| Trade Date | Insider | Title | Buy or Sell | Quantity | Security Type | Price | Proceeds | Transaction Conviction | Position Quantity | Position Value | Positon Conviction | SEC Link | Nature of Ownership | 2020-08-03 | Jay Parrish | Chief Business Officer | Buy | 1,851 | Common Stock | $1.57 | -$2,906.07 | 0.15 [ Low ] | 233,332 | $366,331.24 | 18.66 [High] | Form 4 | - | 2020-08-03 | Jay Parrish | Chief Business Officer | Buy | 9,259 | Common Stock | $1.49 | -$13,795.91 | 0.74 [ Average ] | 231,481 | $344,906.69 | 18.51 [High] | Form 4 | - | 2020-07-28 | Herbert Virgin | EVP, Research & CSO | Sell | 7,900 | Common Stock | $47.99 | $379,121.00 | 0.63 [ Average ] | 0 | $0.00 | - | Form 4 | - | 2020-07-28 | Herbert Virgin | EVP, Research & CSO | Sell | 7,900 | Common Stock | $47.99 | $379,121.00 | 0.63 [ Average ] | 0 | $0.00 | - | Form 4 | - | 2020-07-28 | Herbert Virgin | EVP, Research & CSO | Buy | 7,900 | Common Stock | $1.53 | -$12,087.00 | 0.63 [ Average ] | 7,900 | $12,087.00 | 0.63 [Very Low] | Form 4 | - | 2020-07-14 | Herbert Virgin | EVP, Research & CSO | Sell | 7,900 | Common Stock | $48.85 | $385,915.00 | 0.63 [ Average ] | 0 | $0.00 | - | Form 4 | - | 2020-07-14 | Herbert Virgin | EVP, Research & CSO | Buy | 7,900 | Common Stock | $1.53 | -$12,087.00 | 0.63 [ Average ] | 7,900 | $12,087.00 | 0.63 [Very Low] | Form 4 | - | 2020-07-15 | Phillip Pang | Chief Medical Officer | Sell | 7,500 | Common Stock | $49.52 | $371,400.00 | 0.60 [ Average ] | 15,777 | $781,277.04 | 1.26 [Very Low] | Form 4 | - | 2020-07-15 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $49.54 | $247,700.00 | 0.40 [ Average ] | 23,277 | $1,153,142.58 | 1.86 [Low] | Form 4 | - | 2020-07-15 | Phillip Pang | Chief Medical Officer | Buy | 10,186 | Common Stock | $1.57 | -$15,992.02 | 0.81 [ High ] | 25,963 | $40,761.91 | 2.08 [Low] | Form 4 | - | 2020-07-15 | Phillip Pang | Chief Medical Officer | Buy | 2,314 | Common Stock | $5.17 | -$11,963.38 | 0.19 [ Low ] | 28,277 | $146,192.09 | 2.26 [Low] | Form 4 | - | 2020-04-14 | George A Scangos | President and CEO | Sell | 236,806 | Common Stock | $29.56 | $6,999,985.36 | 18.94 [ Very High ] | 1,907,329 | $56,380,645.24 | 152.53 [Very High] | Form 4 | See footnote | 2020-04-14 | George A Scangos | President and CEO | Buy | 236,806 | Common Stock | $29.56 | -$6,999,985.36 | 18.94 [ Very High ] | 4,713,559 | $139,332,804.04 | 376.95 [Very High] | Form 4 | - | 2020-04-17 | Phillip Pang | Chief Medical Officer | Buy | 8,000 | Common Stock | $0.85 | -$6,800.00 | 0.64 [ Average ] | 15,777 | $13,410.45 | 1.26 [Very Low] | Form 4 | - | 2020-05-01 | Robert J More | - | Sell | 15,758 | Common Stock | $27.90 | $439,648.20 | 1.26 [ High ] | 74,234 | $2,071,128.60 | 5.94 [Average] | Form 4 | - | 2020-05-01 | Robert J More | - | Sell | 2,700 | Common Stock | $28.60 | $77,220.00 | 0.22 [ Low ] | 71,534 | $2,045,872.40 | 5.72 [Average] | Form 4 | - | 2020-05-14 | Jay Parrish | Chief Business Officer | Buy | 75,000 | Common Stock | $1.49 | -$111,750.00 | 6.00 [ Very High ] | 297,222 | $442,860.78 | 23.77 [High] | Form 4 | - | 2020-05-14 | Jay Parrish | Chief Business Officer | Sell | 75,000 | Common Stock | $30.05 | $2,253,750.00 | 6.00 [ Very High ] | 222,222 | $6,677,771.10 | 17.77 [High] | Form 4 | - | 2020-05-14 | Herbert Virgin | EVP, Research & CSO | Buy | 3,805 | Common Stock | $1.53 | -$5,821.65 | 0.30 [ Average ] | 3,805 | $5,821.65 | 0.30 [Very Low] | Form 4 | - | 2020-05-14 | Herbert Virgin | EVP, Research & CSO | Sell | 3,805 | Common Stock | $30.07 | $114,416.35 | 0.30 [ Average ] | 0 | $0.00 | - | Form 4 | - | 2020-05-18 | Herbert Virgin | EVP, Research & CSO | Buy | 1,755 | Common Stock | $1.53 | -$2,685.15 | 0.14 [ Low ] | 1,755 | $2,685.15 | 0.14 [Very Low] | Form 4 | - | 2020-05-18 | Herbert Virgin | EVP, Research & CSO | Sell | 1,755 | Common Stock | $38.00 | $66,690.00 | 0.14 [ Low ] | 0 | $0.00 | - | Form 4 | - | 2020-05-26 | Herbert Virgin | EVP, Research & CSO | Buy | 3,805 | Common Stock | $1.53 | -$5,821.65 | 0.30 [ Average ] | 3,805 | $5,821.65 | 0.30 [Very Low] | Form 4 | - | 2020-05-26 | Herbert Virgin | EVP, Research & CSO | Sell | 3,805 | Common Stock | $34.08 | $129,674.40 | 0.30 [ Average ] | 0 | $0.00 | - | Form 4 | - | 2020-06-01 | Howard Horn | CFO | Sell | 3,286 | Common Stock | $34.53 | $113,465.58 | - | 274,491 | $9,478,174.23 | - | Form 4 | - | 2020-06-01 | Howard Horn | CFO | Sell | 6,714 | Common Stock | $35.38 | $237,541.32 | - | 267,777 | $9,473,950.26 | - | Form 4 | - | 2020-06-01 | Jay Parrish | Chief Business Officer | Buy | 75,000 | Common Stock | $1.49 | -$111,750.00 | - | 297,222 | $442,860.78 | - | Form 4 | - | 2020-06-01 | Jay Parrish | Chief Business Officer | Sell | 75,000 | Common Stock | $35.22 | $2,641,500.00 | - | 222,222 | $7,826,658.84 | - | Form 4 | - | 2020-06-03 | Phillip Pang | Chief Medical Officer | Buy | 12,500 | Common Stock | $5.17 | -$64,625.00 | - | 28,277 | $146,192.09 | - | Form 4 | - | 2020-06-03 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $35.09 | $175,450.00 | - | 23,277 | $816,789.93 | - | Form 4 | - | 2020-06-03 | Phillip Pang | Chief Medical Officer | Sell | 7,500 | Common Stock | $35.06 | $262,950.00 | - | 15,777 | $553,141.62 | - | Form 4 | - | 2020-06-09 | Herbert Virgin | EVP, Research & CSO | Buy | 3,805 | Common Stock | $1.53 | -$5,821.65 | - | 3,805 | $5,821.65 | - | Form 4 | - | 2020-06-09 | Herbert Virgin | EVP, Research & CSO | Sell | 3,805 | Common Stock | $36.28 | $138,045.40 | - | 0 | $0.00 | - | Form 4 | - | 2020-07-13 | Howard Horn | CFO | Sell | 30,000 | Common Stock | $50.06 | $1,501,800.00 | 2.40 [ Very High ] | 177,777 | $8,899,516.62 | 14.22 [Average] | Form 4 | - | 2020-06-17 | Phillip Pang | Chief Medical Officer | Buy | 12,500 | Common Stock | $5.17 | -$64,625.00 | - | 28,277 | $146,192.09 | - | Form 4 | - | 2020-06-17 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $37.27 | $186,350.00 | - | 23,277 | $867,533.79 | - | Form 4 | - | 2020-06-17 | Phillip Pang | Chief Medical Officer | Sell | 7,500 | Common Stock | $37.26 | $279,450.00 | - | 15,777 | $587,851.02 | - | Form 4 | - | 2020-06-19 | Herbert Virgin | EVP, Research & CSO | Buy | 3,510 | Common Stock | $1.53 | -$5,370.30 | - | 3,510 | $5,370.30 | - | Form 4 | - | 2020-06-19 | Herbert Virgin | EVP, Research & CSO | Sell | 1,755 | Common Stock | $38.00 | $66,690.00 | - | 1,755 | $66,690.00 | - | Form 4 | - | 2020-06-19 | Herbert Virgin | EVP, Research & CSO | Sell | 1,755 | Common Stock | $38.00 | $66,690.00 | - | 0 | $0.00 | - | Form 4 | - | 2020-06-19 | Howard Horn | CFO | Sell | 10,000 | Common Stock | $40.00 | $400,000.00 | - | 257,777 | $10,311,080.00 | - | Form 4 | - | 2020-06-23 | Herbert Virgin | EVP, Research & CSO | Buy | 5,560 | Common Stock | $1.53 | -$8,506.80 | - | 5,560 | $8,506.80 | - | Form 4 | - | 2020-06-23 | Herbert Virgin | EVP, Research & CSO | Sell | 5,560 | Common Stock | $38.99 | $216,784.40 | - | 0 | $0.00 | - | Form 4 | - | 2020-06-24 | Herbert Virgin | EVP, Research & CSO | Buy | 9,360 | Common Stock | $1.53 | -$14,320.80 | - | 9,360 | $14,320.80 | - | Form 4 | - | 2020-06-24 | Herbert Virgin | EVP, Research & CSO | Sell | 9,360 | Common Stock | $48.00 | $449,280.00 | - | 0 | $0.00 | - | Form 4 | - | 2020-06-25 | Howard Horn | CFO | Sell | 30,000 | Common Stock | $50.00 | $1,500,000.00 | - | 227,777 | $11,388,850.00 | - | Form 4 | - | 2020-08-03 | Jay Parrish | Chief Business Officer | Sell | 11,110 | Common Stock | $47.65 | $529,391.50 | 0.89 [ High ] | 222,222 | $10,588,878.30 | 17.77 [High] | Form 4 | - | 2020-08-05 | Phillip Pang | Chief Medical Officer | Buy | 12,500 | Common Stock | $1.57 | -$19,625.00 | 0.99 [ High ] | 28,277 | $44,394.89 | 2.24 [Low] | Form 4 | - | 2020-08-05 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $50.91 | $254,550.00 | 0.40 [ Average ] | 23,277 | $1,185,032.07 | 1.85 [Low] | Form 4 | - | 2020-08-05 | Phillip Pang | Chief Medical Officer | Sell | 7,500 | Common Stock | $50.89 | $381,675.00 | 0.59 [ Average ] | 15,777 | $802,891.53 | 1.25 [Very Low] | Form 4 | - | 2020-08-05 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $50.91 | $254,550.00 | 0.40 [ Average ] | 23,277 | $1,185,032.07 | 1.85 [Low] | Form 4 | - | 2020-08-05 | Phillip Pang | Chief Medical Officer | Sell | 7,500 | Common Stock | $50.89 | $381,675.00 | 0.59 [ Average ] | 15,777 | $802,891.53 | 1.25 [Very Low] | Form 4 | - | 2020-08-11 | Herbert Virgin | EVP, Research & CSO | Buy | 7,900 | Common Stock | $1.53 | -$12,087.00 | 0.63 [ Average ] | 7,900 | $12,087.00 | 0.63 [Very Low] | Form 4 | - | 2020-08-11 | Herbert Virgin | EVP, Research & CSO | Sell | 7,900 | Common Stock | $51.08 | $403,532.00 | 0.63 [ Average ] | 0 | $0.00 | - | Form 4 | - | 2020-08-19 | Phillip Pang | Chief Medical Officer | Buy | 10,185 | Common Stock | $1.57 | -$15,990.45 | 0.80 [ High ] | 25,962 | $40,760.34 | 2.04 [Low] | Form 4 | - | 2020-08-19 | Phillip Pang | Chief Medical Officer | Buy | 2,315 | Common Stock | $5.17 | -$11,968.55 | 0.18 [ Low ] | 28,277 | $146,192.09 | 2.23 [Low] | Form 4 | - | 2020-08-19 | Phillip Pang | Chief Medical Officer | Buy | 14,000 | Common Stock | $0.85 | -$11,900.00 | 1.10 [ High ] | 42,277 | $35,935.45 | 3.33 [Low] | Form 4 | - | 2020-08-19 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $50.96 | $254,800.00 | 0.39 [ Average ] | 37,277 | $1,899,635.92 | 2.93 [Low] | Form 4 | - | 2020-08-19 | Phillip Pang | Chief Medical Officer | Sell | 7,500 | Common Stock | $50.94 | $382,050.00 | 0.59 [ Average ] | 29,777 | $1,516,840.38 | 2.34 [Low] | Form 4 | - | 2020-09-01 | Jay Parrish | Chief Business Officer | Buy | 6,943 | Common Stock | $1.57 | -$10,900.51 | 0.55 [ Average ] | 229,165 | $359,789.05 | 18.04 [High] | Form 4 | - | 2020-09-01 | Jay Parrish | Chief Business Officer | Sell | 6,943 | Common Stock | $39.15 | $271,818.45 | 0.55 [ Average ] | 222,222 | $8,699,991.30 | 17.49 [High] | Form 4 | - | 2020-09-02 | Phillip Pang | Chief Medical Officer | Buy | 12,500 | Common Stock | $1.57 | -$19,625.00 | 0.98 [ High ] | 42,277 | $66,374.89 | 3.33 [Low] | Form 4 | - | 2020-09-02 | Phillip Pang | Chief Medical Officer | Sell | 7,500 | Common Stock | $32.88 | $246,600.00 | 0.59 [ Average ] | 34,777 | $1,143,467.76 | 2.74 [Low] | Form 4 | - | 2020-09-02 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $32.91 | $164,550.00 | 0.39 [ Average ] | 29,777 | $979,961.07 | 2.34 [Low] | Form 4 | - | 2020-08-25 | Herbert Virgin | EVP, Research & CSO | Buy | 25,560 | Common Stock | $1.53 | -$39,106.80 | 2.01 [ High ] | 25,560 | $39,106.80 | 2.01 [Low] | Form 4 | - | 2020-08-25 | Herbert Virgin | EVP, Research & CSO | Sell | 5,560 | Common Stock | $42.92 | $238,635.20 | 0.44 [ Average ] | 20,000 | $858,400.00 | 1.57 [Low] | Form 4 | - | 2020-09-08 | Herbert Virgin | EVP, Research & CSO | Buy | 3,805 | Common Stock | $1.53 | -$5,821.65 | 0.30 [ Average ] | 23,805 | $36,421.65 | 1.87 [Low] | Form 4 | - | 2020-09-08 | Herbert Virgin | EVP, Research & CSO | Sell | 1,465 | Common Stock | $30.00 | $43,950.00 | 0.12 [ Low ] | 22,340 | $670,200.00 | 1.76 [Low] | Form 4 | - | 2020-09-08 | Herbert Virgin | EVP, Research & CSO | Sell | 2,340 | Common Stock | $29.98 | $70,153.20 | 0.18 [ Low ] | 20,000 | $599,600.00 | 1.57 [Low] | Form 4 | - | 2020-09-16 | Phillip Pang | Chief Medical Officer | Buy | 9,720 | Common Stock | $1.57 | -$15,260.40 | 0.77 [ Average ] | 39,497 | $62,010.29 | 3.11 [Low] | Form 4 | - | 2020-09-16 | Phillip Pang | Chief Medical Officer | Buy | 465 | Common Stock | $1.53 | -$711.45 | 0.04 [ Very Low ] | 39,962 | $61,141.86 | 3.15 [Low] | Form 4 | - | 2020-09-16 | Phillip Pang | Chief Medical Officer | Buy | 2,315 | Common Stock | $5.17 | -$11,968.55 | 0.18 [ Low ] | 42,277 | $218,572.09 | 3.33 [Low] | Form 4 | - | 2020-09-16 | Phillip Pang | Chief Medical Officer | Sell | 7,500 | Common Stock | $31.88 | $239,100.00 | 0.59 [ Average ] | 34,777 | $1,108,690.76 | 2.74 [Low] | Form 4 | - | 2020-09-16 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $31.92 | $159,600.00 | 0.39 [ Average ] | 29,777 | $950,481.84 | 2.34 [Low] | Form 4 | - | 2020-09-22 | Herbert Virgin | EVP, Research & CSO | Buy | 3,805 | Common Stock | $1.53 | -$5,821.65 | 0.30 [ Average ] | 23,805 | $36,421.65 | 1.87 [Low] | Form 4 | - | 2020-09-22 | Herbert Virgin | EVP, Research & CSO | Sell | 3,805 | Common Stock | $31.71 | $120,656.55 | 0.30 [ Average ] | 20,000 | $634,200.00 | 1.57 [Low] | Form 4 | - | 2020-09-24 | Herbert Virgin | EVP, Research & CSO | Buy | 3,700 | Common Stock | $1.53 | -$5,661.00 | 0.29 [ Low ] | 23,700 | $36,261.00 | 1.87 [Low] | Form 4 | - | 2020-09-29 | Herbert Virgin | EVP, Research & CSO | Buy | 3,510 | Common Stock | $1.53 | -$5,370.30 | 0.28 [ Low ] | 27,210 | $41,631.30 | 2.14 [Low] | Form 4 | - | 2020-09-29 | Herbert Virgin | EVP, Research & CSO | Sell | 3,510 | Common Stock | $38.00 | $133,380.00 | 0.28 [ Low ] | 23,700 | $900,600.00 | 1.87 [Low] | Form 4 | - | 2020-10-01 | Jay Parrish | Chief Business Officer | Buy | 4,630 | Common Stock | $1.49 | -$6,898.70 | 0.36 [ Average ] | 226,852 | $338,009.48 | 17.85 [High] | Form 4 | - | 2020-10-01 | Jay Parrish | Chief Business Officer | Buy | 2,315 | Common Stock | $1.57 | -$3,634.55 | 0.18 [ Low ] | 229,167 | $359,792.19 | 18.04 [High] | Form 4 | - | 2020-10-01 | Jay Parrish | Chief Business Officer | Sell | 6,945 | Common Stock | $34.75 | $241,338.75 | 0.55 [ Average ] | 222,222 | $7,722,214.50 | 17.49 [High] | Form 4 | - | 2020-10-07 | Phillip Pang | Chief Medical Officer | Buy | 10,185 | Common Stock | $1.53 | -$15,583.05 | 0.80 [ High ] | 39,962 | $61,141.86 | 3.15 [Low] | Form 4 | - | 2020-10-07 | Phillip Pang | Chief Medical Officer | Buy | 2,315 | Common Stock | $1.57 | -$3,634.55 | 0.18 [ Low ] | 42,277 | $66,374.89 | 3.33 [Low] | Form 4 | - | 2020-10-07 | Phillip Pang | Chief Medical Officer | Sell | 7,500 | Common Stock | $41.76 | $313,200.00 | 0.59 [ Average ] | 34,777 | $1,452,287.52 | 2.74 [Low] | Form 4 | - | 2020-10-07 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $41.73 | $208,650.00 | 0.39 [ Average ] | 29,777 | $1,242,594.21 | 2.34 [Low] | Form 4 | - | 2020-10-13 | Herbert Virgin | EVP, Research & CSO | Buy | 5,560 | Common Stock | $1.53 | -$8,506.80 | 0.44 [ Average ] | 29,260 | $44,767.80 | 2.30 [Low] | Form 4 | - | 2020-10-13 | Herbert Virgin | EVP, Research & CSO | Sell | 5,560 | Common Stock | $43.03 | $239,246.80 | 0.44 [ Average ] | 23,700 | $1,019,811.00 | 1.87 [Low] | Form 4 | - | 2020-10-21 | Phillip Pang | Chief Medical Officer | Buy | 7,870 | Common Stock | $1.53 | -$12,041.10 | 0.62 [ Average ] | 37,647 | $57,599.91 | 2.96 [Low] | Form 4 | - | 2020-10-21 | Phillip Pang | Chief Medical Officer | Buy | 2,315 | Common Stock | $1.57 | -$3,634.55 | 0.18 [ Low ] | 39,962 | $62,740.34 | 3.15 [Low] | Form 4 | - | 2020-10-21 | Phillip Pang | Chief Medical Officer | Buy | 2,315 | Common Stock | $5.17 | -$11,968.55 | 0.18 [ Low ] | 42,277 | $218,572.09 | 3.33 [Low] | Form 4 | - | 2020-10-21 | Phillip Pang | Chief Medical Officer | Sell | 7,500 | Common Stock | $35.42 | $265,650.00 | 0.59 [ Average ] | 34,777 | $1,231,801.34 | 2.74 [Low] | Form 4 | - | 2020-10-21 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $35.59 | $177,950.00 | 0.39 [ Average ] | 29,777 | $1,059,763.43 | 2.34 [Low] | Form 4 | - | 2020-10-27 | Herbert Virgin | EVP, Research & CSO | Buy | 3,805 | Common Stock | $1.53 | -$5,821.65 | 0.30 [ Average ] | 27,505 | $42,082.65 | 2.16 [Low] | Form 4 | - | 2020-10-27 | Herbert Virgin | EVP, Research & CSO | Sell | 3,805 | Common Stock | $35.04 | $133,327.20 | 0.30 [ Average ] | 23,700 | $830,448.00 | 1.87 [Low] | Form 4 | - | 2020-11-02 | Jay Parrish | Chief Business Officer | Buy | 4,629 | Common Stock | $1.49 | -$6,897.21 | 0.36 [ Average ] | 226,851 | $338,007.99 | 17.85 [High] | Form 4 | - | 2020-11-02 | Jay Parrish | Chief Business Officer | Buy | 2,315 | Common Stock | $1.57 | -$3,634.55 | 0.18 [ Low ] | 229,166 | $359,790.62 | 18.04 [High] | Form 4 | - | 2020-11-02 | Jay Parrish | Chief Business Officer | Sell | 6,944 | Common Stock | $31.27 | $217,138.88 | 0.55 [ Average ] | 222,222 | $6,948,881.94 | 17.49 [High] | Form 4 | - | 2020-11-04 | Phillip Pang | Chief Medical Officer | Buy | 5,000 | Common Stock | $1.53 | -$7,650.00 | 0.39 [ Average ] | 34,777 | $53,208.81 | 2.74 [Low] | Form 4 | - | 2020-10-21 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $31.44 | $157,200.00 | 0.39 [ Average ] | 29,777 | $936,188.88 | 2.34 [Low] | Form 4 | - | 2020-11-10 | Herbert Virgin | EVP, Research & CSO | Buy | 2,340 | Common Stock | $1.53 | -$3,580.20 | 0.18 [ Low ] | 26,040 | $39,841.20 | 2.04 [Low] | Form 4 | - | 2020-11-10 | Herbert Virgin | EVP, Research & CSO | Sell | 2,340 | Common Stock | $26.26 | $61,448.40 | 0.18 [ Low ] | 23,700 | $622,362.00 | 1.86 [Low] | Form 4 | - | 2020-11-12 | Phillip Pang | Chief Medical Officer | Buy | 20,000 | Common Stock | $0.85 | -$17,000.00 | 1.57 [ High ] | 49,777 | $42,310.45 | 3.91 [Low] | Form 4 | - | 2020-11-24 | Herbert Virgin | EVP, Research & CSO | Buy | 2,340 | Common Stock | $1.53 | -$3,580.20 | 0.18 [ Low ] | 26,040 | $39,841.20 | 2.04 [Low] | Form 4 | - | 2020-11-24 | Herbert Virgin | EVP, Research & CSO | Sell | 2,340 | Common Stock | $27.29 | $63,858.60 | 0.18 [ Low ] | 23,700 | $646,773.00 | 1.86 [Low] | Form 4 | - | 2020-11-27 | Herbert Virgin | EVP, Research & CSO | Buy | 2,930 | Common Stock | $1.53 | -$4,482.90 | 0.23 [ Low ] | 26,630 | $40,743.90 | 2.09 [Low] | Form 4 | - | 2020-11-27 | Herbert Virgin | EVP, Research & CSO | Sell | 2,930 | Common Stock | $30.00 | $87,900.00 | 0.23 [ Low ] | 23,700 | $711,000.00 | 1.86 [Low] | Form 4 | - | 2020-11-27 | Phillip Pang | Chief Medical Officer | Buy | 7,500 | Common Stock | $0.85 | -$6,375.00 | 0.59 [ Average ] | 57,277 | $48,685.45 | 4.50 [Low] | Form 4 | - | 2020-12-01 | Jay Parrish | Chief Business Officer | Buy | 4,630 | Common Stock | $1.49 | -$6,898.70 | 0.36 [ Average ] | 226,852 | $338,009.48 | 17.81 [High] | Form 4 | - | 2020-12-01 | Jay Parrish | Chief Business Officer | Buy | 2,315 | Common Stock | $1.57 | -$3,634.55 | 0.18 [ Low ] | 229,167 | $359,792.19 | 17.99 [High] | Form 4 | - | 2020-12-01 | Jay Parrish | Chief Business Officer | Sell | 6,945 | Common Stock | $31.53 | $218,975.85 | 0.55 [ Average ] | 222,222 | $7,006,659.66 | 17.44 [High] | Form 4 | - | 2020-12-08 | Herbert Virgin | EVP, Research & CSO | Buy | 3,805 | Common Stock | $1.53 | -$5,821.65 | 0.30 [ Average ] | 27,505 | $42,082.65 | 2.16 [Low] | Form 4 | - | 2020-12-08 | Herbert Virgin | EVP, Research & CSO | Sell | 3,805 | Common Stock | $31.27 | $118,982.35 | 0.30 [ Average ] | 23,700 | $741,099.00 | 1.86 [Low] | Form 4 | - | 2020-12-22 | Herbert Virgin | EVP, Research & CSO | Buy | 3,805 | Common Stock | $1.53 | -$5,821.65 | 0.30 [ Low ] | 27,505 | $42,082.65 | 2.16 [Low] | Form 4 | - | 2020-12-22 | Herbert Virgin | EVP, Research & CSO | Sell | 3,805 | Common Stock | $31.19 | $118,677.95 | 0.30 [ Low ] | 23,700 | $739,203.00 | 1.86 [Low] | Form 4 | - | 2020-12-24 | Herbert Virgin | EVP, Research & CSO | Buy | 9,500 | Common Stock | $1.53 | -$14,535.00 | 0.75 [ Average ] | 33,200 | $50,796.00 | 2.61 [Low] | Form 4 | - | 2021-01-04 | Jay Parrish | Chief Business Officer | Buy | 6,945 | Common Stock | $1.49 | -$10,348.05 | 0.55 [ Average ] | 229,167 | $341,458.83 | 17.99 [High] | Form 4 | - | 2021-01-04 | Jay Parrish | Chief Business Officer | Sell | 6,945 | Common Stock | $26.32 | $182,792.40 | 0.55 [ Average ] | 222,222 | $5,848,883.04 | 17.44 [High] | Form 4 | - | 2021-01-12 | Herbert Virgin | EVP, Research & CSO | Buy | 3,805 | Common Stock | $1.53 | -$5,821.65 | 0.30 [ Average ] | 37,005 | $56,617.65 | 2.90 [Low] | Form 4 | - | 2021-01-12 | Herbert Virgin | EVP, Research & CSO | Sell | 3,805 | Common Stock | $29.36 | $111,714.80 | 0.30 [ Average ] | 33,200 | $974,752.00 | 2.61 [Low] | Form 4 | - | 2021-01-15 | Herbert Virgin | EVP, Research & CSO | Buy | 10,530 | Common Stock | $1.53 | -$16,110.90 | 0.83 [ High ] | 43,730 | $66,906.90 | 3.43 [Low] | Form 4 | - | 2021-01-15 | Herbert Virgin | EVP, Research & CSO | Sell | 10,530 | Common Stock | $38.00 | $400,140.00 | 0.83 [ High ] | 33,200 | $1,261,600.00 | 2.61 [Low] | Form 4 | - |
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