $48,459.60 | 1.89 [Low] | Form 4 | - | 2021-02-12 | Wagner M. Zago | Chief Scientific Officer | Sell | 7,560 | Ordinary Shares, par value $0.01 per share | $17.07 | $129,049.20 | 1.89 [ High ] | 0 | $0.00 | - | Form 4 | - | 2021-02-12 | Wagner M. Zago | Chief Scientific Officer | Buy | 18,750 | Ordinary Shares, par value $0.01 per share | $13.53 | -$253,687.50 | 4.70 [ Very High ] | 18,750 | $253,687.50 | 4.70 [Low] | Form 4 | - | 2021-02-12 | Wagner M. Zago | Chief Scientific Officer | Sell | 18,750 | Ordinary Shares, par value $0.01 per share | $20.00 | $375,000.00 | 4.70 [ Very High ] | 0 | $0.00 | - | Form 4 | - | 2021-02-12 | Capital, Llc Ecor1 | - | Buy | 62,500 | Ordinary Shares | $20.50 | -$1,281,250.00 | 15.66 [ Very High ] | 9,489,140 | $194,527,370.00 | 2,378.23 [Very High] | Form 4 | See Note 1 | 2021-02-12 | Capital, Llc Ecor1 | - | Buy | 282,800 | Ordinary Shares | $20.08 | -$5,678,624.00 | 70.88 [ Very High ] | 9,771,940 | $196,220,555.20 | 2,449.11 [Very High] | Form 4 | See Note 1 | 2021-02-16 | Capital, Llc Ecor1 | - | Buy | 89,200 | Ordinary Shares | $22.78 | -$2,031,976.00 | 22.36 [ Very High ] | 9,861,140 | $224,636,769.20 | 2,471.46 [Very High] | Form 4 | See Note 1 | 2021-02-17 | Capital, Llc Ecor1 | - | Buy | 198,840 | Ordinary Shares | $23.46 | -$4,664,786.40 | 49.83 [ Very High ] | 10,059,980 | $236,007,130.80 | 2,521.30 [Very High] | Form 4 | See Note 1 | 2021-02-18 | Wagner M. Zago | Chief Scientific Officer | Buy | 7,540 | Ordinary Shares, par value $0.01 per share | $6.41 | -$48,331.40 | 1.89 [ High ] | 7,540 | $48,331.40 | 1.89 [Low] | Form 4 | - | 2021-02-18 | Wagner M. Zago | Chief Scientific Officer | Sell | 7,540 | Ordinary Shares, par value $0.01 per share | $25.50 | $192,270.00 | 1.89 [ High ] | 0 | $0.00 | - | Form 4 | - | 2021-02-18 | Capital, Llc Ecor1 | - | Buy | 44,100 | Ordinary Shares | $3.68 | -$162,288.00 | 11.05 [ Very High ] | 10,104,080 | $37,183,014.40 | 2,532.35 [Very High] | Form 4 | See Note 1 |
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