| Trade Date |
Insider |
Title |
Buy or Sell |
Quantity |
Security Type |
Price |
Proceeds |
Transaction Conviction |
Position Quantity |
Position Value |
Positon Conviction |
SEC Link |
Nature of Ownership |
2020-08-03 | Jay Parrish | Chief Business Officer | Buy | 1,851 | Common Stock | $1.57 | -$2,906.07 | 0.15 [ Low ] | 233,332 | $366,331.24 | 18.66 [High] | Form 4 | - | 2020-08-03 | Jay Parrish | Chief Business Officer | Buy | 9,259 | Common Stock | $1.49 | -$13,795.91 | 0.74 [ Average ] | 231,481 | $344,906.69 | 18.51 [High] | Form 4 | - | 2020-07-28 | Herbert Virgin | EVP, Research & CSO | Sell | 7,900 | Common Stock | $47.99 | $379,121.00 | 0.63 [ Average ] | 0 | $0.00 | - | Form 4 | - | 2020-07-28 | Herbert Virgin | EVP, Research & CSO | Sell | 7,900 | Common Stock | $47.99 | $379,121.00 | 0.63 [ Average ] | 0 | $0.00 | - | Form 4 | - | 2020-07-28 | Herbert Virgin | EVP, Research & CSO | Buy | 7,900 | Common Stock | $1.53 | -$12,087.00 | 0.63 [ Average ] | 7,900 | $12,087.00 | 0.63 [Very Low] | Form 4 | - | 2020-07-14 | Herbert Virgin | EVP, Research & CSO | Sell | 7,900 | Common Stock | $48.85 | $385,915.00 | 0.63 [ Average ] | 0 | $0.00 | - | Form 4 | - | 2020-07-14 | Herbert Virgin | EVP, Research & CSO | Buy | 7,900 | Common Stock | $1.53 | -$12,087.00 | 0.63 [ Average ] | 7,900 | $12,087.00 | 0.63 [Very Low] | Form 4 | - | 2020-07-15 | Phillip Pang | Chief Medical Officer | Sell | 7,500 | Common Stock | $49.52 | $371,400.00 | 0.60 [ Average ] | 15,777 | $781,277.04 | 1.26 [Very Low] | Form 4 | - | 2020-07-15 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $49.54 | $247,700.00 | 0.40 [ Average ] | 23,277 | $1,153,142.58 | 1.86 [Low] | Form 4 | - | 2020-07-15 | Phillip Pang | Chief Medical Officer | Buy | 10,186 | Common Stock | $1.57 | -$15,992.02 | 0.81 [ High ] | 25,963 | $40,761.91 | 2.08 [Low] | Form 4 | - | 2020-07-15 | Phillip Pang | Chief Medical Officer | Buy | 2,314 | Common Stock | $5.17 | -$11,963.38 | 0.19 [ Low ] | 28,277 | $146,192.09 | 2.26 [Low] | Form 4 | - | 2020-04-14 | George A Scangos | President and CEO | Sell | 236,806 | Common Stock | $29.56 | $6,999,985.36 | 18.94 [ Very High ] | 1,907,329 | $56,380,645.24 | 152.53 [Very High] | Form 4 | See footnote | 2020-04-14 | George A Scangos | President and CEO | Buy | 236,806 | Common Stock | $29.56 | -$6,999,985.36 | 18.94 [ Very High ] | 4,713,559 | $139,332,804.04 | 376.95 [Very High] | Form 4 | - | 2020-04-17 | Phillip Pang | Chief Medical Officer | Buy | 8,000 | Common Stock | $0.85 | -$6,800.00 | 0.64 [ Average ] | 15,777 | $13,410.45 | 1.26 [Very Low] | Form 4 | - | 2020-05-01 | Robert J More | - | Sell | 15,758 | Common Stock | $27.90 | $439,648.20 | 1.26 [ High ] | 74,234 | $2,071,128.60 | 5.94 [Average] | Form 4 | - | 2020-05-01 | Robert J More | - | Sell | 2,700 | Common Stock | $28.60 | $77,220.00 | 0.22 [ Low ] | 71,534 | $2,045,872.40 | 5.72 [Average] | Form 4 | - | 2020-05-14 | Jay Parrish | Chief Business Officer | Buy | 75,000 | Common Stock | $1.49 | -$111,750.00 | 6.00 [ Very High ] | 297,222 | $442,860.78 | 23.77 [High] | Form 4 | - | 2020-05-14 | Jay Parrish | Chief Business Officer | Sell | 75,000 | Common Stock | $30.05 | $2,253,750.00 | 6.00 [ Very High ] | 222,222 | $6,677,771.10 | 17.77 [High] | Form 4 | - | 2020-05-14 | Herbert Virgin | EVP, Research & CSO | Buy | 3,805 | Common Stock | $1.53 | -$5,821.65 | 0.30 [ Average ] | 3,805 | $5,821.65 | 0.30 [Very Low] | Form 4 | - | 2020-05-14 | Herbert Virgin | EVP, Research & CSO | Sell | 3,805 | Common Stock | $30.07 | $114,416.35 | 0.30 [ Average ] | 0 | $0.00 | - | Form 4 | - | 2020-05-18 | Herbert Virgin | EVP, Research & CSO | Buy | 1,755 | Common Stock | $1.53 | -$2,685.15 | 0.14 [ Low ] | 1,755 | $2,685.15 | 0.14 [Very Low] | Form 4 | - | 2020-05-18 | Herbert Virgin | EVP, Research & CSO | Sell | 1,755 | Common Stock | $38.00 | $66,690.00 | 0.14 [ Low ] | 0 | $0.00 | - | Form 4 | - | 2020-05-26 | Herbert Virgin | EVP, Research & CSO | Buy | 3,805 | Common Stock | $1.53 | -$5,821.65 | 0.30 [ Average ] | 3,805 | $5,821.65 | 0.30 [Very Low] | Form 4 | - | 2020-05-26 | Herbert Virgin | EVP, Research & CSO | Sell | 3,805 | Common Stock | $34.08 | $129,674.40 | 0.30 [ Average ] | 0 | $0.00 | - | Form 4 | - | 2020-06-01 | Howard Horn | CFO | Sell | 3,286 | Common Stock | $34.53 | $113,465.58 | - | 274,491 | $9,478,174.23 | - | Form 4 | - | 2020-06-01 | Howard Horn | CFO | Sell | 6,714 | Common Stock | $35.38 | $237,541.32 | - | 267,777 | $9,473,950.26 | - | Form 4 | - | 2020-06-01 | Jay Parrish | Chief Business Officer | Buy | 75,000 | Common Stock | $1.49 | -$111,750.00 | - | 297,222 | $442,860.78 | - | Form 4 | - | 2020-06-01 | Jay Parrish | Chief Business Officer | Sell | 75,000 | Common Stock | $35.22 | $2,641,500.00 | - | 222,222 | $7,826,658.84 | - | Form 4 | - | 2020-06-03 | Phillip Pang | Chief Medical Officer | Buy | 12,500 | Common Stock | $5.17 | -$64,625.00 | - | 28,277 | $146,192.09 | - | Form 4 | - | 2020-06-03 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $35.09 | $175,450.00 | - | 23,277 | $816,789.93 | - | Form 4 | - | 2020-06-03 | Phillip Pang | Chief Medical Officer | Sell | 7,500 | Common Stock | $35.06 | $262,950.00 | - | 15,777 | $553,141.62 | - | Form 4 | - | 2020-06-09 | Herbert Virgin | EVP, Research & CSO | Buy | 3,805 | Common Stock | $1.53 | -$5,821.65 | - | 3,805 | $5,821.65 | - | Form 4 | - | 2020-06-09 | Herbert Virgin | EVP, Research & CSO | Sell | 3,805 | Common Stock | $36.28 | $138,045.40 | - | 0 | $0.00 | - | Form 4 | - | 2020-07-13 | Howard Horn | CFO | Sell | 30,000 | Common Stock | $50.06 | $1,501,800.00 | 2.40 [ Very High ] | 177,777 | $8,899,516.62 | 14.22 [Average] | Form 4 | - | 2020-06-17 | Phillip Pang | Chief Medical Officer | Buy | 12,500 | Common Stock | $5.17 | -$64,625.00 | - | 28,277 | $146,192.09 | - | Form 4 | - | 2020-06-17 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $37.27 | $186,350.00 | - | 23,277 | $867,533.79 | - | Form 4 | - | 2020-06-17 | Phillip Pang | Chief Medical Officer | Sell | 7,500 | Common Stock | $37.26 | $279,450.00 | - | 15,777 | $587,851.02 | - | Form 4 | - | 2020-06-19 | Herbert Virgin | EVP, Research & CSO | Buy | 3,510 | Common Stock | $1.53 | -$5,370.30 | - | 3,510 | $5,370.30 | - | Form 4 | - | 2020-06-19 | Herbert Virgin | EVP, Research & CSO | Sell | 1,755 | Common Stock | $38.00 | $66,690.00 | - | 1,755 | $66,690.00 | - | Form 4 | - | 2020-06-19 | Herbert Virgin | EVP, Research & CSO | Sell | 1,755 | Common Stock | $38.00 | $66,690.00 | - | 0 | $0.00 | - | Form 4 | - | 2020-06-19 | Howard Horn | CFO | Sell | 10,000 | Common Stock | $40.00 | $400,000.00 | - | 257,777 | $10,311,080.00 | - | Form 4 | - | 2020-06-23 | Herbert Virgin | EVP, Research & CSO | Buy | 5,560 | Common Stock | $1.53 | -$8,506.80 | - | 5,560 | $8,506.80 | - | Form 4 | - | 2020-06-23 | Herbert Virgin | EVP, Research & CSO | Sell | 5,560 | Common Stock | $38.99 | $216,784.40 | - | 0 | $0.00 | - | Form 4 | - | 2020-06-24 | Herbert Virgin | EVP, Research & CSO | Buy | 9,360 | Common Stock | $1.53 | -$14,320.80 | - | 9,360 | $14,320.80 | - | Form 4 | - | 2020-06-24 | Herbert Virgin | EVP, Research & CSO | Sell | 9,360 | Common Stock | $48.00 | $449,280.00 | - | 0 | $0.00 | - | Form 4 | - | 2020-06-25 | Howard Horn | CFO | Sell | 30,000 | Common Stock | $50.00 | $1,500,000.00 | - | 227,777 | $11,388,850.00 | - | Form 4 | - | 2020-08-03 | Jay Parrish | Chief Business Officer | Sell | 11,110 | Common Stock | $47.65 | $529,391.50 | 0.89 [ High ] | 222,222 | $10,588,878.30 | 17.77 [High] | Form 4 | - | 2020-08-05 | Phillip Pang | Chief Medical Officer | Buy | 12,500 | Common Stock | $1.57 | -$19,625.00 | 0.99 [ High ] | 28,277 | $44,394.89 | 2.24 [Low] | Form 4 | - | 2020-08-05 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $50.91 | $254,550.00 | 0.40 [ Average ] | 23,277 | $1,185,032.07 | 1.85 [Low] | Form 4 | - | 2020-08-05 | Phillip Pang | Chief Medical Officer | Sell | 7,500 | Common Stock | $50.89 | $381,675.00 | 0.59 [ Average ] | 15,777 | $802,891.53 | 1.25 [Very Low] | Form 4 | - | 2020-08-05 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $50.91 | $254,550.00 | 0.40 [ Average ] | 23,277 | $1,185,032.07 | 1.85 [Low] | Form 4 | - | 2020-08-05 | Phillip Pang | Chief Medical Officer | Sell | 7,500 | Common Stock | $50.89 | $381,675.00 | 0.59 [ Average ] | 15,777 | $802,891.53 | 1.25 [Very Low] | Form 4 | - | 2020-08-11 | Herbert Virgin | EVP, Research & CSO | Buy | 7,900 | Common Stock | $1.53 | -$12,087.00 | 0.63 [ Average ] | 7,900 | $12,087.00 | 0.63 [Very Low] | Form 4 | - | 2020-08-11 | Herbert Virgin | EVP, Research & CSO | Sell | 7,900 | Common Stock | $51.08 | $403,532.00 | 0.63 [ Average ] | 0 | $0.00 | - | Form 4 | - | 2020-08-19 | Phillip Pang | Chief Medical Officer | Buy | 10,185 | Common Stock | $1.57 | -$15,990.45 | 0.80 [ High ] | 25,962 | $40,760.34 | 2.04 [Low] | Form 4 | - | 2020-08-19 | Phillip Pang | Chief Medical Officer | Buy | 2,315 | Common Stock | $5.17 | -$11,968.55 | 0.18 [ Low ] | 28,277 | $146,192.09 | 2.23 [Low] | Form 4 | - | 2020-08-19 | Phillip Pang | Chief Medical Officer | Buy | 14,000 | Common Stock | $0.85 | -$11,900.00 | 1.10 [ High ] | 42,277 | $35,935.45 | 3.33 [Low] | Form 4 | - | 2020-08-19 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $50.96 | $254,800.00 | 0.39 [ Average ] | 37,277 | $1,899,635.92 | 2.93 [Low] | Form 4 | - | 2020-08-19 | Phillip Pang | Chief Medical Officer | Sell | 7,500 | Common Stock | $50.94 | $382,050.00 | 0.59 [ Average ] | 29,777 | $1,516,840.38 | 2.34 [Low] | Form 4 | - | 2020-09-01 | Jay Parrish | Chief Business Officer | Buy | 6,943 | Common Stock | $1.57 | -$10,900.51 | 0.55 [ Average ] | 229,165 | $359,789.05 | 18.04 [High] | Form 4 | - | 2020-09-01 | Jay Parrish | Chief Business Officer | Sell | 6,943 | Common Stock | $39.15 | $271,818.45 | 0.55 [ Average ] | 222,222 | $8,699,991.30 | 17.49 [High] | Form 4 | - | 2020-09-02 | Phillip Pang | Chief Medical Officer | Buy | 12,500 | Common Stock | $1.57 | -$19,625.00 | 0.98 [ High ] | 42,277 | $66,374.89 | 3.33 [Low] | Form 4 | - | 2020-09-02 | Phillip Pang | Chief Medical Officer | Sell | 7,500 | Common Stock | $32.88 | $246,600.00 | 0.59 [ Average ] | 34,777 | $1,143,467.76 | 2.74 [Low] | Form 4 | - | 2020-09-02 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $32.91 | $164,550.00 | 0.39 [ Average ] | 29,777 | $979,961.07 | 2.34 [Low] | Form 4 | - | 2020-08-25 | Herbert Virgin | EVP, Research & CSO | Buy | 25,560 | Common Stock | $1.53 | -$39,106.80 | 2.01 [ High ] | 25,560 | $39,106.80 | 2.01 [Low] | Form 4 | - | 2020-08-25 | Herbert Virgin | EVP, Research & CSO | Sell | 5,560 | Common Stock | $42.92 | $238,635.20 | 0.44 [ Average ] | 20,000 | $858,400.00 | 1.57 [Low] | Form 4 | - | 2020-09-08 | Herbert Virgin | EVP, Research & CSO | Buy | 3,805 | Common Stock | $1.53 | -$5,821.65 | 0.30 [ Average ] | 23,805 | $36,421.65 | 1.87 [Low] | Form 4 | - | 2020-09-08 | Herbert Virgin | EVP, Research & CSO | Sell | 1,465 | Common Stock | $30.00 | $43,950.00 | 0.12 [ Low ] | 22,340 | $670,200.00 | 1.76 [Low] | Form 4 | - | 2020-09-08 | Herbert Virgin | EVP, Research & CSO | Sell | 2,340 | Common Stock | $29.98 | $70,153.20 | 0.18 [ Low ] | 20,000 | $599,600.00 | 1.57 [Low] | Form 4 | - | 2020-09-16 | Phillip Pang | Chief Medical Officer | Buy | 9,720 | Common Stock | $1.57 | -$15,260.40 | 0.77 [ Average ] | 39,497 | $62,010.29 | 3.11 [Low] | Form 4 | - | 2020-09-16 | Phillip Pang | Chief Medical Officer | Buy | 465 | Common Stock | $1.53 | -$711.45 | 0.04 [ Very Low ] | 39,962 | $61,141.86 | 3.15 [Low] | Form 4 | - | 2020-09-16 | Phillip Pang | Chief Medical Officer | Buy | 2,315 | Common Stock | $5.17 | -$11,968.55 | 0.18 [ Low ] | 42,277 | $218,572.09 | 3.33 [Low] | Form 4 | - | 2020-09-16 | Phillip Pang | Chief Medical Officer | Sell | 7,500 | Common Stock | $31.88 | $239,100.00 | 0.59 [ Average ] | 34,777 | $1,108,690.76 | 2.74 [Low] | Form 4 | - | 2020-09-16 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $31.92 | $159,600.00 | 0.39 [ Average ] | 29,777 | $950,481.84 | 2.34 [Low] | Form 4 | - | 2020-09-22 | Herbert Virgin | EVP, Research & CSO | Buy | 3,805 | Common Stock | $1.53 | -$5,821.65 | 0.30 [ Average ] | 23,805 | $36,421.65 | 1.87 [Low] | Form 4 | - | 2020-09-22 | Herbert Virgin | EVP, Research & CSO | Sell | 3,805 | Common Stock | $31.71 | $120,656.55 | 0.30 [ Average ] | 20,000 | $634,200.00 | 1.57 [Low] | Form 4 | - | 2020-09-24 | Herbert Virgin | EVP, Research & CSO | Buy | 3,700 | Common Stock | $1.53 | -$5,661.00 | 0.29 [ Low ] | 23,700 | $36,261.00 | 1.87 [Low] | Form 4 | - | 2020-09-29 | Herbert Virgin | EVP, Research & CSO | Buy | 3,510 | Common Stock | $1.53 | -$5,370.30 | 0.28 [ Low ] | 27,210 | $41,631.30 | 2.14 [Low] | Form 4 | - | 2020-09-29 | Herbert Virgin | EVP, Research & CSO | Sell | 3,510 | Common Stock | $38.00 | $133,380.00 | 0.28 [ Low ] | 23,700 | $900,600.00 | 1.87 [Low] | Form 4 | - | 2020-10-01 | Jay Parrish | Chief Business Officer | Buy | 4,630 | Common Stock | $1.49 | -$6,898.70 | 0.36 [ Average ] | 226,852 | $338,009.48 | 17.85 [High] | Form 4 | - | 2020-10-01 | Jay Parrish | Chief Business Officer | Buy | 2,315 | Common Stock | $1.57 | -$3,634.55 | 0.18 [ Low ] | 229,167 | $359,792.19 | 18.04 [High] | Form 4 | - | 2020-10-01 | Jay Parrish | Chief Business Officer | Sell | 6,945 | Common Stock | $34.75 | $241,338.75 | 0.55 [ Average ] | 222,222 | $7,722,214.50 | 17.49 [High] | Form 4 | - | 2020-10-07 | Phillip Pang | Chief Medical Officer | Buy | 10,185 | Common Stock | $1.53 | -$15,583.05 | 0.80 [ High ] | 39,962 | $61,141.86 | 3.15 [Low] | Form 4 | - | 2020-10-07 | Phillip Pang | Chief Medical Officer | Buy | 2,315 | Common Stock | $1.57 | -$3,634.55 | 0.18 [ Low ] | 42,277 | $66,374.89 | 3.33 [Low] | Form 4 | - | 2020-10-07 | Phillip Pang | Chief Medical Officer | Sell | 7,500 | Common Stock | $41.76 | $313,200.00 | 0.59 [ Average ] | 34,777 | $1,452,287.52 | 2.74 [Low] | Form 4 | - | 2020-10-07 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $41.73 | $208,650.00 | 0.39 [ Average ] | 29,777 | $1,242,594.21 | 2.34 [Low] | Form 4 | - | 2020-10-13 | Herbert Virgin | EVP, Research & CSO | Buy | 5,560 | Common Stock | $1.53 | -$8,506.80 | 0.44 [ Average ] | 29,260 | $44,767.80 | 2.30 [Low] | Form 4 | - | 2020-10-13 | Herbert Virgin | EVP, Research & CSO | Sell | 5,560 | Common Stock | $43.03 | $239,246.80 | 0.44 [ Average ] | 23,700 | $1,019,811.00 | 1.87 [Low] | Form 4 | - | 2020-10-21 | Phillip Pang | Chief Medical Officer | Buy | 7,870 | Common Stock | $1.53 | -$12,041.10 | 0.62 [ Average ] | 37,647 | $57,599.91 | 2.96 [Low] | Form 4 | - | 2020-10-21 | Phillip Pang | Chief Medical Officer | Buy | 2,315 | Common Stock | $1.57 | -$3,634.55 | 0.18 [ Low ] | 39,962 | $62,740.34 | 3.15 [Low] | Form 4 | - | 2020-10-21 | Phillip Pang | Chief Medical Officer | Buy | 2,315 | Common Stock | $5.17 | -$11,968.55 | 0.18 [ Low ] | 42,277 | $218,572.09 | 3.33 [Low] | Form 4 | - | 2020-10-21 | Phillip Pang | Chief Medical Officer | Sell | 7,500 | Common Stock | $35.42 | $265,650.00 | 0.59 [ Average ] | 34,777 | $1,231,801.34 | 2.74 [Low] | Form 4 | - | 2020-10-21 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $35.59 | $177,950.00 | 0.39 [ Average ] | 29,777 | $1,059,763.43 | 2.34 [Low] | Form 4 | - | 2020-10-27 | Herbert Virgin | EVP, Research & CSO | Buy | 3,805 | Common Stock | $1.53 | -$5,821.65 | 0.30 [ Average ] | 27,505 | $42,082.65 | 2.16 [Low] | Form 4 | - | 2020-10-27 | Herbert Virgin | EVP, Research & CSO | Sell | 3,805 | Common Stock | $35.04 | $133,327.20 | 0.30 [ Average ] | 23,700 | $830,448.00 | 1.87 [Low] | Form 4 | - | 2020-11-02 | Jay Parrish | Chief Business Officer | Buy | 4,629 | Common Stock | $1.49 | -$6,897.21 | 0.36 [ Average ] | 226,851 | $338,007.99 | 17.85 [High] | Form 4 | - | 2020-11-02 | Jay Parrish | Chief Business Officer | Buy | 2,315 | Common Stock | $1.57 | -$3,634.55 | 0.18 [ Low ] | 229,166 | $359,790.62 | 18.04 [High] | Form 4 | - | 2020-11-02 | Jay Parrish | Chief Business Officer | Sell | 6,944 | Common Stock | $31.27 | $217,138.88 | 0.55 [ Average ] | 222,222 | $6,948,881.94 | 17.49 [High] | Form 4 | - | 2020-11-04 | Phillip Pang | Chief Medical Officer | Buy | 5,000 | Common Stock | $1.53 | -$7,650.00 | 0.39 [ Average ] | 34,777 | $53,208.81 | 2.74 [Low] | Form 4 | - | 2020-10-21 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $31.44 | $157,200.00 | 0.39 [ Average ] | 29,777 | $936,188.88 | 2.34 [Low] | Form 4 | - | 2020-11-10 | Herbert Virgin | EVP, Research & CSO | Buy | 2,340 | Common Stock | $1.53 | -$3,580.20 | 0.18 [ Low ] | 26,040 | $39,841.20 | 2.04 [Low] | Form 4 | - | 2020-11-10 | Herbert Virgin | EVP, Research & CSO | Sell | 2,340 | Common Stock | $26.26 | $61,448.40 | 0.18 [ Low ] | 23,700 | $622,362.00 | 1.86 [Low] | Form 4 | - | 2020-11-12 | Phillip Pang | Chief Medical Officer | Buy | 20,000 | Common Stock | $0.85 | -$17,000.00 | 1.57 [ High ] | 49,777 | $42,310.45 | 3.91 [Low] | Form 4 | - | 2020-11-24 | Herbert Virgin | EVP, Research & CSO | Buy | 2,340 | Common Stock | $1.53 | -$3,580.20 | 0.18 [ Low ] | 26,040 | $39,841.20 | 2.04 [Low] | Form 4 | - | 2020-11-24 | Herbert Virgin | EVP, Research & CSO | Sell | 2,340 | Common Stock | $27.29 | $63,858.60 | 0.18 [ Low ] | 23,700 | $646,773.00 | 1.86 [Low] | Form 4 | - | 2020-11-27 | Herbert Virgin | EVP, Research & CSO | Buy | 2,930 | Common Stock | $1.53 | -$4,482.90 | 0.23 [ Low ] | 26,630 | $40,743.90 | 2.09 [Low] | Form 4 | - | 2020-11-27 | Herbert Virgin | EVP, Research & CSO | Sell | 2,930 | Common Stock | $30.00 | $87,900.00 | 0.23 [ Low ] | 23,700 | $711,000.00 | 1.86 [Low] | Form 4 | - | 2020-11-27 | Phillip Pang | Chief Medical Officer | Buy | 7,500 | Common Stock | $0.85 | -$6,375.00 | 0.59 [ Average ] | 57,277 | $48,685.45 | 4.50 [Low] | Form 4 | - | 2020-12-01 | Jay Parrish | Chief Business Officer | Buy | 4,630 | Common Stock | $1.49 | -$6,898.70 | 0.36 [ Average ] | 226,852 | $338,009.48 | 17.81 [High] | Form 4 | - | 2020-12-01 | Jay Parrish | Chief Business Officer | Buy | 2,315 | Common Stock | $1.57 | -$3,634.55 | 0.18 [ Low ] | 229,167 | $359,792.19 | 17.99 [High] | Form 4 | - | 2020-12-01 | Jay Parrish | Chief Business Officer | Sell | 6,945 | Common Stock | $31.53 | $218,975.85 | 0.55 [ Average ] | 222,222 | $7,006,659.66 | 17.44 [High] | Form 4 | - | 2020-12-08 | Herbert Virgin | EVP, Research & CSO | Buy | 3,805 | Common Stock | $1.53 | -$5,821.65 | 0.30 [ Average ] | 27,505 | $42,082.65 | 2.16 [Low] | Form 4 | - | 2020-12-08 | Herbert Virgin | EVP, Research & CSO | Sell | 3,805 | Common Stock | $31.27 | $118,982.35 | 0.30 [ Average ] | 23,700 | $741,099.00 | 1.86 [Low] | Form 4 | - | 2020-12-22 | Herbert Virgin | EVP, Research & CSO | Buy | 3,805 | Common Stock | $1.53 | -$5,821.65 | 0.30 [ Low ] | 27,505 | $42,082.65 | 2.16 [Low] | Form 4 | - | 2020-12-22 | Herbert Virgin | EVP, Research & CSO | Sell | 3,805 | Common Stock | $31.19 | $118,677.95 | 0.30 [ Low ] | 23,700 | $739,203.00 | 1.86 [Low] | Form 4 | - | 2020-12-24 | Herbert Virgin | EVP, Research & CSO | Buy | 9,500 | Common Stock | $1.53 | -$14,535.00 | 0.75 [ Average ] | 33,200 | $50,796.00 | 2.61 [Low] | Form 4 | - | 2021-01-04 | Jay Parrish | Chief Business Officer | Buy | 6,945 | Common Stock | $1.49 | -$10,348.05 | 0.55 [ Average ] | 229,167 | $341,458.83 | 17.99 [High] | Form 4 | - | 2021-01-04 | Jay Parrish | Chief Business Officer | Sell | 6,945 | Common Stock | $26.32 | $182,792.40 | 0.55 [ Average ] | 222,222 | $5,848,883.04 | 17.44 [High] | Form 4 | - | 2021-01-12 | Herbert Virgin | EVP, Research & CSO | Buy | 3,805 | Common Stock | $1.53 | -$5,821.65 | 0.30 [ Average ] | 37,005 | $56,617.65 | 2.90 [Low] | Form 4 | - | 2021-01-12 | Herbert Virgin | EVP, Research & CSO | Sell | 3,805 | Common Stock | $29.36 | $111,714.80 | 0.30 [ Average ] | 33,200 | $974,752.00 | 2.61 [Low] | Form 4 | - | 2021-01-15 | Herbert Virgin | EVP, Research & CSO | Buy | 10,530 | Common Stock | $1.53 | -$16,110.90 | 0.83 [ High ] | 43,730 | $66,906.90 | 3.43 [Low] | Form 4 | - | 2021-01-15 | Herbert Virgin | EVP, Research & CSO | Sell | 10,530 | Common Stock | $38.00 | $400,140.00 | 0.83 [ High ] | 33,200 | $1,261,600.00 | 2.61 [Low] | Form 4 | - | 2021-01-26 | Herbert Virgin | EVP, Research & CSO | Buy | 31,300 | Common Stock | $1.53 | -$47,889.00 | 2.46 [ High ] | 64,500 | $98,685.00 | 5.06 [Average] | Form 4 | - | 2021-01-26 | Herbert Virgin | EVP, Research & CSO | Sell | 31,300 | Common Stock | $48.17 | $1,507,721.00 | 2.46 [ High ] | 33,200 | $1,599,244.00 | 2.61 [Low] | Form 4 | - | 2021-02-01 | Jay Parrish | Chief Business Officer | Buy | 2,314 | Common Stock | $1.49 | -$3,447.86 | 0.18 [ Low ] | 224,536 | $334,558.64 | 17.63 [High] | Form 4 | - | 2021-02-01 | Jay Parrish | Chief Business Officer | Buy | 4,630 | Common Stock | $1.57 | -$7,269.10 | 0.36 [ Average ] | 229,166 | $359,790.62 | 17.99 [High] | Form 4 | - | 2021-02-01 | Jay Parrish | Chief Business Officer | Sell | 6,944 | Common Stock | $69.91 | $485,455.04 | 0.55 [ Average ] | 222,222 | $15,535,540.02 | 17.44 [High] | Form 4 | - | 2021-02-09 | Herbert Virgin | EVP, Research & CSO | Buy | 7,900 | Common Stock | $1.53 | -$12,087.00 | 0.62 [ Average ] | 41,100 | $62,883.00 | 3.23 [Low] | Form 4 | - | 2021-02-09 | Herbert Virgin | EVP, Research & CSO | Sell | 7,900 | Common Stock | $71.16 | $562,164.00 | 0.62 [ Average ] | 33,200 | $2,362,512.00 | 2.61 [Low] | Form 4 | - | 2021-02-12 | Phillip Pang | Chief Medical Officer | Buy | 10,000 | Common Stock | $0.85 | -$8,500.00 | 0.78 [ Average ] | 67,277 | $57,185.45 | 5.28 [Average] | Form 4 | - | 2021-02-16 | George A Scangos | President and CEO | Buy | 111,000 | Common Stock | $0.00 | $0.00 | - | 4,609,559 | $0.00 | 361.85 [Very High] | Form 4 | - | 2021-02-16 | Steven J. Rice | Chief Administrative Officer | Buy | 20,000 | Common Stock | $0.00 | $0.00 | - | 20,000 | $0.00 | 1.57 [Low] | Form 4 | - | 2021-02-16 | Herbert Virgin | EVP, Research & CSO | Buy | 30,000 | Common Stock | $0.00 | $0.00 | - | 63,200 | $0.00 | 4.96 [Average] | Form 4 | - | 2021-02-16 | Howard Horn | CFO | Buy | 25,000 | Common Stock | $0.00 | $0.00 | - | 202,777 | $0.00 | 15.92 [High] | Form 4 | - | 2021-02-16 | Phillip Pang | Chief Medical Officer | Buy | 10,000 | Common Stock | $0.85 | -$8,500.00 | 0.78 [ Average ] | 77,277 | $65,685.45 | 6.07 [Average] | Form 4 | - | 2021-02-16 | Phillip Pang | Chief Medical Officer | Buy | 32,000 | Common Stock | $0.00 | $0.00 | - | 109,277 | $0.00 | 8.58 [Average] | Form 4 | - | 2021-02-23 | Herbert Virgin | EVP, Research & CSO | Buy | 18,900 | Common Stock | $1.53 | -$28,917.00 | 1.48 [ High ] | 82,100 | $125,613.00 | 6.44 [Average] | Form 4 | - | 2021-02-23 | Herbert Virgin | EVP, Research & CSO | Sell | 7,900 | Common Stock | $63.74 | $503,546.00 | 0.62 [ Average ] | 74,200 | $4,729,508.00 | 5.82 [Average] | Form 4 | - | 2021-03-01 | Jay Parrish | Chief Business Officer | Buy | 4,630 | Common Stock | $1.49 | -$6,898.70 | 0.36 [ Average ] | 13,890 | $20,696.10 | 1.09 [Very Low] | Form 4 | - | 2021-03-01 | Jay Parrish | Chief Business Officer | Buy | 2,314 | Common Stock | $1.57 | -$3,632.98 | 0.18 [ Low ] | 16,204 | $25,440.28 | 1.27 [Low] | Form 4 | - | 2021-03-01 | Jay Parrish | Chief Business Officer | Sell | 6,944 | Common Stock | $63.44 | $440,527.36 | 0.54 [ Average ] | 9,260 | $587,454.40 | 0.72 [Very Low] | Form 4 | - | 2021-03-09 | Herbert Virgin | EVP, Research & CSO | Buy | 5,560 | Common Stock | $1.53 | -$8,506.80 | 0.43 [ Average ] | 79,760 | $122,032.80 | 6.24 [Average] | Form 4 | - | 2021-03-09 | Herbert Virgin | EVP, Research & CSO | Sell | 5,560 | Common Stock | $44.80 | $249,088.00 | 0.43 [ Average ] | 74,200 | $3,324,160.00 | 5.80 [Average] | Form 4 | - | 2021-03-10 | Herbert Virgin | EVP, Research & CSO | Buy | 2,340 | Common Stock | $1.53 | -$3,580.20 | 0.18 [ Low ] | 76,540 | $117,106.20 | 5.99 [Average] | Form 4 | - | 2021-03-10 | Herbert Virgin | EVP, Research & CSO | Sell | 2,340 | Common Stock | $48.00 | $112,320.00 | 0.18 [ Low ] | 74,200 | $3,561,600.00 | 5.80 [Average] | Form 4 | - | 2021-03-23 | Herbert Virgin | EVP, Research & CSO | Buy | 7,900 | Common Stock | $1.53 | -$12,087.00 | 0.62 [ Average ] | 82,100 | $125,613.00 | 6.42 [Average] | Form 4 | - | 2021-03-23 | Herbert Virgin | EVP, Research & CSO | Sell | 7,900 | Common Stock | $53.60 | $423,440.00 | 0.62 [ Average ] | 74,200 | $3,977,120.00 | 5.80 [Average] | Form 4 | - | 2021-03-30 | Arch Venture Partners Ix, Llc | - | Sell | 217,781 | Common Stock | $0.00 | $0.00 | - | 12,268,328 | $0.00 | 959.69 [Very High] | Form 4 | See footnote | 2021-03-30 | Arch Venture Partners Ix, Llc | - | Sell | 282,219 | Common Stock | $0.00 | $0.00 | - | 15,898,335 | $0.00 | 1,243.64 [Very High] | Form 4 | See footnote | 2021-03-30 | Arch Venture Partners Ix, Llc | - | Buy | 3,160 | Common Stock | $0.00 | $0.00 | - | 3,160 | $0.00 | 0.25 [Very Low] | Form 4 | - | 2021-03-30 | Arch Venture Partners Ix, Llc | - | Buy | 1,014 | Common Stock | $0.00 | $0.00 | - | 1,014 | $0.00 | 0.08 [Very Low] | Form 4 | - | 2021-04-01 | Arch Venture Partners Ix, Llc | - | Sell | 217,781 | Common Stock | $0.00 | $0.00 | - | 12,050,547 | $0.00 | 942.65 [Very High] | Form 4 | See footnote | 2021-04-01 | Arch Venture Partners Ix, Llc | - | Sell | 282,219 | Common Stock | $0.00 | $0.00 | - | 15,616,116 | $0.00 | 1,221.56 [Very High] | Form 4 | See footnote | 2021-04-01 | Arch Venture Partners Ix, Llc | - | Buy | 3,160 | Common Stock | $0.00 | $0.00 | - | 6,320 | $0.00 | 0.49 [Very Low] | Form 4 | - | 2021-04-01 | Arch Venture Partners Ix, Llc | - | Buy | 1,016 | Common Stock | $0.00 | $0.00 | - | 2,030 | $0.00 | 0.16 [Very Low] | Form 4 | - | 2021-03-30 | Robert Nelsen | - | Sell | 217,781 | Common Stock | $0.00 | $0.00 | - | 12,268,328 | $0.00 | 959.69 [Very High] | Form 4 | See footnote | 2021-03-30 | Robert Nelsen | - | Sell | 282,219 | Common Stock | $0.00 | $0.00 | - | 15,898,335 | $0.00 | 1,243.64 [Very High] | Form 4 | See footnote | 2021-03-30 | Robert Nelsen | - | Buy | 5,989 | Common Stock | $0.00 | $0.00 | - | 5,989 | $0.00 | 0.47 [Very Low] | Form 4 | - | 2021-04-01 | Robert Nelsen | - | Sell | 217,781 | Common Stock | $0.00 | $0.00 | - | 12,050,547 | $0.00 | 942.65 [Very High] | Form 4 | See footnote | 2021-04-01 | Robert Nelsen | - | Sell | 282,219 | Common Stock | $0.00 | $0.00 | - | 15,616,116 | $0.00 | 1,221.56 [Very High] | Form 4 | See footnote | 2021-04-01 | Robert Nelsen | - | Buy | 5,987 | Common Stock | $0.00 | $0.00 | - | 11,976 | $0.00 | 0.94 [Very Low] | Form 4 | - | 2021-04-01 | Jay Parrish | Chief Business Officer | Buy | 4,629 | Common Stock | $1.49 | -$6,897.21 | 0.36 [ Average ] | 13,889 | $20,694.61 | 1.09 [Very Low] | Form 4 | - | 2021-04-01 | Jay Parrish | Chief Business Officer | Buy | 2,315 | Common Stock | $1.57 | -$3,634.55 | 0.18 [ Low ] | 16,204 | $25,440.28 | 1.27 [Low] | Form 4 | - | 2021-04-01 | Jay Parrish | Chief Business Officer | Sell | 6,944 | Common Stock | $51.40 | $356,921.60 | 0.54 [ Average ] | 9,260 | $475,964.00 | 0.72 [Very Low] | Form 4 | - | 2021-04-13 | Herbert Virgin | EVP, Research & CSO | Sell | 5,560 | Common Stock | $43.57 | $242,249.20 | 0.43 [ Average ] | 88,200 | $3,842,874.00 | 6.89 [Average] | Form 4 | - | 2021-04-13 | Herbert Virgin | EVP, Research & CSO | Buy | 5,560 | Common Stock | $1.53 | -$8,506.80 | 0.43 [ Average ] | 93,760 | $143,452.80 | 7.33 [Average] | Form 4 | - | 2021-04-16 | Herbert Virgin | EVP, Research & CSO | Buy | 3,500 | Common Stock | $1.53 | -$5,355.00 | 0.27 [ Low ] | 91,700 | $140,301.00 | 7.16 [Average] | Form 4 | - | 2021-04-19 | Herbert Virgin | EVP, Research & CSO | Buy | 2,340 | Common Stock | $1.53 | -$3,580.20 | 0.18 [ Low ] | 94,040 | $143,881.20 | 7.35 [Average] | Form 4 | - | 2021-04-19 | Herbert Virgin | EVP, Research & CSO | Sell | 2,340 | Common Stock | $48.00 | $112,320.00 | 0.18 [ Low ] | 91,700 | $4,401,600.00 | 7.16 [Average] | Form 4 | - | 2021-04-27 | Herbert Virgin | EVP, Research & CSO | Buy | 7,900 | Common Stock | $1.53 | -$12,087.00 | 0.62 [ Average ] | 99,600 | $152,388.00 | 7.78 [Average] | Form 4 | - | 2021-04-27 | Herbert Virgin | EVP, Research & CSO | Sell | 7,900 | Common Stock | $49.50 | $391,050.00 | 0.62 [ Average ] | 91,700 | $4,539,150.00 | 7.16 [Average] | Form 4 | - | 2021-05-04 | Herbert Virgin | EVP, Research & CSO | Buy | 1,375 | Common Stock | $1.53 | -$2,103.75 | 0.11 [ Low ] | 93,075 | $142,404.75 | 7.27 [Average] | Form 4 | - | 2021-05-04 | Herbert Virgin | EVP, Research & CSO | Sell | 1,375 | Common Stock | $46.03 | $63,291.25 | 0.11 [ Low ] | 91,700 | $4,220,951.00 | 7.16 [Average] | Form 4 | - | 2021-05-18 | Herbert Virgin | EVP, Research & CSO | Buy | 1,375 | Common Stock | $1.53 | -$2,103.75 | 0.11 [ Low ] | 93,075 | $142,404.75 | 7.16 [Average] | Form 4 | - | 2021-05-18 | Herbert Virgin | EVP, Research & CSO | Sell | 1,375 | Common Stock | $45.03 | $61,916.25 | 0.11 [ Low ] | 91,700 | $4,129,251.00 | 7.05 [Average] | Form 4 | - | 2021-05-19 | Vicki L Sato | - | Sell | 8,328 | Common Stock | $43.35 | $361,018.80 | 0.64 [ Average ] | 1,660,782 | $71,994,899.70 | 127.71 [Very High] | Form 4 | - | 2021-05-19 | Vicki L Sato | - | Sell | 5,403 | Common Stock | $44.18 | $238,704.54 | 0.42 [ Average ] | 1,655,379 | $73,134,644.22 | 127.30 [Very High] | Form 4 | - | 2021-05-19 | Vicki L Sato | - | Sell | 1,443 | Common Stock | $44.96 | $64,877.28 | 0.11 [ Low ] | 1,653,936 | $74,360,962.56 | 127.19 [Very High] | Form 4 | - | 2021-05-19 | Saira Ramasastry | - | Buy | 10,000 | Common Stock | $12.76 | -$127,600.00 | 0.77 [ High ] | 10,000 | $127,600.00 | 0.77 [Very Low] | Form 4 | - | 2021-05-19 | Saira Ramasastry | - | Sell | 10,000 | Common Stock | $43.73 | $437,300.00 | 0.77 [ High ] | 0 | $0.00 | - | Form 4 | - | 2021-05-20 | Robert J More | - | Sell | 2,575 | Common Stock | $43.57 | $112,192.75 | 0.20 [ Low ] | 98,430 | $4,288,595.10 | 7.57 [Average] | Form 4 | - | 2021-05-20 | Robert J More | - | Sell | 9,095 | Common Stock | $44.77 | $407,183.15 | 0.70 [ Average ] | 89,335 | $3,999,527.95 | 6.87 [Average] | Form 4 | - | 2021-05-21 | Vicki L Sato | - | Buy | 3,374 | Common Stock | $0.00 | $0.00 | - | 1,657,310 | $0.00 | 127.45 [Very High] | Form 4 | - | 2021-05-21 | Robert J More | - | Sell | 3,374 | Common Stock | $0.00 | $0.00 | - | 92,709 | $0.00 | 7.13 [Average] | Form 4 | - | 2021-05-21 | Robert Nelsen | - | Buy | 3,374 | Common Stock | $0.00 | $0.00 | - | 27,328 | $0.00 | 2.10 [Low] | Form 4 | - | 2021-05-21 | Phillip A Sharp | - | Buy | 3,374 | Common Stock | $0.00 | $0.00 | - | 108,742 | $0.00 | 8.36 [Average] | Form 4 | - | 2021-05-21 | Robert J Perez | - | Buy | 3,374 | Common Stock | $0.00 | $0.00 | - | 3,374 | $0.00 | 0.26 [Very Low] | Form 4 | - | 2021-05-21 | Dipchand Nishar | - | Buy | 3,374 | Common Stock | $0.00 | $0.00 | - | 3,374 | $0.00 | 0.26 [Very Low] | Form 4 | - | 2021-05-21 | Saira Ramasastry | - | Buy | 3,374 | Common Stock | $0.00 | $0.00 | - | 3,374 | $0.00 | 0.26 [Very Low] | Form 4 | - | 2021-05-21 | Jeffrey S. Hatfield | - | Buy | 3,374 | Common Stock | $0.00 | $0.00 | - | 3,374 | $0.00 | 0.26 [Very Low] | Form 4 | - | 2021-05-21 | Charles Elliott Sigal | - | Buy | 3,374 | Common Stock | $0.00 | $0.00 | - | 3,374 | $0.00 | 0.26 [Very Low] | Form 4 | - | 2021-05-21 | Janet Napolitano | - | Buy | 3,374 | Common Stock | $0.00 | $0.00 | - | 3,374 | $0.00 | 0.26 [Very Low] | Form 4 | - | 2021-06-01 | Herbert Virgin | EVP, Research & CSO | Buy | 1,375 | Common Stock | $1.53 | -$2,103.75 | 0.11 [ Low ] | 93,075 | $142,404.75 | 7.16 [Average] | Form 4 | - | 2021-06-01 | Herbert Virgin | EVP, Research & CSO | Sell | 1,375 | Common Stock | $42.51 | $58,451.25 | 0.11 [ Low ] | 91,700 | $3,898,167.00 | 7.05 [Average] | Form 4 | - | 2021-06-02 | Phillip Pang | Chief Medical Officer | Buy | 10,000 | Common Stock | $0.85 | -$8,500.00 | 0.77 [ High ] | 119,277 | $101,385.45 | 9.17 [Average] | Form 4 | - | 2021-06-02 | Phillip Pang | Chief Medical Officer | Sell | 9,700 | Common Stock | $41.47 | $402,259.00 | 0.75 [ Average ] | 109,577 | $4,544,158.19 | 8.43 [Average] | Form 4 | - | 2021-06-02 | Phillip Pang | Chief Medical Officer | Sell | 300 | Common Stock | $42.18 | $12,654.00 | 0.02 [ Very Low ] | 109,277 | $4,609,303.86 | 8.40 [Average] | Form 4 | - | 2021-06-03 | Robert J More | - | Sell | 11,670 | Common Stock | $44.56 | $520,015.20 | 0.90 [ High ] | 81,039 | $3,611,097.84 | 6.23 [Average] | Form 4 | - | 2021-06-15 | Herbert Virgin | EVP, Research & CSO | Buy | 1,375 | Common Stock | $1.53 | -$2,103.75 | 0.11 [ Low ] | 93,075 | $142,404.75 | 7.16 [Average] | Form 4 | - | 2021-06-15 | Herbert Virgin | EVP, Research & CSO | Sell | 1,375 | Common Stock | $45.29 | $62,273.75 | 0.11 [ Low ] | 91,700 | $4,153,093.00 | 7.05 [Average] | Form 4 | - | 2021-06-16 | Phillip Pang | Chief Medical Officer | Buy | 5,000 | Common Stock | $5.17 | -$25,850.00 | 0.38 [ Average ] | 114,277 | $590,812.09 | 8.79 [Average] | Form 4 | - | 2021-06-16 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $43.67 | $218,350.00 | 0.38 [ Average ] | 109,277 | $4,772,126.59 | 8.40 [Average] | Form 4 | - | 2021-06-17 | Robert J More | - | Sell | 11,670 | Common Stock | $43.95 | $512,896.50 | 0.90 [ High ] | 69,369 | $3,048,767.55 | 5.33 [Average] | Form 4 | - | 2021-06-21 | Vicki L Sato | - | Sell | 11,881 | Common Stock | $46.00 | $546,526.00 | 0.91 [ High ] | 1,645,429 | $75,689,734.00 | 126.53 [Very High] | Form 4 | - | 2021-06-21 | Vicki L Sato | - | Sell | 3,293 | Common Stock | $46.75 | $153,947.75 | 0.25 [ Low ] | 1,642,136 | $76,769,858.00 | 126.28 [Very High] | Form 4 | - | 2021-06-22 | Arch Venture Partners Ix, Llc | - | Sell | 435,562 | Common Stock | $0.00 | $0.00 | - | 11,179,423 | $0.00 | 859.69 [Very High] | Form 4 | See footnote | 2021-06-22 | Arch Venture Partners Ix, Llc | - | Sell | 564,438 | Common Stock | $0.00 | $0.00 | - | 14,487,240 | $0.00 | 1,114.06 [Very High] | Form 4 | See footnote | 2021-06-22 | Arch Venture Partners Ix, Llc | - | Buy | 6,320 | Common Stock | $0.00 | $0.00 | - | 18,962 | $0.00 | 1.46 [Low] | Form 4 | - | 2021-06-22 | Arch Venture Partners Ix, Llc | - | Buy | 2,028 | Common Stock | $0.00 | $0.00 | - | 6,096 | $0.00 | 0.47 [Very Low] | Form 4 | - | 2021-06-22 | Robert Nelsen | - | Sell | 435,562 | Common Stock | $0.00 | $0.00 | - | 11,179,423 | $0.00 | 859.69 [Very High] | Form 4 | See footnote | 2021-06-22 | Robert Nelsen | - | Sell | 564,438 | Common Stock | $0.00 | $0.00 | - | 14,487,240 | $0.00 | 1,114.06 [Very High] | Form 4 | See footnote | 2021-06-22 | Robert Nelsen | - | Buy | 11,974 | Common Stock | $0.00 | $0.00 | - | 35,928 | $0.00 | 2.76 [Low] | Form 4 | - | 2021-06-23 | Herbert Virgin | EVP, Research & CSO | Buy | 8,000 | Common Stock | $1.53 | -$12,240.00 | 0.62 [ Average ] | 99,700 | $152,541.00 | 7.67 [Average] | Form 4 | - | 2021-06-25 | Steven J. Rice | Chief Administrative Officer | Buy | 3 | Common Stock | $12.76 | -$38.28 | - | 20,003 | $255,238.28 | 1.54 [Low] | Form 4 | - | 2021-06-25 | Steven J. Rice | Chief Administrative Officer | Sell | 3 | Common Stock | $50.00 | $150.00 | - | 20,000 | $1,000,000.00 | 1.54 [Low] | Form 4 | - | 2021-06-29 | Herbert Virgin | EVP, Research & CSO | Buy | 1,375 | Common Stock | $1.53 | -$2,103.75 | 0.11 [ Low ] | 101,075 | $154,644.75 | 7.77 [Average] | Form 4 | - | 2021-06-29 | Herbert Virgin | EVP, Research & CSO | Sell | 1,375 | Common Stock | $46.63 | $64,116.25 | 0.11 [ Low ] | 99,700 | $4,649,011.00 | 7.67 [Average] | Form 4 | - | 2021-07-01 | Robert J More | - | Sell | 4,794 | Common Stock | $44.31 | $212,422.14 | 0.37 [ Average ] | 64,575 | $2,861,318.25 | 4.97 [Average] | Form 4 | - | 2021-07-01 | Robert J More | - | Sell | 5,986 | Common Stock | $45.23 | $270,746.78 | 0.46 [ Average ] | 58,589 | $2,649,980.47 | 4.51 [Low] | Form 4 | - | 2021-07-01 | Robert J More | - | Sell | 890 | Common Stock | $46.22 | $41,135.80 | 0.07 [ Very Low ] | 57,699 | $2,666,847.78 | 4.44 [Low] | Form 4 | - | 2021-07-01 | Arch Venture Partners Ix, Llc | - | Sell | 1,742,248 | Common Stock | $0.00 | $0.00 | - | 9,437,175 | $0.00 | 725.71 [Very High] | Form 4 | See footnote | 2021-07-01 | Arch Venture Partners Ix, Llc | - | Sell | 2,257,752 | Common Stock | $0.00 | $0.00 | - | 12,229,488 | $0.00 | 940.44 [Very High] | Form 4 | See footnote | 2021-07-01 | Arch Venture Partners Ix, Llc | - | Buy | 25,279 | Common Stock | $0.00 | $0.00 | - | 44,241 | $0.00 | 3.40 [Low] | Form 4 | - | 2021-07-01 | Arch Venture Partners Ix, Llc | - | Buy | 8,133 | Common Stock | $0.00 | $0.00 | - | 14,229 | $0.00 | 1.09 [Very Low] | Form 4 | - | 2021-07-01 | Robert Nelsen | - | Sell | 1,742,248 | Common Stock | $0.00 | $0.00 | - | 9,437,175 | $0.00 | 725.71 [Very High] | Form 4 | See footnote | 2021-07-01 | Robert Nelsen | - | Sell | 2,257,752 | Common Stock | $0.00 | $0.00 | - | 12,229,488 | $0.00 | 940.44 [Very High] | Form 4 | See footnote | 2021-07-01 | Robert Nelsen | - | Buy | 47,897 | Common Stock | $0.00 | $0.00 | - | 83,825 | $0.00 | 6.45 [Average] | Form 4 | - | 2021-07-07 | Phillip Pang | Chief Medical Officer | Buy | 5,000 | Common Stock | $5.17 | -$25,850.00 | 0.38 [ Average ] | 114,277 | $590,812.09 | 8.79 [Average] | Form 4 | - | 2021-07-07 | Phillip Pang | Chief Medical Officer | Sell | 3,505 | Common Stock | $40.16 | $140,760.80 | 0.27 [ Low ] | 110,772 | $4,448,603.52 | 8.52 [Average] | Form 4 | - | 2021-07-07 | Phillip Pang | Chief Medical Officer | Sell | 1,495 | Common Stock | $40.91 | $61,160.45 | 0.11 [ Low ] | 109,277 | $4,470,522.07 | 8.40 [Average] | Form 4 | - | 2021-07-13 | Herbert Virgin | EVP, Research & CSO | Buy | 1,375 | Common Stock | $1.53 | -$2,103.75 | 0.11 [ Low ] | 101,075 | $154,644.75 | 7.77 [Average] | Form 4 | - | 2021-07-13 | Herbert Virgin | EVP, Research & CSO | Sell | 1,375 | Common Stock | $36.72 | $50,490.00 | 0.11 [ Low ] | 99,700 | $3,660,984.00 | 7.67 [Average] | Form 4 | - | 2021-07-15 | Robert J More | - | Sell | 11,670 | Common Stock | $35.56 | $414,985.20 | 0.90 [ High ] | 46,029 | $1,636,791.24 | 3.54 [Low] | Form 4 | - | 2021-07-19 | Vicki L Sato | - | Sell | 8,811 | Common Stock | $36.74 | $323,716.14 | 0.68 [ Average ] | 1,633,325 | $60,008,360.50 | 125.60 [Very High] | Form 4 | - | 2021-07-19 | Vicki L Sato | - | Sell | 6,363 | Common Stock | $37.84 | $240,775.92 | 0.49 [ Average ] | 1,626,962 | $61,564,242.08 | 125.11 [Very High] | Form 4 | - | 2021-07-21 | Phillip Pang | Chief Medical Officer | Buy | 4,630 | Common Stock | $1.57 | -$7,269.10 | 0.36 [ Average ] | 113,907 | $178,833.99 | 8.76 [Average] | Form 4 | - | 2021-07-21 | Phillip Pang | Chief Medical Officer | Sell | 4,630 | Common Stock | $37.44 | $173,347.20 | 0.36 [ Average ] | 109,277 | $4,091,330.88 | 8.40 [Average] | Form 4 | - | 2021-07-27 | Herbert Virgin | EVP, Research & CSO | Buy | 1,375 | Common Stock | $1.53 | -$2,103.75 | 0.11 [ Low ] | 101,075 | $154,644.75 | 7.77 [Average] | Form 4 | - | 2021-07-27 | Herbert Virgin | EVP, Research & CSO | Sell | 1,375 | Common Stock | $36.72 | $50,490.00 | 0.11 [ Low ] | 99,700 | $3,660,984.00 | 7.67 [Average] | Form 4 | - | 2021-07-01 | Robert J More | - | Buy | 1,671 | Common Stock | $43.53 | -$72,738.63 | 0.13 [ Low ] | 47,700 | $2,076,381.00 | 3.67 [Low] | Form 4 | - | 2021-07-29 | Robert J More | - | Sell | 9,322 | Common Stock | $36.63 | $341,464.86 | 0.72 [ Average ] | 38,378 | $1,405,786.14 | 2.95 [Low] | Form 4 | - | 2021-07-29 | Robert J More | - | Sell | 2,348 | Common Stock | $37.58 | $88,237.84 | 0.18 [ Low ] | 36,030 | $1,354,007.40 | 2.77 [Low] | Form 4 | - | 2021-08-04 | Phillip Pang | Chief Medical Officer | Buy | 5,000 | Common Stock | $5.17 | -$25,850.00 | 0.38 [ Average ] | 114,277 | $590,812.09 | 8.79 [Average] | Form 4 | - | 2021-08-04 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $34.92 | $174,600.00 | 0.38 [ Average ] | 109,277 | $3,815,952.84 | 8.40 [Average] | Form 4 | - | 2021-08-10 | Herbert Virgin | EVP, Research & CSO | Buy | 1,375 | Common Stock | $1.53 | -$2,103.75 | 0.11 [ Low ] | 101,075 | $154,644.75 | 7.74 [Average] | Form 4 | - | 2021-08-10 | Herbert Virgin | EVP, Research & CSO | Sell | 1,375 | Common Stock | $41.00 | $56,375.00 | 0.11 [ Low ] | 99,700 | $4,087,700.00 | 7.63 [Average] | Form 4 | - | 2021-08-18 | Phillip Pang | Chief Medical Officer | Buy | 5,000 | Common Stock | $1.53 | -$7,650.00 | 0.38 [ Average ] | 114,277 | $174,843.81 | 8.75 [Average] | Form 4 | - | 2021-08-18 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $42.23 | $211,150.00 | 0.38 [ Average ] | 109,277 | $4,614,767.71 | 8.37 [Average] | Form 4 | - | 2021-08-19 | Vicki L Sato | - | Sell | 6,129 | Common Stock | $44.36 | $271,882.44 | 0.47 [ Average ] | 1,620,833 | $71,900,151.88 | 124.10 [Very High] | Form 4 | - | 2021-08-19 | Vicki L Sato | - | Sell | 9,045 | Common Stock | $45.52 | $411,728.40 | 0.69 [ Average ] | 1,611,788 | $73,368,589.76 | 123.40 [Very High] | Form 4 | - | 2021-08-23 | Herbert Virgin | EVP, Research & CSO | Buy | 13,750 | Common Stock | $1.53 | -$21,037.50 | 1.05 [ High ] | 113,450 | $173,578.50 | 8.69 [Average] | Form 4 | - | 2021-08-23 | Herbert Virgin | EVP, Research & CSO | Sell | 13,750 | Common Stock | $50.00 | $687,500.00 | 1.05 [ High ] | 99,700 | $4,985,000.00 | 7.63 [Average] | Form 4 | - | 2021-08-23 | Steven J. Rice | Chief Administrative Officer | Buy | 10,000 | Common Stock | $12.76 | -$127,600.00 | 0.77 [ High ] | 30,000 | $382,800.00 | 2.30 [Low] | Form 4 | - | 2021-08-23 | Steven J. Rice | Chief Administrative Officer | Sell | 10,000 | Common Stock | $50.00 | $500,000.00 | 0.77 [ High ] | 20,000 | $1,000,000.00 | 1.53 [Low] | Form 4 | - | 2021-08-24 | Herbert Virgin | EVP, Research & CSO | Buy | 1,375 | Common Stock | $1.53 | -$2,103.75 | 0.11 [ Low ] | 101,075 | $154,644.75 | 7.74 [Average] | Form 4 | - | 2021-08-24 | Herbert Virgin | EVP, Research & CSO | Sell | 1,375 | Common Stock | $48.00 | $66,000.00 | 0.11 [ Low ] | 99,700 | $4,785,600.00 | 7.63 [Average] | Form 4 | - | 2021-08-25 | Herbert Virgin | EVP, Research & CSO | Buy | 2,750 | Common Stock | $1.53 | -$4,207.50 | 0.21 [ Low ] | 102,450 | $156,748.50 | 7.84 [Average] | Form 4 | - | 2021-08-25 | Herbert Virgin | EVP, Research & CSO | Sell | 2,750 | Common Stock | $50.00 | $137,500.00 | 0.21 [ Low ] | 99,700 | $4,985,000.00 | 7.63 [Average] | Form 4 | - | 2021-08-30 | Janet Napolitano | - | Buy | 1,435 | Common Stock | $41.64 | -$59,753.40 | 0.11 [ Low ] | 4,809 | $200,246.76 | 0.37 [Very Low] | Form 4 | - | 2021-08-30 | Janet Napolitano | - | Sell | 1,435 | Common Stock | $51.15 | $73,400.25 | 0.11 [ Low ] | 3,374 | $172,580.10 | 0.26 [Very Low] | Form 4 | - | 2021-09-01 | Phillip Pang | Chief Medical Officer | Buy | 5,000 | Common Stock | $1.53 | -$7,650.00 | 0.38 [ Average ] | 114,277 | $174,843.81 | 8.75 [Average] | Form 4 | - | 2021-09-01 | Phillip Pang | Chief Medical Officer | Sell | 1,888 | Common Stock | $48.72 | $91,983.36 | 0.14 [ Low ] | 112,389 | $5,475,592.08 | 8.60 [Average] | Form 4 | - | 2021-09-01 | Phillip Pang | Chief Medical Officer | Sell | 1,005 | Common Stock | $49.40 | $49,647.00 | 0.08 [ Very Low ] | 111,384 | $5,502,369.60 | 8.53 [Average] | Form 4 | - | 2021-09-01 | Phillip Pang | Chief Medical Officer | Sell | 2,107 | Common Stock | $50.43 | $106,256.01 | 0.16 [ Low ] | 109,277 | $5,510,839.11 | 8.37 [Average] | Form 4 | - | 2021-09-07 | Herbert Virgin | EVP, Research & CSO | Buy | 4,125 | Common Stock | $1.53 | -$6,311.25 | 0.32 [ Average ] | 103,825 | $158,852.25 | 7.95 [Average] | Form 4 | - | 2021-09-07 | Herbert Virgin | EVP, Research & CSO | Sell | 1,375 | Common Stock | $49.00 | $67,375.00 | 0.11 [ Low ] | 102,450 | $5,020,050.00 | 7.84 [Average] | Form 4 | - | 2021-09-07 | Herbert Virgin | EVP, Research & CSO | Sell | 2,750 | Common Stock | $50.00 | $137,500.00 | 0.21 [ Low ] | 99,700 | $4,985,000.00 | 7.63 [Average] | Form 4 | - | 2021-09-15 | Phillip Pang | Chief Medical Officer | Sell | 4,280 | Common Stock | $49.58 | $212,202.40 | 0.33 [ Average ] | 104,997 | $5,205,751.26 | 8.04 [Average] | Form 4 | - | 2021-09-15 | Phillip Pang | Chief Medical Officer | Sell | 720 | Common Stock | $50.36 | $36,259.20 | 0.06 [ Very Low ] | 104,277 | $5,251,389.72 | 7.98 [Average] | Form 4 | - | 2021-09-17 | Vicki L Sato | - | Sell | 11,775 | Common Stock | $52.31 | $615,950.25 | 0.90 [ High ] | 1,600,013 | $83,696,680.03 | 122.50 [Very High] | Form 4 | - | 2021-09-17 | Vicki L Sato | - | Sell | 3,399 | Common Stock | $53.06 | $180,350.94 | 0.26 [ Low ] | 1,596,614 | $84,716,338.84 | 122.24 [Very High] | Form 4 | - | 2021-09-21 | Herbert Virgin | EVP, Research & CSO | Buy | 4,125 | Common Stock | $1.53 | -$6,311.25 | 0.32 [ Average ] | 103,825 | $158,852.25 | 7.95 [Average] | Form 4 | - | 2021-09-21 | Herbert Virgin | EVP, Research & CSO | Sell | 4,125 | Common Stock | $50.00 | $206,250.00 | 0.32 [ Average ] | 99,700 | $4,985,000.00 | 7.63 [Average] | Form 4 | - | 2021-09-22 | Herbert Virgin | EVP, Research & CSO | Buy | 8,000 | Common Stock | $1.53 | -$12,240.00 | 0.61 [ Average ] | 107,700 | $164,781.00 | 8.25 [Average] | Form 4 | - | 2021-09-27 | Phillip Pang | Chief Medical Officer | Buy | 5,000 | Common Stock | $0.85 | -$4,250.00 | 0.38 [ Average ] | 109,277 | $92,885.45 | 8.37 [Average] | Form 4 | - | 2021-10-05 | Herbert Virgin | EVP, Research & CSO | Buy | 1,375 | Common Stock | $1.53 | -$2,103.75 | 0.11 [ Low ] | 109,075 | $166,884.75 | 8.35 [Average] | Form 4 | - | 2021-10-05 | Herbert Virgin | EVP, Research & CSO | Sell | 1,375 | Common Stock | $33.75 | $46,406.25 | 0.11 [ Low ] | 107,700 | $3,634,875.00 | 8.25 [Average] | Form 4 | - | 2021-10-06 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $34.56 | $172,800.00 | 0.38 [ Average ] | 104,277 | $3,603,813.12 | 7.98 [Average] | Form 4 | - | 2021-10-19 | Vicki L Sato | - | Sell | 6,671 | Common Stock | $39.12 | $260,969.52 | 0.51 [ Average ] | 1,589,943 | $62,198,570.16 | 121.73 [Very High] | Form 4 | - | 2021-10-19 | Vicki L Sato | - | Sell | 8,503 | Common Stock | $39.91 | $339,354.73 | 0.65 [ Average ] | 1,581,440 | $63,115,270.40 | 121.08 [Very High] | Form 4 | - | 2021-10-19 | Herbert Virgin | EVP, Research & CSO | Buy | 1,375 | Common Stock | $1.53 | -$2,103.75 | 0.11 [ Low ] | 109,075 | $166,884.75 | 8.35 [Average] | Form 4 | - | 2021-10-19 | Herbert Virgin | EVP, Research & CSO | Sell | 1,375 | Common Stock | $38.87 | $53,446.25 | 0.11 [ Low ] | 107,700 | $4,186,299.00 | 8.25 [Average] | Form 4 | - | 2021-10-20 | Phillip Pang | Chief Medical Officer | Sell | 4,000 | Common Stock | $39.65 | $158,600.00 | 0.31 [ Average ] | 100,277 | $3,975,983.05 | 7.68 [Average] | Form 4 | - | 2021-11-02 | Herbert Virgin | EVP, Research & CSO | Buy | 1,375 | Common Stock | $1.53 | -$2,103.75 | 0.11 [ Low ] | 109,075 | $166,884.75 | 8.35 [Average] | Form 4 | - | 2021-11-02 | Herbert Virgin | EVP, Research & CSO | Sell | 1,375 | Common Stock | $36.94 | $50,792.50 | 0.11 [ Low ] | 107,700 | $3,978,438.00 | 8.25 [Average] | Form 4 | - | 2021-11-03 | Phillip Pang | Chief Medical Officer | Buy | 5,000 | Common Stock | $5.17 | -$25,850.00 | 0.38 [ Average ] | 105,277 | $544,282.09 | 8.06 [Average] | Form 4 | - | 2021-11-03 | Phillip Pang | Chief Medical Officer | Sell | 5,000 | Common Stock | $36.47 | $182,350.00 | 0.38 [ Average ] | 100,277 | $3,657,102.19 | 7.68 [Average] | Form 4 | - | 2021-11-16 | Herbert Virgin | EVP, Research & CSO | Buy | 1,375 | Common Stock | $1.53 | -$2,103.75 | 0.11 [ Low ] | 109,075 | $166,884.75 | 8.33 [Average] | Form 4 | - | 2021-11-16 | Herbert Virgin | EVP, Research & CSO | Sell | 1,375 | Common Stock | $32.67 | $44,921.25 | 0.11 [ Low ] | 107,700 | $3,518,559.00 | 8.23 [Average] | Form 4 | - | 2021-11-17 | Phillip Pang | Chief Medical Officer | Buy | 5,000 | Common Stock | $5.17 | -$25,850.00 | 0.38 [ Average ] | 105,277 | $544,282.09 | 8.04 [Average] | Form 4 | - | 2021-11-17 | Phillip Pang | Chief Medical Officer | Sell | 4,535 | Common Stock | $35.75 | $162,126.25 | 0.35 [ Average ] | 100,742 | $3,601,526.50 | 7.70 [Average] | Form 4 | - | 2021-11-17 | Phillip Pang | Chief Medical Officer | Sell | 465 | Common Stock | $36.80 | $17,112.00 | 0.04 [ Very Low ] | 100,277 | $3,690,193.60 | 7.66 [Average] | Form 4 | - | 2021-11-22 | Arch Venture Partners Ix, Llc | - | Sell | 217,781 | Common Stock | $0.00 | $0.00 | - | 9,219,394 | $0.00 | 704.42 [Very High] | Form 4 | See footnote | 2021-11-22 | Arch Venture Partners Ix, Llc | - | Sell | 282,219 | Common Stock | $0.00 | $0.00 | - | 11,947,269 | $0.00 | 912.84 [Very High] | Form 4 | See footnote | 2021-11-22 | Arch Venture Partners Ix, Llc | - | Buy | 13,057 | Common Stock | $0.00 | $0.00 | - | 57,298 | $0.00 | 4.38 [Low] | Form 4 | - | 2021-11-22 | Arch Venture Partners Ix, Llc | - | Buy | 4,428 | Common Stock | $0.00 | $0.00 | - | 18,657 | $0.00 | 1.43 [Low] | Form 4 | - | 2021-11-22 | Robert Nelsen | - | Sell | 217,781 | Common Stock | $0.00 | $0.00 | - | 9,219,394 | $0.00 | 704.42 [Very High] | Form 4 | See footnote | 2021-11-22 | Robert Nelsen | - | Sell | 282,219 | Common Stock | $0.00 | $0.00 | - | 11,947,269 | $0.00 | 912.84 [Very High] | Form 4 | See footnote | 2021-11-22 | Robert Nelsen | - | Buy | 29,153 | Common Stock | $0.00 | $0.00 | - | 112,978 | $0.00 | 8.63 [Average] | Form 4 | - | 2021-11-26 | Vicki L Sato | - | Sell | 15,174 | Common Stock | $36.80 | $558,403.20 | 1.16 [ High ] | 1,566,266 | $57,638,588.80 | 119.67 [Very High] | Form 4 | - | 2021-11-29 | Arch Venture Partners Ix, Llc | - | Sell | 217,781 | Common Stock | $0.00 | $0.00 | - | 9,001,613 | $0.00 | 687.78 [Very High] | Form 4 | See footnote | 2021-11-29 | Arch Venture Partners Ix, Llc | - | Sell | 282,219 | Common Stock | $0.00 | $0.00 | - | 11,665,050 | $0.00 | 891.28 [Very High] | Form 4 | See footnote | 2021-11-29 | Arch Venture Partners Ix, Llc | - | Buy | 13,057 | Common Stock | $0.00 | $0.00 | - | 70,355 | $0.00 | 5.38 [Average] | Form 4 | - | 2021-11-29 | Arch Venture Partners Ix, Llc | - | Buy | 4,428 | Common Stock | $0.00 | $0.00 | - | 23,085 | $0.00 | 1.76 [Low] | Form 4 | - | 2021-11-29 | Robert Nelsen | - | Sell | 217,781 | Common Stock | $0.00 | $0.00 | - | 9,001,613 | $0.00 | 687.78 [Very High] | Form 4 | See footnote | 2021-11-29 | Robert Nelsen | - | Sell | 282,219 | Common Stock | $0.00 | $0.00 | - | 11,665,050 | $0.00 | 891.28 [Very High] | Form 4 | See footnote | 2021-11-29 | Robert Nelsen | - | Buy | 29,153 | Common Stock | $0.00 | $0.00 | - | 142,131 | $0.00 | 10.86 [Average] | Form 4 | - | 2021-11-29 | Ann M. Hanly | Chief Technology Officer | Buy | 12 | Common Stock | $43.39 | -$499.85 | - | 12 | $499.85 | - | Form 4 | See footnote | 2021-11-30 | Janet Napolitano | - | Buy | 1,435 | Common Stock | $41.64 | -$59,753.40 | 0.11 [ Low ] | 4,809 | $200,246.76 | 0.37 [Very Low] | Form 4 | - | 2021-11-30 | Janet Napolitano | - | Sell | 1,435 | Common Stock | $46.25 | $66,368.75 | 0.11 [ Low ] | 3,374 | $156,047.50 | 0.26 [Very Low] | Form 4 | - | 2021-11-30 | Steven J. Rice | Chief Administrative Officer | Buy | 10,000 | Common Stock | $12.76 | -$127,600.00 | 0.76 [ Average ] | 30,600 | $390,456.00 | 2.34 [Low] | Form 4 | - | 2021-11-30 | Steven J. Rice | Chief Administrative Officer | Sell | 10,000 | Common Stock | $50.00 | $500,000.00 | 0.76 [ Average ] | 20,600 | $1,030,000.00 | 1.57 [Low] | Form 4 | - | 2021-11-30 | Herbert Virgin | EVP, Research & CSO | Buy | 15,125 | Common Stock | $1.53 | -$23,141.25 | 1.16 [ High ] | 122,825 | $187,922.25 | 9.38 [Average] | Form 4 | - | 2021-11-30 | Herbert Virgin | EVP, Research & CSO | Sell | 1,375 | Common Stock | $45.60 | $62,700.00 | 0.11 [ Low ] | 121,450 | $5,538,120.00 | 9.28 [Average] | Form 4 | - | 2021-11-30 | Herbert Virgin | EVP, Research & CSO | Sell | 13,750 | Common Stock | $50.00 | $687,500.00 | 1.05 [ High ] | 107,700 | $5,385,000.00 | 8.23 [Average] | Form 4 | - | 2021-12-01 | Phillip Pang | Chief Medical Officer | Sell | 950 | Common Stock | $41.82 | $39,729.00 | 0.07 [ Very Low ] | 99,327 | $4,153,855.14 | 7.59 [Average] | Form 4 | - | 2021-12-01 | Phillip Pang | Chief Medical Officer | Sell | 4,409 | Common Stock | $43.46 | $191,615.14 | 0.34 [ Average ] | 94,918 | $4,125,136.28 | 7.25 [Average] | Form 4 | - | 2021-12-01 | Phillip Pang | Chief Medical Officer | Sell | 2,050 | Common Stock | $44.10 | $90,405.00 | 0.16 [ Low ] | 92,868 | $4,095,478.80 | 7.10 [Average] | Form 4 | - | 2021-12-01 | Phillip Pang | Chief Medical Officer | Sell | 91 | Common Stock | $44.97 | $4,092.27 | - | 92,777 | $4,172,181.69 | 7.09 [Average] | Form 4 | - |
